JP2013542195A5 - - Google Patents
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- JP2013542195A5 JP2013542195A5 JP2013530396A JP2013530396A JP2013542195A5 JP 2013542195 A5 JP2013542195 A5 JP 2013542195A5 JP 2013530396 A JP2013530396 A JP 2013530396A JP 2013530396 A JP2013530396 A JP 2013530396A JP 2013542195 A5 JP2013542195 A5 JP 2013542195A5
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- 239000000203 mixture Substances 0.000 claims description 49
- 230000001225 therapeutic effect Effects 0.000 claims description 26
- 238000000034 method Methods 0.000 claims description 22
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 14
- 239000008103 glucose Substances 0.000 claims description 14
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims description 14
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims description 12
- 229930182817 methionine Natural products 0.000 claims description 12
- 206010003694 Atrophy Diseases 0.000 claims description 11
- 230000037444 atrophy Effects 0.000 claims description 11
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims description 8
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 8
- 238000002512 chemotherapy Methods 0.000 claims description 6
- 230000005855 radiation Effects 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 229940127089 cytotoxic agent Drugs 0.000 claims description 5
- 239000002254 cytotoxic agent Substances 0.000 claims description 5
- 231100000599 cytotoxic agent Toxicity 0.000 claims description 5
- 210000000813 small intestine Anatomy 0.000 claims description 5
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims description 4
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 claims description 4
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 4
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims description 4
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims description 4
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims description 4
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims description 4
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims description 4
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims description 4
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims description 4
- 235000001014 amino acid Nutrition 0.000 claims description 4
- 229940024606 amino acid Drugs 0.000 claims description 4
- 150000001413 amino acids Chemical class 0.000 claims description 4
- 229960001230 asparagine Drugs 0.000 claims description 4
- 235000009582 asparagine Nutrition 0.000 claims description 4
- 235000003704 aspartic acid Nutrition 0.000 claims description 4
- 229960005261 aspartic acid Drugs 0.000 claims description 4
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims description 4
- 239000003792 electrolyte Substances 0.000 claims description 4
- 229960002949 fluorouracil Drugs 0.000 claims description 4
- 229960000310 isoleucine Drugs 0.000 claims description 4
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims description 4
- GLVAUDGFNGKCSF-UHFFFAOYSA-N mercaptopurine Chemical compound S=C1NC=NC2=C1NC=N2 GLVAUDGFNGKCSF-UHFFFAOYSA-N 0.000 claims description 4
- 239000000843 powder Substances 0.000 claims description 4
- 238000002661 proton therapy Methods 0.000 claims description 4
- WYWHKKSPHMUBEB-UHFFFAOYSA-N tioguanine Chemical compound N1C(N)=NC(=S)C2=C1N=CN2 WYWHKKSPHMUBEB-UHFFFAOYSA-N 0.000 claims description 4
- 229960004799 tryptophan Drugs 0.000 claims description 4
- 238000010521 absorption reaction Methods 0.000 claims description 3
- 230000006378 damage Effects 0.000 claims description 3
- 210000002490 intestinal epithelial cell Anatomy 0.000 claims description 3
- 230000007413 intestinal health Effects 0.000 claims description 3
- VSNHCAURESNICA-NJFSPNSNSA-N 1-oxidanylurea Chemical compound N[14C](=O)NO VSNHCAURESNICA-NJFSPNSNSA-N 0.000 claims description 2
- 206010009900 Colitis ulcerative Diseases 0.000 claims description 2
- 208000011231 Crohn disease Diseases 0.000 claims description 2
- 108010016626 Dipeptides Proteins 0.000 claims description 2
- 208000004232 Enteritis Diseases 0.000 claims description 2
- 239000004471 Glycine Substances 0.000 claims description 2
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims description 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims description 2
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims description 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 2
- 239000004472 Lysine Substances 0.000 claims description 2
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims description 2
- 239000004473 Threonine Substances 0.000 claims description 2
- 201000006704 Ulcerative Colitis Diseases 0.000 claims description 2
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims description 2
- 238000012084 abdominal surgery Methods 0.000 claims description 2
- 150000008209 arabinosides Chemical class 0.000 claims description 2
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims description 2
- 229960004316 cisplatin Drugs 0.000 claims description 2
- 150000002016 disaccharides Chemical class 0.000 claims description 2
- 201000010099 disease Diseases 0.000 claims description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 2
- 208000000718 duodenal ulcer Diseases 0.000 claims description 2
- VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 claims description 2
- 229960005420 etoposide Drugs 0.000 claims description 2
- 239000000796 flavoring agent Substances 0.000 claims description 2
- 229960000390 fludarabine Drugs 0.000 claims description 2
- GIUYCYHIANZCFB-FJFJXFQQSA-N fludarabine phosphate Chemical compound C1=NC=2C(N)=NC(F)=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O GIUYCYHIANZCFB-FJFJXFQQSA-N 0.000 claims description 2
- 235000013355 food flavoring agent Nutrition 0.000 claims description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 2
- 229960001428 mercaptopurine Drugs 0.000 claims description 2
- 239000011707 mineral Substances 0.000 claims description 2
- 150000002772 monosaccharides Chemical class 0.000 claims description 2
- 230000001737 promoting effect Effects 0.000 claims description 2
- 150000003431 steroids Chemical class 0.000 claims description 2
- 229960003087 tioguanine Drugs 0.000 claims description 2
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims description 2
- 239000004474 valine Substances 0.000 claims description 2
- 235000013343 vitamin Nutrition 0.000 claims description 2
- 239000011782 vitamin Substances 0.000 claims description 2
- 229940088594 vitamin Drugs 0.000 claims description 2
- 229930003231 vitamin Natural products 0.000 claims description 2
- 150000003722 vitamin derivatives Chemical class 0.000 claims description 2
- 231100000433 cytotoxic Toxicity 0.000 claims 1
- 230000001472 cytotoxic effect Effects 0.000 claims 1
- 230000036541 health Effects 0.000 claims 1
- 230000000968 intestinal effect Effects 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 239000004615 ingredient Substances 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 235000007882 dietary composition Nutrition 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38631710P | 2010-09-24 | 2010-09-24 | |
| US61/386,317 | 2010-09-24 | ||
| US201161431629P | 2011-01-11 | 2011-01-11 | |
| US61/431,629 | 2011-01-11 | ||
| PCT/US2011/053265 WO2012040707A2 (en) | 2010-09-24 | 2011-09-26 | Materials and methods for improving gastrointestinal function |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016167829A Division JP6425356B2 (ja) | 2010-09-24 | 2016-08-30 | 胃腸機能を改善するための材料および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013542195A JP2013542195A (ja) | 2013-11-21 |
| JP2013542195A5 true JP2013542195A5 (enExample) | 2014-12-04 |
| JP6000253B2 JP6000253B2 (ja) | 2016-09-28 |
Family
ID=45871248
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013530396A Active JP6000253B2 (ja) | 2010-09-24 | 2011-09-26 | 胃腸機能を改善するための材料および方法 |
| JP2016167829A Active JP6425356B2 (ja) | 2010-09-24 | 2016-08-30 | 胃腸機能を改善するための材料および方法 |
| JP2018187236A Active JP6698777B2 (ja) | 2010-09-24 | 2018-10-02 | 胃腸機能を改善するための材料および方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016167829A Active JP6425356B2 (ja) | 2010-09-24 | 2016-08-30 | 胃腸機能を改善するための材料および方法 |
| JP2018187236A Active JP6698777B2 (ja) | 2010-09-24 | 2018-10-02 | 胃腸機能を改善するための材料および方法 |
Country Status (17)
| Country | Link |
|---|---|
| US (7) | US8993522B2 (enExample) |
| EP (5) | EP2624825B1 (enExample) |
| JP (3) | JP6000253B2 (enExample) |
| KR (4) | KR102205124B1 (enExample) |
| CN (2) | CN105663106A (enExample) |
| AP (1) | AP2013006826A0 (enExample) |
| AU (2) | AU2011305124B2 (enExample) |
| BR (1) | BR112013006044B1 (enExample) |
| CA (1) | CA2809489C (enExample) |
| EA (1) | EA030970B8 (enExample) |
| ES (2) | ES2639888T3 (enExample) |
| IL (1) | IL277166B (enExample) |
| MX (2) | MX2013003282A (enExample) |
| NZ (1) | NZ607189A (enExample) |
| PH (1) | PH12013500441A1 (enExample) |
| SG (1) | SG188293A1 (enExample) |
| WO (1) | WO2012040707A2 (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP6000253B2 (ja) | 2010-09-24 | 2016-09-28 | ユニバーシティ オブ フロリダ リサーチ ファンデーション インコーポレーティッド | 胃腸機能を改善するための材料および方法 |
| BR112013018469B1 (pt) * | 2011-01-19 | 2022-03-03 | Fractyl Health, Inc | Dispositivos e métodos para tratamento de tecidos |
| AU2013216871B2 (en) | 2012-02-08 | 2017-08-17 | University Of Florida Research Foundation, Inc. | Materials and methods for treating diarrhea |
| CN110522744B (zh) * | 2013-03-11 | 2023-04-07 | 佛罗里达大学研究基金会有限公司 | 用于改善肺功能和用于预防和/或治疗辐射诱发的肺并发症的材料和方法 |
| EP3049151B1 (en) | 2013-09-27 | 2019-12-25 | Mevion Medical Systems, Inc. | Particle beam scanning |
| US10675487B2 (en) | 2013-12-20 | 2020-06-09 | Mevion Medical Systems, Inc. | Energy degrader enabling high-speed energy switching |
| US9962560B2 (en) | 2013-12-20 | 2018-05-08 | Mevion Medical Systems, Inc. | Collimator and energy degrader |
| US9661736B2 (en) | 2014-02-20 | 2017-05-23 | Mevion Medical Systems, Inc. | Scanning system for a particle therapy system |
| WO2016085735A1 (en) | 2014-11-24 | 2016-06-02 | Entrinsic Health Solutions, Llc | Amino acid compositions for the treatment of symptoms of disease |
| EP3254115A4 (en) * | 2015-02-05 | 2018-06-20 | University of Florida Research Foundation, Inc. | Use of nhe3 as biomarker for radiation biodosimetry |
| US20160339086A1 (en) * | 2015-05-19 | 2016-11-24 | Suzy Cohen | Compositions and methods for treating thyroid disease |
| US10786689B2 (en) | 2015-11-10 | 2020-09-29 | Mevion Medical Systems, Inc. | Adaptive aperture |
| CN105685973B (zh) * | 2016-02-04 | 2018-08-24 | 中山大学附属第六医院 | 一种肠内营养剂 |
| US10702590B2 (en) | 2016-04-12 | 2020-07-07 | Script Essentials, Llc | Compositions and methods for treating thyroid disease |
| EP3481503B1 (en) | 2016-07-08 | 2021-04-21 | Mevion Medical Systems, Inc. | Treatment planning |
| EP3494968A4 (en) * | 2016-08-05 | 2020-04-15 | The University Of Tokyo | COMPOSITION FOR USE IN TREATING T-CELL LEUKEMIA / LYMPHOMA IN ADULTS AND METHOD FOR THE PRODUCTION THEREOF |
| JP7267546B2 (ja) | 2016-10-04 | 2023-05-02 | ユニバーシティ オブ フロリダ リサーチ ファンデーション インコーポレーティッド | アミノ酸組成物及びその使用 |
| US11103730B2 (en) | 2017-02-23 | 2021-08-31 | Mevion Medical Systems, Inc. | Automated treatment in particle therapy |
| WO2019006253A1 (en) | 2017-06-30 | 2019-01-03 | Mevion Medical Systems, Inc. | CONFIGURABLE COLLIMATOR CONTROLLED BY LINEAR MOTORS |
| WO2019070753A1 (en) * | 2017-10-02 | 2019-04-11 | University Of Florida Research Foundation, Incorporated | AMINO ACID COMPOSITIONS AND METHODS FOR TREATING DIARRHEA |
| EP3691628A1 (en) | 2017-10-02 | 2020-08-12 | University of Florida Research Foundation, Incorporated | Materials and methods for inhibiting tumor growth |
| EP3773539A4 (en) * | 2018-04-04 | 2022-05-18 | University of Florida Research Foundation, Incorporated | COMPOSITIONS FOR THE TREATMENT OF THE SKIN |
| CN109601761A (zh) * | 2018-11-01 | 2019-04-12 | 山东大学 | 一种大菱鲆肠炎病的营养性修复剂 |
| US11291861B2 (en) | 2019-03-08 | 2022-04-05 | Mevion Medical Systems, Inc. | Delivery of radiation by column and generating a treatment plan therefor |
| EP3958855A4 (en) * | 2019-04-26 | 2023-01-18 | Increvet, Inc. | METHODS FOR REDUCING WEIGHT LOSS OR INCREASING WEIGHT OF A FELINE IN NEED |
| RU2699222C1 (ru) * | 2019-04-29 | 2019-09-04 | Алексей Владимирович Воронов | Солевой электролитный раствор для проведения энтеральных инфузий |
| PH12021553125A1 (en) * | 2019-06-14 | 2022-08-01 | Cj Cheiljedang Corp | Composition for preventing, treating, or improving gastrointestinal diseases comprising strain of genus corynebacterium and culture thereof |
| WO2021096479A1 (en) * | 2019-11-11 | 2021-05-20 | Trim-Edicine, Inc. | Treatment for inflammatory bowel disease and radiation-induced intestinal injury |
| IT202000000442A1 (it) | 2020-01-13 | 2021-07-13 | Professional Dietetics Spa | Composizioni comprendenti amino acidi per l'uso nella prevenzione e nel trattamento di effetti collaterali della chemioterapia |
| CN115916185B (zh) * | 2020-06-02 | 2025-09-26 | 佛罗里达大学研究基金会公司 | 用于治疗腹泻的制剂和方法 |
| WO2022006397A1 (en) * | 2020-07-02 | 2022-01-06 | University Of Florida Research Foundation, Incorporated | Formulations for promoting hydration and methods of use thereof |
| IT202200013354A1 (it) * | 2022-06-23 | 2023-12-23 | Professional Dietetics Spa | Composizioni comprendenti amminoacidi per l'uso nella prevenzione e/o nel trattamento di malattie intestinali |
| US11878073B1 (en) | 2022-09-20 | 2024-01-23 | Entrinsic, LLC | Generation of hydration-targeted formulations and methods of use therein |
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