JP2013541503A5 - - Google Patents
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- Publication number
- JP2013541503A5 JP2013541503A5 JP2013523380A JP2013523380A JP2013541503A5 JP 2013541503 A5 JP2013541503 A5 JP 2013541503A5 JP 2013523380 A JP2013523380 A JP 2013523380A JP 2013523380 A JP2013523380 A JP 2013523380A JP 2013541503 A5 JP2013541503 A5 JP 2013541503A5
- Authority
- JP
- Japan
- Prior art keywords
- aryl
- alkyl
- pharmaceutical composition
- heterocycle
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000003118 aryl group Chemical group 0.000 claims 46
- 239000008194 pharmaceutical composition Substances 0.000 claims 42
- 125000000217 alkyl group Chemical group 0.000 claims 35
- 125000000623 heterocyclic group Chemical group 0.000 claims 34
- 125000004450 alkenylene group Chemical group 0.000 claims 16
- 125000004419 alkynylene group Chemical group 0.000 claims 16
- 229910052736 halogen Inorganic materials 0.000 claims 16
- 150000002367 halogens Chemical group 0.000 claims 16
- 125000006832 (C1-C10) alkylene group Chemical group 0.000 claims 15
- 229910052739 hydrogen Inorganic materials 0.000 claims 13
- 239000001257 hydrogen Substances 0.000 claims 11
- 229910052731 fluorine Inorganic materials 0.000 claims 10
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 9
- 229910052801 chlorine Inorganic materials 0.000 claims 9
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 claims 8
- 125000005865 C2-C10alkynyl group Chemical group 0.000 claims 8
- 229910052794 bromium Inorganic materials 0.000 claims 7
- 150000008267 fucoses Chemical class 0.000 claims 7
- 229910052740 iodine Inorganic materials 0.000 claims 6
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 6
- 241000124008 Mammalia Species 0.000 claims 5
- 150000001323 aldoses Chemical class 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 239000012453 solvate Substances 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- 125000006575 electron-withdrawing group Chemical group 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- -1 benzyloxymethyl Chemical group 0.000 claims 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 230000033581 fucosylation Effects 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 125000005103 alkyl silyl group Chemical group 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 230000000890 antigenic effect Effects 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 150000001540 azides Chemical class 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 230000002163 immunogen Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- ARYZCSRUUPFYMY-UHFFFAOYSA-N methoxysilane Chemical compound CO[SiH3] ARYZCSRUUPFYMY-UHFFFAOYSA-N 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 0 *C1[C@@](*)C(*)O[C@@](*)C1* Chemical compound *C1[C@@](*)C(*)O[C@@](*)C1* 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37111610P | 2010-08-05 | 2010-08-05 | |
| US61/371,116 | 2010-08-05 | ||
| PCT/US2011/046857 WO2012019165A2 (en) | 2010-08-05 | 2011-08-05 | Methods of inhibition of protein fucosylation in vivo using fucose analogs |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016076930A Division JP6113887B2 (ja) | 2010-08-05 | 2016-04-07 | フコースアナログを用いるイン・ビボでのタンパク質フコシル化の阻害方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013541503A JP2013541503A (ja) | 2013-11-14 |
| JP2013541503A5 true JP2013541503A5 (enExample) | 2014-09-25 |
| JP5918235B2 JP5918235B2 (ja) | 2016-05-18 |
Family
ID=45560106
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013523380A Active JP5918235B2 (ja) | 2010-08-05 | 2011-08-05 | フコースアナログを用いるイン・ビボでのタンパク質フコシル化の阻害方法 |
| JP2016076930A Active JP6113887B2 (ja) | 2010-08-05 | 2016-04-07 | フコースアナログを用いるイン・ビボでのタンパク質フコシル化の阻害方法 |
| JP2017049534A Active JP6622238B2 (ja) | 2010-08-05 | 2017-03-15 | フコースアナログを用いるイン・ビボでのタンパク質フコシル化の阻害方法 |
| JP2019210313A Pending JP2020040974A (ja) | 2010-08-05 | 2019-11-21 | フコースアナログを用いるイン・ビボでのタンパク質フコシル化の阻害方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016076930A Active JP6113887B2 (ja) | 2010-08-05 | 2016-04-07 | フコースアナログを用いるイン・ビボでのタンパク質フコシル化の阻害方法 |
| JP2017049534A Active JP6622238B2 (ja) | 2010-08-05 | 2017-03-15 | フコースアナログを用いるイン・ビボでのタンパク質フコシル化の阻害方法 |
| JP2019210313A Pending JP2020040974A (ja) | 2010-08-05 | 2019-11-21 | フコースアナログを用いるイン・ビボでのタンパク質フコシル化の阻害方法 |
Country Status (21)
| Country | Link |
|---|---|
| US (4) | US9504702B2 (enExample) |
| EP (2) | EP3513794A3 (enExample) |
| JP (4) | JP5918235B2 (enExample) |
| KR (2) | KR101950520B1 (enExample) |
| CN (2) | CN103402525B (enExample) |
| AU (3) | AU2011285490B2 (enExample) |
| CA (1) | CA2803388C (enExample) |
| CY (1) | CY1121419T1 (enExample) |
| DK (1) | DK2608796T3 (enExample) |
| ES (1) | ES2711622T3 (enExample) |
| HU (1) | HUE043370T2 (enExample) |
| IL (2) | IL224487A (enExample) |
| MX (1) | MX356671B (enExample) |
| NZ (1) | NZ606250A (enExample) |
| PL (1) | PL2608796T3 (enExample) |
| PT (1) | PT2608796T (enExample) |
| RU (2) | RU2017122482A (enExample) |
| SI (1) | SI2608796T1 (enExample) |
| TR (1) | TR201902439T4 (enExample) |
| WO (1) | WO2012019165A2 (enExample) |
| ZA (1) | ZA201300653B (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2282773B2 (en) | 2008-05-02 | 2025-03-05 | Seagen Inc. | Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation |
| PL2608796T3 (pl) * | 2010-08-05 | 2019-04-30 | Seattle Genetics Inc | Hamowanie fukozylacji białka w warunkach in vivo za pomocą analogów fukozy |
| CA2882725C (en) | 2012-08-23 | 2021-03-09 | Regents Of The University Of Minnesota | Treatment of sickle cell disease and inflammatory conditions |
| EP2958905B1 (en) | 2013-02-22 | 2017-03-29 | Amgen Inc. | Carbohydrate phosphonate derivatives as modulators of glycosylation |
| CN106699886A (zh) * | 2015-07-13 | 2017-05-24 | 西藏海思科药业集团股份有限公司 | 抗体依赖性细胞介导的细胞毒性(adcc)增强的奥法木抗体 |
| JP6906520B2 (ja) | 2015-12-04 | 2021-07-21 | シージェン インコーポレイテッド | チェックポイント阻害剤と組みわせて２−デオキシ−２−フルオロ−ｌ−フコースを用いる癌治療 |
| ES2908067T3 (es) * | 2016-05-10 | 2022-04-27 | Ares Trading Sa | Métodos para modular los perfiles de galactosilación proteicos de proteínas recombinantes empleando peracetil galactosa |
| JP2018002666A (ja) * | 2016-07-04 | 2018-01-11 | 国立研究開発法人理化学研究所 | フコース類似体と糖を検出する方法 |
| KR102687149B1 (ko) | 2017-06-07 | 2024-07-24 | 씨젠 인크. | 감소된 표면 푸코실화를 갖는 t 세포 및 이를 생산하고 사용하는 방법 |
| WO2019108639A1 (en) | 2017-12-01 | 2019-06-06 | Pfizer Inc. | Anti-cxcr5 antibodies and compositions and uses thereof |
| MY206031A (en) | 2018-03-29 | 2024-11-26 | Pfizer | Lfa3 variants and compositions and uses thereof |
| AU2019324170A1 (en) | 2018-08-23 | 2021-02-18 | Seagen, Inc. | Anti-TIGIT antibodies |
| JP7446587B2 (ja) * | 2018-12-27 | 2024-03-12 | 慶應義塾 | 抗ヒトノロウイルス剤 |
| CN114761427B (zh) * | 2019-12-19 | 2025-10-03 | 默克专利股份公司 | 用于调节蛋白质的糖基化谱的方法和组合物 |
| TWI877278B (zh) * | 2019-12-30 | 2025-03-21 | 美商思進公司 | 以非海藻糖苷化抗－ｃｄ７０抗體治療癌症之方法 |
| IL272389A (en) | 2020-01-30 | 2021-08-31 | Yeda Res & Dev | Kits containing antibodies to PD-L1 and their uses in therapy |
| KR20230047357A (ko) * | 2020-06-03 | 2023-04-07 | 시몬 프레이저 유니버스티 | 단백질 푸코실화 억제제 및 이의 용도 |
| KR20230158005A (ko) | 2021-03-18 | 2023-11-17 | 씨젠 인크. | 생물학적 활성 화합물의 내재화된 접합체로부터의 선택적 약물 방출 |
| MX2023014515A (es) | 2021-06-07 | 2024-01-29 | Amgen Inc | Uso de fucosidasa para controlar el nivel de afucosilacion de proteinas glucosiladas. |
| CN113413465B (zh) * | 2021-06-15 | 2022-06-03 | 北京大学 | 岩藻糖基化抑制剂在抗癌导致炎症中的应用 |
| US12116382B2 (en) | 2022-11-28 | 2024-10-15 | Hongene Biotech Corporation | Functionalized N-acetylgalactosamine analogs |
| WO2024191807A1 (en) | 2023-03-10 | 2024-09-19 | Seagen Inc. | Methods of treating cancer with anti-tigit antibodies |
Family Cites Families (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4440780A (en) | 1979-06-01 | 1984-04-03 | Chevron Research Company | Fungicidal 3-(N-acyl-N-arylamino)-and 3-(N-thionoacyl-N-arylamino)-gamma-butyrolactones and gamma-thiobutyrolactones |
| JPH0660189B2 (ja) | 1986-01-22 | 1994-08-10 | 財団法人微生物化学研究会 | ２，６−ジデオキシ−２−フルオロ−ｌ−タロピラノ−ス又はその誘導体とその製造法 |
| FR2630914A1 (fr) | 1988-05-04 | 1989-11-10 | Hoechst Sa Laboratoires | Nouveaux analogues du l-fucose, leur procede de preparation, application de ces analogues a la preparation de nouveaux glycals, anthracyclines obtenues a l'aide de ces glycals et utilisation desdites anthracyclines en tant que medicaments |
| KR100211417B1 (ko) | 1990-11-30 | 1999-10-01 | 유충식 | L-탈로피라노시드 유도체 및 그의 제조방법 |
| US5461143A (en) | 1991-03-18 | 1995-10-24 | The Scripps Research Institute | Oligosaccharide enzyme substrates and inhibitors: methods and compositions |
| US5210078A (en) | 1991-04-30 | 1993-05-11 | The Biomembrane Institute | Trifluoromethyl analogs of fucose and uses thereof |
| ATE174925T1 (de) | 1991-10-15 | 1999-01-15 | Scripps Research Inst | Herstellung von fucosylierten kohlenhydraten durch enzymatische fucosylierungs-synthese der zuckernukleotide; und in situ regeneration von gdp-fucose |
| DE69425439D1 (de) | 1993-09-29 | 2000-09-07 | Nissin Food Products Ltd | In stellung 21 substituierte steroide |
| US5481143A (en) | 1993-11-15 | 1996-01-02 | Burdick; Brian K. | Self starting brushless d.c. motor |
| FR2723947B1 (fr) | 1994-08-31 | 1996-09-27 | Adir | Nouveaux composes tetrahydropyraniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| DE19524515A1 (de) | 1995-07-05 | 1997-01-09 | Deutsches Krebsforsch | Saccharid-Konjugate |
| US6713287B1 (en) | 1995-10-24 | 2004-03-30 | The Scripps Research Institute | Enzymatic synthesis of L-fucose and L-fucose analogs |
| WO1998018805A2 (en) * | 1996-10-28 | 1998-05-07 | Novartis Ag | Sugar derivatives as sialyl lewis x mimetics |
| US5770407A (en) | 1996-12-10 | 1998-06-23 | The Scripps Research Institute | Process for preparing nucleotide inhibitors of glycosyltransferases |
| JP4451933B2 (ja) | 1996-12-27 | 2010-04-14 | 住友化学株式会社 | 遺伝子操作による植物へのｐｐｏ阻害性除草剤耐性付与法 |
| US6075134A (en) | 1997-05-15 | 2000-06-13 | The Regents Of The University Of California | Glycoconjugates and methods |
| JPH1135593A (ja) | 1997-07-18 | 1999-02-09 | Daikin Ind Ltd | ２−フルオロフコシル−ｎ−アロイルグルコサミン誘導体及びその中間物、並びにそれらの製造方法 |
| US6670330B1 (en) | 2000-05-01 | 2003-12-30 | Theodore J. Lampidis | Cancer chemotherapy with 2-deoxy-D-glucose |
| US7265084B2 (en) | 2001-10-10 | 2007-09-04 | Neose Technologies, Inc. | Glycopegylation methods and proteins/peptides produced by the methods |
| US7214660B2 (en) | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
| WO2003085118A1 (en) | 2002-04-09 | 2003-10-16 | Kyowa Hakko Kogyo Co., Ltd. | Process for producing antibody composition |
| CA2513399A1 (en) | 2003-01-10 | 2004-07-29 | Threshold Pharmaceuticals, Inc. | Treatment of cancer with 2-deoxyglucose |
| US7691603B2 (en) | 2003-04-09 | 2010-04-06 | Novo Nordisk A/S | Intracellular formation of peptide conjugates |
| MXPA05010773A (es) | 2003-04-09 | 2005-12-12 | Neose Technologies Inc | Metodos de glicopegilacion y proteinas/peptidos producidos por los metodos. |
| US7332334B2 (en) | 2003-04-18 | 2008-02-19 | Oklahoma Medical Research Foundation | Hematopoietic stem cells treated by in vitro fucosylation and methods of use |
| JPWO2005017155A1 (ja) | 2003-06-18 | 2006-10-12 | 中外製薬株式会社 | フコーストランスポーター |
| CA2542130A1 (en) | 2003-10-09 | 2005-04-21 | Kyowa Hakko Kogyo Co., Ltd. | Cell genomically modified to produce polypeptides with an altered glycosylation pattern |
| BRPI0417750A (pt) | 2003-12-23 | 2007-04-10 | Progen Ind Ltd | composto da fórmula; composição farmacêutica ou veterinária; uso do composto, e método para prevenção e tratamento na área de glicosaminoglicano (gag) miméticos |
| DE102004032421A1 (de) | 2004-07-05 | 2006-01-26 | Bayer Cropscience Ag | Phenylsubstituierte [1.2]-Oxazin-3,5-dion-und Dihydropyron-Derivate |
| US7393836B2 (en) | 2004-07-06 | 2008-07-01 | Boehringer Ingelheim International Gmbh | D-xylopyranosyl-substituted phenyl derivatives, medicaments containing such compounds, their use and process for their manufacture |
| EP1829961A4 (en) | 2004-12-22 | 2008-06-04 | Chugai Pharmaceutical Co Ltd | PROCESS FOR PREPARING ANTIBODY USING A CELL WHOSE FUCOSE CARRIER FUNCTION IS INHIBITED |
| ES2477765T3 (es) | 2005-04-19 | 2014-07-17 | Seattle Genetics, Inc. | Agentes de unión al anti-cd70 humanizado y usos de los mismos |
| AR058129A1 (es) | 2005-10-21 | 2008-01-23 | Genzyme Corp | Productos terapeuticos basados en anticuerpos con actividad de adcc mejorada |
| ATE485037T1 (de) | 2005-11-28 | 2010-11-15 | Univ Ramot | Krebsbehandlung mittels fts und 2-deoxyglucose |
| NZ569450A (en) | 2005-12-21 | 2012-01-12 | Viventia Biotech Inc | An isolated protein comprising a cancer-associated variant of Mammalian Scratch |
| WO2007081031A1 (ja) | 2006-01-16 | 2007-07-19 | Hokkaido University | 糖転移酵素阻害剤 |
| EP4092418A1 (en) | 2006-02-10 | 2022-11-23 | Life Technologies Corporation | Oligosaccharide modification and labeling of proteins |
| WO2007101148A2 (en) | 2006-02-24 | 2007-09-07 | Board Of Regents, The University Of Texas System | Hexose compounds to treat cancer |
| CA2642189A1 (en) | 2006-02-24 | 2007-09-07 | University Of Miami | Mannose derivatives for killing tumor cells |
| US8816050B2 (en) | 2006-03-22 | 2014-08-26 | The Scripps Research Institute | Method of preparing glycopeptides |
| US9149489B2 (en) | 2006-04-27 | 2015-10-06 | Board Of Regents, University Of Texas System | Inhibitors of glycolysis useful in the treatment of brain tumors |
| WO2009108926A1 (en) | 2008-02-29 | 2009-09-03 | Board Of Regents, The University Of Texas System | Inhibitors of glycolysis useful in the treatment of brain tumors |
| CA2663536A1 (en) | 2006-10-24 | 2008-05-02 | Trubion Pharmaceuticals, Inc. | Materials and methods for improved immunoglycoproteins |
| CA2677747A1 (en) | 2007-02-09 | 2008-08-21 | Glycomimetics, Inc. | Methods of use of glycomimetics with replacements for hexoses and n-acetyl hexosamines |
| WO2008131024A1 (en) | 2007-04-17 | 2008-10-30 | Board Of Regents, The University Of Texas System | Iodo-hexose compounds useful to treat cancer |
| CN101062939A (zh) | 2007-05-17 | 2007-10-31 | 北京热景生物技术有限公司 | 检测肝癌岩藻糖基化高尔基蛋白gp73的装置及试剂盒 |
| US7968687B2 (en) | 2007-10-19 | 2011-06-28 | Seattle Genetics, Inc. | CD19 binding agents and uses thereof |
| AU2009223054A1 (en) | 2008-03-11 | 2009-09-17 | Genentech, Inc. | Antibodies with enhanced ADCC function |
| EP2282773B2 (en) * | 2008-05-02 | 2025-03-05 | Seagen Inc. | Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation |
| WO2009143078A2 (en) | 2008-05-19 | 2009-11-26 | Board Of Regents, The University Of Texas System | Methods of treating brain cancer using hexose compounds |
| WO2009143515A2 (en) | 2008-05-23 | 2009-11-26 | University Of Miami | Treatment using continuous low dose application of sugar analogs |
| EP2303286A4 (en) * | 2008-06-16 | 2011-12-28 | Academia Sinica | COMPOSITIONS FOR GENERATING IMMUNE REACTIONS SPECIFIC TO GLOBO H AND SSEA3 AND THEIR USES IN CANCER TREATMENT |
| WO2010111713A2 (en) | 2009-03-27 | 2010-09-30 | Zacharon Pharmaceuticals, Inc. | N-linked glycan biosynthesis modulators |
| WO2011137528A1 (en) * | 2010-05-06 | 2011-11-10 | Simon Fraser University | Methods and compounds for inhibiting glycosyltransferases |
| US20110288880A1 (en) | 2010-05-07 | 2011-11-24 | Patient Care Automation Services, Inc. | Targeted health care messaging |
| PL2608796T3 (pl) | 2010-08-05 | 2019-04-30 | Seattle Genetics Inc | Hamowanie fukozylacji białka w warunkach in vivo za pomocą analogów fukozy |
| JP2014505058A (ja) | 2011-01-11 | 2014-02-27 | ザ・ユニバーシティ・オブ・テキサス・エム・ディー・アンダーソン・キャンサー | 増殖性および炎症性皮膚疾患の治療用単糖ベース化合物 |
| US8979675B2 (en) | 2012-04-25 | 2015-03-17 | Nike, Inc. | Golf ball core having radial appendages |
| CA2882725C (en) | 2012-08-23 | 2021-03-09 | Regents Of The University Of Minnesota | Treatment of sickle cell disease and inflammatory conditions |
| JP6906520B2 (ja) | 2015-12-04 | 2021-07-21 | シージェン インコーポレイテッド | チェックポイント阻害剤と組みわせて２−デオキシ−２−フルオロ−ｌ−フコースを用いる癌治療 |
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2011
- 2011-08-05 PL PL11815404T patent/PL2608796T3/pl unknown
- 2011-08-05 US US13/814,083 patent/US9504702B2/en active Active
- 2011-08-05 AU AU2011285490A patent/AU2011285490B2/en active Active
- 2011-08-05 RU RU2017122482A patent/RU2017122482A/ru not_active Application Discontinuation
- 2011-08-05 CA CA2803388A patent/CA2803388C/en active Active
- 2011-08-05 TR TR2019/02439T patent/TR201902439T4/tr unknown
- 2011-08-05 KR KR1020137005545A patent/KR101950520B1/ko not_active Expired - Fee Related
- 2011-08-05 CN CN201180038334.2A patent/CN103402525B/zh active Active
- 2011-08-05 JP JP2013523380A patent/JP5918235B2/ja active Active
- 2011-08-05 EP EP18206850.2A patent/EP3513794A3/en not_active Withdrawn
- 2011-08-05 SI SI201131673T patent/SI2608796T1/sl unknown
- 2011-08-05 KR KR1020197004266A patent/KR20190022884A/ko not_active Ceased
- 2011-08-05 MX MX2013001303A patent/MX356671B/es active IP Right Grant
- 2011-08-05 CN CN201710076003.7A patent/CN107007615A/zh active Pending
- 2011-08-05 WO PCT/US2011/046857 patent/WO2012019165A2/en not_active Ceased
- 2011-08-05 RU RU2013109415A patent/RU2625768C2/ru active
- 2011-08-05 DK DK11815404.6T patent/DK2608796T3/en active
- 2011-08-05 EP EP11815404.6A patent/EP2608796B1/en active Active
- 2011-08-05 HU HUE11815404A patent/HUE043370T2/hu unknown
- 2011-08-05 ES ES11815404T patent/ES2711622T3/es active Active
- 2011-08-05 PT PT11815404T patent/PT2608796T/pt unknown
- 2011-08-05 NZ NZ606250A patent/NZ606250A/en unknown
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2013
- 2013-01-24 ZA ZA2013/00653A patent/ZA201300653B/en unknown
- 2013-01-30 IL IL224487A patent/IL224487A/en active IP Right Grant
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2016
- 2016-02-08 IL IL244019A patent/IL244019B/en active IP Right Grant
- 2016-04-07 JP JP2016076930A patent/JP6113887B2/ja active Active
- 2016-06-29 AU AU2016204495A patent/AU2016204495A1/en not_active Abandoned
- 2016-10-21 US US15/299,894 patent/US10342811B2/en active Active
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2017
- 2017-03-15 JP JP2017049534A patent/JP6622238B2/ja active Active
- 2017-12-20 AU AU2017279653A patent/AU2017279653A1/en not_active Abandoned
-
2019
- 2019-02-20 CY CY20191100218T patent/CY1121419T1/el unknown
- 2019-06-25 US US16/452,160 patent/US11033561B2/en active Active
- 2019-11-21 JP JP2019210313A patent/JP2020040974A/ja active Pending
-
2021
- 2021-05-07 US US17/315,144 patent/US20210260086A1/en not_active Abandoned
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