JP2013541503A5 - - Google Patents
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- JP2013541503A5 JP2013541503A5 JP2013523380A JP2013523380A JP2013541503A5 JP 2013541503 A5 JP2013541503 A5 JP 2013541503A5 JP 2013523380 A JP2013523380 A JP 2013523380A JP 2013523380 A JP2013523380 A JP 2013523380A JP 2013541503 A5 JP2013541503 A5 JP 2013541503A5
- Authority
- JP
- Japan
- Prior art keywords
- aryl
- alkyl
- pharmaceutical composition
- heterocycle
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 *C1[C@@](*)C(*)O[C@@](*)C1* Chemical compound *C1[C@@](*)C(*)O[C@@](*)C1* 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37111610P | 2010-08-05 | 2010-08-05 | |
| US61/371,116 | 2010-08-05 | ||
| PCT/US2011/046857 WO2012019165A2 (en) | 2010-08-05 | 2011-08-05 | Methods of inhibition of protein fucosylation in vivo using fucose analogs |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016076930A Division JP6113887B2 (ja) | 2010-08-05 | 2016-04-07 | フコースアナログを用いるイン・ビボでのタンパク質フコシル化の阻害方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013541503A JP2013541503A (ja) | 2013-11-14 |
| JP2013541503A5 true JP2013541503A5 (enExample) | 2014-09-25 |
| JP5918235B2 JP5918235B2 (ja) | 2016-05-18 |
Family
ID=45560106
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013523380A Expired - Fee Related JP5918235B2 (ja) | 2010-08-05 | 2011-08-05 | フコースアナログを用いるイン・ビボでのタンパク質フコシル化の阻害方法 |
| JP2016076930A Expired - Fee Related JP6113887B2 (ja) | 2010-08-05 | 2016-04-07 | フコースアナログを用いるイン・ビボでのタンパク質フコシル化の阻害方法 |
| JP2017049534A Active JP6622238B2 (ja) | 2010-08-05 | 2017-03-15 | フコースアナログを用いるイン・ビボでのタンパク質フコシル化の阻害方法 |
| JP2019210313A Pending JP2020040974A (ja) | 2010-08-05 | 2019-11-21 | フコースアナログを用いるイン・ビボでのタンパク質フコシル化の阻害方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016076930A Expired - Fee Related JP6113887B2 (ja) | 2010-08-05 | 2016-04-07 | フコースアナログを用いるイン・ビボでのタンパク質フコシル化の阻害方法 |
| JP2017049534A Active JP6622238B2 (ja) | 2010-08-05 | 2017-03-15 | フコースアナログを用いるイン・ビボでのタンパク質フコシル化の阻害方法 |
| JP2019210313A Pending JP2020040974A (ja) | 2010-08-05 | 2019-11-21 | フコースアナログを用いるイン・ビボでのタンパク質フコシル化の阻害方法 |
Country Status (21)
| Country | Link |
|---|---|
| US (4) | US9504702B2 (enExample) |
| EP (2) | EP3513794A3 (enExample) |
| JP (4) | JP5918235B2 (enExample) |
| KR (2) | KR20190022884A (enExample) |
| CN (2) | CN103402525B (enExample) |
| AU (3) | AU2011285490B2 (enExample) |
| CA (1) | CA2803388C (enExample) |
| CY (1) | CY1121419T1 (enExample) |
| DK (1) | DK2608796T3 (enExample) |
| ES (1) | ES2711622T3 (enExample) |
| HU (1) | HUE043370T2 (enExample) |
| IL (2) | IL224487A (enExample) |
| MX (1) | MX356671B (enExample) |
| NZ (1) | NZ606250A (enExample) |
| PL (1) | PL2608796T3 (enExample) |
| PT (1) | PT2608796T (enExample) |
| RU (2) | RU2625768C2 (enExample) |
| SI (1) | SI2608796T1 (enExample) |
| TR (1) | TR201902439T4 (enExample) |
| WO (1) | WO2012019165A2 (enExample) |
| ZA (1) | ZA201300653B (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102076865B (zh) | 2008-05-02 | 2016-03-16 | 西雅图基因公司 | 用于制造核心岩藻糖基化降低的抗体和抗体衍生物的方法和组合物 |
| EP3513794A3 (en) * | 2010-08-05 | 2019-10-16 | Seattle Genetics, Inc. | Fucose analogs for inhibition of protein fucosylation in vivo |
| US10350228B2 (en) | 2012-08-23 | 2019-07-16 | Seattle Genetics, Inc. | Treatment of sickle cell disease and inflammatory conditions |
| WO2014130613A2 (en) | 2013-02-22 | 2014-08-28 | Amgen Inc. | Carbohydrate phosphonate derivatives as modulators of glycosylation |
| CN106699886A (zh) * | 2015-07-13 | 2017-05-24 | 西藏海思科药业集团股份有限公司 | 抗体依赖性细胞介导的细胞毒性(adcc)增强的奥法木抗体 |
| SG10202005298RA (en) * | 2015-12-04 | 2020-07-29 | Seattle Genetics Inc | Cancer treatment using 2-deoxy-2-fluoro-l-fucose in combination with a checkpoint inhibitor |
| CA3022769A1 (en) * | 2016-05-10 | 2017-11-16 | Ares Trading S.A. | Methods for modulating protein galactosylation profiles of recombinant proteins using peracetyl galactose |
| JP2018002666A (ja) * | 2016-07-04 | 2018-01-11 | 国立研究開発法人理化学研究所 | フコース類似体と糖を検出する方法 |
| US11891644B2 (en) * | 2017-06-07 | 2024-02-06 | Seagen Inc. | T cells with reduced surface fucosylation and methods of making and using the same |
| BR112020010753A2 (pt) | 2017-12-01 | 2020-11-24 | The Regents Of The University Of California | anticorpos anti-cxcr5 e composições e usos dos mesmos |
| CA3094756A1 (en) | 2018-03-29 | 2019-10-03 | Pfizer Inc. | Lfa3 variants and compositions and uses thereof |
| BR112021003156A2 (pt) | 2018-08-23 | 2021-05-11 | Seagen, Inc. | composição, anticorpo que se liga ao tigit humano, formulação farmacêutica, polinucleotídeo isolado, vetor, célula hospedeira, métodos para a produção de um anticorpo que se liga ao tigit humano e de anticorpos afucosilados que se ligam a tigit e para o tratamento de um câncer, e, kit. |
| JP7446587B2 (ja) * | 2018-12-27 | 2024-03-12 | 慶應義塾 | 抗ヒトノロウイルス剤 |
| US20230022796A1 (en) * | 2019-12-19 | 2023-01-26 | Merck Patent Gmbh | Methods and compositions for modulating the glycosylation profile of proteins |
| TWI877278B (zh) * | 2019-12-30 | 2025-03-21 | 美商思進公司 | 以非海藻糖苷化抗－ｃｄ７０抗體治療癌症之方法 |
| IL272389A (en) | 2020-01-30 | 2021-08-31 | Yeda Res & Dev | Kits containing antibodies to PD-L1 and their uses in therapy |
| KR20230047357A (ko) * | 2020-06-03 | 2023-04-07 | 시몬 프레이저 유니버스티 | 단백질 푸코실화 억제제 및 이의 용도 |
| CA3213636A1 (en) | 2021-03-18 | 2022-09-22 | Seagen Inc. | Selective drug release from internalized conjugates of biologically active compounds |
| AR126089A1 (es) | 2021-06-07 | 2023-09-13 | Amgen Inc | Uso de fucosidasa para controlar el nivel de afucosilación de proteínas glucosiladas |
| CN113413465B (zh) * | 2021-06-15 | 2022-06-03 | 北京大学 | 岩藻糖基化抑制剂在抗癌导致炎症中的应用 |
| WO2024118503A1 (en) | 2022-11-28 | 2024-06-06 | Hongene Biotech Corporation | Functionalized n-acetylgalactosamine analogs |
| WO2024191807A1 (en) | 2023-03-10 | 2024-09-19 | Seagen Inc. | Methods of treating cancer with anti-tigit antibodies |
| WO2025262564A1 (en) | 2024-06-17 | 2025-12-26 | Pfizer Inc. | Use of anti-cxcr5 antibodies |
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| US4440780A (en) | 1979-06-01 | 1984-04-03 | Chevron Research Company | Fungicidal 3-(N-acyl-N-arylamino)-and 3-(N-thionoacyl-N-arylamino)-gamma-butyrolactones and gamma-thiobutyrolactones |
| JPH0660189B2 (ja) | 1986-01-22 | 1994-08-10 | 財団法人微生物化学研究会 | ２，６−ジデオキシ−２−フルオロ−ｌ−タロピラノ−ス又はその誘導体とその製造法 |
| FR2630914A1 (fr) | 1988-05-04 | 1989-11-10 | Hoechst Sa Laboratoires | Nouveaux analogues du l-fucose, leur procede de preparation, application de ces analogues a la preparation de nouveaux glycals, anthracyclines obtenues a l'aide de ces glycals et utilisation desdites anthracyclines en tant que medicaments |
| KR100211417B1 (ko) | 1990-11-30 | 1999-10-01 | 유충식 | L-탈로피라노시드 유도체 및 그의 제조방법 |
| US5461143A (en) | 1991-03-18 | 1995-10-24 | The Scripps Research Institute | Oligosaccharide enzyme substrates and inhibitors: methods and compositions |
| US5210078A (en) * | 1991-04-30 | 1993-05-11 | The Biomembrane Institute | Trifluoromethyl analogs of fucose and uses thereof |
| AU675209B2 (en) | 1991-10-15 | 1997-01-30 | Scripps Research Institute, The | Production of fucosylated carbohydrates by enzymatic fucosylation synthesis of sugar nucleotides; and in situ regeneration of GDP-fucose |
| EP0721956B1 (en) | 1993-09-29 | 2000-08-02 | Nissin Shokuhin Kabushiki Kaisha | 21-substituted steroid compound |
| US5481143A (en) | 1993-11-15 | 1996-01-02 | Burdick; Brian K. | Self starting brushless d.c. motor |
| FR2723947B1 (fr) | 1994-08-31 | 1996-09-27 | Adir | Nouveaux composes tetrahydropyraniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| DE19524515A1 (de) | 1995-07-05 | 1997-01-09 | Deutsches Krebsforsch | Saccharid-Konjugate |
| US6713287B1 (en) | 1995-10-24 | 2004-03-30 | The Scripps Research Institute | Enzymatic synthesis of L-fucose and L-fucose analogs |
| AU5313798A (en) * | 1996-10-28 | 1998-05-22 | Novartis Ag | Organic compounds |
| US5770407A (en) | 1996-12-10 | 1998-06-23 | The Scripps Research Institute | Process for preparing nucleotide inhibitors of glycosyltransferases |
| JP4451933B2 (ja) | 1996-12-27 | 2010-04-14 | 住友化学株式会社 | 遺伝子操作による植物へのｐｐｏ阻害性除草剤耐性付与法 |
| US6075134A (en) | 1997-05-15 | 2000-06-13 | The Regents Of The University Of California | Glycoconjugates and methods |
| JPH1135593A (ja) | 1997-07-18 | 1999-02-09 | Daikin Ind Ltd | ２−フルオロフコシル−ｎ−アロイルグルコサミン誘導体及びその中間物、並びにそれらの製造方法 |
| US6670330B1 (en) | 2000-05-01 | 2003-12-30 | Theodore J. Lampidis | Cancer chemotherapy with 2-deoxy-D-glucose |
| US7214660B2 (en) | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
| US7265084B2 (en) | 2001-10-10 | 2007-09-04 | Neose Technologies, Inc. | Glycopegylation methods and proteins/peptides produced by the methods |
| CA2481837A1 (en) | 2002-04-09 | 2003-10-16 | Kyowa Hakko Kogyo Co., Ltd. | Production process for antibody composition |
| CA2513399A1 (en) | 2003-01-10 | 2004-07-29 | Threshold Pharmaceuticals, Inc. | Treatment of cancer with 2-deoxyglucose |
| NZ542586A (en) | 2003-04-09 | 2009-11-27 | Biogenerix Ag | Method of forming a covalent conjugate between a G-CSF peptide and PEG |
| EP1613261A4 (en) | 2003-04-09 | 2011-01-26 | Novo Nordisk As | INTRA-CELLULAR FORMATION OF PEPTIDE CONJUGATES |
| US7332334B2 (en) | 2003-04-18 | 2008-02-19 | Oklahoma Medical Research Foundation | Hematopoietic stem cells treated by in vitro fucosylation and methods of use |
| ES2348008T3 (es) | 2003-06-18 | 2010-11-26 | Chugai Seiyaku Kabushiki Kaisha | Transportador de fucosa. |
| JPWO2005035741A1 (ja) | 2003-10-09 | 2006-12-21 | 協和醗酵工業株式会社 | ゲノムが改変された細胞 |
| JP2007515434A (ja) | 2003-12-23 | 2007-06-14 | プロジェン インダストリーズ リミテッド | グリコサミノグリカン（ｇａｇ）模倣物 |
| DE102004032421A1 (de) | 2004-07-05 | 2006-01-26 | Bayer Cropscience Ag | Phenylsubstituierte [1.2]-Oxazin-3,5-dion-und Dihydropyron-Derivate |
| US7393836B2 (en) | 2004-07-06 | 2008-07-01 | Boehringer Ingelheim International Gmbh | D-xylopyranosyl-substituted phenyl derivatives, medicaments containing such compounds, their use and process for their manufacture |
| JPWO2006067847A1 (ja) | 2004-12-22 | 2008-06-12 | 中外製薬株式会社 | フコーストランスポーターの機能が阻害された細胞を用いた抗体の作製方法 |
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| ATE536373T1 (de) | 2005-10-21 | 2011-12-15 | Genzyme Corp | Therapiemittel auf antikörperbasis mit erhöhter adcc-aktivität |
| ATE485037T1 (de) | 2005-11-28 | 2010-11-15 | Univ Ramot | Krebsbehandlung mittels fts und 2-deoxyglucose |
| JP5380075B2 (ja) | 2005-12-21 | 2014-01-08 | ヴィヴェンティア バイオテクノロジーズ インコーポレーティッド | がん関連抗原 |
| WO2007081031A1 (ja) * | 2006-01-16 | 2007-07-19 | Hokkaido University | 糖転移酵素阻害剤 |
| WO2008029281A2 (en) | 2006-02-10 | 2008-03-13 | Invitrogen Corporation | Labeling and detection of post translationally modified proteins |
| WO2007101148A2 (en) | 2006-02-24 | 2007-09-07 | Board Of Regents, The University Of Texas System | Hexose compounds to treat cancer |
| US8242167B2 (en) | 2006-02-24 | 2012-08-14 | University Of Miami | Mannose derivatives for killing tumor cells |
| EP1996609B1 (en) | 2006-03-22 | 2016-08-03 | The Scripps Research Institute | Method of preparing glycopeptides |
| WO2009108926A1 (en) | 2008-02-29 | 2009-09-03 | Board Of Regents, The University Of Texas System | Inhibitors of glycolysis useful in the treatment of brain tumors |
| US9149489B2 (en) | 2006-04-27 | 2015-10-06 | Board Of Regents, University Of Texas System | Inhibitors of glycolysis useful in the treatment of brain tumors |
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| CN101062939A (zh) | 2007-05-17 | 2007-10-31 | 北京热景生物技术有限公司 | 检测肝癌岩藻糖基化高尔基蛋白gp73的装置及试剂盒 |
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| EP2271669A1 (en) | 2008-03-11 | 2011-01-12 | Genentech, Inc. | Antibodies with enhanced adcc function |
| CN102076865B (zh) | 2008-05-02 | 2016-03-16 | 西雅图基因公司 | 用于制造核心岩藻糖基化降低的抗体和抗体衍生物的方法和组合物 |
| WO2009143078A2 (en) | 2008-05-19 | 2009-11-26 | Board Of Regents, The University Of Texas System | Methods of treating brain cancer using hexose compounds |
| WO2009143515A2 (en) | 2008-05-23 | 2009-11-26 | University Of Miami | Treatment using continuous low dose application of sugar analogs |
| JP2011524375A (ja) * | 2008-06-16 | 2011-09-01 | アカデミア シニカ | ＧｌｏｂｏＨおよびＳＳＥＡ３に特異的な免疫反応を誘起する組成物および癌治療におけるその使用 |
| US20120100609A1 (en) | 2009-03-27 | 2012-04-26 | Crawford Brett E | N-linked glycan biosynthesis modulators |
| US20150259371A1 (en) * | 2010-05-06 | 2015-09-17 | Simon Fraser University | Methods and compounds for inhibiting glycosyltransferases |
| US20110288880A1 (en) | 2010-05-07 | 2011-11-24 | Patient Care Automation Services, Inc. | Targeted health care messaging |
| EP3513794A3 (en) | 2010-08-05 | 2019-10-16 | Seattle Genetics, Inc. | Fucose analogs for inhibition of protein fucosylation in vivo |
| WO2012097052A2 (en) | 2011-01-11 | 2012-07-19 | Intertech Bio, Llc | Monosaccharide-based compounds for the treatment of proliferative and inflammatory dermatological diseases |
| US8979675B2 (en) | 2012-04-25 | 2015-03-17 | Nike, Inc. | Golf ball core having radial appendages |
| US10350228B2 (en) | 2012-08-23 | 2019-07-16 | Seattle Genetics, Inc. | Treatment of sickle cell disease and inflammatory conditions |
| SG10202005298RA (en) | 2015-12-04 | 2020-07-29 | Seattle Genetics Inc | Cancer treatment using 2-deoxy-2-fluoro-l-fucose in combination with a checkpoint inhibitor |
-
2011
- 2011-08-05 EP EP18206850.2A patent/EP3513794A3/en not_active Withdrawn
- 2011-08-05 PT PT11815404T patent/PT2608796T/pt unknown
- 2011-08-05 SI SI201131673T patent/SI2608796T1/sl unknown
- 2011-08-05 KR KR1020197004266A patent/KR20190022884A/ko not_active Ceased
- 2011-08-05 RU RU2013109415A patent/RU2625768C2/ru active
- 2011-08-05 CN CN201180038334.2A patent/CN103402525B/zh active Active
- 2011-08-05 DK DK11815404.6T patent/DK2608796T3/en active
- 2011-08-05 HU HUE11815404A patent/HUE043370T2/hu unknown
- 2011-08-05 ES ES11815404T patent/ES2711622T3/es active Active
- 2011-08-05 JP JP2013523380A patent/JP5918235B2/ja not_active Expired - Fee Related
- 2011-08-05 EP EP11815404.6A patent/EP2608796B1/en active Active
- 2011-08-05 TR TR2019/02439T patent/TR201902439T4/tr unknown
- 2011-08-05 CA CA2803388A patent/CA2803388C/en active Active
- 2011-08-05 CN CN201710076003.7A patent/CN107007615A/zh active Pending
- 2011-08-05 WO PCT/US2011/046857 patent/WO2012019165A2/en not_active Ceased
- 2011-08-05 NZ NZ606250A patent/NZ606250A/en not_active IP Right Cessation
- 2011-08-05 US US13/814,083 patent/US9504702B2/en active Active
- 2011-08-05 RU RU2017122482A patent/RU2017122482A/ru not_active Application Discontinuation
- 2011-08-05 MX MX2013001303A patent/MX356671B/es active IP Right Grant
- 2011-08-05 AU AU2011285490A patent/AU2011285490B2/en not_active Ceased
- 2011-08-05 PL PL11815404T patent/PL2608796T3/pl unknown
- 2011-08-05 KR KR1020137005545A patent/KR101950520B1/ko not_active Expired - Fee Related
-
2013
- 2013-01-24 ZA ZA2013/00653A patent/ZA201300653B/en unknown
- 2013-01-30 IL IL224487A patent/IL224487A/en active IP Right Grant
-
2016
- 2016-02-08 IL IL244019A patent/IL244019B/en active IP Right Grant
- 2016-04-07 JP JP2016076930A patent/JP6113887B2/ja not_active Expired - Fee Related
- 2016-06-29 AU AU2016204495A patent/AU2016204495A1/en not_active Abandoned
- 2016-10-21 US US15/299,894 patent/US10342811B2/en active Active
-
2017
- 2017-03-15 JP JP2017049534A patent/JP6622238B2/ja active Active
- 2017-12-20 AU AU2017279653A patent/AU2017279653A1/en not_active Abandoned
-
2019
- 2019-02-20 CY CY20191100218T patent/CY1121419T1/el unknown
- 2019-06-25 US US16/452,160 patent/US11033561B2/en active Active
- 2019-11-21 JP JP2019210313A patent/JP2020040974A/ja active Pending
-
2021
- 2021-05-07 US US17/315,144 patent/US20210260086A1/en not_active Abandoned
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