ES2711622T3 - Inhibición de la fucosilación in vivo usando análogos de fucosa - Google Patents
Inhibición de la fucosilación in vivo usando análogos de fucosa Download PDFInfo
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- ES2711622T3 ES2711622T3 ES11815404T ES11815404T ES2711622T3 ES 2711622 T3 ES2711622 T3 ES 2711622T3 ES 11815404 T ES11815404 T ES 11815404T ES 11815404 T ES11815404 T ES 11815404T ES 2711622 T3 ES2711622 T3 ES 2711622T3
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- Prior art keywords
- fucose
- cancer
- treatment
- fucose analogue
- prophylaxis
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- 125000003118 aryl group Chemical group 0.000 claims abstract description 94
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- A61K2039/515—Animal cells
- A61K2039/5152—Tumor cells
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
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- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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| CA2975228C (en) | 2008-05-02 | 2020-07-21 | Seattle Genetics, Inc. | Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation |
| EP2608796B1 (en) * | 2010-08-05 | 2018-11-21 | Seattle Genetics, Inc. | Inhibition of protein fucosylation in vivo using fucose analogs |
| CA2882725C (en) | 2012-08-23 | 2021-03-09 | Regents Of The University Of Minnesota | Treatment of sickle cell disease and inflammatory conditions |
| WO2014130613A2 (en) | 2013-02-22 | 2014-08-28 | Amgen Inc. | Carbohydrate phosphonate derivatives as modulators of glycosylation |
| CN106699886A (zh) * | 2015-07-13 | 2017-05-24 | 西藏海思科药业集团股份有限公司 | 抗体依赖性细胞介导的细胞毒性(adcc)增强的奥法木抗体 |
| EA201891340A1 (ru) * | 2015-12-04 | 2018-11-30 | Сиэтл Дженетикс, Инк. | Лечение рака с использованием 2-дезокси-2-фтор-l-фукозы в комбинации с ингибитором контрольных точек |
| CN109072273B (zh) * | 2016-05-10 | 2022-04-15 | 阿雷斯贸易股份有限公司 | 使用全乙酰基半乳糖调节重组蛋白的蛋白质半乳糖基化概况的方法 |
| JP2018002666A (ja) * | 2016-07-04 | 2018-01-11 | 国立研究開発法人理化学研究所 | フコース類似体と糖を検出する方法 |
| KR102687149B1 (ko) * | 2017-06-07 | 2024-07-24 | 씨젠 인크. | 감소된 표면 푸코실화를 갖는 t 세포 및 이를 생산하고 사용하는 방법 |
| MX2020005662A (es) | 2017-12-01 | 2020-08-20 | Pfizer | Anticuerpos anti-cxcr5 y composiciones y usos de los mismos. |
| WO2019190984A1 (en) | 2018-03-29 | 2019-10-03 | Pfizer Inc. | Lfa3 variants and compositions and uses thereof |
| MA53434A (fr) | 2018-08-23 | 2021-12-01 | Seagen Inc | Anticorps anti-tigit |
| US20220062315A1 (en) * | 2018-12-27 | 2022-03-03 | Keio University | Anti-human norovirus agent |
| KR20220115998A (ko) * | 2019-12-19 | 2022-08-19 | 메르크 파텐트 게엠베하 | 단백질의 글리코실화 프로파일을 조절하기 위한 방법 및 조성물 |
| TWI877278B (zh) * | 2019-12-30 | 2025-03-21 | 美商思進公司 | 以非海藻糖苷化抗－ｃｄ７０抗體治療癌症之方法 |
| IL272389A (en) | 2020-01-30 | 2021-08-31 | Yeda Res & Dev | Kits containing antibodies to PD-L1 and their uses in therapy |
| JP2023528400A (ja) * | 2020-06-03 | 2023-07-04 | サイモン フレイザー ユニヴァーシティー | タンパク質フコシル化の阻害剤及びその用途 |
| IL305883A (en) | 2021-03-18 | 2023-11-01 | Seagen Inc | Selective release of drugs from internalized conjugates of biologically active compounds |
| AR126089A1 (es) | 2021-06-07 | 2023-09-13 | Amgen Inc | Uso de fucosidasa para controlar el nivel de afucosilación de proteínas glucosiladas |
| CN113413465B (zh) * | 2021-06-15 | 2022-06-03 | 北京大学 | 岩藻糖基化抑制剂在抗癌导致炎症中的应用 |
| WO2024118503A1 (en) | 2022-11-28 | 2024-06-06 | Hongene Biotech Corporation | Functionalized n-acetylgalactosamine analogs |
| WO2024191807A1 (en) | 2023-03-10 | 2024-09-19 | Seagen Inc. | Methods of treating cancer with anti-tigit antibodies |
| WO2025262564A1 (en) | 2024-06-17 | 2025-12-26 | Pfizer Inc. | Use of anti-cxcr5 antibodies |
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