JP2014505660A5 - - Google Patents

Download PDF

Info

Publication number
JP2014505660A5
JP2014505660A5 JP2013539220A JP2013539220A JP2014505660A5 JP 2014505660 A5 JP2014505660 A5 JP 2014505660A5 JP 2013539220 A JP2013539220 A JP 2013539220A JP 2013539220 A JP2013539220 A JP 2013539220A JP 2014505660 A5 JP2014505660 A5 JP 2014505660A5
Authority
JP
Japan
Prior art keywords
alkyl
halo
hydroxy
alkoxy
heteroaryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2013539220A
Other languages
English (en)
Japanese (ja)
Other versions
JP5950926B2 (ja
JP2014505660A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2011/070084 external-priority patent/WO2012065958A1/en
Publication of JP2014505660A publication Critical patent/JP2014505660A/ja
Publication of JP2014505660A5 publication Critical patent/JP2014505660A5/ja
Application granted granted Critical
Publication of JP5950926B2 publication Critical patent/JP5950926B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2013539220A 2010-11-16 2011-11-14 造影剤誘発性腎症の処置方法 Expired - Fee Related JP5950926B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41417410P 2010-11-16 2010-11-16
US61/414,174 2010-11-16
PCT/EP2011/070084 WO2012065958A1 (en) 2010-11-16 2011-11-14 Method of treating contrast-induced nephropathy

Publications (3)

Publication Number Publication Date
JP2014505660A JP2014505660A (ja) 2014-03-06
JP2014505660A5 true JP2014505660A5 (enExample) 2015-01-08
JP5950926B2 JP5950926B2 (ja) 2016-07-13

Family

ID=44993552

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013539220A Expired - Fee Related JP5950926B2 (ja) 2010-11-16 2011-11-14 造影剤誘発性腎症の処置方法

Country Status (20)

Country Link
US (2) US8993631B2 (enExample)
EP (1) EP2640375B1 (enExample)
JP (1) JP5950926B2 (enExample)
KR (1) KR101886894B1 (enExample)
CN (2) CN103313708B (enExample)
AU (1) AU2011331296C1 (enExample)
BR (1) BR112013011876A2 (enExample)
CA (1) CA2817784C (enExample)
CL (1) CL2013001383A1 (enExample)
EA (1) EA029672B1 (enExample)
ES (1) ES2587447T3 (enExample)
IL (1) IL226351A (enExample)
MA (1) MA35085B1 (enExample)
MX (1) MX2013005543A (enExample)
PH (1) PH12013500993A1 (enExample)
PL (1) PL2640375T3 (enExample)
PT (1) PT2640375T (enExample)
SG (1) SG190229A1 (enExample)
TW (1) TWI576331B (enExample)
WO (1) WO2012065958A1 (enExample)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2651896B1 (en) 2010-12-15 2015-08-12 Theravance Biopharma R&D IP, LLC Neprilysin inhibitors
SG191175A1 (en) 2010-12-15 2013-07-31 Theravance Inc Neprilysin inhibitors
WO2012154249A1 (en) 2011-02-17 2012-11-15 Theravance, Inc. Substituted aminobutyric derivatives as neprilysin inhibitors
CN103380119B (zh) 2011-02-17 2016-02-17 施万生物制药研发Ip有限责任公司 作为脑啡肽酶抑制剂的经取代的氨基丁酸衍生物
CA2835281A1 (en) 2011-05-31 2012-12-06 Theravance, Inc. Neprilysin inhibitors
CN103596928B (zh) 2011-05-31 2017-02-15 施万生物制药研发Ip有限责任公司 脑啡肽酶抑制剂
US9499487B2 (en) 2011-05-31 2016-11-22 Theravance Biopharma R&D Ip, Llc Neprilysin inhibitors
TWI560172B (en) 2011-11-02 2016-12-01 Theravance Biopharma R&D Ip Llc Neprilysin inhibitors
CA2871292A1 (en) 2012-05-31 2013-12-05 Theravance Biopharma R&D Ip, Llc Nitric oxide donor neprilysin inhibitors
ES2710932T3 (es) 2012-06-08 2019-04-29 Theravance Biopharma R&D Ip Llc Inhibidores de neprilisina
BR112014030743B1 (pt) 2012-06-08 2022-09-06 Theravance Biopharma R&D Ip, Llc Composto inibidor de neprilisina, processo para a preparação do referido composto, composição farmacêutica e uso do referido composto
KR102104954B1 (ko) 2012-08-08 2020-04-27 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 네프릴리신 억제제
KR20150119107A (ko) * 2013-02-14 2015-10-23 노파르티스 아게 개선된 생체내 효능을 갖는 nep 억제제로서의 치환된 비스페닐 부탄산 유도체
WO2014126979A1 (en) * 2013-02-14 2014-08-21 Novartis Ag Substituted bisphenyl butanoic phosphonic acid derivatives as nep (neutral endopeptidase) inhibitors
HUE034210T2 (hu) 2013-03-05 2018-02-28 Theravance Biopharma R&D Ip Llc Neprilizininhibitorok
MX2016009759A (es) 2014-01-30 2016-11-17 Theravance Biopharma R&D Ip Llc Inhibidores de neprilisina.
CA2934936A1 (en) 2014-01-30 2015-08-06 Theravance Biopharma R&D Ip, Llc Neprilysin inhibitors
WO2016037098A1 (en) * 2014-09-04 2016-03-10 Concert Pharmaceuticals, Inc. Deuterated sacubitril
CN104557600B (zh) * 2015-01-26 2016-05-04 苏州明锐医药科技有限公司 沙库比曲的制备方法
MY187899A (en) 2015-02-11 2021-10-27 Theravance Biopharma R&D Ip Llc (2s,4r)-5-(5'-chloro-2'-fluorobiphenyl-4-yl)-4-(ethoxyoxalylamino)-2-hydroxymethyl-2-methylpentanoic acid as neprilysin inhibitor
LT3259255T (lt) 2015-02-19 2021-04-26 Theravance Biopharma R&D Ip, Llc (2r,4r)-5-(5`-chlor-2`-fluorbifenil-4-il)-2-hidroksi-4-[(5-metiloksazol-2-karbonil)amino]pentano rūgštis
US10233144B2 (en) * 2015-03-20 2019-03-19 Crystal Pharmatech Co., Ltd. Crystalline form of AHU377, preparation method and use thereof
CN105061263B (zh) * 2015-08-11 2017-03-15 苏州楚凯药业有限公司 一种nep抑制剂中间体的制备方法
CN105523964B (zh) * 2015-12-09 2017-05-24 苏州楚凯药业有限公司 一种抗心衰药物中间体的制备方法
KR20220035991A (ko) 2016-03-08 2022-03-22 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 (2s,4r)-5-(5'-클로로-2'-플루오로-[1,1'-비페닐]-4-일)-2-(에톡시메틸)-4-(3-히드록시이속사졸-5-카르복사미도)-2-메틸펜탄산 결정 및 그 용도
WO2017152755A1 (zh) * 2016-03-10 2017-09-14 深圳市塔吉瑞生物医药有限公司 一种取代的联苯基化合物及其药物组合物
CN105963569A (zh) * 2016-06-25 2016-09-28 许风英 一种预防缓解碘造影剂副作用的中药制剂
CN107602399B (zh) * 2016-07-11 2020-09-25 江西东邦药业有限公司 一种脑啡肽酶抑制剂中间体的制备方法
CN107382785B (zh) * 2017-08-09 2019-11-01 常州制药厂有限公司 一种沙库必曲关键中间体的制备方法
FR3072379B1 (fr) * 2017-10-18 2020-08-07 Pharmasynthese Nouveaux derives de la strombine et leur utilisation en cosmetique
UY38072A (es) 2018-02-07 2019-10-01 Novartis Ag Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos
EP3986853A1 (en) 2019-06-19 2022-04-27 NMD Pharma A/S Compounds for the treatment of neuromuscular disorders
CN110711544A (zh) * 2019-10-12 2020-01-21 浙江理工大学上虞工业技术研究院有限公司 一种自粘性芳香微胶囊的制备方法
KR102308991B1 (ko) 2020-04-08 2021-10-06 압타바이오 주식회사 조영제 유발 급성 신부전 치료제
US20230201179A1 (en) 2020-04-08 2023-06-29 Aptabio Therapeutics Inc. Agent for treating contrast-induced acute kidney injury
WO2022030665A1 (ko) 2020-08-05 2022-02-10 경상대학교병원 조영제-유발 신독성 예방 또는 치료용 약학 조성물

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB447841A (en) 1933-12-23 1936-05-27 Anton Tolk Improvements in and relating to compression refrigerating machines
PT72878B (en) 1980-04-24 1983-03-29 Merck & Co Inc Process for preparing mannich-base hydroxamic acid pro-drugs for the improved delivery of non-steroidal anti-inflammatory agents
US4610816A (en) 1980-12-18 1986-09-09 Schering Corporation Substituted dipeptides as inhibitors of enkephalinases
US4640816A (en) 1984-08-31 1987-02-03 California Institute Of Technology Metastable alloy materials produced by solid state reaction of compacted, mechanically deformed mixtures
US4929641B1 (en) 1988-05-11 1994-08-30 Schering Corp Mercapto-acylamino acid antihypertensives
EP0254032A3 (en) 1986-06-20 1990-09-05 Schering Corporation Neutral metalloendopeptidase inhibitors in the treatment of hypertension
FR2623498B1 (fr) 1987-11-24 1990-04-06 Bioprojet Soc Civ Nouveaux composes enantiomeres derives d'amino-acides, leur procede de preparation et leurs applications therapeutiques
GB8811873D0 (en) 1988-05-19 1988-06-22 Pfizer Ltd Therapeutic agents
GB8820844D0 (en) 1988-09-05 1988-10-05 Pfizer Ltd Therapeutic agents
FR2652087B1 (fr) * 1989-09-15 1993-10-15 Bioprojet Ste Civile Derives d'amino-acides, leur procede de preparation et leurs applications therapeutiques.
US5599951A (en) 1989-09-15 1997-02-04 Societe Civile Bioprojet Amino acid derivatives, the process for their preparation and their applications to therapy
FR2673105B1 (fr) 1991-02-26 1995-01-13 Bioprojet Soc Civ Nouvelles compositions pharmaceutiques, notamment pour le traitement des colopathies fonctionnelles, et procedes de preparation de compositions et de medicaments, notamment pour le traitement de ces affections.
US5155100A (en) 1991-05-01 1992-10-13 Ciba-Geigy Corporation Phosphono/biaryl substituted dipeptide derivatives
US5217996A (en) * 1992-01-22 1993-06-08 Ciba-Geigy Corporation Biaryl substituted 4-amino-butyric acid amides
US5514696A (en) 1992-05-06 1996-05-07 Bristol-Myers Squibb Co. Phenyl sulfonamide endothelin antagonists
RU2124503C1 (ru) 1992-05-18 1999-01-10 И.Р.Сквибб энд Санз, Инк. Гетероциклические азотсодержащие производные карбоновой кислоты, способ их получения и фармацевтическая композиция
US5508272A (en) * 1993-06-15 1996-04-16 Bristol-Myers Squibb Company Compounds containing a fused bicycle ring and processes therefor
US5612359A (en) 1994-08-26 1997-03-18 Bristol-Myers Squibb Company Substituted biphenyl isoxazole sulfonamides
US5780473A (en) 1995-02-06 1998-07-14 Bristol-Myers Squibb Company Substituted biphenyl sulfonamide endothelin antagonists
DE19510566A1 (de) * 1995-03-23 1996-09-26 Kali Chemie Pharma Gmbh Benzazepin-, Benzoxazepin- und Benzothiazepin-N-essigsäurederivate sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
TW536540B (en) 1997-01-30 2003-06-11 Bristol Myers Squibb Co Endothelin antagonists: N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl]-4'-(2-oxazolyl)[1,1'-biphe
US5846985A (en) 1997-03-05 1998-12-08 Bristol-Myers Squibb Co. Substituted biphenyl isoxazole sulfonamides
US6660756B2 (en) 2001-03-28 2003-12-09 Pfizer Inc. N-phenpropylcyclopentyl-substituted glutaramide derivatives as inhibitors of neutral endopeptidase
NZ527012A (en) 2001-03-28 2005-03-24 Pfizer N-phenpropylcyclopentyl-substituted glutaramide derivatives as NEP inhibitors for FSAD
DE60202602T2 (de) 2001-04-12 2006-03-23 Sanofi-Aventis Deutschland Gmbh Mercaptoacetylamid-derivate, prozess zur herstellung sowie deren verwendung
US20030040534A1 (en) 2001-04-16 2003-02-27 Hughes David E. Enantiomers of N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide
TW200407310A (en) 2002-06-07 2004-05-16 Glaxo Group Ltd Compounds
JP2007524596A (ja) 2003-02-28 2007-08-30 トランスフォーム・ファーマシューティカルズ・インコーポレイテッド 共結晶医薬組成物
CN1832928B (zh) 2003-06-26 2012-07-04 诺瓦提斯公司 以5元杂环为基础的p38激酶抑制剂
AU2004284420A1 (en) 2003-09-24 2005-05-06 Vertex Pharmaceuticals Incorporated 4-azole substituted imidazole compositions useful as inhibitors or c-Met receptor tyrosine kinase
US20050267072A1 (en) * 2004-05-14 2005-12-01 Solvay Pharmaceuticals Gmbh Pharmaceutical compositions containing dually acting inhibitors of neutral endopeptidase for the treatment of sexual dysfunction
WO2006015885A1 (en) 2004-08-13 2006-02-16 University College Dublin, National University Of Ireland, Dublin Amino acid dehydrogenase-derived biocatalysts
AU2006215583B2 (en) 2005-02-18 2011-05-12 Solvay Pharmaceuticals Gmbh Pharmaceutical compositions comprising NEP-inhibitors, inhibitors of the endogenous endothelin producing system and diuretics
US20060205625A1 (en) 2005-02-18 2006-09-14 Solvay Pharmaceuticals Gmbh Pharmaceutical compositions comprising NEP-inhibitors, inhibitors of the endogenous endothelin producing system and diuretics
WO2007048787A1 (fr) 2005-10-25 2007-05-03 Pharmaleads Derives d'amino-acides contenant un groupement disulfanyle comme inhibiteurs mixtes de la neprilysine et de l 'aminopeptidase n
WO2007109456A2 (en) 2006-03-16 2007-09-27 Pharmacopeia, Inc. Substituted biphenyl isoxazole sulfonamides as dual angiotensin endothelin receptor antagonists
EP1903027A1 (en) 2006-09-13 2008-03-26 Novartis AG Process for preparing biaryl substituted 4-amino-butyric acid or derivatives thereof and their use in the production of NEP inhibitors
PT2121578T (pt) 2007-01-12 2016-11-14 Novartis Ag Processo de preparação de ácido 5-bifenil-4-amino-2-metil-pentanoico
TW200838501A (en) * 2007-02-02 2008-10-01 Theravance Inc Dual-acting antihypertensive agents
TWI448284B (zh) 2007-04-24 2014-08-11 Theravance Inc 雙效抗高血壓劑
WO2009035543A1 (en) 2007-09-07 2009-03-19 Theravance, Inc. Dual-acting antihypertensive agents
US7989484B2 (en) 2008-04-29 2011-08-02 Theravance, Inc. Dual-acting antihypertensive agents
JP5420761B2 (ja) 2009-05-28 2014-02-19 ノバルティス アーゲー ネプリリシン阻害剤としての置換アミノプロピオン酸誘導体
KR20120041702A (ko) 2009-05-28 2012-05-02 노파르티스 아게 네프릴리신 억제제로서의 치환된 아미노부티르산 유도체
JO2967B1 (en) * 2009-11-20 2016-03-15 نوفارتس ايه جي Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors

Similar Documents

Publication Publication Date Title
JP2014505660A5 (enExample)
PE20241127A1 (es) Compuestos triciclicos como inhibidores de kras
MX2022008066A (es) Compuestos triciclicos sustituidos.
BR112013025634A2 (pt) inibidores de hsp90
JP2008535902A5 (enExample)
JP2015518004A5 (enExample)
RU2013121788A (ru) Ингибиторы репликации вич
EA200970535A1 (ru) Антибактериальные производные хинолина
CR20200418A (es) Inhibidores de orginasa y sus mètodos de uso antecedentes
RU2014135436A (ru) Комбинация ингибитора rtk с антиэстрогеном и ее применение для лечения рака
RU2010126056A (ru) Органические соединения
JP2011521938A5 (enExample)
EA201391263A1 (ru) Комбинированные терапии гематологических опухолей
JP2011516498A5 (enExample)
MX2010007374A (es) Nuevos derivados de c-21-ceto lupano, preparacion y uso de los mismos.
JP2013522368A5 (enExample)
RU2012110380A (ru) Новое производное 5-фторурацила
RU2019141734A (ru) Терапевтические соединения и композиции и способы их применения
RU2013136895A (ru) Новое бициклическое соединение или его соль
RU2007118727A (ru) Ингибиторы mif
RU2013136861A (ru) Новое производное индола или индазола или его соль
RU2009128970A (ru) Производные изосорбидмононитрата для лечения кишечных заболеваний
RU2014112320A (ru) Ингибитор pi3k, предназначенный для применения для лечения рака кости или для предупреждения метастатической диссеминации первичных раковых клеток в кость
WO2010073078A3 (en) Heterocyclic compounds as hdac inhibitors
RU2015155438A (ru) Ингибиторы вирусной репликации, способ их получения и их терапевтические применения