JP2008511634A5 - - Google Patents
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- Publication number
- JP2008511634A5 JP2008511634A5 JP2007530141A JP2007530141A JP2008511634A5 JP 2008511634 A5 JP2008511634 A5 JP 2008511634A5 JP 2007530141 A JP2007530141 A JP 2007530141A JP 2007530141 A JP2007530141 A JP 2007530141A JP 2008511634 A5 JP2008511634 A5 JP 2008511634A5
- Authority
- JP
- Japan
- Prior art keywords
- galactosylceramide
- alkene
- glycosylceramide
- group
- alkane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CC(C(C([C@]1O)O)O)(OC[C@](C(*)O)NC(*)=O)O[C@@]1(CO)N Chemical compound CC(C(C([C@]1O)O)O)(OC[C@](C(*)O)NC(*)=O)O[C@@]1(CO)N 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60536204P | 2004-08-27 | 2004-08-27 | |
| US60/605,362 | 2004-08-27 | ||
| PCT/US2005/030330 WO2006026389A2 (en) | 2004-08-27 | 2005-08-26 | Ceramide derivatives as modulators of immunity and autoimmunity |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012152661A Division JP2012211182A (ja) | 2004-08-27 | 2012-07-06 | 免疫及び自己免疫の調節因子としてのセラミド誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008511634A JP2008511634A (ja) | 2008-04-17 |
| JP2008511634A5 true JP2008511634A5 (enExample) | 2008-10-16 |
| JP5226311B2 JP5226311B2 (ja) | 2013-07-03 |
Family
ID=36000590
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007530141A Expired - Fee Related JP5226311B2 (ja) | 2004-08-27 | 2005-08-26 | 免疫及び自己免疫の調節因子としてのセラミド誘導体 |
| JP2012152661A Withdrawn JP2012211182A (ja) | 2004-08-27 | 2012-07-06 | 免疫及び自己免疫の調節因子としてのセラミド誘導体 |
| JP2014185949A Expired - Fee Related JP5870327B2 (ja) | 2004-08-27 | 2014-09-12 | 免疫及び自己免疫の調節因子としてのセラミド誘導体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012152661A Withdrawn JP2012211182A (ja) | 2004-08-27 | 2012-07-06 | 免疫及び自己免疫の調節因子としてのセラミド誘導体 |
| JP2014185949A Expired - Fee Related JP5870327B2 (ja) | 2004-08-27 | 2014-09-12 | 免疫及び自己免疫の調節因子としてのセラミド誘導体 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7772380B2 (enExample) |
| EP (1) | EP1784196B1 (enExample) |
| JP (3) | JP5226311B2 (enExample) |
| KR (2) | KR101377116B1 (enExample) |
| CN (1) | CN101010086B (enExample) |
| AU (1) | AU2005280163B2 (enExample) |
| CA (1) | CA2577009C (enExample) |
| IL (1) | IL181054A (enExample) |
| NZ (1) | NZ553320A (enExample) |
| WO (1) | WO2006026389A2 (enExample) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9809654B2 (en) | 2002-09-27 | 2017-11-07 | Vaccinex, Inc. | Targeted CD1d molecules |
| US7645873B2 (en) | 2003-03-20 | 2010-01-12 | The Scripps Research Institute | 6″-amino-6″-deoxygalactosylceramides |
| US8022043B2 (en) * | 2004-08-27 | 2011-09-20 | Albert Einstein College Of Medicine Of Yeshiva University | Ceramide derivatives as modulators of immunity and autoimmunity |
| EP1784196B1 (en) * | 2004-08-27 | 2016-12-21 | Albert Einstein College Of Medicine Of Yeshiva University | Ceramide derivatives as modulators of immunity and autoimmunity |
| GB0419846D0 (en) | 2004-09-07 | 2004-10-13 | Chiron Srl | Vaccine adjuvants for saccharides |
| US7534434B2 (en) | 2004-12-28 | 2009-05-19 | The Rockefeller University | Glycolipids and analogues thereof as antigens for NK T cells |
| US7923013B2 (en) | 2004-12-28 | 2011-04-12 | The Rockefeller University | Glycolipids and analogues thereof as antigens for NKT cells |
| US20100129339A1 (en) * | 2005-10-06 | 2010-05-27 | Riken | Nkt cell-stimulating agent for administration through upper respiratory tract mucous membrane |
| GB0605247D0 (en) * | 2006-03-15 | 2006-04-26 | Chiron Srl | Compositions and methods for immunisation |
| BRPI0710668A2 (pt) | 2006-04-07 | 2011-08-16 | Scripps Res Insittute | alfa-galactosil ceramidas modificadas para marcar e estimular células t matadoras naturais |
| CA2655947C (en) | 2006-06-30 | 2016-08-02 | The Scripps Research Institute | Compositions comprising nkt cell agonist compounds and methods of use |
| JP2010504332A (ja) * | 2006-09-19 | 2010-02-12 | ヒューマン バイオモレキュラル リサーチ インスティテュート | アルツハイマー病の診断方法及び遺伝子マーカー |
| WO2008047174A1 (en) * | 2006-10-18 | 2008-04-24 | Centre National De La Recherche Scientifique | Alpha-galactosylceramide analogs, their methods of manufacture, intermediate compounds useful in these methods, and pharmaceutical compositions containing them |
| KR100868959B1 (ko) * | 2006-12-30 | 2008-11-17 | 재단법인서울대학교산학협력재단 | 알파-갈락토실세라마이드 유도체, 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는면역보조용 약학적 조성물 |
| WO2008103392A2 (en) * | 2007-02-21 | 2008-08-28 | Vaccinex, Inc. | Modulation of nkt cell activity with antigen-loaded cdid molecules |
| JP2010519274A (ja) | 2007-02-21 | 2010-06-03 | フラームス・インテルウニフェルシタイル・インステイチュート・フォール・ビオテヒノロヒー・ヴェーゼットウェー(ヴェーイーベー・ヴェーゼットウェー) | TNFおよびα−ガラクトシルセラミドを使用する併用療法 |
| CA2685125A1 (en) * | 2007-04-25 | 2008-11-06 | Immurx, Inc. | Adjuvant combinations comprising an nkt activator, a cd40 agonist, and optionally an antigen and use thereof for inducing a synergistic enhancement in cellular immunity |
| US8916164B2 (en) * | 2007-08-29 | 2014-12-23 | Abivax | Methods of enhancing adjuvaticity of vaccine compositions |
| CA2702344C (en) | 2007-10-12 | 2016-09-27 | Luigi Panza | Analogues of glycolipids useful as immunoadjuvants |
| EP2058011A1 (en) | 2007-11-07 | 2009-05-13 | Wittycell | Nkt cell activating gycolipids covalently bound antigens and/or drug |
| US7928077B2 (en) * | 2008-07-11 | 2011-04-19 | Academia Sinica | Alpha-galactosyl ceramide analogs and their use as immunotherapies |
| WO2010027479A2 (en) | 2008-09-08 | 2010-03-11 | Children's Medical Center Corporation | Mucosal delivery of therapeutic molecules, proteins, or particles coupled to ceramide lipids |
| JP5574432B2 (ja) * | 2008-09-11 | 2014-08-20 | 独立行政法人理化学研究所 | エステル化α−ガラクトシルセラミド類 |
| JP5809560B2 (ja) | 2008-10-08 | 2015-11-11 | アビヴァックス | インフルエンザに対して使用するためのワクチン組成物 |
| EP2385980B1 (en) * | 2009-01-08 | 2018-04-18 | Albert Einstein College of Medicine, Inc. | Bacterial vaccines with cell wall-associated ceramide-like glycolipids and uses thereof |
| KR20110045545A (ko) * | 2009-10-27 | 2011-05-04 | 서울대학교산학협력단 | 신규 알파-갈락토실세라마이드 유도체, 이의 약학적으로 허용 가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 면역보조용 약학적 조성물 |
| US8835613B2 (en) * | 2010-03-12 | 2014-09-16 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | β-mannosylceramide and stimulation of NKT cell anti-tumor immunity |
| WO2013007792A1 (en) * | 2011-07-14 | 2013-01-17 | Thurgauische Stiftung Für Wissenschaft Und Forschung | Novel th2 polarizing compounds |
| EP2755688A4 (en) | 2011-10-27 | 2014-08-06 | Nkt Therapeutics Inc | HUMANIZED ANTIBODIES AGAINST INKT |
| EP2785353A4 (en) * | 2011-11-28 | 2015-06-17 | Uti Limited Partnership | PROPHYLACTIC COMPOSITIONS FOR THE MANAGEMENT OF MICROBIAL INFECTIONS IN PATIENTS WITH CEREBRAL INJURY |
| US10227290B2 (en) | 2012-02-07 | 2019-03-12 | The Regents Of The University Of California | Glycosphingolipids for use in modulating immune responses |
| KR101969814B1 (ko) * | 2012-02-24 | 2019-04-18 | 주식회사 진영바이오 | 글리코실 세라마이드 화합물 및 그 제조방법 |
| AU2013237497B2 (en) * | 2012-03-19 | 2016-05-12 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Carbohydrate-glycolipid conjugate vaccines |
| US9708601B2 (en) | 2012-04-26 | 2017-07-18 | Vaccinex, Inc. | Fusion proteins to facilitate selection of cells infected with specific immunoglobulin gene recombinant vaccinia virus |
| KR102099764B1 (ko) * | 2012-04-26 | 2020-04-10 | 리가가쿠 겐큐쇼 | 신규 카르바메이트 당지질 및 그 용도 |
| KR102162619B1 (ko) * | 2012-07-26 | 2020-10-08 | 빅토리아 링크 엘티디 | 유기 화합물 |
| US20150224129A1 (en) | 2012-10-03 | 2015-08-13 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the prophylactic treatment of bacterial superinfections post-influenza with invariant nkt cell agonists |
| CA2925878A1 (en) | 2012-10-12 | 2014-04-17 | The Brigham And Women's Hospital, Inc. | Glycosphingolipids and methods of use thereof |
| US9861702B2 (en) | 2012-10-22 | 2018-01-09 | Wisconsin Alumni Research Foundation | Lipid-conjugated rhamnose for immune system recruitment and oncotherapy |
| CA2893918C (en) * | 2012-12-06 | 2020-11-24 | Callaghan Innovation Research Limited | Conjugate compounds |
| US9371352B2 (en) | 2013-02-08 | 2016-06-21 | Vaccinex, Inc. | Modified glycolipids and methods of making and using the same |
| CN105339379B (zh) * | 2013-02-08 | 2019-11-26 | 瓦克纳斯有限公司 | 改性的糖脂及其制备和使用方法 |
| CN105247068A (zh) * | 2013-03-15 | 2016-01-13 | 珀金埃尔默健康科学股份有限公司 | 与溶酶体贮积症的测试相关的化合物和方法 |
| CN105682666B (zh) * | 2013-09-06 | 2021-06-01 | 中央研究院 | 使用醣脂激活人类iNKT细胞 |
| CN105461681A (zh) * | 2014-09-05 | 2016-04-06 | 中国科学院生态环境研究中心 | 具有抗肿瘤活性的krn7000类似物及合成方法 |
| TWI745275B (zh) * | 2014-09-08 | 2021-11-11 | 中央研究院 | 使用醣脂激活人類iNKT細胞 |
| KR101589633B1 (ko) * | 2014-09-18 | 2016-02-01 | 한국과학기술연구원 | 당세라마이드 유도체 및 이의 제조방법 |
| CN104497065B (zh) * | 2014-11-24 | 2017-10-24 | 浙江大学 | α‑半乳糖神经酰胺新异构体及其用途 |
| CN104497064B (zh) * | 2014-11-24 | 2017-10-24 | 浙江大学 | α‑半乳糖神经酰胺新异构体及其合成方法 |
| CN105384785B (zh) * | 2015-11-24 | 2018-06-19 | 中国人民解放军第二军医大学 | 含有半乳糖类脂肪酸衍生物的制备方法及其在医药领域的应用 |
| PT3445397T (pt) | 2016-04-22 | 2023-01-13 | Vaccinex Inc | Exibição de proteína integral de membrana sobre viriões envelopados extracelulares de poxvírus |
| WO2017207040A1 (en) | 2016-06-01 | 2017-12-07 | Vib Vzw | ANTI-CANCER THERAPY USING A LEPTIN ANTAGONIST AND AN iNKT-CELL ACTIVATOR |
| IL264343B2 (en) | 2016-08-02 | 2024-05-01 | Vaccinex Inc | Improved methods for producing polynucleotide libraries in vaccinia virus/eukaryotic cells |
| AU2018354422A1 (en) | 2017-10-27 | 2020-05-28 | Children's Medical Center Corporation | Short chain ceramide-based lipids and uses thereof |
| US11771771B2 (en) | 2018-04-12 | 2023-10-03 | Children's Medical Center Corporation | Ceramide-like lipid-based delivery vehicles and uses thereof |
| CN109701009A (zh) * | 2019-01-03 | 2019-05-03 | 华中师范大学 | 疫苗制剂及其应用 |
| KR102146226B1 (ko) * | 2019-03-07 | 2020-08-20 | 경희대학교 산학협력단 | 피토세라마이드 또는 이의 약학적으로 허용가능한 염을 유효성분으로 포함하는 신경계 자가면역질환의 예방 또는 치료용 조성물 |
| WO2022102557A1 (ja) * | 2020-11-12 | 2022-05-19 | 国立研究開発法人理化学研究所 | 擬似糖脂質誘導体並びにその合成中間体、製造方法及び用途 |
| EP4301374A4 (en) * | 2021-03-01 | 2025-09-10 | Deciduous Therapeutics Inc | COMPOUNDS FOR ACTIVATING INVARIANT NATURAL KILLER T CELLS AND METHODS OF USE IN ELIMINATING INFLAMMATORY SENESCENT CELLS |
| WO2023096715A2 (en) * | 2021-10-22 | 2023-06-01 | President And Fellows Of Harvard College | Immunomodulatory glycosphingolipids and methods of use thereof |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5936076A (en) * | 1991-08-29 | 1999-08-10 | Kirin Beer Kabushiki Kaisha | αgalactosylceramide derivatives |
| US5849716A (en) * | 1992-10-22 | 1998-12-15 | Kirin Beer Kabushiki Kaisha | Sphingoglycolipids, their preparation, and therapeutic methods of use |
| US6238676B1 (en) * | 1992-12-10 | 2001-05-29 | Brigham And Women's Hospital | Presentation of hydrophobic antigens to T-cells by CD1 molecules |
| US5853737A (en) * | 1992-12-10 | 1998-12-29 | Brigham And Women's Hospital | Method for inducing a CD1-restricted immune response |
| US5679347A (en) * | 1992-12-10 | 1997-10-21 | Brigham And Women's Hospital | Methods of isolating CD1-presented antigens, vaccines comprising CD1-presented antigens, and cell lines for use in said methods |
| ATE176237T1 (de) * | 1993-04-15 | 1999-02-15 | Kirin Brewery | Sphingoglycolipid und verwendung davon |
| US5973128A (en) * | 1996-11-22 | 1999-10-26 | The Hospital For Sick Children Research And Development Lp | Glycolipid mimics and methods of use thereof |
| JP2004131481A (ja) * | 1997-04-10 | 2004-04-30 | Kirin Brewery Co Ltd | α−グリコシルセラミドを含有するNKT細胞活性化剤 |
| ES2235324T3 (es) * | 1997-04-10 | 2005-07-01 | Kirin Beer Kabushiki Kaisha | Empleo de a-glicosilceramidas para la obtencion de un agente terapeutico para enfermedades autoinmunes. |
| WO1999034209A1 (en) * | 1997-12-31 | 1999-07-08 | The Brigham And Women's Hospital, Inc. | DIAGNOSTIC AND THERAPEUTIC METHODS BASED UPON Vα24JαQ T CELLS |
| WO2003009812A2 (en) * | 2001-07-25 | 2003-02-06 | New York University | Use of glycosylceramides as adjuvants for vaccines against infections and cancer |
| EP1437358B1 (en) * | 2001-08-16 | 2006-10-18 | Daiichi Asubio Pharma Co., Ltd. | Novel glycolipid and remedial agent for autoimmune disease containing the same as active ingredient |
| CA2493690C (en) * | 2002-06-13 | 2011-11-08 | New York University | Synthetic c-glycolipid and its use for treating cancer, infectious diseases and autoimmune diseases |
| US20060116331A1 (en) * | 2002-09-27 | 2006-06-01 | Biomira, Inc. | Glycosylceramide analogues |
| US7732583B2 (en) * | 2003-02-14 | 2010-06-08 | Japan As Represented By President Of National Center Of Neurology And Psychiatry | Glycolipids and synthetic method thereof as well as their synthetic intermediates, and synthetic intermediates, and synthetic method thereof |
| EP1784196B1 (en) * | 2004-08-27 | 2016-12-21 | Albert Einstein College Of Medicine Of Yeshiva University | Ceramide derivatives as modulators of immunity and autoimmunity |
-
2005
- 2005-08-26 EP EP05808439.3A patent/EP1784196B1/en not_active Expired - Lifetime
- 2005-08-26 JP JP2007530141A patent/JP5226311B2/ja not_active Expired - Fee Related
- 2005-08-26 NZ NZ553320A patent/NZ553320A/en not_active IP Right Cessation
- 2005-08-26 US US11/211,653 patent/US7772380B2/en not_active Expired - Fee Related
- 2005-08-26 WO PCT/US2005/030330 patent/WO2006026389A2/en not_active Ceased
- 2005-08-26 CN CN2005800289881A patent/CN101010086B/zh not_active Expired - Fee Related
- 2005-08-26 CA CA2577009A patent/CA2577009C/en not_active Expired - Fee Related
- 2005-08-26 KR KR1020077003168A patent/KR101377116B1/ko not_active Expired - Fee Related
- 2005-08-26 KR KR1020127025454A patent/KR20120116511A/ko not_active Ceased
- 2005-08-26 AU AU2005280163A patent/AU2005280163B2/en not_active Ceased
-
2007
- 2007-01-30 IL IL181054A patent/IL181054A/en active IP Right Grant
-
2012
- 2012-07-06 JP JP2012152661A patent/JP2012211182A/ja not_active Withdrawn
-
2014
- 2014-09-12 JP JP2014185949A patent/JP5870327B2/ja not_active Expired - Fee Related
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