CN101010086B - 作为免疫和自身免疫调节剂的神经酰胺衍生物 - Google Patents
作为免疫和自身免疫调节剂的神经酰胺衍生物 Download PDFInfo
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- CN101010086B CN101010086B CN2005800289881A CN200580028988A CN101010086B CN 101010086 B CN101010086 B CN 101010086B CN 2005800289881 A CN2005800289881 A CN 2005800289881A CN 200580028988 A CN200580028988 A CN 200580028988A CN 101010086 B CN101010086 B CN 101010086B
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- 0 *C([C@](CO[C@](C(O)=C1O)OC(CO)[C@@]1O)NC(*)=O)O Chemical compound *C([C@](CO[C@](C(O)=C1O)OC(CO)[C@@]1O)NC(*)=O)O 0.000 description 2
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- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
- C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
- C07H15/06—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical being a hydroxyalkyl group esterified by a fatty acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
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- Chemical & Material Sciences (AREA)
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- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
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- Pharmacology & Pharmacy (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Genetics & Genomics (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Neurology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Microbiology (AREA)
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- Epidemiology (AREA)
- Mycology (AREA)
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- Urology & Nephrology (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60536204P | 2004-08-27 | 2004-08-27 | |
| US60/605,362 | 2004-08-27 | ||
| PCT/US2005/030330 WO2006026389A2 (en) | 2004-08-27 | 2005-08-26 | Ceramide derivatives as modulators of immunity and autoimmunity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101010086A CN101010086A (zh) | 2007-08-01 |
| CN101010086B true CN101010086B (zh) | 2013-05-29 |
Family
ID=36000590
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2005800289881A Expired - Fee Related CN101010086B (zh) | 2004-08-27 | 2005-08-26 | 作为免疫和自身免疫调节剂的神经酰胺衍生物 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7772380B2 (enExample) |
| EP (1) | EP1784196B1 (enExample) |
| JP (3) | JP5226311B2 (enExample) |
| KR (2) | KR20120116511A (enExample) |
| CN (1) | CN101010086B (enExample) |
| AU (1) | AU2005280163B2 (enExample) |
| CA (1) | CA2577009C (enExample) |
| IL (1) | IL181054A (enExample) |
| NZ (1) | NZ553320A (enExample) |
| WO (1) | WO2006026389A2 (enExample) |
Families Citing this family (60)
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|---|---|---|---|---|
| US9809654B2 (en) | 2002-09-27 | 2017-11-07 | Vaccinex, Inc. | Targeted CD1d molecules |
| US7645873B2 (en) | 2003-03-20 | 2010-01-12 | The Scripps Research Institute | 6″-amino-6″-deoxygalactosylceramides |
| KR20120116511A (ko) * | 2004-08-27 | 2012-10-22 | 알버트 아인슈타인 컬리지 오브 메디신 오브 예쉬바 유니버시티 | 면역 및 자가면역의 조절제로서의 세라마이드 유도체 |
| US8022043B2 (en) * | 2004-08-27 | 2011-09-20 | Albert Einstein College Of Medicine Of Yeshiva University | Ceramide derivatives as modulators of immunity and autoimmunity |
| GB0419846D0 (en) | 2004-09-07 | 2004-10-13 | Chiron Srl | Vaccine adjuvants for saccharides |
| US7923013B2 (en) | 2004-12-28 | 2011-04-12 | The Rockefeller University | Glycolipids and analogues thereof as antigens for NKT cells |
| JP5090928B2 (ja) * | 2004-12-28 | 2012-12-05 | ザ ロックフェラー ユニバーシティ | Nkt細胞に対する抗原としての糖脂質及びその類似体 |
| US20100129339A1 (en) * | 2005-10-06 | 2010-05-27 | Riken | Nkt cell-stimulating agent for administration through upper respiratory tract mucous membrane |
| GB0605247D0 (en) * | 2006-03-15 | 2006-04-26 | Chiron Srl | Compositions and methods for immunisation |
| SI2056842T1 (sl) | 2006-04-07 | 2013-02-28 | The Scripps Research Institute | Modificiran galaktosil-ceramid za zdravljenje kancerogenih obolenj |
| AU2007269299B2 (en) * | 2006-06-30 | 2013-01-17 | Brigham Young University | Adjuvants and methods of use |
| WO2008048410A2 (en) * | 2006-09-19 | 2008-04-24 | Human Biomolecular Research Institute | Diagnostic methods and genetic markers for alzheimer disease |
| WO2008047174A1 (en) * | 2006-10-18 | 2008-04-24 | Centre National De La Recherche Scientifique | Alpha-galactosylceramide analogs, their methods of manufacture, intermediate compounds useful in these methods, and pharmaceutical compositions containing them |
| KR100868959B1 (ko) * | 2006-12-30 | 2008-11-17 | 재단법인서울대학교산학협력재단 | 알파-갈락토실세라마이드 유도체, 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는면역보조용 약학적 조성물 |
| JP2010519274A (ja) | 2007-02-21 | 2010-06-03 | フラームス・インテルウニフェルシタイル・インステイチュート・フォール・ビオテヒノロヒー・ヴェーゼットウェー(ヴェーイーベー・ヴェーゼットウェー) | TNFおよびα−ガラクトシルセラミドを使用する併用療法 |
| AU2008219020B2 (en) | 2007-02-21 | 2013-08-22 | Vaccinex, Inc. | Modulation of NKT cell activity with antigen-loaded CDId molecules |
| US8802098B2 (en) | 2007-04-25 | 2014-08-12 | Immurx, Inc. | Methods of promoting antitumor immunity by administering CD40 agonists and alpha-galactosyl ceramide |
| US8916164B2 (en) | 2007-08-29 | 2014-12-23 | Abivax | Methods of enhancing adjuvaticity of vaccine compositions |
| WO2009060305A2 (en) | 2007-10-12 | 2009-05-14 | Luigi Panza | Analogues of glycolipids useful as immunoadjuvants |
| EP2058011A1 (en) | 2007-11-07 | 2009-05-13 | Wittycell | Nkt cell activating gycolipids covalently bound antigens and/or drug |
| US7928077B2 (en) * | 2008-07-11 | 2011-04-19 | Academia Sinica | Alpha-galactosyl ceramide analogs and their use as immunotherapies |
| WO2010027479A2 (en) | 2008-09-08 | 2010-03-11 | Children's Medical Center Corporation | Mucosal delivery of therapeutic molecules, proteins, or particles coupled to ceramide lipids |
| JP5574432B2 (ja) * | 2008-09-11 | 2014-08-20 | 独立行政法人理化学研究所 | エステル化α−ガラクトシルセラミド類 |
| CN102215864A (zh) | 2008-10-08 | 2011-10-12 | 威蒂赛尔公司 | 用于抗流感的疫苗组合物 |
| PT2385980T (pt) * | 2009-01-08 | 2018-06-26 | Albert Einstein College Medicine Inc | Vacinas bacterianas com glicolípidos do tipo ceramida associados à parede celular e utilização dos mesmos |
| KR20110045545A (ko) * | 2009-10-27 | 2011-05-04 | 서울대학교산학협력단 | 신규 알파-갈락토실세라마이드 유도체, 이의 약학적으로 허용 가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 면역보조용 약학적 조성물 |
| WO2011112889A2 (en) * | 2010-03-12 | 2011-09-15 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | β-MANNOSYLCERAMIDE AND STIMULATION OF NKT CELL ANTI-TUMOR IMMUNITY |
| WO2013007792A1 (en) * | 2011-07-14 | 2013-01-17 | Thurgauische Stiftung Für Wissenschaft Und Forschung | Novel th2 polarizing compounds |
| HK1199405A1 (en) | 2011-10-27 | 2015-07-03 | Nkt治疗公司 | Humanized antibodies to inkt |
| CA2857226A1 (en) * | 2011-11-28 | 2013-06-06 | Uti Limited Partnership | Prophylactic compositions for management of microbial infections in patients with brain injury |
| EP2811831B1 (en) | 2012-02-07 | 2018-04-11 | The Regents Of The University Of California | Glycosphingolipids for use in modulating immune responses |
| KR101969814B1 (ko) * | 2012-02-24 | 2019-04-18 | 주식회사 진영바이오 | 글리코실 세라마이드 화합물 및 그 제조방법 |
| JP5933106B2 (ja) * | 2012-03-19 | 2016-06-08 | マックス プランク ゲゼルシャフト ツゥアー フェデルゥン デル ヴィッセンシャフテン エー フォー | 炭水化物−糖脂質共役ワクチン |
| US9708601B2 (en) | 2012-04-26 | 2017-07-18 | Vaccinex, Inc. | Fusion proteins to facilitate selection of cells infected with specific immunoglobulin gene recombinant vaccinia virus |
| KR102099764B1 (ko) * | 2012-04-26 | 2020-04-10 | 리가가쿠 겐큐쇼 | 신규 카르바메이트 당지질 및 그 용도 |
| US9586985B2 (en) * | 2012-07-26 | 2017-03-07 | Victoria Link Limited | Organic compounds as proantigens for natural killer T cells |
| US20150224129A1 (en) | 2012-10-03 | 2015-08-13 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the prophylactic treatment of bacterial superinfections post-influenza with invariant nkt cell agonists |
| WO2014059220A1 (en) | 2012-10-12 | 2014-04-17 | The Brigham And Women's Hospital, Inc. | Glycosphingolipids and methods of use thereof |
| US9861702B2 (en) | 2012-10-22 | 2018-01-09 | Wisconsin Alumni Research Foundation | Lipid-conjugated rhamnose for immune system recruitment and oncotherapy |
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| JP6466907B2 (ja) | 2013-03-15 | 2019-02-06 | パーキンエルマー・ヘルス・サイエンシーズ・インコーポレイテッドPerkinelmer Health Sciences, Inc. | ライソゾーム病の検査に関する化合物および方法 |
| KR102298172B1 (ko) * | 2013-09-06 | 2021-09-06 | 아카데미아 시니카 | 변화된 글리코실 그룹을 갖는 당지질을 사용한 인간 iNKT 세포 활성화 |
| CN105461681A (zh) * | 2014-09-05 | 2016-04-06 | 中国科学院生态环境研究中心 | 具有抗肿瘤活性的krn7000类似物及合成方法 |
| KR102422375B1 (ko) * | 2014-09-08 | 2022-07-18 | 아카데미아 시니카 | 당지질을 사용한 인간 iNKT 세포 활성화 |
| KR101589633B1 (ko) * | 2014-09-18 | 2016-02-01 | 한국과학기술연구원 | 당세라마이드 유도체 및 이의 제조방법 |
| CN104497064B (zh) * | 2014-11-24 | 2017-10-24 | 浙江大学 | α‑半乳糖神经酰胺新异构体及其合成方法 |
| CN104497065B (zh) * | 2014-11-24 | 2017-10-24 | 浙江大学 | α‑半乳糖神经酰胺新异构体及其用途 |
| CN105384785B (zh) * | 2015-11-24 | 2018-06-19 | 中国人民解放军第二军医大学 | 含有半乳糖类脂肪酸衍生物的制备方法及其在医药领域的应用 |
| SG11201808554TA (en) | 2016-04-22 | 2018-11-29 | Vaccinex Inc | Integral membrane protein display on poxvirus extracellular enveloped virions |
| WO2017207040A1 (en) | 2016-06-01 | 2017-12-07 | Vib Vzw | ANTI-CANCER THERAPY USING A LEPTIN ANTAGONIST AND AN iNKT-CELL ACTIVATOR |
| SG11201900595YA (en) | 2016-08-02 | 2019-02-27 | Vaccinex Inc | Improved methods for producing polynucleotide libraries in vaccinia virus/eukaryotic cells |
| CA3080521A1 (en) | 2017-10-27 | 2019-05-02 | Children's Medical Center Corporation | Short chain ceramide-based lipids and uses thereof |
| CA3096398A1 (en) | 2018-04-12 | 2019-10-17 | Children's Medical Center Corporation | Ceramide-like lipid-based delivery vehicles and uses thereof |
| CN109701009A (zh) * | 2019-01-03 | 2019-05-03 | 华中师范大学 | 疫苗制剂及其应用 |
| KR102146226B1 (ko) * | 2019-03-07 | 2020-08-20 | 경희대학교 산학협력단 | 피토세라마이드 또는 이의 약학적으로 허용가능한 염을 유효성분으로 포함하는 신경계 자가면역질환의 예방 또는 치료용 조성물 |
| WO2022102557A1 (ja) * | 2020-11-12 | 2022-05-19 | 国立研究開発法人理化学研究所 | 擬似糖脂質誘導体並びにその合成中間体、製造方法及び用途 |
| IL305579A (en) * | 2021-03-01 | 2023-10-01 | Deciduous Therapeutics Inc | Compounds for activating invariant natural killer T cells and methods for use in eliminating inflammatory senescent cells |
| WO2023096715A2 (en) * | 2021-10-22 | 2023-06-01 | President And Fellows Of Harvard College | Immunomodulatory glycosphingolipids and methods of use thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5936076A (en) * | 1991-08-29 | 1999-08-10 | Kirin Beer Kabushiki Kaisha | αgalactosylceramide derivatives |
| US6747010B2 (en) * | 1997-04-10 | 2004-06-08 | Kirin Beer Kabushiki Kaisha | NKT cell-activating agents containing α-glycosylceramides |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2147629C (en) * | 1992-10-22 | 2005-03-22 | Koji Akimoto | Novel sphingoglycolipids and the use thereof |
| US6238676B1 (en) * | 1992-12-10 | 2001-05-29 | Brigham And Women's Hospital | Presentation of hydrophobic antigens to T-cells by CD1 molecules |
| US5853737A (en) * | 1992-12-10 | 1998-12-29 | Brigham And Women's Hospital | Method for inducing a CD1-restricted immune response |
| US5679347A (en) * | 1992-12-10 | 1997-10-21 | Brigham And Women's Hospital | Methods of isolating CD1-presented antigens, vaccines comprising CD1-presented antigens, and cell lines for use in said methods |
| AU683653B2 (en) * | 1993-04-15 | 1997-11-20 | Kirin Pharma Kabushiki Kaisha | Novel sphingoglycolipid and use thereof |
| US5973128A (en) * | 1996-11-22 | 1999-10-26 | The Hospital For Sick Children Research And Development Lp | Glycolipid mimics and methods of use thereof |
| JP2004131481A (ja) * | 1997-04-10 | 2004-04-30 | Kirin Brewery Co Ltd | α−グリコシルセラミドを含有するNKT細胞活性化剤 |
| AU2087799A (en) * | 1997-12-31 | 1999-07-19 | Brigham And Women's Hospital | Diagnostic and therapeutic methods based upon valpha24jalphaq t cells |
| EP1434859A2 (en) * | 2001-07-25 | 2004-07-07 | New York University | Use of glycosylceramides as adjuvants for vaccines against infections and cancer |
| BR0211968A (pt) * | 2001-08-16 | 2004-09-28 | Daiichi Suntory Pharma Co Ltd | Glicolipìdio útil no tratamento de doenças autoimunes e medicamento do mesmo |
| JP2005533057A (ja) * | 2002-06-13 | 2005-11-04 | ニューヨーク・ユニバーシティ | 合成c−糖脂質、ならびに癌、感染性疾患および自己免疫疾患を処置するための合成c−糖脂質の使用 |
| EP1572114A2 (en) * | 2002-09-27 | 2005-09-14 | Biomira, Inc. | Glycosylceramide analogues |
| CN100537585C (zh) * | 2003-02-14 | 2009-09-09 | 阿斯比奥制药株式会社 | 糖脂衍生物及其制造方法,以及其合成中间体及其制造方法 |
| KR20120116511A (ko) * | 2004-08-27 | 2012-10-22 | 알버트 아인슈타인 컬리지 오브 메디신 오브 예쉬바 유니버시티 | 면역 및 자가면역의 조절제로서의 세라마이드 유도체 |
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2005
- 2005-08-26 KR KR1020127025454A patent/KR20120116511A/ko not_active Ceased
- 2005-08-26 WO PCT/US2005/030330 patent/WO2006026389A2/en not_active Ceased
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- 2005-08-26 EP EP05808439.3A patent/EP1784196B1/en not_active Expired - Lifetime
- 2005-08-26 CN CN2005800289881A patent/CN101010086B/zh not_active Expired - Fee Related
- 2005-08-26 AU AU2005280163A patent/AU2005280163B2/en not_active Ceased
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5936076A (en) * | 1991-08-29 | 1999-08-10 | Kirin Beer Kabushiki Kaisha | αgalactosylceramide derivatives |
| US6747010B2 (en) * | 1997-04-10 | 2004-06-08 | Kirin Beer Kabushiki Kaisha | NKT cell-activating agents containing α-glycosylceramides |
Also Published As
| Publication number | Publication date |
|---|---|
| NZ553320A (en) | 2011-02-25 |
| EP1784196B1 (en) | 2016-12-21 |
| JP5870327B2 (ja) | 2016-02-24 |
| WO2006026389A3 (en) | 2006-05-26 |
| JP5226311B2 (ja) | 2013-07-03 |
| CA2577009A1 (en) | 2006-03-09 |
| EP1784196A4 (en) | 2012-05-30 |
| CN101010086A (zh) | 2007-08-01 |
| KR20070023825A (ko) | 2007-02-28 |
| AU2005280163B2 (en) | 2011-11-24 |
| IL181054A0 (en) | 2007-07-04 |
| JP2008511634A (ja) | 2008-04-17 |
| CA2577009C (en) | 2017-05-02 |
| IL181054A (en) | 2013-10-31 |
| US7772380B2 (en) | 2010-08-10 |
| AU2005280163A1 (en) | 2006-03-09 |
| KR101377116B1 (ko) | 2014-03-24 |
| JP2015007125A (ja) | 2015-01-15 |
| KR20120116511A (ko) | 2012-10-22 |
| EP1784196A2 (en) | 2007-05-16 |
| JP2012211182A (ja) | 2012-11-01 |
| US20060052316A1 (en) | 2006-03-09 |
| WO2006026389A2 (en) | 2006-03-09 |
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