AU2005280163B2 - Ceramide derivatives as modulators of immunity and autoimmunity - Google Patents

Ceramide derivatives as modulators of immunity and autoimmunity Download PDF

Info

Publication number
AU2005280163B2
AU2005280163B2 AU2005280163A AU2005280163A AU2005280163B2 AU 2005280163 B2 AU2005280163 B2 AU 2005280163B2 AU 2005280163 A AU2005280163 A AU 2005280163A AU 2005280163 A AU2005280163 A AU 2005280163A AU 2005280163 B2 AU2005280163 B2 AU 2005280163B2
Authority
AU
Australia
Prior art keywords
cell
galactosylceramide
cells
xch
mammal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2005280163A
Other languages
English (en)
Other versions
AU2005280163A1 (en
Inventor
Steven A. Porcelli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Albert Einstein College of Medicine
Original Assignee
Albert Einstein College of Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Albert Einstein College of Medicine filed Critical Albert Einstein College of Medicine
Publication of AU2005280163A1 publication Critical patent/AU2005280163A1/en
Application granted granted Critical
Publication of AU2005280163B2 publication Critical patent/AU2005280163B2/en
Assigned to ALBERT EINSTEIN COLLEGE OF MEDICINE, INC. reassignment ALBERT EINSTEIN COLLEGE OF MEDICINE, INC. Request to Amend Deed and Register Assignors: ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/06—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical being a hydroxyalkyl group esterified by a fatty acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Neurology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Rheumatology (AREA)
  • Mycology (AREA)
  • Transplantation (AREA)
  • Endocrinology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Obesity (AREA)
AU2005280163A 2004-08-27 2005-08-26 Ceramide derivatives as modulators of immunity and autoimmunity Ceased AU2005280163B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US60536204P 2004-08-27 2004-08-27
US60/605,362 2004-08-27
PCT/US2005/030330 WO2006026389A2 (en) 2004-08-27 2005-08-26 Ceramide derivatives as modulators of immunity and autoimmunity

Publications (2)

Publication Number Publication Date
AU2005280163A1 AU2005280163A1 (en) 2006-03-09
AU2005280163B2 true AU2005280163B2 (en) 2011-11-24

Family

ID=36000590

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2005280163A Ceased AU2005280163B2 (en) 2004-08-27 2005-08-26 Ceramide derivatives as modulators of immunity and autoimmunity

Country Status (10)

Country Link
US (1) US7772380B2 (enExample)
EP (1) EP1784196B1 (enExample)
JP (3) JP5226311B2 (enExample)
KR (2) KR20120116511A (enExample)
CN (1) CN101010086B (enExample)
AU (1) AU2005280163B2 (enExample)
CA (1) CA2577009C (enExample)
IL (1) IL181054A (enExample)
NZ (1) NZ553320A (enExample)
WO (1) WO2006026389A2 (enExample)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9809654B2 (en) 2002-09-27 2017-11-07 Vaccinex, Inc. Targeted CD1d molecules
US7645873B2 (en) 2003-03-20 2010-01-12 The Scripps Research Institute 6″-amino-6″-deoxygalactosylceramides
WO2006026389A2 (en) * 2004-08-27 2006-03-09 Albert Einstein College Of Medicine Of Yeshiva University Ceramide derivatives as modulators of immunity and autoimmunity
US8022043B2 (en) * 2004-08-27 2011-09-20 Albert Einstein College Of Medicine Of Yeshiva University Ceramide derivatives as modulators of immunity and autoimmunity
GB0419846D0 (en) 2004-09-07 2004-10-13 Chiron Srl Vaccine adjuvants for saccharides
US7923013B2 (en) 2004-12-28 2011-04-12 The Rockefeller University Glycolipids and analogues thereof as antigens for NKT cells
US7534434B2 (en) 2004-12-28 2009-05-19 The Rockefeller University Glycolipids and analogues thereof as antigens for NK T cells
US20100129339A1 (en) * 2005-10-06 2010-05-27 Riken Nkt cell-stimulating agent for administration through upper respiratory tract mucous membrane
GB0605247D0 (en) * 2006-03-15 2006-04-26 Chiron Srl Compositions and methods for immunisation
ES2397975T3 (es) 2006-04-07 2013-03-12 The Scrips Research Institute Galactosilceramida modificada para el tratamiento de enfermedades cancerosas
WO2008005824A1 (en) 2006-06-30 2008-01-10 The Scripps Research Institute Adjuvants and methods of use
WO2008048410A2 (en) * 2006-09-19 2008-04-24 Human Biomolecular Research Institute Diagnostic methods and genetic markers for alzheimer disease
WO2008047174A1 (en) * 2006-10-18 2008-04-24 Centre National De La Recherche Scientifique Alpha-galactosylceramide analogs, their methods of manufacture, intermediate compounds useful in these methods, and pharmaceutical compositions containing them
KR100868959B1 (ko) * 2006-12-30 2008-11-17 재단법인서울대학교산학협력재단 알파-갈락토실세라마이드 유도체, 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는면역보조용 약학적 조성물
WO2008101951A1 (en) 2007-02-21 2008-08-28 Vib Vzw Combination therapy using tnf and alfa-galactosyl ceramide
CA2678618C (en) 2007-02-21 2019-03-12 Vaccinex, Inc. Modulation of nkt cell activity with antigen-loaded cd1d molecules
AU2008246149B2 (en) 2007-04-25 2013-09-12 Immurx, Inc. Adjuvant combinations of NKT activator, CD40 agonist, and optional antigen, the use through inducing synergistic cellular immunity
US8916164B2 (en) 2007-08-29 2014-12-23 Abivax Methods of enhancing adjuvaticity of vaccine compositions
JP5416125B2 (ja) 2007-10-12 2014-02-12 ルイジ パンツァ， 免疫アジュバントとして有用な糖脂質の類似体
EP2058011A1 (en) 2007-11-07 2009-05-13 Wittycell Nkt cell activating gycolipids covalently bound antigens and/or drug
US7928077B2 (en) * 2008-07-11 2011-04-19 Academia Sinica Alpha-galactosyl ceramide analogs and their use as immunotherapies
US9457097B2 (en) 2008-09-08 2016-10-04 Children's Medical Corporation Mucosal delivery of therapeutic molecules, proteins, or particles coupled to ceramide lipids
EP2336144B1 (en) * 2008-09-11 2015-01-21 Riken Esterified alpha-galactosylceramide
WO2010040710A1 (en) 2008-10-08 2010-04-15 Wittycell Vaccine composition for use against influenza
AU2010203451B2 (en) * 2009-01-08 2016-06-30 Albert Einstein College Of Medicine, Inc. Bacterial vaccines with cell wall-associated ceramide-like glycolipids and uses thereof
KR20110045545A (ko) * 2009-10-27 2011-05-04 서울대학교산학협력단 신규 알파-갈락토실세라마이드 유도체, 이의 약학적으로 허용 가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 면역보조용 약학적 조성물
US8835613B2 (en) * 2010-03-12 2014-09-16 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services β-mannosylceramide and stimulation of NKT cell anti-tumor immunity
WO2013007792A1 (en) * 2011-07-14 2013-01-17 Thurgauische Stiftung Für Wissenschaft Und Forschung Novel th2 polarizing compounds
US9932402B2 (en) * 2011-10-27 2018-04-03 Nkt Therapeutics Inc. Humanized antibodies to iNKT
CA2857226A1 (en) * 2011-11-28 2013-06-06 Uti Limited Partnership Prophylactic compositions for management of microbial infections in patients with brain injury
EP2811831B1 (en) 2012-02-07 2018-04-11 The Regents Of The University Of California Glycosphingolipids for use in modulating immune responses
KR101969814B1 (ko) * 2012-02-24 2019-04-18 주식회사 진영바이오 글리코실 세라마이드 화합물 및 그 제조방법
DK2827899T3 (en) * 2012-03-19 2015-10-26 Max Planck Ges Zur Förderung Der Wissenschaften E V Polysaccharide-glycolipid conjugate vaccines
US9708601B2 (en) 2012-04-26 2017-07-18 Vaccinex, Inc. Fusion proteins to facilitate selection of cells infected with specific immunoglobulin gene recombinant vaccinia virus
SG11201406924UA (en) * 2012-04-26 2014-11-27 Riken New carbamate glycolipid and use thereof
EP2877481B1 (en) * 2012-07-26 2019-11-27 Victoria Link Limited Organic compounds
JP2015531384A (ja) 2012-10-03 2015-11-02 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル インバリアントｎｋｔ細胞アゴニストを用いたインフルエンザ後の細菌重複感染の予防的処置のための方法及び薬学的組成物
CA2925878A1 (en) 2012-10-12 2014-04-17 The Brigham And Women's Hospital, Inc. Glycosphingolipids and methods of use thereof
US9861702B2 (en) 2012-10-22 2018-01-09 Wisconsin Alumni Research Foundation Lipid-conjugated rhamnose for immune system recruitment and oncotherapy
CA2893918C (en) * 2012-12-06 2020-11-24 Callaghan Innovation Research Limited Conjugate compounds
US9371352B2 (en) 2013-02-08 2016-06-21 Vaccinex, Inc. Modified glycolipids and methods of making and using the same
NZ710949A (en) * 2013-02-08 2020-02-28 Vaccinex Inc Modified glycolipids and methods of making and using the same
TWI773147B (zh) * 2013-03-15 2022-08-01 美商珀金埃爾默健康科技公司 關於用於溶酶體儲積症之測試的化合物及方法
KR102298172B1 (ko) * 2013-09-06 2021-09-06 아카데미아 시니카 변화된 글리코실 그룹을 갖는 당지질을 사용한 인간 iNKT 세포 활성화
CN105461681A (zh) * 2014-09-05 2016-04-06 中国科学院生态环境研究中心 具有抗肿瘤活性的krn7000类似物及合成方法
TWI745275B (zh) * 2014-09-08 2021-11-11 中央研究院 使用醣脂激活人類ｉＮＫＴ細胞
KR101589633B1 (ko) * 2014-09-18 2016-02-01 한국과학기술연구원 당세라마이드 유도체 및 이의 제조방법
CN104497064B (zh) * 2014-11-24 2017-10-24 浙江大学 α‑半乳糖神经酰胺新异构体及其合成方法
CN104497065B (zh) * 2014-11-24 2017-10-24 浙江大学 α‑半乳糖神经酰胺新异构体及其用途
CN105384785B (zh) * 2015-11-24 2018-06-19 中国人民解放军第二军医大学 含有半乳糖类脂肪酸衍生物的制备方法及其在医药领域的应用
PT3445397T (pt) 2016-04-22 2023-01-13 Vaccinex Inc Exibição de proteína integral de membrana sobre viriões envelopados extracelulares de poxvírus
WO2017207040A1 (en) 2016-06-01 2017-12-07 Vib Vzw ANTI-CANCER THERAPY USING A LEPTIN ANTAGONIST AND AN iNKT-CELL ACTIVATOR
EP3494131B1 (en) 2016-08-02 2024-09-18 Vaccinex, Inc. Improved methods for producing polynucleotide libraries in vaccinia virus/eukaryotic cells
JP2021501161A (ja) 2017-10-27 2021-01-14 ザ チルドレンズ メディカル センター コーポレーション 短鎖セラミドベースの脂質およびその使用
WO2019200293A1 (en) 2018-04-12 2019-10-17 Children's Medical Center Corporation Ceramide-like lipid-based delivery vehicles and uses thereof
CN109701009A (zh) * 2019-01-03 2019-05-03 华中师范大学 疫苗制剂及其应用
KR102146226B1 (ko) * 2019-03-07 2020-08-20 경희대학교 산학협력단 피토세라마이드 또는 이의 약학적으로 허용가능한 염을 유효성분으로 포함하는 신경계 자가면역질환의 예방 또는 치료용 조성물
WO2022102557A1 (ja) * 2020-11-12 2022-05-19 国立研究開発法人理化学研究所 擬似糖脂質誘導体並びにその合成中間体、製造方法及び用途
JP2024512318A (ja) * 2021-03-01 2024-03-19 ディシジュアス セラピューティクス， インコーポレイテッド インバリアントナチュラルキラーｔ細胞を活性化するための化合物および炎症性老化細胞の排除における使用の方法
WO2023096715A2 (en) * 2021-10-22 2023-06-01 President And Fellows Of Harvard College Immunomodulatory glycosphingolipids and methods of use thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5936076A (en) * 1991-08-29 1999-08-10 Kirin Beer Kabushiki Kaisha αgalactosylceramide derivatives
WO2004028475A2 (en) * 2002-09-27 2004-04-08 Biomira, Inc. Glycosylceramide analogues
US6747010B2 (en) * 1997-04-10 2004-06-08 Kirin Beer Kabushiki Kaisha NKT cell-activating agents containing α-glycosylceramides

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100281264B1 (ko) 1992-10-22 2001-02-01 마나배 게이사꾸 신규한 스핀고당 지질 및 그의 사용
US5853737A (en) 1992-12-10 1998-12-29 Brigham And Women's Hospital Method for inducing a CD1-restricted immune response
US5679347A (en) 1992-12-10 1997-10-21 Brigham And Women's Hospital Methods of isolating CD1-presented antigens, vaccines comprising CD1-presented antigens, and cell lines for use in said methods
US6238676B1 (en) 1992-12-10 2001-05-29 Brigham And Women's Hospital Presentation of hydrophobic antigens to T-cells by CD1 molecules
CN1045302C (zh) 1993-04-15 1999-09-29 麒麟麦酒株式会社 新型(神经)鞘糖脂、含有它们的药物组合物及其用途
US5973128A (en) * 1996-11-22 1999-10-26 The Hospital For Sick Children Research And Development Lp Glycolipid mimics and methods of use thereof
JP2004131481A (ja) * 1997-04-10 2004-04-30 Kirin Brewery Co Ltd α−グリコシルセラミドを含有するＮＫＴ細胞活性化剤
US6162609A (en) 1997-12-31 2000-12-19 The Brigham And Women's Hospital, Inc. Diagnostic and therapeutic methods based upon Vα24JαQT cells
EP1434859A2 (en) 2001-07-25 2004-07-07 New York University Use of glycosylceramides as adjuvants for vaccines against infections and cancer
EP1437358B1 (en) * 2001-08-16 2006-10-18 Daiichi Asubio Pharma Co., Ltd. Novel glycolipid and remedial agent for autoimmune disease containing the same as active ingredient
US7273852B2 (en) 2002-06-13 2007-09-25 The Research Foundation Of The City University Of New York Synthetic C-glycolipid and its use for treating cancer, infectious diseases and autoimmune diseases
CA2515396A1 (en) * 2003-02-14 2004-08-26 Daiichi Suntory Pharma Co., Ltd. New glycolipids and synthetic method thereof as well as their synthetic intermediates,and synthetic method thereof
WO2006026389A2 (en) * 2004-08-27 2006-03-09 Albert Einstein College Of Medicine Of Yeshiva University Ceramide derivatives as modulators of immunity and autoimmunity

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5936076A (en) * 1991-08-29 1999-08-10 Kirin Beer Kabushiki Kaisha αgalactosylceramide derivatives
US6747010B2 (en) * 1997-04-10 2004-06-08 Kirin Beer Kabushiki Kaisha NKT cell-activating agents containing α-glycosylceramides
WO2004028475A2 (en) * 2002-09-27 2004-04-08 Biomira, Inc. Glycosylceramide analogues

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Bhat et al., "Galactosyl ceramide or a derivative is an essential component of the neural receptor for human immunodeficiency virus type 1envelope glycoprotein gp120", Neurobiology, vol. 88, 1991, pages 7131-7134 *

Also Published As

Publication number Publication date
JP5870327B2 (ja) 2016-02-24
CA2577009C (en) 2017-05-02
IL181054A0 (en) 2007-07-04
EP1784196A4 (en) 2012-05-30
CN101010086B (zh) 2013-05-29
KR20120116511A (ko) 2012-10-22
US7772380B2 (en) 2010-08-10
JP2015007125A (ja) 2015-01-15
EP1784196B1 (en) 2016-12-21
US20060052316A1 (en) 2006-03-09
AU2005280163A1 (en) 2006-03-09
JP5226311B2 (ja) 2013-07-03
CA2577009A1 (en) 2006-03-09
KR101377116B1 (ko) 2014-03-24
EP1784196A2 (en) 2007-05-16
IL181054A (en) 2013-10-31
WO2006026389A2 (en) 2006-03-09
JP2008511634A (ja) 2008-04-17
JP2012211182A (ja) 2012-11-01
WO2006026389A3 (en) 2006-05-26
CN101010086A (zh) 2007-08-01
NZ553320A (en) 2011-02-25
KR20070023825A (ko) 2007-02-28

Similar Documents

Publication Publication Date Title
AU2005280163B2 (en) Ceramide derivatives as modulators of immunity and autoimmunity
US8022043B2 (en) Ceramide derivatives as modulators of immunity and autoimmunity
AU2009268381B2 (en) Alpha-galactosyl ceramide analogs and their use as immunotherapies, adjuvants, and antiviral, antibacterial, and anticancer agents
US9517243B2 (en) Beta-mannosylceramide and stimulation of NKT cell anti-tumor immunity
CA2683681A1 (en) Alpha-galactosyl ceramide analogs and their use as immunotherapies
CA2591232A1 (en) Glycolipids and analogues thereof as antigens for nk t cells
AU2013293646B2 (en) Organic compounds
DK2231196T3 (en) Increase in the immune response by peptide-antigen binding
JP6487854B2 (ja) 修飾された糖脂質並びにその製造および使用方法
TW202110459A (zh) 皂苷共軛物及含其之疫苗或藥物組合物
Pauwels Synthesis of new α-GalCer analogues as iNKT cell targeting agents
NZ613614B2 (en) Sphingoglycolipid compounds and uses

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
HB Alteration of name in register

Owner name: ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.

Free format text: FORMER NAME(S): ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY

MK14 Patent ceased section 143(a) (annual fees not paid) or expired