JP2013539771A5 - - Google Patents

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JP2013539771A5
JP2013539771A5 JP2013533178A JP2013533178A JP2013539771A5 JP 2013539771 A5 JP2013539771 A5 JP 2013539771A5 JP 2013533178 A JP2013533178 A JP 2013533178A JP 2013533178 A JP2013533178 A JP 2013533178A JP 2013539771 A5 JP2013539771 A5 JP 2013539771A5
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formula
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alkyl
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cycloalkyl
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JP2013533178A
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Japanese (ja)
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JP2013539771A (ja
JP5937087B2 (ja
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Priority claimed from PCT/EP2011/067696 external-priority patent/WO2012049153A1/en
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Publication of JP2013539771A5 publication Critical patent/JP2013539771A5/ja
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JP2013533178A 2010-10-12 2011-10-11 ジヒドロプテリジノン及びその中間体を製造する方法 Active JP5937087B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP10187194 2010-10-12
EP10187194.5 2010-10-12
PCT/EP2011/067696 WO2012049153A1 (en) 2010-10-12 2011-10-11 Process for manufacturing dihydropteridinones and intermediates thereof

Publications (3)

Publication Number Publication Date
JP2013539771A JP2013539771A (ja) 2013-10-28
JP2013539771A5 true JP2013539771A5 (https=) 2014-12-04
JP5937087B2 JP5937087B2 (ja) 2016-06-22

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ID=43902841

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JP2013533178A Active JP5937087B2 (ja) 2010-10-12 2011-10-11 ジヒドロプテリジノン及びその中間体を製造する方法

Country Status (18)

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US (1) US8546566B2 (https=)
EP (1) EP2627656B1 (https=)
JP (1) JP5937087B2 (https=)
KR (1) KR20140005877A (https=)
CN (1) CN103168040A (https=)
AU (1) AU2011315552B2 (https=)
BR (1) BR112013008883A2 (https=)
CA (1) CA2813838A1 (https=)
CL (1) CL2013000730A1 (https=)
DK (1) DK2627656T3 (https=)
EA (1) EA024256B1 (https=)
ES (1) ES2509741T3 (https=)
IL (1) IL224602A (https=)
MX (1) MX2013003994A (https=)
NZ (1) NZ606700A (https=)
PH (1) PH12013500694A1 (https=)
PL (1) PL2627656T3 (https=)
WO (1) WO2012049153A1 (https=)

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US9358233B2 (en) 2010-11-29 2016-06-07 Boehringer Ingelheim International Gmbh Method for treating acute myeloid leukemia
US9370535B2 (en) 2011-05-17 2016-06-21 Boehringer Ingelheim International Gmbh Method for treatment of advanced solid tumors
US20150031699A1 (en) 2013-07-26 2015-01-29 Boehringer Ingelheim International Gmbh Treatment of myelodysplastic syndrome
CN104003989B (zh) * 2014-05-26 2015-11-11 苏州明锐医药科技有限公司 伏拉塞替及其中间体的制备方法
US9867831B2 (en) 2014-10-01 2018-01-16 Boehringer Ingelheim International Gmbh Combination treatment of acute myeloid leukemia and myelodysplastic syndrome
CN105646398B (zh) * 2014-12-05 2018-09-07 上海医药工业研究院 N-((1r,4r)-4-(4-(环丙基甲基)哌嗪-1-基)环己基)乙酰胺的制备方法
CN108610343A (zh) * 2018-06-12 2018-10-02 杨文思 一种用于治疗癌症的表皮生长因子受体抑制剂及其合成方法
JPWO2020130125A1 (ja) 2018-12-21 2021-11-04 第一三共株式会社 抗体−薬物コンジュゲートとキナーゼ阻害剤の組み合わせ

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