BR112013008883A2 - processo para a fabricação de di-hidropteridinonas - Google Patents
processo para a fabricação de di-hidropteridinonasInfo
- Publication number
- BR112013008883A2 BR112013008883A2 BR112013008883A BR112013008883A BR112013008883A2 BR 112013008883 A2 BR112013008883 A2 BR 112013008883A2 BR 112013008883 A BR112013008883 A BR 112013008883A BR 112013008883 A BR112013008883 A BR 112013008883A BR 112013008883 A2 BR112013008883 A2 BR 112013008883A2
- Authority
- BR
- Brazil
- Prior art keywords
- dihydropteridinones
- manufacture
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
- C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
- C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
- C07D295/033—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to carbocyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10187194 | 2010-10-12 | ||
| PCT/EP2011/067696 WO2012049153A1 (en) | 2010-10-12 | 2011-10-11 | Process for manufacturing dihydropteridinones and intermediates thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112013008883A2 true BR112013008883A2 (pt) | 2017-10-10 |
Family
ID=43902841
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112013008883A BR112013008883A2 (pt) | 2010-10-12 | 2011-10-11 | processo para a fabricação de di-hidropteridinonas |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US8546566B2 (https=) |
| EP (1) | EP2627656B1 (https=) |
| JP (1) | JP5937087B2 (https=) |
| KR (1) | KR20140005877A (https=) |
| CN (1) | CN103168040A (https=) |
| AU (1) | AU2011315552B2 (https=) |
| BR (1) | BR112013008883A2 (https=) |
| CA (1) | CA2813838A1 (https=) |
| CL (1) | CL2013000730A1 (https=) |
| DK (1) | DK2627656T3 (https=) |
| EA (1) | EA024256B1 (https=) |
| ES (1) | ES2509741T3 (https=) |
| IL (1) | IL224602A (https=) |
| MX (1) | MX2013003994A (https=) |
| NZ (1) | NZ606700A (https=) |
| PH (1) | PH12013500694A1 (https=) |
| PL (1) | PL2627656T3 (https=) |
| WO (1) | WO2012049153A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060058311A1 (en) | 2004-08-14 | 2006-03-16 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation |
| US20060035903A1 (en) * | 2004-08-14 | 2006-02-16 | Boehringer Ingelheim International Gmbh | Storage stable perfusion solution for dihydropteridinones |
| US7439358B2 (en) | 2006-02-08 | 2008-10-21 | Boehringer Ingelheim International Gmbh | Specific salt, anhydrous and crystalline form of a dihydropteridione derivative |
| US8546566B2 (en) | 2010-10-12 | 2013-10-01 | Boehringer Ingelheim International Gmbh | Process for manufacturing dihydropteridinones and intermediates thereof |
| US9358233B2 (en) | 2010-11-29 | 2016-06-07 | Boehringer Ingelheim International Gmbh | Method for treating acute myeloid leukemia |
| US9370535B2 (en) | 2011-05-17 | 2016-06-21 | Boehringer Ingelheim International Gmbh | Method for treatment of advanced solid tumors |
| EP3024464A1 (en) | 2013-07-26 | 2016-06-01 | Boehringer Ingelheim International GmbH | Treatment of myelodysplastic syndrome |
| CN104003989B (zh) * | 2014-05-26 | 2015-11-11 | 苏州明锐医药科技有限公司 | 伏拉塞替及其中间体的制备方法 |
| US9867831B2 (en) | 2014-10-01 | 2018-01-16 | Boehringer Ingelheim International Gmbh | Combination treatment of acute myeloid leukemia and myelodysplastic syndrome |
| CN105646398B (zh) * | 2014-12-05 | 2018-09-07 | 上海医药工业研究院 | N-((1r,4r)-4-(4-(环丙基甲基)哌嗪-1-基)环己基)乙酰胺的制备方法 |
| CN108610343A (zh) * | 2018-06-12 | 2018-10-02 | 杨文思 | 一种用于治疗癌症的表皮生长因子受体抑制剂及其合成方法 |
| US20220040324A1 (en) | 2018-12-21 | 2022-02-10 | Daiichi Sankyo Company, Limited | Combination of antibody-drug conjugate and kinase inhibitor |
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| WO2010025073A1 (en) * | 2008-08-28 | 2010-03-04 | Takeda Pharmaceutical Company Limited | Dihydroimidazo [ 1, 5-f] pteridines as polo-like kinase inhibitors |
| JP5815411B2 (ja) | 2008-12-30 | 2015-11-17 | ライジェル ファーマシューティカルズ， インコーポレイテッド | ピリミジンジアミンキナーゼ阻害剤 |
| WO2011069962A1 (en) | 2009-12-07 | 2011-06-16 | Boehringer Ingelheim International Gmbh | Bibw 2992 for use in the treatment of triple negative breast cancer |
| JP5841548B2 (ja) | 2010-02-17 | 2016-01-13 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ジヒドロプテリジノン、その製造方法及び使用 |
| US8546566B2 (en) | 2010-10-12 | 2013-10-01 | Boehringer Ingelheim International Gmbh | Process for manufacturing dihydropteridinones and intermediates thereof |
| US9358233B2 (en) | 2010-11-29 | 2016-06-07 | Boehringer Ingelheim International Gmbh | Method for treating acute myeloid leukemia |
| US20130131069A1 (en) | 2011-05-13 | 2013-05-23 | Boehringer Ingelheim International Gmbh | Method for treatment of solid malignancies including advanced or metastatic solid malignancies |
| US9370535B2 (en) | 2011-05-17 | 2016-06-21 | Boehringer Ingelheim International Gmbh | Method for treatment of advanced solid tumors |
-
2011
- 2011-09-15 US US13/233,066 patent/US8546566B2/en active Active
- 2011-10-11 PH PH1/2013/500694A patent/PH12013500694A1/en unknown
- 2011-10-11 WO PCT/EP2011/067696 patent/WO2012049153A1/en not_active Ceased
- 2011-10-11 JP JP2013533178A patent/JP5937087B2/ja active Active
- 2011-10-11 NZ NZ606700A patent/NZ606700A/en not_active IP Right Cessation
- 2011-10-11 EA EA201300443A patent/EA024256B1/ru not_active IP Right Cessation
- 2011-10-11 CA CA2813838A patent/CA2813838A1/en not_active Abandoned
- 2011-10-11 EP EP11767449.9A patent/EP2627656B1/en active Active
- 2011-10-11 MX MX2013003994A patent/MX2013003994A/es active IP Right Grant
- 2011-10-11 KR KR1020137009470A patent/KR20140005877A/ko not_active Ceased
- 2011-10-11 BR BR112013008883A patent/BR112013008883A2/pt not_active IP Right Cessation
- 2011-10-11 PL PL11767449T patent/PL2627656T3/pl unknown
- 2011-10-11 CN CN2011800493287A patent/CN103168040A/zh active Pending
- 2011-10-11 ES ES11767449.9T patent/ES2509741T3/es active Active
- 2011-10-11 DK DK11767449.9T patent/DK2627656T3/da active
- 2011-10-11 AU AU2011315552A patent/AU2011315552B2/en not_active Ceased
-
2013
- 2013-02-07 IL IL224602A patent/IL224602A/en not_active IP Right Cessation
- 2013-03-18 CL CL2013000730A patent/CL2013000730A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2627656B1 (en) | 2014-08-20 |
| US8546566B2 (en) | 2013-10-01 |
| EP2627656A1 (en) | 2013-08-21 |
| IL224602A (en) | 2016-04-21 |
| MX2013003994A (es) | 2013-06-05 |
| CL2013000730A1 (es) | 2013-08-09 |
| DK2627656T3 (da) | 2014-09-08 |
| PL2627656T3 (pl) | 2015-02-27 |
| US20120238754A1 (en) | 2012-09-20 |
| CN103168040A (zh) | 2013-06-19 |
| AU2011315552A1 (en) | 2013-02-21 |
| PH12013500694A1 (en) | 2015-06-19 |
| CA2813838A1 (en) | 2012-04-19 |
| EA024256B1 (ru) | 2016-08-31 |
| NZ606700A (en) | 2015-06-26 |
| AU2011315552B2 (en) | 2015-05-21 |
| JP5937087B2 (ja) | 2016-06-22 |
| EA201300443A1 (ru) | 2013-11-29 |
| JP2013539771A (ja) | 2013-10-28 |
| ES2509741T3 (es) | 2014-10-17 |
| WO2012049153A1 (en) | 2012-04-19 |
| KR20140005877A (ko) | 2014-01-15 |
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