JP2007520434A5 - - Google Patents

Download PDF

Info

Publication number
JP2007520434A5
JP2007520434A5 JP2006517302A JP2006517302A JP2007520434A5 JP 2007520434 A5 JP2007520434 A5 JP 2007520434A5 JP 2006517302 A JP2006517302 A JP 2006517302A JP 2006517302 A JP2006517302 A JP 2006517302A JP 2007520434 A5 JP2007520434 A5 JP 2007520434A5
Authority
JP
Japan
Prior art keywords
formula
compound
group
salt
ammonium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2006517302A
Other languages
English (en)
Japanese (ja)
Other versions
JP4825129B2 (ja
JP2007520434A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2004/019135 external-priority patent/WO2004113295A1/en
Publication of JP2007520434A publication Critical patent/JP2007520434A/ja
Publication of JP2007520434A5 publication Critical patent/JP2007520434A5/ja
Application granted granted Critical
Publication of JP4825129B2 publication Critical patent/JP4825129B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

JP2006517302A 2003-06-17 2004-06-15 （１ｒ，２ｓ，５ｓ）−６，６−ジメチル−３−アザビシクロ［３，１，０］ヘキサン−２−カルボキシレートまたはその塩の調製のためのプロセスおよび中間体 Expired - Fee Related JP4825129B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US47951603P 2003-06-17 2003-06-17
US60/479,516 2003-06-17
PCT/US2004/019135 WO2004113295A1 (en) 2003-06-17 2004-06-15 Process and intermediates for the preparation of (1r,2s,5s)-6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylates or salts thereof

Publications (3)

Publication Number Publication Date
JP2007520434A JP2007520434A (ja) 2007-07-26
JP2007520434A5 true JP2007520434A5 (https=) 2007-09-06
JP4825129B2 JP4825129B2 (ja) 2011-11-30

Family

ID=33539184

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006517302A Expired - Fee Related JP4825129B2 (ja) 2003-06-17 2004-06-15 （１ｒ，２ｓ，５ｓ）−６，６−ジメチル−３−アザビシクロ［３，１，０］ヘキサン−２−カルボキシレートまたはその塩の調製のためのプロセスおよび中間体

Country Status (12)

Country Link
US (3) US7309717B2 (https=)
EP (1) EP1633711B1 (https=)
JP (1) JP4825129B2 (https=)
CN (2) CN101823965B (https=)
AT (1) ATE489365T1 (https=)
CA (1) CA2526635C (https=)
DE (1) DE602004030239D1 (https=)
ES (1) ES2354817T3 (https=)
MX (1) MXPA05013752A (https=)
SG (1) SG180022A1 (https=)
WO (1) WO2004113295A1 (https=)
ZA (1) ZA201006378B (https=)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR049635A1 (es) * 2004-05-06 2006-08-23 Schering Corp (1r,2s,5s)-n-((1s)-3-amino-1-(ciclobutilmetil)-2,3-dioxopropil)-3-((2s)-2-((((1,1-dimetiletil)amino)carbonil)amino)-3,3-dimetil-1-oxobutil)-6,6-dimetil-3-azabiciclo(3.1.0)hexan-2-carboxamida como inhibidor de la ns3/ns4a serina proteasa del virus de la hepatitis c
US20060276407A1 (en) * 2005-06-02 2006-12-07 Schering Corporation Methods of treating hepatitis C virus
AU2006252623A1 (en) * 2005-06-02 2006-12-07 Schering Corporation Controlled-release formulation useful for treating disorders associated with hepatitis C virus
WO2006130552A2 (en) * 2005-06-02 2006-12-07 Schering Corporation Methods of treating hepatitis c virus
US20060276404A1 (en) * 2005-06-02 2006-12-07 Anima Ghosal Medicaments and methods combining a HCV protease inhibitor and an AKR competitor
US20070237818A1 (en) * 2005-06-02 2007-10-11 Malcolm Bruce A Controlled-release formulation of HCV protease inhibitor and methods using the same
US20070021351A1 (en) * 2005-06-02 2007-01-25 Schering Corporation Liver/plasma concentration ratio for dosing hepatitis C virus protease inhibitor
US20060281689A1 (en) * 2005-06-02 2006-12-14 Schering Corporation Method for modulating activity of HCV protease through use of a novel HCV protease inhibitor to reduce duration of treatment period
NZ563365A (en) * 2005-06-02 2011-02-25 Schering Corp Combination of HCV protease inhibitors with a surfactant
AU2006252519B2 (en) 2005-06-02 2012-08-30 Merck Sharp & Dohme Corp. HCV protease inhibitors in combination with food
AR056805A1 (es) * 2005-11-14 2007-10-24 Schering Corp Un proceso para oxidacion para la preparcion de n- (3- amino-1- ( ciclobutilmetil) -2,3- dioxopropil ) -3-(n-(( ter-butilamino) carbonil )-3- metil- l- valil) -6,6- dimetil-3- azabiciclo (3.1.0) hexano -2- carboxamida y compuestos ralacionados
WO2007075790A1 (en) * 2005-12-22 2007-07-05 Schering Corporation Process for the preparation of 6, 6-dimethyl-3-azabicyclo-[3.1.0]-hexane compounds and enantiomeric salts thereof
WO2007074391A2 (en) * 2005-12-28 2007-07-05 Bakulesh Mafatlal Khamar Preparation of a key intermediate in the synthesis of rosuvastatin
EP2007789B1 (en) 2006-04-11 2015-05-20 Novartis AG Spirocyclic HCV/HIV inhibitors and their uses
JP5272325B2 (ja) * 2006-04-17 2013-08-28 住友化学株式会社 多環式プロリン誘導体またはその酸付加塩の製造方法
JP5272324B2 (ja) * 2006-04-17 2013-08-28 住友化学株式会社 Ｎ−ｔｅｒｔ−ブトキシカルボニル−２−ピロリジノン類およびその製造方法
CN101415676A (zh) 2006-04-17 2009-04-22 住友化学株式会社 N-叔丁氧基羰基-2-吡咯烷酮类及其制造方法
US20090118519A1 (en) * 2006-04-17 2009-05-07 Sumitomo Chemical Company, Limited Production Method of Polycyclic Lactams
CN101421238B (zh) 2006-04-17 2013-01-09 住友化学株式会社 多环式脯氨酸衍生物或其酸加成盐的制造方法
JP2010513492A (ja) * 2006-12-19 2010-04-30 シェーリング コーポレイション ３−（アミノ）−３−（シクロブチルメチル）−２−（ヒドロキシ）−プロピオンアミド塩酸塩の調製
AR068756A1 (es) * 2007-10-10 2009-12-02 Novartis Ag Compuestos peptidicos, formulacion farmaceutica y sus usos como moduladores del virus de la hepatitis c
EP2225203A1 (en) * 2007-11-28 2010-09-08 Schering Corporation Dehydrohalogenation process for the preparation of intermediates useful in providing 6,6-dimethyl-3-azabicyclo-[3.1.0]-hexane compounds
EP2294054A4 (en) * 2008-06-05 2012-04-18 Dsm Ip Assets Bv PROCESS FOR PREPARATION OF (4S, 5R) -SEMIESTER
MX2010014500A (es) 2008-06-24 2011-05-30 Codexis Inc Procedimientos biocataliticos para la preparacion de compuestos de prolina biciclica fusionada sustancialmente estereomericamente puros.
US8188137B2 (en) 2008-08-15 2012-05-29 Avila Therapeutics, Inc. HCV protease inhibitors and uses thereof
CN102300464B (zh) 2008-11-17 2014-11-12 安那迪斯药品股份有限公司 制备脱氧呋喃核糖化合物的方法
US8512690B2 (en) 2009-04-10 2013-08-20 Novartis Ag Derivatised proline containing peptide compounds as protease inhibitors
CN101863866B (zh) * 2009-04-16 2012-07-04 上海联友制药技术有限公司 3,3-二甲基环丙烷-1,2-二甲酸酐的合成方法
EP2459525B1 (en) 2009-07-29 2017-03-01 Merck Sharp & Dohme Corp. Enantio- and stereo-specific syntheses of -amino- - hydroxy amides
CN102070575B (zh) * 2010-12-28 2012-10-17 上海北卡医药技术有限公司 卡隆酸酐的合成方法
CN102127040B (zh) * 2010-12-30 2013-05-01 西安彩晶光电科技股份有限公司 6,6-二甲基-3-氧杂双环[3.1.0]己烷-2,4-二酮的制备方法
FR2972453B1 (fr) * 2011-03-09 2013-11-29 Minakem Nouveau procede de synthese du (1r,2s,5s)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylate de methyle ou de l'un de ses sels
JP2013010738A (ja) * 2011-05-31 2013-01-17 Sumitomo Chemical Co Ltd エステル化合物の製造方法
JP2013010734A (ja) * 2011-06-03 2013-01-17 Sumitomo Chemical Co Ltd Ｎ−置換ラクタム化合物の製造方法
JP2013010732A (ja) * 2011-06-03 2013-01-17 Sumitomo Chemical Co Ltd プロリン化合物の製造方法
JP2013010733A (ja) * 2011-06-03 2013-01-17 Sumitomo Chemical Co Ltd ヘミアミナール化合物の製造方法及びシアノアミン化合物の製造方法
AR091192A1 (es) 2012-05-30 2015-01-21 Chemo Iberica Sa Procedimiento multicomponente para la preparacion de compuestos biciclicos
CN103435532B (zh) * 2013-09-02 2015-07-08 苏州永健生物医药有限公司 波普瑞韦中间体的合成方法
CN104151279A (zh) * 2014-08-26 2014-11-19 广西梧松林化集团有限公司 卡龙酸酐的合成方法
CN114539125B (zh) * 2022-03-07 2024-02-09 杭州国瑞生物科技有限公司 一种帕西洛韦中间体的合成方法
CN114478690B (zh) * 2022-03-08 2024-01-02 新发药业有限公司 一种6,6-二甲基-3-氮杂双环[3.1.0]己烷衍生物的制备方法
WO2023175526A1 (en) * 2022-03-16 2023-09-21 Laurus Labs Limited Process for preparation of azabicyclo [3.1.0] hexane intermediates
CN114605309B (zh) * 2022-03-23 2023-07-21 浙江新和成股份有限公司 一种氮杂双环衍生物的合成方法
CN114989067B (zh) * 2022-07-18 2022-10-28 苏州奥普拓新材料有限公司 一种帕罗韦德中间体的合成方法
CN115947679B (zh) * 2022-12-16 2024-06-07 杭州澳赛诺生物科技有限公司 一种6,6-二甲基-3-杂氮-双环[3.1.0]己烷-2-羧酸甲酯的合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2376120A1 (fr) * 1976-12-30 1978-07-28 Roussel Uclaf Procede de preparation d'esters d'alcoyle inferieur d'acides cis ou trans 3-formyl cyclopropane 1-carboxyliques 2,2-disubstitues racemiques
CA1117127A (en) * 1978-06-27 1982-01-26 Janet A. Day Derivatives of 3-azabicyclo(3.1.0)hexane and a process for their preparation
CA1117128A (en) * 1978-10-27 1982-01-26 Derek A. Wood 2-cyano-3-azabicyclo(3.1.0)hexane
DK1385870T3 (da) * 2000-07-21 2010-07-05 Schering Corp Peptider som inhibitorer af NS3-serinprotease fra hepatitis C-virus
US7244721B2 (en) 2000-07-21 2007-07-17 Schering Corporation Peptides as NS3-serine protease inhibitors of hepatitis C virus
IL144815A (en) * 2000-08-11 2005-07-25 Sumitomo Chemical Co Process for producing carbonyl or hydroxy compound

Similar Documents

Publication Publication Date Title
JP2007520434A5 (https=)
CA2526635A1 (en) Process and intermediates for the preparation of (1r,2s,5s)-6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylates or salts thereof
US8853210B2 (en) Methods and intermediates for preparing pharmaceutical agents
US10696681B2 (en) Process for preparing beta 3 agonists and intermediates
KR101222679B1 (ko) 시타글립틴의 제조 방법 및 이에 사용되는 중간체
JPH09188679A (ja) アザビシクロ化合物の製造方法
CN103080088B (zh) 用于合成药物的中间体化合物的制备方法
BR112012024682B1 (pt) processos para contactar, para fabricar e para formar um composto, bem como composto
CN1041918C (zh) 芳基哌啶甲醇的制法
KR20030053026A (ko) 스핑고신의 합성을 위한 제조방법
CN1270960A (zh) 生长激素促分泌素的制备方法
US5380849A (en) Process for optically pure decahydroisoqiunolines
JP2007515459A (ja) トルテロジンを得るための方法
JP2015506952A (ja) モルフィナンから誘導されたオキサゾリジンと有機金属試薬との反応によるモルフィンアナログの製造方法
CN1903833A (zh) 一种制备托特罗定及其l－酒石酸盐的方法
US6951963B2 (en) Process for preparing N-protected β-amino aldehyde compounds
JP2006517202A5 (https=)
JP4529419B2 (ja) 光学活性含フッ素化合物類、及びこれらの製造方法
JPH05213839A (ja) 新規な置換２，３−ジアミノ酸
JP4187822B2 (ja) 光学活性４−ヒドロキシ−２−ピロリドンの製造方法
JP4524845B2 (ja) アミノ基を有する光学活性アリルアルコール誘導体の製造方法、および光学活性化合物
US8242290B2 (en) Process for the preparation of renin inhibitors
TW520359B (en) Practical syntheses of chiral trans-3,4-disubstituted piperidines and the intermediates
JP2005306804A (ja) 光学活性３−キヌクリジノールの製造方法
JPS647973B2 (https=)