JP2013539015A5 - - Google Patents
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- JP2013539015A5 JP2013539015A5 JP2013520854A JP2013520854A JP2013539015A5 JP 2013539015 A5 JP2013539015 A5 JP 2013539015A5 JP 2013520854 A JP2013520854 A JP 2013520854A JP 2013520854 A JP2013520854 A JP 2013520854A JP 2013539015 A5 JP2013539015 A5 JP 2013539015A5
- Authority
- JP
- Japan
- Prior art keywords
- complex
- compound
- alkyl
- carbons
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 30
- -1 acyl azide Chemical class 0.000 claims 20
- 125000000217 alkyl group Chemical group 0.000 claims 16
- 125000003118 aryl group Chemical group 0.000 claims 13
- 125000001072 heteroaryl group Chemical group 0.000 claims 12
- 229910052736 halogen Inorganic materials 0.000 claims 10
- 150000002367 halogens Chemical class 0.000 claims 9
- 229910052739 hydrogen Inorganic materials 0.000 claims 9
- 239000001257 hydrogen Substances 0.000 claims 9
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 9
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims 8
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 8
- 229920001222 biopolymer Polymers 0.000 claims 7
- 230000009870 specific binding Effects 0.000 claims 7
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical group OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 claims 6
- 125000003545 alkoxy group Chemical group 0.000 claims 6
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims 6
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 5
- 125000003710 aryl alkyl group Chemical group 0.000 claims 5
- 125000005382 boronyl group Chemical group 0.000 claims 5
- 125000000753 cycloalkyl group Chemical group 0.000 claims 5
- 125000000623 heterocyclic group Chemical group 0.000 claims 5
- 125000005499 phosphonyl group Chemical group 0.000 claims 5
- 150000003573 thiols Chemical class 0.000 claims 5
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 5
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 claims 4
- PEEHTFAAVSWFBL-UHFFFAOYSA-N Maleimide Chemical compound O=C1NC(=O)C=C1 PEEHTFAAVSWFBL-UHFFFAOYSA-N 0.000 claims 4
- 239000002202 Polyethylene glycol Substances 0.000 claims 4
- 150000001412 amines Chemical class 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 4
- 150000002148 esters Chemical class 0.000 claims 4
- 150000002540 isothiocyanates Chemical class 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 229920001223 polyethylene glycol Polymers 0.000 claims 4
- 125000004429 atom Chemical group 0.000 claims 3
- 230000003915 cell function Effects 0.000 claims 3
- 230000000295 complement effect Effects 0.000 claims 3
- 108091034117 Oligonucleotide Proteins 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 238000006243 chemical reaction Methods 0.000 claims 2
- 150000004676 glycans Chemical class 0.000 claims 2
- 238000012544 monitoring process Methods 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 229920001282 polysaccharide Polymers 0.000 claims 2
- 239000005017 polysaccharide Substances 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 150000003461 sulfonyl halides Chemical class 0.000 claims 2
- QGKMIGUHVLGJBR-UHFFFAOYSA-M (4z)-1-(3-methylbutyl)-4-[[1-(3-methylbutyl)quinolin-1-ium-4-yl]methylidene]quinoline;iodide Chemical group [I-].C12=CC=CC=C2N(CCC(C)C)C=CC1=CC1=CC=[N+](CCC(C)C)C2=CC=CC=C12 QGKMIGUHVLGJBR-UHFFFAOYSA-M 0.000 claims 1
- BCHZICNRHXRCHY-UHFFFAOYSA-N 2h-oxazine Chemical compound N1OC=CC=C1 BCHZICNRHXRCHY-UHFFFAOYSA-N 0.000 claims 1
- DWAOUXYZOSPAOH-UHFFFAOYSA-N 4-[2-(diethylamino)ethoxy]furo[3,2-g]chromen-7-one;hydrochloride Chemical compound [Cl-].O1C(=O)C=CC2=C1C=C1OC=CC1=C2OCC[NH+](CC)CC DWAOUXYZOSPAOH-UHFFFAOYSA-N 0.000 claims 1
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical group NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims 1
- 108090001008 Avidin Proteins 0.000 claims 1
- NOWKCMXCCJGMRR-UHFFFAOYSA-N Aziridine Chemical compound C1CN1 NOWKCMXCCJGMRR-UHFFFAOYSA-N 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 102000004856 Lectins Human genes 0.000 claims 1
- 108090001090 Lectins Proteins 0.000 claims 1
- 102000004895 Lipoproteins Human genes 0.000 claims 1
- 108090001030 Lipoproteins Proteins 0.000 claims 1
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 claims 1
- 239000004698 Polyethylene Substances 0.000 claims 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 1
- 108010090804 Streptavidin Proteins 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 150000001299 aldehydes Chemical class 0.000 claims 1
- 150000001350 alkyl halides Chemical class 0.000 claims 1
- 150000008064 anhydrides Chemical class 0.000 claims 1
- 210000004102 animal cell Anatomy 0.000 claims 1
- 150000001502 aryl halides Chemical class 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 150000001540 azides Chemical class 0.000 claims 1
- 239000012620 biological material Substances 0.000 claims 1
- ZADPBFCGQRWHPN-UHFFFAOYSA-N boronic acid Chemical compound OBO ZADPBFCGQRWHPN-UHFFFAOYSA-N 0.000 claims 1
- 238000000423 cell based assay Methods 0.000 claims 1
- 239000002131 composite material Substances 0.000 claims 1
- 150000004696 coordination complex Chemical class 0.000 claims 1
- 239000002158 endotoxin Substances 0.000 claims 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 1
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 claims 1
- 125000003827 glycol group Chemical group 0.000 claims 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 1
- 230000001678 irradiating effect Effects 0.000 claims 1
- 239000012948 isocyanate Substances 0.000 claims 1
- 150000002513 isocyanates Chemical class 0.000 claims 1
- 239000002523 lectin Substances 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 229920006008 lipopolysaccharide Polymers 0.000 claims 1
- 239000002502 liposome Substances 0.000 claims 1
- 239000011859 microparticle Substances 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 150000003904 phospholipids Chemical class 0.000 claims 1
- IEQIEDJGQAUEQZ-UHFFFAOYSA-N phthalocyanine Chemical compound N1C(N=C2C3=CC=CC=C3C(N=C3C4=CC=CC=C4C(=N4)N3)=N2)=C(C=CC=C2)C2=C1N=C1C2=CC=CC=C2C4=N1 IEQIEDJGQAUEQZ-UHFFFAOYSA-N 0.000 claims 1
- 229910052697 platinum Inorganic materials 0.000 claims 1
- 229920000573 polyethylene Polymers 0.000 claims 1
- 230000009257 reactivity Effects 0.000 claims 1
- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 claims 1
- 229910052711 selenium Inorganic materials 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 claims 1
- 125000001273 sulfonato group Chemical group [O-]S(*)(=O)=O 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39999510P | 2010-07-21 | 2010-07-21 | |
| US61/399,995 | 2010-07-21 | ||
| US13/181,107 | 2011-07-12 | ||
| US13/181,107 US8623324B2 (en) | 2010-07-21 | 2011-07-12 | Luminescent dyes with a water-soluble intramolecular bridge and their biological conjugates |
| PCT/US2011/044776 WO2012012595A2 (en) | 2010-07-21 | 2011-07-21 | Luminescent dyes with a water-soluble intramolecular bridge and their biological conjugates |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013539015A JP2013539015A (ja) | 2013-10-17 |
| JP2013539015A5 true JP2013539015A5 (enExample) | 2014-09-04 |
| JP5819426B2 JP5819426B2 (ja) | 2015-11-24 |
Family
ID=44629873
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013520854A Active JP5819426B2 (ja) | 2010-07-21 | 2011-07-21 | 水溶性の分子内橋を持つ発光性色素およびそれらの生物学的複合体 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8623324B2 (enExample) |
| EP (1) | EP2596065B1 (enExample) |
| JP (1) | JP5819426B2 (enExample) |
| CA (1) | CA2806025C (enExample) |
| ES (1) | ES2667858T3 (enExample) |
| WO (1) | WO2012012595A2 (enExample) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2251454T3 (da) | 2009-05-13 | 2014-10-13 | Sio2 Medical Products Inc | Coating og inspektion af beholder |
| US9458536B2 (en) | 2009-07-02 | 2016-10-04 | Sio2 Medical Products, Inc. | PECVD coating methods for capped syringes, cartridges and other articles |
| US11624115B2 (en) | 2010-05-12 | 2023-04-11 | Sio2 Medical Products, Inc. | Syringe with PECVD lubrication |
| US9878101B2 (en) | 2010-11-12 | 2018-01-30 | Sio2 Medical Products, Inc. | Cyclic olefin polymer vessels and vessel coating methods |
| US9272095B2 (en) | 2011-04-01 | 2016-03-01 | Sio2 Medical Products, Inc. | Vessels, contact surfaces, and coating and inspection apparatus and methods |
| AU2012318242A1 (en) | 2011-11-11 | 2013-05-30 | Sio2 Medical Products, Inc. | Passivation, pH protective or lubricity coating for pharmaceutical package, coating process and apparatus |
| US11116695B2 (en) | 2011-11-11 | 2021-09-14 | Sio2 Medical Products, Inc. | Blood sample collection tube |
| WO2013148498A1 (en) | 2012-03-27 | 2013-10-03 | Ventana Medical Systems, Inc. | Signaling conjugates and methods of use |
| EP2846755A1 (en) | 2012-05-09 | 2015-03-18 | SiO2 Medical Products, Inc. | Saccharide protective coating for pharmaceutical package |
| US20150297800A1 (en) | 2012-07-03 | 2015-10-22 | Sio2 Medical Products, Inc. | SiOx BARRIER FOR PHARMACEUTICAL PACKAGE AND COATING PROCESS |
| PL2888257T3 (pl) | 2012-08-21 | 2018-02-28 | Janssen Pharmaceutica Nv | Hapteny kwetiapiny do zastosowania w testach immunologicznych |
| JP6270845B2 (ja) | 2012-08-21 | 2018-01-31 | ヤンセン ファーマシューティカ エヌ．ベー． | アリピプラゾールに対する抗体及びその使用 |
| CN104736564B (zh) | 2012-08-21 | 2019-02-05 | 詹森药业有限公司 | 喹硫平半抗原的抗体及其用途 |
| ES2701062T3 (es) | 2012-08-21 | 2019-02-20 | Janssen Pharmaceutica Nv | Haptenos de olanzapina |
| CA2882595C (en) | 2012-08-21 | 2019-06-04 | Ortho-Clinical Diagnostics, Inc. | Antibodies to olanzapine haptens and use thereof |
| PL2888263T3 (pl) | 2012-08-21 | 2018-10-31 | Janssen Pharmaceutica Nv | Hapteny rysperydonu i paliperydonu |
| EP2888277A4 (en) | 2012-08-21 | 2016-05-18 | Ortho Clinical Diagnostics Inc | ANTIBODIES AGAINST PALIPERIDONE AND USE THEREOF |
| PT2888593T (pt) | 2012-08-21 | 2018-12-12 | Janssen Pharmaceutica Nv | Anticorpos contra risperidona e utilizações dos mesmos |
| CN110054694B (zh) | 2012-08-21 | 2024-02-20 | 詹森药业有限公司 | 阿立哌唑半抗原的抗体及其用途 |
| PL2888592T3 (pl) | 2012-08-21 | 2018-03-30 | Janssen Pharmaceutica Nv | Przeciwciała względem kwetiapiny i ich zastosowania |
| PT2888284T (pt) | 2012-08-21 | 2022-11-18 | Janssen Pharmaceutica Nv | Anticorpos dirigidos contra haptenos de risperidona e a sua utilização |
| CA2882489A1 (en) | 2012-08-21 | 2014-02-27 | Ortho-Clinical Diagnostics, Inc. | Antibodies to paliperidone haptens and use thereof |
| WO2014031662A2 (en) | 2012-08-21 | 2014-02-27 | Ortho-Clinical Diagnostics, Inc | Antibodies to olanzapine and use thereof |
| PT3321254T (pt) | 2012-08-21 | 2020-10-20 | Janssen Pharmaceutica Nv | Haptenos de aripiprazol e seu uso em imunoensaios |
| PL2888258T3 (pl) | 2012-08-21 | 2019-10-31 | Janssen Pharmaceutica Nv | Hapteny paliperydonu |
| ES2628529T3 (es) | 2012-10-24 | 2017-08-03 | Tintes de cianina-azaindolina sustituidos con hidroxamato, y bioconjugados de los mismos | |
| CA2890066C (en) | 2012-11-01 | 2021-11-09 | Sio2 Medical Products, Inc. | Coating inspection method |
| WO2014078666A1 (en) | 2012-11-16 | 2014-05-22 | Sio2 Medical Products, Inc. | Method and apparatus for detecting rapid barrier coating integrity characteristics |
| EP2925903B1 (en) | 2012-11-30 | 2022-04-13 | Si02 Medical Products, Inc. | Controlling the uniformity of pecvd deposition on medical syringes, cartridges, and the like |
| US9764093B2 (en) | 2012-11-30 | 2017-09-19 | Sio2 Medical Products, Inc. | Controlling the uniformity of PECVD deposition |
| EP2961858B1 (en) | 2013-03-01 | 2022-09-07 | Si02 Medical Products, Inc. | Coated syringe. |
| CN105392916B (zh) | 2013-03-11 | 2019-03-08 | Sio2医药产品公司 | 涂布包装材料 |
| US9937099B2 (en) | 2013-03-11 | 2018-04-10 | Sio2 Medical Products, Inc. | Trilayer coated pharmaceutical packaging with low oxygen transmission rate |
| EP2971227B1 (en) | 2013-03-15 | 2017-11-15 | Si02 Medical Products, Inc. | Coating method. |
| CN103288673B (zh) * | 2013-05-28 | 2015-05-06 | 广东药学院 | 一种铂配体及其配合物 |
| EP3693493A1 (en) | 2014-03-28 | 2020-08-12 | SiO2 Medical Products, Inc. | Antistatic coatings for plastic vessels |
| US20150017658A1 (en) * | 2014-05-19 | 2015-01-15 | National Institute Of Standards And Technology | Stain, process for staining and acquiring normalized signal |
| US11077233B2 (en) | 2015-08-18 | 2021-08-03 | Sio2 Medical Products, Inc. | Pharmaceutical and other packaging with low oxygen transmission rate |
| WO2017105928A1 (en) * | 2015-12-16 | 2017-06-22 | Becton, Dickinson And Company | Photostable fluorescent polymeric tandem dyes including luminescent metal complexes |
| WO2017106501A1 (en) | 2015-12-17 | 2017-06-22 | Janssen Pharmaceutica Nv | Antibodies to risperidone and use thereof |
| JP6994461B2 (ja) | 2015-12-17 | 2022-02-04 | ヤンセン ファーマシューティカ エヌ．ベー． | クエチアピンに対する抗体及びその使用 |
| KR102705120B1 (ko) * | 2016-02-26 | 2024-09-09 | 어질런트 테크놀러지스, 인코포레이티드 | 친핵체의 표지화를 개선시키기 위한 비스피리딘의 용도 |
| KR102836360B1 (ko) | 2016-04-15 | 2025-07-23 | 베크만 컬터, 인코포레이티드 | 광활성 거대분자 및 그의 용도 |
| DE102016012162A1 (de) * | 2016-10-11 | 2018-04-12 | Rijksuniversiteit Groningen | Synthese und Struktur chemisch schaltbarer Fluoreszenzsonden auf der Basis von Aminosäuren |
| CN107857788B (zh) * | 2017-07-06 | 2021-04-13 | 江南大学 | 糖基化氟硼二吡咯衍生物、表面糖修饰的纳米胶束及其制备方法和应用 |
| CN108982447B (zh) * | 2018-07-19 | 2020-12-01 | 曲阜师范大学 | 一种用于检测肼的比率式荧光探针的制备方法及应用 |
| US20200048469A1 (en) * | 2018-08-07 | 2020-02-13 | Becton, Dickinson And Company | Polymeric tandem dyes having pendant narrow emission acceptor |
| EP3940000B1 (en) * | 2019-03-14 | 2023-11-22 | Korea University Research and Business Foundation | Carrageenan derivative, probe for labelling macrophages, and method for preparing same |
| CN111454715B (zh) * | 2020-03-30 | 2023-03-21 | 西南大学 | 一种耐水室温磷光材料的制备方法和应用 |
| EP4190795A4 (en) * | 2020-07-30 | 2024-08-28 | FUJIFILM Corporation | Compound, and labeled biological substance in which same is used |
| GB2605404A (en) * | 2021-03-30 | 2022-10-05 | Sumitomo Chemical Co | Sequencing method |
| WO2024129493A1 (en) * | 2022-12-13 | 2024-06-20 | Becton, Dickinson And Company | Sulfonate-containing water-solubilizing peptides |
Family Cites Families (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB870753A (en) | 1957-07-04 | 1961-06-21 | Ilford Ltd | Improvements in or relating to methine dyes |
| US3864644A (en) | 1971-03-22 | 1975-02-04 | Eastman Kodak Co | Dye lasers including rigidized carbocyanine dyes |
| US4011086A (en) | 1975-10-14 | 1977-03-08 | Eastman Kodak Company | Photographic emulsions and elements containing rigidized carbocyanine dyes |
| US4711955A (en) | 1981-04-17 | 1987-12-08 | Yale University | Modified nucleotides and methods of preparing and using same |
| US5171534A (en) | 1984-01-16 | 1992-12-15 | California Institute Of Technology | Automated DNA sequencing technique |
| US5366603A (en) | 1984-03-29 | 1994-11-22 | Li-Cor, Inc. | Sequencing near infrared and infrared fluorescence labeled DNA for detecting useing laser diodes |
| US6086737A (en) | 1984-03-29 | 2000-07-11 | Li-Cor, Inc. | Sequencing near infrared and infrared fluorescence labeled DNA for detecting using laser diodes and suitable labels therefor |
| US6048982A (en) | 1986-04-18 | 2000-04-11 | Carnegie Mellon University | Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods |
| US5627027A (en) | 1986-04-18 | 1997-05-06 | Carnegie Mellon University | Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods |
| US5569587A (en) | 1986-04-18 | 1996-10-29 | Carnegie Mellon University | Method for labeling and detecting materials employing luminescent arysulfonate cyanine dyes |
| US5268486A (en) | 1986-04-18 | 1993-12-07 | Carnegie-Mellon Unversity | Method for labeling and detecting materials employing arylsulfonate cyanine dyes |
| CA1340806C (en) | 1986-07-02 | 1999-11-02 | James Merrill Prober | Method, system and reagents for dna sequencing |
| US5047519A (en) | 1986-07-02 | 1991-09-10 | E. I. Du Pont De Nemours And Company | Alkynylamino-nucleotides |
| US4774339A (en) | 1987-08-10 | 1988-09-27 | Molecular Probes, Inc. | Chemically reactive dipyrrometheneboron difluoride dyes |
| US5049673A (en) | 1987-10-30 | 1991-09-17 | The Regents Of The University Of California | Fluorescent indicator dyes for calcium working at long wavelengths |
| US5162508A (en) | 1987-12-18 | 1992-11-10 | Compagnie Oris Industrie | Rare earth cryptates, processes for their preparation, synthesis intermediates and application as fluorescent tracers |
| US4997928A (en) | 1988-09-15 | 1991-03-05 | E. I. Du Pont De Nemours And Company | Fluorescent reagents for the preparation of 5'-tagged oligonucleotides |
| US4981977A (en) | 1989-06-09 | 1991-01-01 | Carnegie-Mellon University | Intermediate for and fluorescent cyanine dyes containing carboxylic acid groups |
| US5433896A (en) | 1994-05-20 | 1995-07-18 | Molecular Probes, Inc. | Dibenzopyrrometheneboron difluoride dyes |
| US5453517A (en) | 1992-02-25 | 1995-09-26 | Molecular Probes, Inc. | Reactive derivatives of bapta used to make ion-selective chelators |
| US5648270A (en) | 1995-02-06 | 1997-07-15 | Molecular Probes, Inc. | Methods of sensing with fluorescent conjugates of metal-chelating nitrogen heterocycles |
| US5274113A (en) | 1991-11-01 | 1993-12-28 | Molecular Probes, Inc. | Long wavelength chemically reactive dipyrrometheneboron difluoride dyes and conjugates |
| US5405975A (en) | 1993-03-29 | 1995-04-11 | Molecular Probes, Inc. | Fluorescent ion-selective diaryldiaza crown ether conjugates |
| US5567588A (en) | 1990-06-11 | 1996-10-22 | University Research Corporation | Systematic evolution of ligands by exponential enrichment: Solution SELEX |
| US5714327A (en) | 1990-07-19 | 1998-02-03 | Kreatech Diagnostics | Platinum-containing compounds, methods for their preparation and applications thereof |
| NL9001639A (nl) | 1990-07-19 | 1992-02-17 | Amc Amsterdam | Pt-houdende verbinding, werkwijze voor de bereiding ervan, alsmede toepassing van dergelijke verbindingen. |
| YU187991A (sh) | 1990-12-11 | 1994-09-09 | Hoechst Aktiengesellschaft | 3-(2)-amino-ali tiol-modifikovani, s fluorescentnom bojom vezani nukleozidi, nukleotidi i oligonukleotidi, postupak za njihovo dobijanje i njihova upotreba |
| US5248782A (en) | 1990-12-18 | 1993-09-28 | Molecular Probes, Inc. | Long wavelength heteroaryl-substituted dipyrrometheneboron difluoride dyes |
| US5187288A (en) | 1991-05-22 | 1993-02-16 | Molecular Probes, Inc. | Ethenyl-substituted dipyrrometheneboron difluoride dyes and their synthesis |
| US5539082A (en) | 1993-04-26 | 1996-07-23 | Nielsen; Peter E. | Peptide nucleic acids |
| US5831098A (en) | 1992-03-16 | 1998-11-03 | Minnesota Mining And Manufacturing Company | 2-methyl-4,4a-dihydro-3H-carbazolium salts and dyes derived therefrom |
| WO1994005688A1 (en) | 1992-09-03 | 1994-03-17 | Applied Biosystems, Inc. | 4,7-dichlorofluorescein dyes as molecular probes |
| US5808044A (en) | 1993-01-22 | 1998-09-15 | Pharmacia Biotech Inc. | Indocarbocyanine and benzindocarbocyanine phosphoramidites |
| US5516911A (en) | 1993-12-30 | 1996-05-14 | The United States Of America As Represented By The Department Of Health And Human Services | Fluorescent intracellular calcium indicators |
| US5453505A (en) | 1994-06-30 | 1995-09-26 | Biometric Imaging, Inc. | N-heteroaromatic ion and iminium ion substituted cyanine dyes for use as fluorescence labels |
| US6150510A (en) | 1995-11-06 | 2000-11-21 | Aventis Pharma Deutschland Gmbh | Modified oligonucleotides, their preparation and their use |
| DE4445065A1 (de) | 1994-12-07 | 1996-06-13 | Diagnostikforschung Inst | Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung |
| US6127134A (en) | 1995-04-20 | 2000-10-03 | Carnegie Mellon University | Difference gel electrophoresis using matched multiple dyes |
| US6008373A (en) | 1995-06-07 | 1999-12-28 | Carnegie Mellon University | Fluorescent labeling complexes with large stokes shift formed by coupling together cyanine and other fluorochromes capable of resonance energy transfer |
| US5684142A (en) | 1995-06-07 | 1997-11-04 | Oncor, Inc. | Modified nucleotides for nucleic acid labeling |
| US6004536A (en) | 1995-11-14 | 1999-12-21 | Molecular Probes, Inc. | Lipophilic cyanine dyes with enchanced aqueous solubilty |
| US5668268A (en) | 1995-11-27 | 1997-09-16 | Hybridon, Inc. | Passivated polymer supports for nucleic acid synthesis |
| US5714386A (en) | 1996-01-11 | 1998-02-03 | Board Of Trustees Of The Leland Stanford Junior University | Cy7-allophycocyanin conjugates for use in multiplex fluorescence detection assays |
| US6162931A (en) | 1996-04-12 | 2000-12-19 | Molecular Probes, Inc. | Fluorinated xanthene derivatives |
| WO1997046099A1 (en) * | 1996-06-06 | 1997-12-11 | Neorx Corporation | Liver retention clearing agents |
| US5877310A (en) | 1997-04-25 | 1999-03-02 | Carnegie Mellon University | Glycoconjugated fluorescent labeling reagents |
| US6130101A (en) | 1997-09-23 | 2000-10-10 | Molecular Probes, Inc. | Sulfonated xanthene derivatives |
| US6133445A (en) | 1997-12-17 | 2000-10-17 | Carnegie Mellon University | Rigidized trimethine cyanine dyes |
| US6002003A (en) | 1998-04-14 | 1999-12-14 | Beckman Instruments, Inc. | Cyanine dye activating group with improved coupling selectivity |
| JP2002528723A (ja) | 1998-10-27 | 2002-09-03 | モレキュラー・プロウブズ・インコーポレーテッド | 遷移金属錯体を含有する発光タンパク質染色剤 |
| EP1196398A4 (en) | 1999-07-06 | 2002-11-06 | Surromed Inc | BRIDGED FLUORESCENT DYES, THEIR PRODUCTION AND USE IN DETECTION METHODS |
| US6329205B1 (en) | 1999-08-31 | 2001-12-11 | Molecular Probes, Inc. | Detection method using luminescent europium-based protein stains |
| FR2810406B1 (fr) | 2000-06-15 | 2002-09-20 | Cis Bio Int | Nouveaux cryptates de terre rare peu sensibles a l'extinction de fluorescence |
| WO2002026891A1 (en) | 2000-09-29 | 2002-04-04 | Molecular Probes, Inc. | Modified carbocyanine dyes and their conjugates |
| EP1341557A2 (en) * | 2000-10-27 | 2003-09-10 | Beth Israel Deaconess Medical Center | Non-isotopic detection of osteoblastic activity in vivo using modified bisphosphonates |
| JP2003121956A (ja) * | 2001-10-11 | 2003-04-23 | Fuji Photo Film Co Ltd | ハロゲン化銀写真感光材料 |
| US6800637B2 (en) | 2002-09-12 | 2004-10-05 | Wyeth | Antidepressant indolealkyl derivatives of heterocycle-fused benzodioxan methylamines |
| WO2004101709A1 (en) | 2003-05-09 | 2004-11-25 | Applera Corporation | Phenyl xanthene dyes |
| WO2005000218A2 (en) * | 2003-05-31 | 2005-01-06 | Washington University | Macrocyclic cyanine and indocyanine bioconjugates provide improved biomedical applications |
| DE10329860A1 (de) | 2003-07-02 | 2005-01-20 | Atto-Tec Gmbh | Sulfonamidderivate polycyclischer Farbstoffe für analytische Anwendungen |
| US7344701B2 (en) | 2004-02-03 | 2008-03-18 | Biosearch Technologies, Inc. | Xanthene dyes |
| US7465810B2 (en) * | 2004-10-25 | 2008-12-16 | Anaspec, Inc. | Reactive 1,3′-crosslinked carbocyanine |
| US20070007754A1 (en) | 2005-07-11 | 2007-01-11 | Rybinski Anthony V | Air bag chute |
| WO2007038659A1 (en) * | 2005-09-26 | 2007-04-05 | Invitrogen Corporation | Violet laser excitable dyes and their method of use |
| BRPI0616803B1 (pt) | 2005-10-03 | 2017-04-25 | Ciba Specialty Chemicals Holding Inc | corantes de xanteno, seu processo de preparação, método para tingir as fibras, e composição |
| WO2007114398A1 (ja) * | 2006-03-31 | 2007-10-11 | Wako Pure Chemical Industries, Ltd. | ピラゾール系シアニン色素 |
| US7745645B2 (en) * | 2007-01-22 | 2010-06-29 | Pierce Biotechnology, Inc. | Sulfonamide derivatives of xanthene compounds |
| US7960420B2 (en) | 2007-12-21 | 2011-06-14 | Joyant Pharmaceuticals, Inc | Diazonamide analogs with improved solubility |
-
2011
- 2011-07-12 US US13/181,107 patent/US8623324B2/en active Active
- 2011-07-21 EP EP11741365.8A patent/EP2596065B1/en active Active
- 2011-07-21 JP JP2013520854A patent/JP5819426B2/ja active Active
- 2011-07-21 WO PCT/US2011/044776 patent/WO2012012595A2/en not_active Ceased
- 2011-07-21 ES ES11741365.8T patent/ES2667858T3/es active Active
- 2011-07-21 CA CA2806025A patent/CA2806025C/en active Active
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