JP2010508295A5 - - Google Patents
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- JP2010508295A5 JP2010508295A5 JP2009534880A JP2009534880A JP2010508295A5 JP 2010508295 A5 JP2010508295 A5 JP 2010508295A5 JP 2009534880 A JP2009534880 A JP 2009534880A JP 2009534880 A JP2009534880 A JP 2009534880A JP 2010508295 A5 JP2010508295 A5 JP 2010508295A5
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- JP
- Japan
- Prior art keywords
- substituted
- compound
- compound according
- alkyl
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 72
- -1 amino, substituted amino, aminocarbonyl Chemical group 0.000 claims 38
- 210000004027 cell Anatomy 0.000 claims 35
- 238000000034 method Methods 0.000 claims 28
- 125000001072 heteroaryl group Chemical group 0.000 claims 18
- 125000000217 alkyl group Chemical group 0.000 claims 16
- 125000000623 heterocyclic group Chemical group 0.000 claims 16
- 125000000547 substituted alkyl group Chemical group 0.000 claims 16
- 125000003545 alkoxy group Chemical group 0.000 claims 10
- 125000004414 alkyl thio group Chemical group 0.000 claims 10
- 125000003118 aryl group Chemical group 0.000 claims 10
- 125000000753 cycloalkyl group Chemical group 0.000 claims 9
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 9
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 8
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 8
- 125000003107 substituted aryl group Chemical group 0.000 claims 8
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 8
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 8
- 150000003573 thiols Chemical class 0.000 claims 8
- 125000002252 acyl group Chemical group 0.000 claims 7
- 125000004442 acylamino group Chemical group 0.000 claims 6
- 125000005415 substituted alkoxy group Chemical group 0.000 claims 6
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical group C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 claims 4
- 125000004423 acyloxy group Chemical group 0.000 claims 4
- 125000004682 aminothiocarbonyl group Chemical group NC(=S)* 0.000 claims 4
- 230000033077 cellular process Effects 0.000 claims 4
- 125000004093 cyano group Chemical group *C#N 0.000 claims 4
- 125000001475 halogen functional group Chemical group 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 230000001678 irradiating effect Effects 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 4
- 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 claims 4
- 230000002194 synthesizing effect Effects 0.000 claims 4
- 125000003441 thioacyl group Chemical group 0.000 claims 4
- 125000003342 alkenyl group Chemical group 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 125000005017 substituted alkenyl group Chemical group 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 108090000862 Ion Channels Proteins 0.000 claims 2
- 102000004310 Ion Channels Human genes 0.000 claims 2
- 206010057249 Phagocytosis Diseases 0.000 claims 2
- 239000012491 analyte Substances 0.000 claims 2
- 239000013060 biological fluid Substances 0.000 claims 2
- 239000000872 buffer Substances 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 230000008878 coupling Effects 0.000 claims 2
- 238000010168 coupling process Methods 0.000 claims 2
- 238000005859 coupling reaction Methods 0.000 claims 2
- 230000001419 dependent effect Effects 0.000 claims 2
- 125000006575 electron-withdrawing group Chemical group 0.000 claims 2
- 210000003722 extracellular fluid Anatomy 0.000 claims 2
- 238000000855 fermentation Methods 0.000 claims 2
- 230000004151 fermentation Effects 0.000 claims 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 2
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Chemical group CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 claims 2
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Chemical group C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 claims 2
- 210000002977 intracellular fluid Anatomy 0.000 claims 2
- QDLAGTHXVHQKRE-UHFFFAOYSA-N lichenxanthone Natural products COC1=CC(O)=C2C(=O)C3=C(C)C=C(OC)C=C3OC2=C1 QDLAGTHXVHQKRE-UHFFFAOYSA-N 0.000 claims 2
- 150000002632 lipids Chemical class 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 238000012544 monitoring process Methods 0.000 claims 2
- UHOVQNZJYSORNB-UHFFFAOYSA-N monobenzene Natural products C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims 2
- 210000002569 neuron Anatomy 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- CTSLXHKWHWQRSH-UHFFFAOYSA-N oxalyl chloride Chemical compound ClC(=O)C(Cl)=O CTSLXHKWHWQRSH-UHFFFAOYSA-N 0.000 claims 2
- 230000008782 phagocytosis Effects 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- UGNWTBMOAKPKBL-UHFFFAOYSA-N tetrachloro-1,4-benzoquinone Chemical compound ClC1=C(Cl)C(=O)C(Cl)=C(Cl)C1=O UGNWTBMOAKPKBL-UHFFFAOYSA-N 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- 125000001834 xanthenyl group Chemical group C1=CC=CC=2OC3=CC=CC=C3C(C12)* 0.000 claims 2
- 125000002373 5 membered heterocyclic group Chemical group 0.000 claims 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims 1
- 108090000312 Calcium Channels Proteins 0.000 claims 1
- 102000003922 Calcium Channels Human genes 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 235000013361 beverage Nutrition 0.000 claims 1
- 238000004166 bioassay Methods 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000000601 blood cell Anatomy 0.000 claims 1
- 210000001124 body fluid Anatomy 0.000 claims 1
- 239000010839 body fluid Substances 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 239000012930 cell culture fluid Substances 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 239000012320 chlorinating reagent Substances 0.000 claims 1
- 210000004748 cultured cell Anatomy 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 230000007613 environmental effect Effects 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 238000002189 fluorescence spectrum Methods 0.000 claims 1
- 239000011521 glass Substances 0.000 claims 1
- 230000036039 immunity Effects 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 238000002493 microarray Methods 0.000 claims 1
- 239000011859 microparticle Substances 0.000 claims 1
- 210000003205 muscle Anatomy 0.000 claims 1
- 210000003061 neural cell Anatomy 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 229910052698 phosphorus Inorganic materials 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 229920005597 polymer membrane Polymers 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 210000003296 saliva Anatomy 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000013535 sea water Substances 0.000 claims 1
- 229910052710 silicon Inorganic materials 0.000 claims 1
- 239000010703 silicon Substances 0.000 claims 1
- 239000002689 soil Substances 0.000 claims 1
- 125000004426 substituted alkynyl group Chemical group 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 210000002700 urine Anatomy 0.000 claims 1
- 230000002792 vascular Effects 0.000 claims 1
- 239000002351 wastewater Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 0 CN*(*)c(cc1)cc(O2)c1C(c(cc(c(*(*)*=*)c1)P)c1ONC)=C(C=C1)C2=CC1=*(NC)NC Chemical compound CN*(*)c(cc1)cc(O2)c1C(c(cc(c(*(*)*=*)c1)P)c1ONC)=C(C=C1)C2=CC1=*(NC)NC 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86331806P | 2006-10-27 | 2006-10-27 | |
| US60/863,318 | 2006-10-27 | ||
| US94032307P | 2007-05-25 | 2007-05-25 | |
| US60/940,323 | 2007-05-25 | ||
| PCT/US2007/082617 WO2008076524A2 (en) | 2006-10-27 | 2007-10-26 | Fluorogenic ph sensitive dyes and their method of use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014157304A Division JP5847257B2 (ja) | 2006-10-27 | 2014-08-01 | 蛍光発生性ｐＨ感受性色素およびその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010508295A JP2010508295A (ja) | 2010-03-18 |
| JP2010508295A5 true JP2010508295A5 (enExample) | 2011-09-15 |
| JP5636189B2 JP5636189B2 (ja) | 2014-12-03 |
Family
ID=39536938
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009534880A Active JP5636189B2 (ja) | 2006-10-27 | 2007-10-26 | 蛍光発生性ｐＨ感受性色素およびその使用方法 |
| JP2014157304A Expired - Fee Related JP5847257B2 (ja) | 2006-10-27 | 2014-08-01 | 蛍光発生性ｐＨ感受性色素およびその使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014157304A Expired - Fee Related JP5847257B2 (ja) | 2006-10-27 | 2014-08-01 | 蛍光発生性ｐＨ感受性色素およびその使用方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (6) | US20080274907A1 (enExample) |
| EP (2) | EP2064290B1 (enExample) |
| JP (2) | JP5636189B2 (enExample) |
| WO (1) | WO2008076524A2 (enExample) |
Families Citing this family (44)
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| EP2064290B1 (en) | 2006-10-27 | 2013-10-09 | Life Technologies Corporation | Fluorogenic ph sensitive dyes and their method of use |
| JP5895297B2 (ja) * | 2012-02-10 | 2016-03-30 | 国立大学法人京都工芸繊維大学 | 蛍光体およびその利用 |
| WO2013134686A1 (en) * | 2012-03-09 | 2013-09-12 | Promega Corporation | pH SENSORS |
| EP2855596B1 (en) * | 2012-05-30 | 2019-02-27 | Life Technologies Corporation | FLUOROGENIC pH-SENSITIVE DYES AND THEIR METHODS OF USE |
| US9023998B2 (en) * | 2013-02-25 | 2015-05-05 | Carnegie Mellon University | Near infrared fluorogen and fluorescent activating proteins for in vivo imaging and live-cell biosensing |
| EP3019559A4 (en) | 2013-08-22 | 2017-04-05 | Sony Corporation | Water soluble fluorescent or colored dyes and methods for their use |
| EP3702783A1 (en) * | 2013-12-11 | 2020-09-02 | Analiza, Inc. | Methods for determining cells such as circulating cancer or fetal cells |
| US9709556B2 (en) | 2013-12-11 | 2017-07-18 | Analiza, Inc. | Devices and methods for determining and/or isolating circulating cancer cells |
| US20150160246A1 (en) | 2013-12-11 | 2015-06-11 | Analiza, Inc. | Devices and methods for determining and/or isolating cells such as circulating cancer or fetal cells |
| EP2889299A1 (en) * | 2013-12-24 | 2015-07-01 | Paris Sciences et Lettres - Quartier Latin | Fluorescent red emitting functionalizable pH probes |
| KR101829159B1 (ko) | 2014-01-16 | 2018-02-13 | 소니 주식회사 | 수용성 형광 또는 유색 염료 |
| EP3502693A1 (en) * | 2014-05-16 | 2019-06-26 | Life Technologies Corporation | Cell tracking reagents and their methods of use |
| KR102676814B1 (ko) | 2015-02-26 | 2024-06-21 | 소니그룹주식회사 | 접합 그룹을 포함하는 수용성 형광 또는 착색 염료 |
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| US10865434B2 (en) * | 2015-04-21 | 2020-12-15 | General Automation Lab Technologies Inc. | High resolution systems, kits, apparatus, and methods for screening microorganisms and other high throughput microbiology applications |
| JP6849599B2 (ja) | 2015-05-11 | 2021-03-24 | ソニー株式会社 | 超明色ダイマーまたはポリマー染料 |
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| JP7068191B2 (ja) | 2016-06-06 | 2022-05-16 | ソニーグループ株式会社 | 蛍光または有色レポーター基を含むイオン性ポリマー |
| JP2018018251A (ja) * | 2016-07-27 | 2018-02-01 | ファナック株式会社 | 数値制御装置 |
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| WO2020162335A1 (ja) * | 2019-02-05 | 2020-08-13 | 株式会社Adeka | キサンテン化合物 |
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| WO2021045890A1 (en) * | 2019-09-05 | 2021-03-11 | The Regents Of The University Of California | Cellular potassium imaging using a ratiometric fluorescent sensor |
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-
2007
- 2007-10-26 EP EP07871255.1A patent/EP2064290B1/en active Active
- 2007-10-26 WO PCT/US2007/082617 patent/WO2008076524A2/en not_active Ceased
- 2007-10-26 EP EP13187570.0A patent/EP2727965B1/en not_active Not-in-force
- 2007-10-26 JP JP2009534880A patent/JP5636189B2/ja active Active
- 2007-10-29 US US11/927,588 patent/US20080274907A1/en not_active Abandoned
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2012
- 2012-09-13 US US13/614,995 patent/US20130102021A1/en not_active Abandoned
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2014
- 2014-08-01 JP JP2014157304A patent/JP5847257B2/ja not_active Expired - Fee Related
- 2014-08-08 US US14/455,550 patent/US9910051B2/en active Active
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2015
- 2015-11-10 US US14/937,736 patent/US9939454B2/en active Active
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2018
- 2018-02-19 US US15/899,021 patent/US10845373B2/en active Active
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2020
- 2020-09-21 US US17/027,391 patent/US11867698B2/en active Active
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