JP2010508295A5 - - Google Patents

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JP2010508295A5
JP2010508295A5 JP2009534880A JP2009534880A JP2010508295A5 JP 2010508295 A5 JP2010508295 A5 JP 2010508295A5 JP 2009534880 A JP2009534880 A JP 2009534880A JP 2009534880 A JP2009534880 A JP 2009534880A JP 2010508295 A5 JP2010508295 A5 JP 2010508295A5
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JP2010508295A (ja
JP5636189B2 (ja
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JP2009534880A 2006-10-27 2007-10-26 蛍光発生性ｐＨ感受性色素およびその使用方法 Active JP5636189B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US86331806P 2006-10-27 2006-10-27
US60/863,318 2006-10-27
US94032307P 2007-05-25 2007-05-25
US60/940,323 2007-05-25
PCT/US2007/082617 WO2008076524A2 (en) 2006-10-27 2007-10-26 Fluorogenic ph sensitive dyes and their method of use

Related Child Applications (1)

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JP2014157304A Division JP5847257B2 (ja) 2006-10-27 2014-08-01 蛍光発生性ｐＨ感受性色素およびその使用方法

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JP2010508295A JP2010508295A (ja) 2010-03-18
JP2010508295A5 true JP2010508295A5 (enExample) 2011-09-15
JP5636189B2 JP5636189B2 (ja) 2014-12-03

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JP2009534880A Active JP5636189B2 (ja) 2006-10-27 2007-10-26 蛍光発生性ｐＨ感受性色素およびその使用方法
JP2014157304A Expired - Fee Related JP5847257B2 (ja) 2006-10-27 2014-08-01 蛍光発生性ｐＨ感受性色素およびその使用方法

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US (6) US20080274907A1 (enExample)
EP (2) EP2064290B1 (enExample)
JP (2) JP5636189B2 (enExample)
WO (1) WO2008076524A2 (enExample)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5636189B2 (ja) 2006-10-27 2014-12-03 ライフ テクノロジーズ コーポレーション 蛍光発生性ｐＨ感受性色素およびその使用方法
JP5895297B2 (ja) * 2012-02-10 2016-03-30 国立大学法人京都工芸繊維大学 蛍光体およびその利用
US9702824B2 (en) 2012-03-09 2017-07-11 Promega Corporation pH sensors
WO2013180811A1 (en) * 2012-05-30 2013-12-05 Life Technologies Corporation FLUOROGENIC pH-SENSITIVE DYES AND THEIR METHODS OF USE
US9023998B2 (en) * 2013-02-25 2015-05-05 Carnegie Mellon University Near infrared fluorogen and fluorescent activating proteins for in vivo imaging and live-cell biosensing
JP6190534B2 (ja) 2013-08-22 2017-08-30 ソニー株式会社 水溶性蛍光染料又は有色染料及びその使用方法
US9709556B2 (en) 2013-12-11 2017-07-18 Analiza, Inc. Devices and methods for determining and/or isolating circulating cancer cells
EP3080341B1 (en) * 2013-12-11 2020-02-12 Analiza, Inc. Methods for determining and/or isolating cells such as circulating cancer or fetal cells
US20150160246A1 (en) 2013-12-11 2015-06-11 Analiza, Inc. Devices and methods for determining and/or isolating cells such as circulating cancer or fetal cells
EP2889299A1 (en) * 2013-12-24 2015-07-01 Paris Sciences et Lettres - Quartier Latin Fluorescent red emitting functionalizable pH probes
EP3094687B1 (en) 2014-01-16 2020-02-12 Sony Corporation Water soluble fluorescent or colored dyes
EP3502693A1 (en) * 2014-05-16 2019-06-26 Life Technologies Corporation Cell tracking reagents and their methods of use
KR102676814B1 (ko) 2015-02-26 2024-06-21 소니그룹주식회사 접합 그룹을 포함하는 수용성 형광 또는 착색 염료
JP6982500B2 (ja) * 2015-02-26 2021-12-17 ソニーグループ株式会社 フェニルエチニルナフタレン染料およびそれらの使用方法
US10865434B2 (en) * 2015-04-21 2020-12-15 General Automation Lab Technologies Inc. High resolution systems, kits, apparatus, and methods for screening microorganisms and other high throughput microbiology applications
US10865310B2 (en) 2015-05-11 2020-12-15 Sony Corporation Of America Ultra bright dimeric or polymeric dyes
JP6600527B2 (ja) * 2015-10-15 2019-10-30 自然免疫制御技術研究組合 貪食能評価方法及び蛍光測定方法
CN107580618A (zh) 2016-04-01 2018-01-12 索尼公司 超亮二聚或多聚染料
CN109415574B (zh) 2016-04-01 2021-05-28 索尼公司 具有刚性间隔基团的超亮二聚体或聚合物染料
JP7069033B2 (ja) 2016-04-06 2022-05-17 ソニーグループ株式会社 スペーシングリンカー基を有する超明色ダイマーまたはポリマー染料
WO2017197014A2 (en) 2016-05-10 2017-11-16 Sony Corporation Compositions comprising a polymeric dye and a cyclodextrin and uses thereof
JP7527537B2 (ja) 2016-05-10 2024-08-05 ソニーグループ株式会社 ペプチド骨格を有する超明色ポリマー染料
AU2017264861B2 (en) 2016-05-11 2021-09-23 Sony Group Corporation Ultra bright dimeric or polymeric dyes
WO2017214165A1 (en) 2016-06-06 2017-12-14 Sony Corporation Ionic polymers comprising fluorescent or colored reporter groups
JP2018018251A (ja) * 2016-07-27 2018-02-01 ファナック株式会社 数値制御装置
US12018159B2 (en) 2016-07-29 2024-06-25 Sony Group Corporation Ultra bright dimeric or polymeric dyes and methods for preparation of the same
JP7551056B2 (ja) 2017-10-05 2024-09-17 ソニーグループ株式会社 プログラマブルなポリマー薬物
EP3691689A1 (en) 2017-10-05 2020-08-12 Sony Corporation Programmable dendritic drugs
JP2021503450A (ja) 2017-11-16 2021-02-12 ソニー株式会社 プログラム可能なポリマー薬
JP7813098B2 (ja) 2018-01-12 2026-02-12 ソニーグループ株式会社 生物学的に活性な化合物を含む剛性間隔基を有するポリマー
JP2021510698A (ja) 2018-01-12 2021-04-30 ソニー株式会社 生物学的に活性な化合物を含むホスホアルキルリボースポリマー
CN111565757A (zh) 2018-01-12 2020-08-21 索尼公司 包含生物活性化合物的磷酸烷基聚合物
KR102742386B1 (ko) 2018-03-19 2024-12-16 소니그룹주식회사 형광 신호 향상을 위한 2가 금속의 사용
WO2019182766A1 (en) 2018-03-21 2019-09-26 Sony Corporation Polymeric tandem dyes with linker groups
KR102854332B1 (ko) 2018-06-27 2025-09-03 소니그룹주식회사 디옥시리보오스를 포함하는 링커 군을 갖는 중합체성 염료
EP3820944A1 (en) 2018-07-13 2021-05-19 Sony Corporation Polymeric dyes having a backbone comprising organophosphate units
WO2020018946A1 (en) * 2018-07-19 2020-01-23 University Of Washington Systems and methods for accurate optical ph sensing of biofilms
WO2020162335A1 (ja) * 2019-02-05 2020-08-13 株式会社Adeka キサンテン化合物
WO2020205465A1 (en) * 2019-03-29 2020-10-08 Purdue Research Foundation Ph-dependent composition matters useful for study and diagnosis of alzheimer's disease
WO2021045890A1 (en) * 2019-09-05 2021-03-11 The Regents Of The University Of California Cellular potassium imaging using a ratiometric fluorescent sensor
WO2021062176A2 (en) 2019-09-26 2021-04-01 Sony Corporation Polymeric tandem dyes with linker groups
JP7816141B2 (ja) 2019-09-30 2026-02-18 ソニーグループ株式会社 ヌクレオチドプローブ
GB2593878B (en) * 2020-03-31 2024-02-21 Sumitomo Chemical Co Light-emitting marker
EP4256078A1 (en) 2020-12-07 2023-10-11 Sony Group Corporation Spacing linker group design for brightness enhancement in dimeric or polymeric dyes
CN112939957B (zh) * 2021-02-03 2022-09-23 山西大学 一种苯并吲哚衍生物In-XY1及其合成方法和应用
CN116003448B (zh) * 2022-11-07 2024-06-11 淮阴工学院 一种含吲哚啉多烯键识别Aβ纤维的BODIPY近红外荧光探针及其制备方法
CN115710190A (zh) * 2022-11-16 2023-02-24 常州佳德医药科技有限公司 4-甲氧基-2-氨基-n,n-二甲基苯胺、制备方法及应用

Family Cites Families (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB320345A (en) * 1928-07-07 1929-10-07 Ici Ltd Process for the manufacture of new xanthen dyes and their use
FR1391547A (fr) * 1963-05-02 1965-03-05 Kodak Pathe Nouveau produit photographique portant une marque d'identification
FR2275461A1 (fr) * 1974-06-18 1976-01-16 Labaz Nouveaux stabilisants des polymeres et copolymeres du chlorure de vinyle
GB1574959A (en) * 1977-04-05 1980-09-10 Lepetit Spa Benzofuran derivatives
US4711955A (en) 1981-04-17 1987-12-08 Yale University Modified nucleotides and methods of preparing and using same
US4603209A (en) 1984-09-07 1986-07-29 The Regents Of The University Of California Fluorescent indicator dyes for calcium ions
US4812409A (en) 1986-01-31 1989-03-14 Eastman Kodak Company Hydrolyzable fluorescent substrates and analytical determinations using same
JPS62216792A (ja) * 1986-03-19 1987-09-24 Mitsubishi Chem Ind Ltd 光学記録媒体
US5569587A (en) 1986-04-18 1996-10-29 Carnegie Mellon University Method for labeling and detecting materials employing luminescent arysulfonate cyanine dyes
US5268486A (en) 1986-04-18 1993-12-07 Carnegie-Mellon Unversity Method for labeling and detecting materials employing arylsulfonate cyanine dyes
US5627027A (en) 1986-04-18 1997-05-06 Carnegie Mellon University Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods
US6048982A (en) 1986-04-18 2000-04-11 Carnegie Mellon University Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods
US5047519A (en) 1986-07-02 1991-09-10 E. I. Du Pont De Nemours And Company Alkynylamino-nucleotides
US4810636A (en) 1986-12-09 1989-03-07 Miles Inc. Chromogenic acridinone enzyme substrates
US4945171A (en) * 1987-08-10 1990-07-31 Molecular Probes, Inc. Xanthene dyes having a fused (C) benzo ring
US4774339A (en) 1987-08-10 1988-09-27 Molecular Probes, Inc. Chemically reactive dipyrrometheneboron difluoride dyes
US5049673A (en) * 1987-10-30 1991-09-17 The Regents Of The University Of California Fluorescent indicator dyes for calcium working at long wavelengths
JPH01161106A (ja) 1987-12-17 1989-06-23 Hitachi Ltd 電気容量型歪ゲージ
US4849362A (en) 1988-05-19 1989-07-18 Smithkline Beckman Corporation Fluorescent intracellular calcium indicators
JPH0262875A (ja) * 1988-05-23 1990-03-02 Wakunaga Pharmaceut Co Ltd 新規イソインドリン誘導体
US5132432A (en) 1989-09-22 1992-07-21 Molecular Probes, Inc. Chemically reactive pyrenyloxy sulfonic acid dyes
LU87611A1 (fr) * 1989-10-20 1991-05-07 Oreal Composition tinctoriale pour fibres keratiniques contenant des precurseurs de colorants par oxydation et des coupleurs amino indoliques,procedes de teinture mettant en oeuvre ces compositions et composes nouveaux
US5227487A (en) 1990-04-16 1993-07-13 Molecular Probes, Inc. Certain tricyclic and pentacyclic-hetero nitrogen rhodol dyes
US5648270A (en) 1995-02-06 1997-07-15 Molecular Probes, Inc. Methods of sensing with fluorescent conjugates of metal-chelating nitrogen heterocycles
US5501980A (en) 1994-05-20 1996-03-26 Molecular Probes, Inc. Benzazolylcoumarin-based ion indicators
US5459276A (en) 1994-05-20 1995-10-17 Molecular Probes, Inc. Benzazolylcoumarin-based ion indicators for heavy metals
US5453517A (en) 1992-02-25 1995-09-26 Molecular Probes, Inc. Reactive derivatives of bapta used to make ion-selective chelators
US5274113A (en) 1991-11-01 1993-12-28 Molecular Probes, Inc. Long wavelength chemically reactive dipyrrometheneboron difluoride dyes and conjugates
US5433896A (en) 1994-05-20 1995-07-18 Molecular Probes, Inc. Dibenzopyrrometheneboron difluoride dyes
US5405975A (en) 1993-03-29 1995-04-11 Molecular Probes, Inc. Fluorescent ion-selective diaryldiaza crown ether conjugates
US5714327A (en) 1990-07-19 1998-02-03 Kreatech Diagnostics Platinum-containing compounds, methods for their preparation and applications thereof
US5248782A (en) 1990-12-18 1993-09-28 Molecular Probes, Inc. Long wavelength heteroaryl-substituted dipyrrometheneboron difluoride dyes
US5451343A (en) 1991-05-20 1995-09-19 Spectra Group Limited, Inc. Fluorone and pyronin y derivatives
US5187288A (en) 1991-05-22 1993-02-16 Molecular Probes, Inc. Ethenyl-substituted dipyrrometheneboron difluoride dyes and their synthesis
US5242805A (en) 1991-08-23 1993-09-07 Molecular Probes, Inc. Long wavelength lipophilic fluorogenic glycosidase substrates
EP0603266B1 (en) 1991-08-23 1999-05-12 Molecular Probes, Inc. Use of haloalkyl derivatives of reporter molecules to analyze metabolic activity in cells
JP3093848B2 (ja) * 1991-12-10 2000-10-03 三菱化学株式会社 チアゾ−ル系化合物
CA2087413A1 (en) * 1992-01-17 1993-07-18 Joseph R. Lakowicz Fluorescent energy transfer immunoassay
US5278644A (en) 1992-02-03 1994-01-11 Hughes Aircraft Company Pseudo cross-couple for non-linear detectors
US5352803A (en) 1992-03-30 1994-10-04 Abbott Laboratories 5(6)-methyl substituted fluorescein derivatives
US5773227A (en) * 1993-06-23 1998-06-30 Molecular Probes, Inc. Bifunctional chelating polysaccharides
US5798276A (en) 1995-06-07 1998-08-25 Molecular Probes, Inc. Reactive derivatives of sulforhodamine 101 with enhanced hydrolytic stability
US6162931A (en) 1996-04-12 2000-12-19 Molecular Probes, Inc. Fluorinated xanthene derivatives
US5847162A (en) 1996-06-27 1998-12-08 The Perkin Elmer Corporation 4, 7-Dichlororhodamine dyes
US6017712A (en) 1996-06-27 2000-01-25 Lee; Linda 4,7-dichlororhodamine dyes
US6080852A (en) 1996-06-27 2000-06-27 The Perkin-Elmer Corporation 4,7-dichlororhodamine dyes
ES2116229B1 (es) * 1996-07-19 1999-03-01 Consejo Superior Investigacion Metodo de diferenciacion bacteriana basado en la determinacion de actividades aminopeptidasicas.
US5846737A (en) 1996-07-26 1998-12-08 Molecular Probes, Inc. Conjugates of sulforhodamine fluorophores with enhanced fluorescence
US5830912A (en) 1996-11-15 1998-11-03 Molecular Probes, Inc. Derivatives of 6,8-difluoro-7-hydroxycoumarin
US5696157A (en) 1996-11-15 1997-12-09 Molecular Probes, Inc. Sulfonated derivatives of 7-aminocoumarin
EP1000941B1 (en) * 1997-07-02 2003-08-13 Nagano, Testuo Diaminorhodamine derivatives
JP4549528B2 (ja) 1997-07-28 2010-09-22 ジーイー・ヘルスケア・リミテッド シアニン色素
JPH1161062A (ja) 1997-08-20 1999-03-05 Oji Paper Co Ltd クラフト粘着テープ
US6130101A (en) 1997-09-23 2000-10-10 Molecular Probes, Inc. Sulfonated xanthene derivatives
JP3983404B2 (ja) 1999-01-13 2007-09-26 本田技研工業株式会社 レーダ搭載車両用ゲート
US6664047B1 (en) 1999-04-30 2003-12-16 Molecular Probes, Inc. Aza-benzazolium containing cyanine dyes
CA2376955A1 (en) 1999-07-06 2001-01-11 Surromed, Inc. Bridged fluorescent dyes, their preparation and their use in assays
US6441197B1 (en) * 2000-01-20 2002-08-27 Daiichi Pure Chemicals Co., Ltd. Diaminofluorescein derivative
CA2417816A1 (en) 2000-08-04 2002-02-14 Molecular Probes, Inc. Derivatives of 1,2-dihydro-7-hydroxyquinolines containing fused rings
US6756231B1 (en) * 2000-08-18 2004-06-29 Daiichi Pure Chemicals Co., Ltd. Diaminorhodamine derivative
ATE352586T2 (de) 2000-09-29 2007-02-15 Molecular Probes Inc Modifizierte carbocyaninfarbstoffe und deren konjugate
AU2003299466A1 (en) * 2002-05-03 2004-06-07 Molecular Probes, Inc. Compositions and methods for detection and isolation of phosphorylated molecules
JP4206378B2 (ja) * 2002-07-08 2009-01-07 哲雄 長野 蛍光プローブ
US20050233307A1 (en) * 2002-09-12 2005-10-20 Kyle Gee Site-specific labeling of affinity tags in fusion proteins
US7005518B2 (en) * 2002-10-25 2006-02-28 Li-Cor, Inc. Phthalocyanine dyes
GB0307855D0 (en) * 2003-04-04 2003-05-14 Novartis Ag Organic compounds
TWI351961B (en) * 2003-05-16 2011-11-11 Sinphar Pharmaceutical Co Ltd Pharmaceutical composition for enhancing immunity,
EP1633892A4 (en) 2003-06-10 2007-10-24 Univ Boston DETECTION METHODS FOR LUNG DISEASES
EP1656936A4 (en) * 2003-08-06 2010-03-17 Signal Creation Inc Macrophage activation INHIBITORS
WO2005085811A1 (ja) * 2004-03-04 2005-09-15 Daiichi Pure Chemicals Co., Ltd. 蛍光プローブ
GB0407836D0 (en) * 2004-04-06 2004-05-12 Univ Cambridge Tech Fluorescent dyes and complexes
JP5017113B2 (ja) 2004-08-19 2012-09-05 ブラッド セル ストレージ， インコーポレイテッド 蛍光ｐＨ検出システムおよび関連する方法
CN1660783A (zh) * 2004-12-13 2005-08-31 大连理工大学 多酰胺荧光化合物及其在正离子超敏光信号识别中的应用
JP4920192B2 (ja) * 2005-02-28 2012-04-18 パイロットインキ株式会社 可逆熱変色性マイクロカプセル顔料
JP5636189B2 (ja) 2006-10-27 2014-12-03 ライフ テクノロジーズ コーポレーション 蛍光発生性ｐＨ感受性色素およびその使用方法

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