JP2010539456A5 - - Google Patents
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- Publication number
- JP2010539456A5 JP2010539456A5 JP2010524354A JP2010524354A JP2010539456A5 JP 2010539456 A5 JP2010539456 A5 JP 2010539456A5 JP 2010524354 A JP2010524354 A JP 2010524354A JP 2010524354 A JP2010524354 A JP 2010524354A JP 2010539456 A5 JP2010539456 A5 JP 2010539456A5
- Authority
- JP
- Japan
- Prior art keywords
- reporter
- peroxidase
- parts
- target site
- linker group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 15
- 102000003992 Peroxidases Human genes 0.000 claims 8
- 239000000126 substance Chemical group 0.000 claims 6
- 125000005647 linker group Chemical group 0.000 claims 5
- 239000000758 substrate Substances 0.000 claims 5
- 239000003431 cross linking reagent Substances 0.000 claims 4
- 102000004190 Enzymes Human genes 0.000 claims 3
- 108090000790 Enzymes Proteins 0.000 claims 3
- 108040007629 peroxidase activity proteins Proteins 0.000 claims 3
- KSEBMYQBYZTDHS-HWKANZROSA-M (E)-Ferulic acid Natural products COC1=CC(\C=C\C([O-])=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-M 0.000 claims 2
- 108010001336 Horseradish Peroxidase Proteins 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- KSEBMYQBYZTDHS-HWKANZROSA-N ferulic acid Chemical compound COC1=CC(\C=C\C(O)=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-N 0.000 claims 2
- 229940114124 ferulic acid Drugs 0.000 claims 2
- KSEBMYQBYZTDHS-UHFFFAOYSA-N ferulic acid Natural products COC1=CC(C=CC(O)=O)=CC=C1O KSEBMYQBYZTDHS-UHFFFAOYSA-N 0.000 claims 2
- 235000001785 ferulic acid Nutrition 0.000 claims 2
- 239000005267 main chain polymer Substances 0.000 claims 2
- 150000003384 small molecules Chemical group 0.000 claims 2
- 230000009870 specific binding Effects 0.000 claims 2
- QURCVMIEKCOAJU-UHFFFAOYSA-N trans-isoferulic acid Natural products COC1=CC=C(C=CC(O)=O)C=C1O QURCVMIEKCOAJU-UHFFFAOYSA-N 0.000 claims 2
- GEYOCULIXLDCMW-UHFFFAOYSA-N 1,2-phenylenediamine Chemical compound NC1=CC=CC=C1N GEYOCULIXLDCMW-UHFFFAOYSA-N 0.000 claims 1
- 244000068988 Glycine max Species 0.000 claims 1
- 235000010469 Glycine max Nutrition 0.000 claims 1
- 239000000090 biomarker Substances 0.000 claims 1
- 238000000151 deposition Methods 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- -1 peroxide compound Chemical class 0.000 claims 1
- 230000002285 radioactive effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US99420607P | 2007-09-18 | 2007-09-18 | |
| US60/994,206 | 2007-09-18 | ||
| PCT/DK2008/000327 WO2009036760A2 (en) | 2007-09-18 | 2008-09-16 | A rapid and sensitive method for detection of biological targets |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010539456A JP2010539456A (ja) | 2010-12-16 |
| JP2010539456A5 true JP2010539456A5 (enExample) | 2011-10-06 |
| JP5639889B2 JP5639889B2 (ja) | 2014-12-10 |
Family
ID=40121988
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010524354A Active JP5639889B2 (ja) | 2007-09-18 | 2008-09-16 | 生物学的標的の高速で高感度な検出方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US9377465B2 (enExample) |
| EP (1) | EP2201058B1 (enExample) |
| JP (1) | JP5639889B2 (enExample) |
| CN (1) | CN101836117B (enExample) |
| CA (1) | CA2698390C (enExample) |
| ES (1) | ES2624450T3 (enExample) |
| WO (1) | WO2009036760A2 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8435735B2 (en) | 2009-02-19 | 2013-05-07 | Dako Denmark A/S | Methods and compounds for detection of molecular targets |
| CN104714007B (zh) * | 2009-10-20 | 2017-04-12 | 丹麦达科有限公司 | 单个靶实体的免疫化学检测 |
| AU2011274619B2 (en) | 2010-07-06 | 2016-11-10 | Interna Technologies Bv | miRNA and its diagnostic and therapeutic uses in diseases or conditions associated with melanoma, or in diseases or conditions associated with activated BRAF pathway |
| WO2012062318A1 (en) | 2010-11-08 | 2012-05-18 | Dako Denmark A/S | Quantification of single target molecules in histological samples |
| US10150999B2 (en) | 2010-11-17 | 2018-12-11 | Interpace Diagnostics, Llc | miRNAs as biomarkers for distinguishing benign from malignant thyroid neoplasms |
| WO2012076010A1 (en) | 2010-12-06 | 2012-06-14 | Dako Denmark A/S | Combined histological stain |
| CN102565411B (zh) * | 2010-12-08 | 2014-05-28 | 中国科学院生物物理研究所 | 示踪磁性纳米颗粒的新方法 |
| EP2699691B1 (en) | 2011-04-19 | 2017-10-18 | Dako Denmark A/S | New method for enzyme-mediated signal amplification |
| EP2718348A4 (en) * | 2011-06-07 | 2015-02-18 | Diagnostic Innovations Llc | COLOR-PRODUCING DIAGNOSTIC SYSTEMS AND REAGENTS AND METHODS THEREFOR |
| US10648970B2 (en) | 2011-11-08 | 2020-05-12 | Agilent Technologies, Inc. | Method for evaluation of target in histological sample |
| WO2013148498A1 (en) | 2012-03-27 | 2013-10-03 | Ventana Medical Systems, Inc. | Signaling conjugates and methods of use |
| EP3404116B1 (en) | 2013-03-15 | 2022-10-19 | The University of Chicago | Methods and compositions related to t-cell activity |
| US9890417B2 (en) | 2014-11-03 | 2018-02-13 | Agilent Technologies, Inc. | Signal amplification of fluorescence in situ hybridization |
| JP6841609B2 (ja) | 2015-07-10 | 2021-03-10 | ３スキャン インコーポレイテッド | 組織学的染色の空間的多重化 |
| US11360098B2 (en) | 2015-09-28 | 2022-06-14 | Quest Diagnostics Investments Llc | Amyloid beta detection by mass spectrometry |
| WO2017103678A2 (en) * | 2015-12-18 | 2017-06-22 | Dako Denmark A/S | Chromogenic peroxidase substrates |
| CN105987840B (zh) * | 2016-06-03 | 2018-09-28 | 浙江世纪康大医疗科技股份有限公司 | 一种柠檬酸抗原修复液 |
| CN105987839B (zh) * | 2016-06-03 | 2018-09-28 | 浙江世纪康大医疗科技股份有限公司 | 一种edta-柠檬酸抗原修复液 |
| CN109085338B (zh) * | 2018-09-13 | 2021-07-13 | 武汉伊莱瑞特生物科技股份有限公司 | Ecl底物液及其制备方法和应用 |
| US11237170B2 (en) | 2018-12-04 | 2022-02-01 | Aat Bioquest, Inc. | Styryl phenols, derivatives and their use in methods of analyte detection |
| CN120820711B (zh) * | 2025-09-16 | 2025-12-26 | 中翰盛泰生物技术股份有限公司 | 检测试剂盒及应用、标志物检测系统、标志物检测方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU612370B2 (en) | 1987-05-21 | 1991-07-11 | Micromet Ag | Targeted multifunctional proteins |
| ATE151110T1 (de) | 1988-09-02 | 1997-04-15 | Protein Eng Corp | Herstellung und auswahl von rekombinantproteinen mit verschiedenen bindestellen |
| ATE102631T1 (de) | 1988-11-11 | 1994-03-15 | Medical Res Council | Klonierung von immunglobulin sequenzen aus den variabelen domaenen. |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5196306A (en) | 1989-03-29 | 1993-03-23 | E. I. Du Pont De Nemours And Company | Method for the detection or quantitation of an analyte using an analyte dependent enzyme activation system |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| US5688966A (en) | 1996-07-26 | 1997-11-18 | E. I. Du Pont De Nemours And Company | Compounds and method for synthesizing sulfoindocyanine dyes |
| US5863748A (en) | 1997-03-14 | 1999-01-26 | New Life Science Products, Inc. | p-Hydroxycinnamoyl-containing substrates for an analyte dependent enzyme activation system |
| IL123451A (en) | 1998-02-25 | 2003-07-06 | Ehud Keinan | Method and kit for the detection of peroxide-based explosives |
| US6372937B1 (en) | 1998-11-09 | 2002-04-16 | Mark Norman Bobrow | Enhanced catalyzed reporter deposition |
| US6531319B1 (en) | 2000-05-10 | 2003-03-11 | Keshab D. Pant | Method of detecting colon cancer |
| US6670113B2 (en) * | 2001-03-30 | 2003-12-30 | Nanoprobes | Enzymatic deposition and alteration of metals |
| US6617125B2 (en) | 2001-06-29 | 2003-09-09 | Perkinelmer Life Sciences, Inc. | Compositions for enhanced catalyzed reporter deposition |
| WO2007023390A2 (en) | 2005-07-01 | 2007-03-01 | Dako Denmark A/S | Immunohistochemistry detection method |
| US8435735B2 (en) * | 2009-02-19 | 2013-05-07 | Dako Denmark A/S | Methods and compounds for detection of molecular targets |
| CN104714007B (zh) * | 2009-10-20 | 2017-04-12 | 丹麦达科有限公司 | 单个靶实体的免疫化学检测 |
-
2008
- 2008-09-16 CN CN200880112656.5A patent/CN101836117B/zh active Active
- 2008-09-16 WO PCT/DK2008/000327 patent/WO2009036760A2/en not_active Ceased
- 2008-09-16 EP EP08801362.8A patent/EP2201058B1/en active Active
- 2008-09-16 ES ES08801362.8T patent/ES2624450T3/es active Active
- 2008-09-16 JP JP2010524354A patent/JP5639889B2/ja active Active
- 2008-09-16 US US12/678,937 patent/US9377465B2/en active Active
- 2008-09-16 CA CA2698390A patent/CA2698390C/en not_active Expired - Fee Related
-
2016
- 2016-05-26 US US15/165,823 patent/US10168335B2/en active Active
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