JP2009536525A5 - - Google Patents
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- JP2009536525A5 JP2009536525A5 JP2009509885A JP2009509885A JP2009536525A5 JP 2009536525 A5 JP2009536525 A5 JP 2009536525A5 JP 2009509885 A JP2009509885 A JP 2009509885A JP 2009509885 A JP2009509885 A JP 2009509885A JP 2009536525 A5 JP2009536525 A5 JP 2009536525A5
- Authority
- JP
- Japan
- Prior art keywords
- ligation
- probe
- domain
- target domain
- target
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000000523 sample Substances 0.000 claims 47
- 238000000034 method Methods 0.000 claims 17
- 230000000295 complement effect Effects 0.000 claims 14
- 239000000758 substrate Substances 0.000 claims 7
- 102000003960 Ligases Human genes 0.000 claims 6
- 108090000364 Ligases Proteins 0.000 claims 6
- 238000006243 chemical reaction Methods 0.000 claims 6
- 230000003321 amplification Effects 0.000 claims 4
- 238000006911 enzymatic reaction Methods 0.000 claims 4
- 238000003199 nucleic acid amplification method Methods 0.000 claims 4
- 125000003729 nucleotide group Chemical group 0.000 claims 4
- 230000000087 stabilizing effect Effects 0.000 claims 3
- 108700011259 MicroRNAs Proteins 0.000 claims 1
- 239000011324 bead Substances 0.000 claims 1
- 230000027455 binding Effects 0.000 claims 1
- 239000002299 complementary DNA Substances 0.000 claims 1
- 108020004999 messenger RNA Proteins 0.000 claims 1
- 239000002679 microRNA Substances 0.000 claims 1
- 238000013508 migration Methods 0.000 claims 1
- 230000005012 migration Effects 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 230000000269 nucleophilic effect Effects 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 150000007970 thio esters Chemical class 0.000 claims 1
- 238000006276 transfer reaction Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74689706P | 2006-05-10 | 2006-05-10 | |
| PCT/US2007/011448 WO2007133703A2 (en) | 2006-05-10 | 2007-05-10 | Detection of nucleic acid targets using chemically reactive oligonucleotide probes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009536525A JP2009536525A (ja) | 2009-10-15 |
| JP2009536525A5 true JP2009536525A5 (enExample) | 2012-07-26 |
Family
ID=38694509
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009509885A Pending JP2009536525A (ja) | 2006-05-10 | 2007-05-10 | 化学反応性オリゴヌクレオチドプローブを使用した核酸標的の検出 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US10829803B2 (enExample) |
| EP (2) | EP2677039B8 (enExample) |
| JP (1) | JP2009536525A (enExample) |
| CA (1) | CA2651815A1 (enExample) |
| WO (1) | WO2007133703A2 (enExample) |
Families Citing this family (83)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2677039B8 (en) | 2006-05-10 | 2022-10-05 | DxTerity Diagnostics Incorporated | Detection of nucleic acid targets using chemically reactive oligonucleotide probes |
| US11001881B2 (en) | 2006-08-24 | 2021-05-11 | California Institute Of Technology | Methods for detecting analytes |
| US11525156B2 (en) | 2006-07-28 | 2022-12-13 | California Institute Of Technology | Multiplex Q-PCR arrays |
| US8048626B2 (en) | 2006-07-28 | 2011-11-01 | California Institute Of Technology | Multiplex Q-PCR arrays |
| US11560588B2 (en) | 2006-08-24 | 2023-01-24 | California Institute Of Technology | Multiplex Q-PCR arrays |
| CN101586150B (zh) * | 2008-05-23 | 2016-09-28 | 陕西佰美基因股份有限公司 | 检测探针、通用寡核苷酸芯片及核酸检测方法及其用途 |
| CA2757300C (en) * | 2009-04-01 | 2018-01-09 | Dxterity Diagnostics Incorporated | Chemical ligation dependent probe amplification (clpa) |
| US20190300945A1 (en) | 2010-04-05 | 2019-10-03 | Prognosys Biosciences, Inc. | Spatially Encoded Biological Assays |
| US10787701B2 (en) | 2010-04-05 | 2020-09-29 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
| PT2556171E (pt) | 2010-04-05 | 2015-12-21 | Prognosys Biosciences Inc | Ensaios biológicos codificados espacialmente |
| EP2603607B1 (en) | 2010-08-11 | 2016-04-06 | Celula, Inc. | Genotyping dna |
| GB201106254D0 (en) | 2011-04-13 | 2011-05-25 | Frisen Jonas | Method and product |
| US20140170653A1 (en) * | 2011-04-15 | 2014-06-19 | Life Technologies Corporation | Chemical ligation |
| KR102085242B1 (ko) | 2011-05-17 | 2020-03-05 | 디엑스테리티 다이아그노스틱스 인코포레이티드 | 표적 핵산 검출을 위한 방법 및 조성물 |
| AU2013315800A1 (en) | 2012-09-11 | 2015-03-12 | Theranos Ip Company, Llc | Information management systems and methods using a biological signature |
| DK3511423T4 (da) | 2012-10-17 | 2024-07-29 | Spatial Transcriptomics Ab | Fremgangsmåder og produkt til optimering af lokaliseret eller rumlig detektion af genekspression i en vævsprøve |
| EP4234716A3 (en) | 2013-06-25 | 2023-12-06 | Prognosys Biosciences, Inc. | Methods for determining spatial patterns of biological targets in a sample |
| EP3066218B1 (en) * | 2013-11-05 | 2018-12-26 | HTG Molecular Diagnostics, Inc. | Methods for detecting nucleic acids |
| AU2014364180B2 (en) * | 2013-12-09 | 2021-03-04 | Illumina, Inc. | Methods and compositions for targeted nucleic acid sequencing |
| US11859246B2 (en) | 2013-12-11 | 2024-01-02 | Accuragen Holdings Limited | Methods and compositions for enrichment of amplification products |
| US11286519B2 (en) | 2013-12-11 | 2022-03-29 | Accuragen Holdings Limited | Methods and compositions for enrichment of amplification products |
| EP3495506B1 (en) | 2013-12-11 | 2023-07-12 | AccuraGen Holdings Limited | Methods for detecting rare sequence variants |
| EP2949759B1 (en) | 2014-05-27 | 2017-07-26 | Université Paris Sud 11 | Multiplexed homogeneous oligonucleotide detection |
| US9757095B2 (en) | 2014-06-10 | 2017-09-12 | Dxterity Diagnostics Incorporated | Devices and methods for collecting and stabilizing biological samples |
| US9463201B2 (en) | 2014-10-19 | 2016-10-11 | M.G. Therapeutics Ltd | Compositions and methods for the treatment of meibomian gland dysfunction |
| JP6616574B2 (ja) * | 2015-01-30 | 2019-12-04 | 倉敷紡績株式会社 | 目視判定可能な遺伝子検査 |
| EP4119677B1 (en) | 2015-04-10 | 2023-06-28 | Spatial Transcriptomics AB | Spatially distinguished, multiplex nucleic acid analysis of biological specimens |
| KR20180090251A (ko) | 2015-09-28 | 2018-08-10 | 아주라 오프탈믹스 엘티디 | 마이봄샘 지질 분비를 증가시키기 위한 티올 및 이황화물 함유 약제 |
| HK1259101A1 (zh) | 2015-10-09 | 2019-11-22 | Accuragen Holdings Limited | 用於富集扩增产物的方法及组合物 |
| US12163184B2 (en) | 2015-12-03 | 2024-12-10 | Accuragen Holdings Limited | Methods and compositions for forming ligation products |
| WO2017155858A1 (en) | 2016-03-07 | 2017-09-14 | Insilixa, Inc. | Nucleic acid sequence identification using solid-phase cyclic single base extension |
| EP3442519A4 (en) | 2016-04-14 | 2019-12-04 | Azura Opthalmics Ltd. | SELDISULFID COMPOSITIONS FOR USE IN THE TREATMENT OF THE MEIBOM DRESSING DYSFUNCTION |
| WO2017201102A1 (en) | 2016-05-16 | 2017-11-23 | Accuragen Holdings Limited | Method of improved sequencing by strand identification |
| CN106018523B (zh) * | 2016-07-27 | 2018-08-31 | 中国水产科学研究院 | 用于鉴别大西洋鲑和虹鳟的生物传感检测方法 |
| WO2018035170A1 (en) | 2016-08-15 | 2018-02-22 | Accuragen Holdings Limited | Compositions and methods for detecting rare sequence variants |
| US11203782B2 (en) | 2018-03-29 | 2021-12-21 | Accuragen Holdings Limited | Compositions and methods comprising asymmetric barcoding |
| CN112601823A (zh) | 2018-06-12 | 2021-04-02 | 安可济控股有限公司 | 用于形成连接产物的方法和组合物 |
| US11519033B2 (en) | 2018-08-28 | 2022-12-06 | 10X Genomics, Inc. | Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample |
| US12385083B2 (en) | 2018-12-10 | 2025-08-12 | 10X Genomics, Inc. | Methods of using master / copy arrays for spatial detection |
| US11649485B2 (en) | 2019-01-06 | 2023-05-16 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
| US11926867B2 (en) | 2019-01-06 | 2024-03-12 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
| CN119510370A (zh) | 2019-03-14 | 2025-02-25 | 因斯利克萨公司 | 基于时间门控的荧光检测的方法和系统 |
| EP3947718A4 (en) * | 2019-04-02 | 2022-12-21 | Enumera Molecular, Inc. | METHODS, SYSTEMS AND COMPOSITIONS FOR COUNTING NUCLEIC ACID MOLECULES |
| WO2020227444A1 (en) * | 2019-05-08 | 2020-11-12 | Crosslife Technologies Inc. | Rapid nucleic acid detection without sample preparation |
| EP3976820A1 (en) | 2019-05-30 | 2022-04-06 | 10X Genomics, Inc. | Methods of detecting spatial heterogeneity of a biological sample |
| EP4025711A2 (en) | 2019-11-08 | 2022-07-13 | 10X Genomics, Inc. | Enhancing specificity of analyte binding |
| WO2021133849A1 (en) | 2019-12-23 | 2021-07-01 | 10X Genomics, Inc. | Methods for spatial analysis using rna-templated ligation |
| WO2021133842A1 (en) | 2019-12-23 | 2021-07-01 | 10X Genomics, Inc. | Compositions and methods for using fixed biological samples in partition-based assays |
| CN115279458A (zh) | 2020-01-10 | 2022-11-01 | 阿祖拉眼科有限公司 | 组合物和敏感性说明 |
| US12365942B2 (en) | 2020-01-13 | 2025-07-22 | 10X Genomics, Inc. | Methods of decreasing background on a spatial array |
| US12405264B2 (en) | 2020-01-17 | 2025-09-02 | 10X Genomics, Inc. | Electrophoretic system and method for analyte capture |
| US11702693B2 (en) | 2020-01-21 | 2023-07-18 | 10X Genomics, Inc. | Methods for printing cells and generating arrays of barcoded cells |
| US11732299B2 (en) | 2020-01-21 | 2023-08-22 | 10X Genomics, Inc. | Spatial assays with perturbed cells |
| US20210230681A1 (en) | 2020-01-24 | 2021-07-29 | 10X Genomics, Inc. | Methods for spatial analysis using proximity ligation |
| US12076701B2 (en) | 2020-01-31 | 2024-09-03 | 10X Genomics, Inc. | Capturing oligonucleotides in spatial transcriptomics |
| US11898205B2 (en) | 2020-02-03 | 2024-02-13 | 10X Genomics, Inc. | Increasing capture efficiency of spatial assays |
| US12110541B2 (en) | 2020-02-03 | 2024-10-08 | 10X Genomics, Inc. | Methods for preparing high-resolution spatial arrays |
| US11732300B2 (en) | 2020-02-05 | 2023-08-22 | 10X Genomics, Inc. | Increasing efficiency of spatial analysis in a biological sample |
| US12129516B2 (en) | 2020-02-07 | 2024-10-29 | 10X Genomics, Inc. | Quantitative and automated permeabilization performance evaluation for spatial transcriptomics |
| US12281357B1 (en) | 2020-02-14 | 2025-04-22 | 10X Genomics, Inc. | In situ spatial barcoding |
| US11891654B2 (en) | 2020-02-24 | 2024-02-06 | 10X Genomics, Inc. | Methods of making gene expression libraries |
| EP4549582A3 (en) | 2020-04-22 | 2025-06-18 | 10x Genomics, Inc. | Methods for spatial analysis using targeted rna depletion |
| EP4553168A3 (en) | 2020-05-22 | 2025-08-27 | 10x Genomics, Inc. | Spatial analysis to detect sequence variants |
| WO2021236929A1 (en) | 2020-05-22 | 2021-11-25 | 10X Genomics, Inc. | Simultaneous spatio-temporal measurement of gene expression and cellular activity |
| WO2021242834A1 (en) | 2020-05-26 | 2021-12-02 | 10X Genomics, Inc. | Method for resetting an array |
| US12031177B1 (en) | 2020-06-04 | 2024-07-09 | 10X Genomics, Inc. | Methods of enhancing spatial resolution of transcripts |
| ES2981265T3 (es) | 2020-06-08 | 2024-10-08 | 10X Genomics Inc | Métodos para determinar un margen quirúrgico y métodos de uso del mismo |
| WO2021252591A1 (en) | 2020-06-10 | 2021-12-16 | 10X Genomics, Inc. | Methods for determining a location of an analyte in a biological sample |
| EP4450639B1 (en) | 2020-06-25 | 2025-10-15 | 10X Genomics, Inc. | Spatial analysis of dna methylation |
| US12209280B1 (en) | 2020-07-06 | 2025-01-28 | 10X Genomics, Inc. | Methods of identifying abundance and location of an analyte in a biological sample using second strand synthesis |
| US11761038B1 (en) | 2020-07-06 | 2023-09-19 | 10X Genomics, Inc. | Methods for identifying a location of an RNA in a biological sample |
| US11981960B1 (en) | 2020-07-06 | 2024-05-14 | 10X Genomics, Inc. | Spatial analysis utilizing degradable hydrogels |
| US11981958B1 (en) | 2020-08-20 | 2024-05-14 | 10X Genomics, Inc. | Methods for spatial analysis using DNA capture |
| US11926822B1 (en) | 2020-09-23 | 2024-03-12 | 10X Genomics, Inc. | Three-dimensional spatial analysis |
| US11827935B1 (en) | 2020-11-19 | 2023-11-28 | 10X Genomics, Inc. | Methods for spatial analysis using rolling circle amplification and detection probes |
| EP4121555A1 (en) | 2020-12-21 | 2023-01-25 | 10X Genomics, Inc. | Methods, compositions, and systems for capturing probes and/or barcodes |
| WO2022221425A1 (en) | 2021-04-14 | 2022-10-20 | 10X Genomics, Inc. | Methods of measuring mislocalization of an analyte |
| WO2022236054A1 (en) | 2021-05-06 | 2022-11-10 | 10X Genomics, Inc. | Methods for increasing resolution of spatial analysis |
| EP4582555A3 (en) | 2021-06-03 | 2025-10-22 | 10X Genomics, Inc. | Methods, compositions, kits, and systems for enhancing analyte capture for spatial analysis |
| EP4196605B1 (en) | 2021-09-01 | 2024-12-04 | 10X Genomics, Inc. | Methods for blocking a capture probe on a spatial array |
| EP4419707A1 (en) | 2021-11-10 | 2024-08-28 | 10X Genomics, Inc. | Methods, compositions, and kits for determining the location of an analyte in a biological sample |
| WO2023102118A2 (en) | 2021-12-01 | 2023-06-08 | 10X Genomics, Inc. | Methods, compositions, and systems for improved in situ detection of analytes and spatial analysis |
| IL319606A (en) * | 2022-09-14 | 2025-05-01 | Univ Illinois | Targeted Amplification Process for Recycling (TRAP) |
Family Cites Families (75)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4469863A (en) * | 1980-11-12 | 1984-09-04 | Ts O Paul O P | Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof |
| US5235033A (en) * | 1985-03-15 | 1993-08-10 | Anti-Gene Development Group | Alpha-morpholino ribonucleoside derivatives and polymers thereof |
| US5034506A (en) * | 1985-03-15 | 1991-07-23 | Anti-Gene Development Group | Uncharged morpholino-based polymers having achiral intersubunit linkages |
| CA1323293C (en) | 1987-12-11 | 1993-10-19 | Keith C. Backman | Assay using template-dependent nucleic acid probe reorganization |
| US5216141A (en) * | 1988-06-06 | 1993-06-01 | Benner Steven A | Oligonucleotide analogs containing sulfur linkages |
| ATE144556T1 (de) * | 1988-06-24 | 1996-11-15 | Amgen Inc | Verfahren und mittel zum nachweis von nukleinsäuresequenzen |
| JP2955759B2 (ja) | 1988-07-20 | 1999-10-04 | セゲブ・ダイアグノスティックス・インコーポレイテッド | 核酸配列を増幅及び検出する方法 |
| US5185243A (en) | 1988-08-25 | 1993-02-09 | Syntex (U.S.A.) Inc. | Method for detection of specific nucleic acid sequences |
| ES2089038T3 (es) | 1990-01-26 | 1996-10-01 | Abbott Lab | Procedimiento mejorado para amplificar acidos nucleicos blanco aplicable para la reaccion en cadena de polimerasa y ligasa. |
| US5602240A (en) * | 1990-07-27 | 1997-02-11 | Ciba Geigy Ag. | Backbone modified oligonucleotide analogs |
| US5386023A (en) | 1990-07-27 | 1995-01-31 | Isis Pharmaceuticals | Backbone modified oligonucleotide analogs and preparation thereof through reductive coupling |
| IL99025A0 (en) | 1990-08-15 | 1992-07-15 | Astra Ab | Novel process for the detection of pathogens using dna probes |
| US5683874A (en) * | 1991-03-27 | 1997-11-04 | Research Corporation Technologies, Inc. | Single-stranded circular oligonucleotides capable of forming a triplex with a target sequence |
| DK51092D0 (da) | 1991-05-24 | 1992-04-15 | Ole Buchardt | Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf |
| US5644048A (en) | 1992-01-10 | 1997-07-01 | Isis Pharmaceuticals, Inc. | Process for preparing phosphorothioate oligonucleotides |
| US5346994A (en) | 1992-01-28 | 1994-09-13 | Piotr Chomczynski | Shelf-stable product and process for isolating RNA, DNA and proteins |
| US5681943A (en) * | 1993-04-12 | 1997-10-28 | Northwestern University | Method for covalently linking adjacent oligonucleotides |
| AU684279B2 (en) | 1993-04-12 | 1997-12-11 | Northwestern University | Method of forming oligonucleotides |
| US6077668A (en) * | 1993-04-15 | 2000-06-20 | University Of Rochester | Highly sensitive multimeric nucleic acid probes |
| US5714320A (en) | 1993-04-15 | 1998-02-03 | University Of Rochester | Rolling circle synthesis of oligonucleotides and amplification of select randomized circular oligonucleotides |
| US5846709A (en) * | 1993-06-15 | 1998-12-08 | Imclone Systems Incorporated | Chemical process for amplifying and detecting nucleic acid sequences |
| US5808036A (en) | 1993-09-01 | 1998-09-15 | Research Corporation Technologies Inc. | Stem-loop oligonucleotides containing parallel and antiparallel binding domains |
| CA2105364A1 (en) | 1993-09-01 | 1995-03-02 | Eric T. Kool | Stem-loop oligonucleotides containing parallel and antiparallel binding domains |
| US5591578A (en) | 1993-12-10 | 1997-01-07 | California Institute Of Technology | Nucleic acid mediated electron transfer |
| US5824473A (en) | 1993-12-10 | 1998-10-20 | California Institute Of Technology | Nucleic acid mediated electron transfer |
| US5637684A (en) | 1994-02-23 | 1997-06-10 | Isis Pharmaceuticals, Inc. | Phosphoramidate and phosphorothioamidate oligomeric compounds |
| US5876924A (en) | 1994-06-22 | 1999-03-02 | Mount Sinai School Of Medicine | Nucleic acid amplification method hybridization signal amplification method (HSAM) |
| WO1996015271A1 (en) | 1994-11-16 | 1996-05-23 | Abbott Laboratories | Multiplex ligations-dependent amplification |
| US5674683A (en) * | 1995-03-21 | 1997-10-07 | Research Corporation Technologies, Inc. | Stem-loop and circular oligonucleotides and method of using |
| US5780613A (en) | 1995-08-01 | 1998-07-14 | Northwestern University | Covalent lock for self-assembled oligonucleotide constructs |
| EP2368897B1 (en) * | 1996-02-09 | 2016-10-19 | Cornell Research Foundation, Inc. | Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays |
| US6218108B1 (en) | 1997-05-16 | 2001-04-17 | Research Corporation Technologies, Inc. | Nucleoside analogs with polycyclic aromatic groups attached, methods of synthesis and uses therefor |
| ATE308553T1 (de) | 1996-06-07 | 2005-11-15 | Amersham Biosciences Sv Corp | Nukleinsäurevermittelter elektronentransfer |
| US6984491B2 (en) | 1996-07-29 | 2006-01-10 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
| WO1998020162A2 (en) | 1996-11-05 | 1998-05-14 | Clinical Micro Sensors | Electrodes linked via conductive oligomers to nucleic acids |
| US7090804B2 (en) | 1998-01-27 | 2006-08-15 | Clinical Mirco Sensors, Inc. | Amplification of nucleic acids with electronic detection |
| WO1999055914A1 (en) * | 1998-04-29 | 1999-11-04 | Trustees Of Boston University | Methods and compositions pertaining to pd-loops |
| US7033753B1 (en) * | 1999-01-15 | 2006-04-25 | University Of Rochester | Compositions and methods for nonenzymatic ligation of oligonucleotides and detection of genetic polymorphisms |
| US6942771B1 (en) | 1999-04-21 | 2005-09-13 | Clinical Micro Sensors, Inc. | Microfluidic systems in the electrochemical detection of target analytes |
| WO2001066802A1 (en) * | 2000-03-09 | 2001-09-13 | Genetag Technology, Inc. | SYSTEMS AND METHODS TO QUANTIFY AND AMPLIFY BOTH SIGNALING AND PROBES FOR cDNA CHIPS AND GENES EXPRESSION MICROARRAYS |
| US6297016B1 (en) | 1999-10-08 | 2001-10-02 | Applera Corporation | Template-dependent ligation with PNA-DNA chimeric probes |
| US6479650B1 (en) * | 1999-12-14 | 2002-11-12 | Research Corporation Technologies, Inc. | Fluorescent nucleoside analogs and combinatorial fluorophore arrays comprising same |
| EP1130113A1 (en) | 2000-02-15 | 2001-09-05 | Johannes Petrus Schouten | Multiplex ligation dependent amplification assay |
| EP1313880A2 (en) | 2000-05-30 | 2003-05-28 | PE Corporation (NY) | Methods for detecting target nucleic acids using coupled ligation and amplification |
| US6887664B2 (en) | 2000-06-06 | 2005-05-03 | Applera Corporation | Asynchronous primed PCR |
| ATE348191T1 (de) | 2000-07-03 | 2007-01-15 | Applera Corp | Polynukleotid-sequenzassay |
| US6635425B2 (en) * | 2001-01-05 | 2003-10-21 | Molecular Staging, Inc. | 5′-thio phosphate directed ligation of oligonucleotides and use in detection of single nucleotide polymorphisms |
| US20050142545A1 (en) * | 2001-04-11 | 2005-06-30 | Conn Michael M. | Methods for identifying small molecules that bind specific rna structural motifs |
| WO2002083952A1 (en) | 2001-04-12 | 2002-10-24 | Caliper Technologies Corp. | Systems and methods for high throughput genetic analysis |
| FI20021325A0 (fi) | 2002-07-05 | 2002-07-05 | Valtion Teknillinen | Menetelmä ja reagenssipakkaus yksittäisten polynukleotidien määrän määrittämiseksi |
| JP2006510348A (ja) * | 2002-07-18 | 2006-03-30 | ザ・ボード・オブ・トラスティーズ・オブ・ザ・レランド・スタンフォード・ジュニア・ユニバーシティ | 蛍光消光脱離基を用いる化学ライゲーションの検出 |
| JP2006500033A (ja) | 2002-09-19 | 2006-01-05 | アプレラ コーポレイション | 標的を検出するための方法および組成物 |
| WO2004027082A2 (en) * | 2002-09-19 | 2004-04-01 | Applera Corporation | Methods and compositions for detecting targets |
| US20040259105A1 (en) * | 2002-10-03 | 2004-12-23 | Jian-Bing Fan | Multiplex nucleic acid analysis using archived or fixed samples |
| US7459273B2 (en) | 2002-10-04 | 2008-12-02 | Affymetrix, Inc. | Methods for genotyping selected polymorphism |
| US20040235005A1 (en) * | 2002-10-23 | 2004-11-25 | Ernest Friedlander | Methods and composition for detecting targets |
| US20040110134A1 (en) * | 2002-12-05 | 2004-06-10 | Wenz H. Michael | Methods for quantitating nucleic acids using coupled ligation and amplification |
| KR100959101B1 (ko) * | 2003-02-20 | 2010-05-25 | 삼성전자주식회사 | Pcr 반응기 및 pcr 반응기의 입구와 출구의 개폐를조절하는 방법 |
| GB0304371D0 (en) * | 2003-02-26 | 2003-04-02 | Solexa Ltd | DNA Sequence analysis |
| US7198900B2 (en) * | 2003-08-29 | 2007-04-03 | Applera Corporation | Multiplex detection compositions, methods, and kits |
| ATE462801T1 (de) | 2003-11-04 | 2010-04-15 | Applied Biosystems Llc | Konkatamere ligationsprodukte: zusammensetzungen, verfahren und kits dafür |
| EP1702216B1 (en) | 2004-01-09 | 2015-11-04 | Life Technologies Corporation | Phosphor particle coded beads |
| US20050208503A1 (en) * | 2004-03-16 | 2005-09-22 | Handy Yowanto | Chemical ligation of nucleic acids |
| WO2005094532A2 (en) * | 2004-03-24 | 2005-10-13 | Applera Corporation | Encoding and decoding reactions for determining target polynucleotides |
| WO2006076017A2 (en) | 2004-04-30 | 2006-07-20 | Applera Corporation | Methods and kits for identifying target nucleotides in mixed populations |
| US7745614B2 (en) * | 2004-09-03 | 2010-06-29 | The Board Of Trustees Of The Leland Stanford Junior University | Universal linker compositions for the release or transfer of chemical agents from a polynucleotide |
| US7563570B2 (en) * | 2004-10-29 | 2009-07-21 | Pangaea Biotech | Method of determining a chemotherapeutic regimen for non small cell lung cancer based on BRCA1 expression |
| US7799530B2 (en) | 2005-09-23 | 2010-09-21 | Celera Corporation | Genetic polymorphisms associated with cardiovascular disorders and drug response, methods of detection and uses thereof |
| EP2677039B8 (en) | 2006-05-10 | 2022-10-05 | DxTerity Diagnostics Incorporated | Detection of nucleic acid targets using chemically reactive oligonucleotide probes |
| US20080242560A1 (en) | 2006-11-21 | 2008-10-02 | Gunderson Kevin L | Methods for generating amplified nucleic acid arrays |
| CA2757300C (en) | 2009-04-01 | 2018-01-09 | Dxterity Diagnostics Incorporated | Chemical ligation dependent probe amplification (clpa) |
| US9609769B2 (en) | 2010-07-29 | 2017-03-28 | Rockwell Automation Technologies, Inc. | System and method for ventilating and isolating electrical equipment |
| KR102085242B1 (ko) * | 2011-05-17 | 2020-03-05 | 디엑스테리티 다이아그노스틱스 인코포레이티드 | 표적 핵산 검출을 위한 방법 및 조성물 |
| WO2014143762A2 (en) | 2013-03-15 | 2014-09-18 | Armour Technologies, Inc. | Medical device curving apparatus, system, and method of use |
| FR3054894A1 (fr) | 2016-08-03 | 2018-02-09 | Stmicroelectronics (Crolles 2) Sas | Dispositif integre photonique a compacite amelioree |
-
2007
- 2007-05-10 EP EP13150067.0A patent/EP2677039B8/en active Active
- 2007-05-10 CA CA002651815A patent/CA2651815A1/en not_active Abandoned
- 2007-05-10 JP JP2009509885A patent/JP2009536525A/ja active Pending
- 2007-05-10 WO PCT/US2007/011448 patent/WO2007133703A2/en not_active Ceased
- 2007-05-10 US US11/801,990 patent/US10829803B2/en active Active
- 2007-05-10 EP EP07794804A patent/EP2021514A2/en not_active Withdrawn
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