JP2017522015A5 - - Google Patents
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- Publication number
- JP2017522015A5 JP2017522015A5 JP2016574431A JP2016574431A JP2017522015A5 JP 2017522015 A5 JP2017522015 A5 JP 2017522015A5 JP 2016574431 A JP2016574431 A JP 2016574431A JP 2016574431 A JP2016574431 A JP 2016574431A JP 2017522015 A5 JP2017522015 A5 JP 2017522015A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- probe
- primer
- nucleic acid
- reaction mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000000523 sample Substances 0.000 claims 25
- 239000011541 reaction mixture Substances 0.000 claims 9
- 108091093037 Peptide nucleic acid Proteins 0.000 claims 8
- 239000002773 nucleotide Substances 0.000 claims 7
- 125000003729 nucleotide group Chemical group 0.000 claims 7
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 6
- 238000000034 method Methods 0.000 claims 5
- 108091093088 Amplicon Proteins 0.000 claims 2
- 108700020796 Oncogene Proteins 0.000 claims 1
- 241000713810 Rat sarcoma virus Species 0.000 claims 1
- 239000007850 fluorescent dye Substances 0.000 claims 1
- 102000054765 polymorphisms of proteins Human genes 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462016312P | 2014-06-24 | 2014-06-24 | |
| US62/016,312 | 2014-06-24 | ||
| PCT/US2015/037268 WO2015200377A1 (en) | 2014-06-24 | 2015-06-23 | Detection of single nucleotide polymorphisms in human kras |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017522015A JP2017522015A (ja) | 2017-08-10 |
| JP2017522015A5 true JP2017522015A5 (enExample) | 2018-08-02 |
Family
ID=53514418
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016574431A Abandoned JP2017522015A (ja) | 2014-06-24 | 2015-06-23 | ヒトｋｒａｓ中における１塩基多型の検出 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US9909187B2 (enExample) |
| EP (1) | EP3161151A1 (enExample) |
| JP (1) | JP2017522015A (enExample) |
| CN (1) | CN106414738A (enExample) |
| WO (1) | WO2015200377A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6754202B2 (ja) * | 2016-03-15 | 2020-09-09 | アークレイ株式会社 | Ｋ−ｒａｓ遺伝子増幅用フォワードプライマーセット、Ｋ−ｒａｓ遺伝子増幅用キット、Ｋ−ｒａｓ遺伝子増幅方法、多型解析方法、及び薬効判定方法 |
| CA3022947A1 (en) | 2016-05-04 | 2017-11-09 | Children's Hospital & Research Center At Oakland | Rapid extraction of nucleic acids from clinical samples for downstream applications |
| KR102192651B1 (ko) * | 2017-08-23 | 2020-12-17 | 노을 주식회사 | 시약을 저장하는 저장 매체 및 이를 이용한 검사 방법 및 검사 모듈 |
| CA3073073A1 (en) * | 2017-09-08 | 2019-03-14 | F. Hoffmann-La Roche Ag | Diagnostic and therapeutic methods for cancer |
| CN107937524A (zh) * | 2017-12-05 | 2018-04-20 | 中源协和基因科技有限公司 | 人类kras基因突变检测试剂盒及检测方法 |
| WO2020049485A1 (en) * | 2018-09-05 | 2020-03-12 | Inivata Ltd. | Method of treating a cancer patient without the need for a tissue biopsy |
| CN110452983B (zh) * | 2019-07-05 | 2022-09-20 | 凯威康达(厦门)生物医药科技有限公司 | 一种检测kras基因12密码子6种热点突变的引物、探针、检测体系和试剂盒及方法 |
| EP4247972A4 (en) * | 2020-11-17 | 2024-10-16 | CY Molecular Diagnostics, Inc | Compositions and methods for high sensitivity detection of rare mutations |
| CN112795653A (zh) * | 2021-02-08 | 2021-05-14 | 深圳市核子基因科技有限公司 | Kras基因突变检测的引物探针组、试剂盒及其应用 |
| CN117858956A (zh) * | 2021-08-25 | 2024-04-09 | 南京金斯瑞生物科技有限公司 | 一种用于检测单碱基突变的引物组和基因芯片方法 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1202962A (en) | 1982-10-19 | 1986-04-08 | David P. Clifford | Substituted n-phenyl-n'-benzoyl ureas and their use as insecticides and acaricides |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4965188A (en) | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
| US5310893A (en) | 1986-03-31 | 1994-05-10 | Hoffmann-La Roche Inc. | Method for HLA DP typing |
| US5604099A (en) | 1986-03-13 | 1997-02-18 | Hoffmann-La Roche Inc. | Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids |
| CA1284931C (en) | 1986-03-13 | 1991-06-18 | Henry A. Erlich | Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids |
| US5322770A (en) | 1989-12-22 | 1994-06-21 | Hoffman-Laroche Inc. | Reverse transcription with thermostable DNA polymerases - high temperature reverse transcription |
| US5310652A (en) | 1986-08-22 | 1994-05-10 | Hoffman-La Roche Inc. | Reverse transcription with thermostable DNA polymerase-high temperature reverse transcription |
| US5693517A (en) | 1987-06-17 | 1997-12-02 | Roche Molecular Systems, Inc. | Reagents and methods for coupled high temperature reverse transcription and polymerase chain reactions |
| US5561058A (en) | 1986-08-22 | 1996-10-01 | Hoffmann-La Roche Inc. | Methods for coupled high temperatures reverse transcription and polymerase chain reactions |
| DE3750503T2 (de) | 1986-10-22 | 1995-02-09 | Abbott Lab | Chemilumineszierende Acridinium- und Phenantridiniumsalze. |
| US5539082A (en) | 1993-04-26 | 1996-07-23 | Nielsen; Peter E. | Peptide nucleic acids |
| DK51092D0 (da) | 1991-05-24 | 1992-04-15 | Ole Buchardt | Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf |
| CA2081582A1 (en) | 1991-11-05 | 1993-05-06 | Teodorica Bugawan | Methods and reagents for hla class i dna typing |
| US5484908A (en) | 1991-11-26 | 1996-01-16 | Gilead Sciences, Inc. | Oligonucleotides containing 5-propynyl pyrimidines |
| WO1993010820A1 (en) | 1991-11-26 | 1993-06-10 | Gilead Sciences, Inc. | Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines |
| TW393513B (en) | 1991-11-26 | 2000-06-11 | Isis Pharmaceuticals Inc | Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines |
| US5502177A (en) | 1993-09-17 | 1996-03-26 | Gilead Sciences, Inc. | Pyrimidine derivatives for labeled binding partners |
| US6028183A (en) | 1997-11-07 | 2000-02-22 | Gilead Sciences, Inc. | Pyrimidine derivatives and oligonucleotides containing same |
| US6007992A (en) | 1997-11-10 | 1999-12-28 | Gilead Sciences, Inc. | Pyrimidine derivatives for labeled binding partners |
| EP1319710A4 (en) | 2000-09-19 | 2005-02-09 | Takara Bio Inc | PROCESS FOR FORMING COMPLEXES |
| US20030211483A1 (en) | 2002-05-09 | 2003-11-13 | Schroeder Benjamin G. | Methods for the enrichment of low-abundance polynucleotides |
| JP5162133B2 (ja) | 2003-12-03 | 2013-03-13 | アボット・ラボラトリーズ | 二本鎖直鎖核酸プローブ及びその使用 |
| CN101423866A (zh) * | 2007-10-31 | 2009-05-06 | 上海长海医院 | 检测K-ras基因突变的PNA、探针、引物及方法 |
| JP6147502B2 (ja) * | 2009-10-27 | 2017-06-14 | スウィフト バイオサイエンシーズ， インコーポレイテッド | ポリヌクレオチドプライマー及びプローブ |
| EP2426217A1 (en) * | 2010-09-03 | 2012-03-07 | Centre National de la Recherche Scientifique (CNRS) | Analytical methods for cell free nucleic acids and applications |
| WO2012112582A2 (en) * | 2011-02-14 | 2012-08-23 | Swift Biosciences, Inc. | Polynucleotide primers and probes |
| US9556473B2 (en) * | 2011-02-15 | 2017-01-31 | Leica Biosystems Newcastle Ltd | Methods for identifying nucleic acid sequences |
| CN102304581B (zh) | 2011-09-01 | 2013-10-30 | 广州好芝生物科技有限公司 | 用于检测kras基因突变的试剂盒及其检测方法 |
| CN103114146B (zh) | 2013-02-28 | 2015-03-11 | 张戈 | 一种检测K-ras基因突变的试剂盒及其检测方法 |
-
2015
- 2015-06-23 WO PCT/US2015/037268 patent/WO2015200377A1/en not_active Ceased
- 2015-06-23 JP JP2016574431A patent/JP2017522015A/ja not_active Abandoned
- 2015-06-23 US US14/748,155 patent/US9909187B2/en not_active Expired - Fee Related
- 2015-06-23 CN CN201580020715.6A patent/CN106414738A/zh active Pending
- 2015-06-23 EP EP15734517.4A patent/EP3161151A1/en not_active Withdrawn
-
2018
- 2018-01-24 US US15/878,851 patent/US20180171417A1/en not_active Abandoned
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