JP2009502196A5 - - Google Patents
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- JP2009502196A5 JP2009502196A5 JP2008525040A JP2008525040A JP2009502196A5 JP 2009502196 A5 JP2009502196 A5 JP 2009502196A5 JP 2008525040 A JP2008525040 A JP 2008525040A JP 2008525040 A JP2008525040 A JP 2008525040A JP 2009502196 A5 JP2009502196 A5 JP 2009502196A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- complement
- oligonucleotides
- nucleotides
- oligonucleotide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 150000007523 nucleic acids Chemical class 0.000 claims description 6
- 230000003321 amplification Effects 0.000 claims description 3
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 3
- 238000001514 detection method Methods 0.000 claims description 2
- 108091034117 Oligonucleotide Proteins 0.000 claims 19
- 238000000034 method Methods 0.000 claims 18
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims 11
- 230000000295 complement effect Effects 0.000 claims 11
- 239000002773 nucleotide Substances 0.000 claims 10
- 125000003729 nucleotide group Chemical group 0.000 claims 10
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 241000829111 Human polyomavirus 1 Species 0.000 claims 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
- 238000009396 hybridization Methods 0.000 claims 3
- 241000701460 JC polyomavirus Species 0.000 claims 2
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims 1
- 239000000523 sample Substances 0.000 description 4
- 238000003556 assay Methods 0.000 description 3
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70521705P | 2005-08-02 | 2005-08-02 | |
| US11/246,904 US7892795B2 (en) | 2005-08-02 | 2005-10-06 | Methods and compositions for detecting BK virus |
| PCT/US2006/029243 WO2007016275A2 (en) | 2005-08-02 | 2006-07-25 | Methods and compositions for detecting bk virus |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009502196A JP2009502196A (ja) | 2009-01-29 |
| JP2009502196A5 true JP2009502196A5 (enExample) | 2009-09-10 |
Family
ID=37709186
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008525040A Pending JP2009502196A (ja) | 2005-08-02 | 2006-07-25 | Ｂｋウイルス検出のための方法および組成物 |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US7892795B2 (enExample) |
| EP (2) | EP2662456A1 (enExample) |
| JP (1) | JP2009502196A (enExample) |
| CN (3) | CN110423844B (enExample) |
| AU (1) | AU2006275803B2 (enExample) |
| CA (1) | CA2617635C (enExample) |
| ES (1) | ES2552725T3 (enExample) |
| WO (1) | WO2007016275A2 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7892795B2 (en) | 2005-08-02 | 2011-02-22 | Focus Diagnostics, Inc. | Methods and compositions for detecting BK virus |
| EP2257648A4 (en) * | 2008-02-19 | 2011-07-27 | Intelligentmdx Inc | OPTIMIZED PROBES AND PRIMERS AND METHOD FOR THEIR USE TO DETECT AND QUANTIFY THE BK VIRUS |
| US20110091866A1 (en) * | 2008-02-20 | 2011-04-21 | Kosuke Ken Iwaki | Detection of polyomavirus |
| WO2009126517A2 (en) * | 2008-04-09 | 2009-10-15 | Intelligent Medical Devices, Inc. | Optimized probes and primers and methods of using same for the detection, quantification and grouping of hiv-1 |
| CN102344970B (zh) * | 2010-07-27 | 2013-01-23 | 温州医学院附属第一医院 | 同时检测人cmv和bk病毒dna的引物序列及定量检测试剂盒 |
| CN102154523B (zh) * | 2011-04-07 | 2013-01-02 | 温岭市第一人民医院 | 检测人bk病毒核酸的引物与荧光探针及其应用 |
| CN102690894B (zh) * | 2011-06-08 | 2013-05-01 | 中国人民解放军第三〇九医院 | 一种bk病毒的检测方法、其试剂盒及应用 |
| CN103093120A (zh) * | 2011-11-08 | 2013-05-08 | 北京健数通生物计算技术有限公司 | 高通量检测脊椎动物病原体基因芯片的探针设计方法 |
| CN104745723A (zh) * | 2015-01-30 | 2015-07-01 | 湖北永邦医疗科技有限公司 | 一种用于检测bk病毒的引物、探针和试剂盒 |
| US10793923B2 (en) | 2016-11-09 | 2020-10-06 | Roche Molecular Systems, Inc. | Compositions and methods for detection of BK virus |
| CA3092817A1 (en) * | 2018-03-02 | 2019-09-06 | Academisch Ziekenhuis Leiden H.O.D.N. Lumc | Inhibition of polyomavirus replication |
| FR3082524B1 (fr) * | 2018-06-18 | 2022-03-25 | Univ Paris Sud | Methode de stratification du risque de nephropathie a bk-virus apres transplantation renale |
| CA3116895A1 (en) * | 2018-10-22 | 2020-04-30 | Gen-Probe Incorporated | Compositions and methods for amplifying, detecting or quantifying human polyomavirus bk virus |
| KR102347899B1 (ko) * | 2019-06-21 | 2022-01-06 | 울산대학교 산학협력단 | 신장이식 후 bk 바이러스 신병증의 진단 또는 예후 예측을 위한 소변 엑소좀 바이오마커 |
| CN111733298B (zh) * | 2020-08-25 | 2020-11-20 | 圣湘生物科技股份有限公司 | 检测多瘤病毒并分型的组合物、试剂盒、方法及其用途 |
| TWI833069B (zh) * | 2021-03-17 | 2024-02-21 | 國防醫學院 | 核酸探針組、核酸側流檢測套組以及該核酸側流檢測套組之用途 |
| CN114107571B (zh) * | 2022-01-18 | 2024-06-21 | 复旦大学附属中山医院 | 用于bk病毒lamp检测的试剂盒 |
| CN115029485A (zh) * | 2022-06-20 | 2022-09-09 | 广东永诺医疗科技有限公司 | 一种基于微滴式数字pcr的bkv病毒检测试剂盒 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4318846A (en) | 1979-09-07 | 1982-03-09 | Syva Company | Novel ether substituted fluorescein polyamino acid compounds as fluorescers and quenchers |
| US4458066A (en) | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
| US4415732A (en) | 1981-03-27 | 1983-11-15 | University Patents, Inc. | Phosphoramidite compounds and processes |
| US4605735A (en) | 1983-02-14 | 1986-08-12 | Wakunaga Seiyaku Kabushiki Kaisha | Oligonucleotide derivatives |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4757141A (en) | 1985-08-26 | 1988-07-12 | Applied Biosystems, Incorporated | Amino-derivatized phosphite and phosphate linking agents, phosphoramidite precursors, and useful conjugates thereof |
| US4889818A (en) | 1986-08-22 | 1989-12-26 | Cetus Corporation | Purified thermostable enzyme |
| US5541308A (en) * | 1986-11-24 | 1996-07-30 | Gen-Probe Incorporated | Nucleic acid probes for detection and/or quantitation of non-viral organisms |
| US5283174A (en) | 1987-09-21 | 1994-02-01 | Gen-Probe, Incorporated | Homogenous protection assay |
| US6004745A (en) | 1987-09-21 | 1999-12-21 | Gen-Probe Incorporated | Hybridization protection assay |
| US5639604A (en) | 1987-09-21 | 1997-06-17 | Gen-Probe Incorporated | Homogeneous protection assay |
| US5585481A (en) | 1987-09-21 | 1996-12-17 | Gen-Probe Incorporated | Linking reagents for nucleotide probes |
| US4914210A (en) | 1987-10-02 | 1990-04-03 | Cetus Corporation | Oligonucleotide functionalizing reagents |
| US5185439A (en) | 1987-10-05 | 1993-02-09 | Gen-Probe Incorporated | Acridinium ester labelling and purification of nucleotide probes |
| JP2650159B2 (ja) | 1988-02-24 | 1997-09-03 | アクゾ・ノベル・エヌ・ベー | 核酸増幅方法 |
| CA1340807C (en) | 1988-02-24 | 1999-11-02 | Lawrence T. Malek | Nucleic acid amplification process |
| US5849481A (en) | 1990-07-27 | 1998-12-15 | Chiron Corporation | Nucleic acid hybridization assays employing large comb-type branched polynucleotides |
| US5213796A (en) | 1991-05-06 | 1993-05-25 | Dana Farber Cancer Institute | Assay for polyomavirus in humans and uses thereof |
| US5538848A (en) | 1994-11-16 | 1996-07-23 | Applied Biosystems Division, Perkin-Elmer Corp. | Method for detecting nucleic acid amplification using self-quenching fluorescence probe |
| US6127121A (en) * | 1998-04-03 | 2000-10-03 | Epoch Pharmaceuticals, Inc. | Oligonucleotides containing pyrazolo[3,4-D]pyrimidines for hybridization and mismatch discrimination |
| JP2003525911A (ja) | 2000-03-08 | 2003-09-02 | ニューロサーチ、アクティーゼルスカブ | プロドラッグに対する内皮細胞の感受性を高める方法 |
| US6605602B1 (en) | 2001-09-28 | 2003-08-12 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Method of treating BK virus nephropathy |
| NZ532531A (en) * | 2001-12-08 | 2007-01-26 | Seegene Inc | Annealing control primer for improving annealing specificity in nucleic acid amplification |
| US7892795B2 (en) * | 2005-08-02 | 2011-02-22 | Focus Diagnostics, Inc. | Methods and compositions for detecting BK virus |
| EP2013222B1 (en) * | 2006-04-28 | 2013-02-13 | Alnylam Pharmaceuticals Inc. | Compositions and methods for inhibiting expression of a gene from the jc virus |
| US20080003565A1 (en) * | 2006-05-02 | 2008-01-03 | Government Of The Us, As Represented By The Secretary, Department Of Health And Human Services | Viral nucleic acid microarray and method of use |
-
2005
- 2005-10-06 US US11/246,904 patent/US7892795B2/en active Active
-
2006
- 2006-07-25 ES ES06788689.5T patent/ES2552725T3/es active Active
- 2006-07-25 CN CN201910529553.9A patent/CN110423844B/zh active Active
- 2006-07-25 EP EP12196497.7A patent/EP2662456A1/en not_active Withdrawn
- 2006-07-25 CN CN201510303094.4A patent/CN104862422B/zh active Active
- 2006-07-25 WO PCT/US2006/029243 patent/WO2007016275A2/en not_active Ceased
- 2006-07-25 AU AU2006275803A patent/AU2006275803B2/en active Active
- 2006-07-25 EP EP06788689.5A patent/EP1910578B1/en active Active
- 2006-07-25 CN CN200680034771.6A patent/CN101511995B/zh active Active
- 2006-07-25 JP JP2008525040A patent/JP2009502196A/ja active Pending
- 2006-07-25 CA CA2617635A patent/CA2617635C/en active Active
-
2011
- 2011-01-12 US US13/005,490 patent/US8748092B2/en active Active
-
2014
- 2014-04-29 US US14/264,462 patent/US9745638B2/en not_active Expired - Lifetime
-
2017
- 2017-08-22 US US15/683,036 patent/US10801078B2/en not_active Expired - Lifetime
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