JP2017522015A - ヒトｋｒａｓ中における１塩基多型の検出 - Google Patents

ヒトｋｒａｓ中における１塩基多型の検出 Download PDF

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Publication number
JP2017522015A
JP2017522015A JP2016574431A JP2016574431A JP2017522015A JP 2017522015 A JP2017522015 A JP 2017522015A JP 2016574431 A JP2016574431 A JP 2016574431A JP 2016574431 A JP2016574431 A JP 2016574431A JP 2017522015 A JP2017522015 A JP 2017522015A
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Japan
Prior art keywords
seq
primer
probe
kras
sample
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JP2016574431A
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English (en)
Japanese (ja)
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JP2017522015A5 (enExample
Inventor
ホ、シアオラン、ワイ．
シャー、アンクル、エイチ．
チェン、シャオディ
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アボツト・モレキユラー・インコーポレイテツド
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Publication of JP2017522015A publication Critical patent/JP2017522015A/ja
Publication of JP2017522015A5 publication Critical patent/JP2017522015A5/ja
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2016574431A 2014-06-24 2015-06-23 ヒトｋｒａｓ中における１塩基多型の検出 Abandoned JP2017522015A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462016312P 2014-06-24 2014-06-24
US62/016,312 2014-06-24
PCT/US2015/037268 WO2015200377A1 (en) 2014-06-24 2015-06-23 Detection of single nucleotide polymorphisms in human kras

Publications (2)

Publication Number Publication Date
JP2017522015A true JP2017522015A (ja) 2017-08-10
JP2017522015A5 JP2017522015A5 (enExample) 2018-08-02

Family

ID=53514418

Family Applications (1)

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JP2016574431A Abandoned JP2017522015A (ja) 2014-06-24 2015-06-23 ヒトｋｒａｓ中における１塩基多型の検出

Country Status (5)

Country Link
US (2) US9909187B2 (enExample)
EP (1) EP3161151A1 (enExample)
JP (1) JP2017522015A (enExample)
CN (1) CN106414738A (enExample)
WO (1) WO2015200377A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023549569A (ja) * 2020-11-17 2023-11-27 シーワイ・モレキュラー・ディアグノスティクス・インコーポレイテッド 希少変異の高感度検出のための組成物および方法

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Publication number Priority date Publication date Assignee Title
JP6754202B2 (ja) * 2016-03-15 2020-09-09 アークレイ株式会社 Ｋ−ｒａｓ遺伝子増幅用フォワードプライマーセット、Ｋ−ｒａｓ遺伝子増幅用キット、Ｋ−ｒａｓ遺伝子増幅方法、多型解析方法、及び薬効判定方法
AU2017261283B2 (en) * 2016-05-04 2023-02-09 Children's Hospital & Research Center At Oakland Rapid extraction of nucleic acids from clinical samples for downstream applications
KR102192651B1 (ko) * 2017-08-23 2020-12-17 노을 주식회사 시약을 저장하는 저장 매체 및 이를 이용한 검사 방법 및 검사 모듈
KR102811888B1 (ko) * 2017-09-08 2025-05-27 에프. 호프만-라 로슈 아게 암의 진단 및 치료 방법
CN107937524A (zh) * 2017-12-05 2018-04-20 中源协和基因科技有限公司 人类kras基因突变检测试剂盒及检测方法
US11377698B2 (en) * 2018-09-05 2022-07-05 Inivata Ltd. Method of treating a cancer patient without the need for a tissue biopsy
CN110452983B (zh) * 2019-07-05 2022-09-20 凯威康达(厦门)生物医药科技有限公司 一种检测kras基因12密码子6种热点突变的引物、探针、检测体系和试剂盒及方法
CN112795653A (zh) * 2021-02-08 2021-05-14 深圳市核子基因科技有限公司 Kras基因突变检测的引物探针组、试剂盒及其应用
US20250092445A1 (en) * 2021-08-25 2025-03-20 Manjing Genscript Biotech Co., Ltd. Primer set and gene chip method for detecting single base mutation

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CA1202962A (en) 1982-10-19 1986-04-08 David P. Clifford Substituted n-phenyl-n'-benzoyl ureas and their use as insecticides and acaricides
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US5604099A (en) 1986-03-13 1997-02-18 Hoffmann-La Roche Inc. Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids
US5310893A (en) 1986-03-31 1994-05-10 Hoffmann-La Roche Inc. Method for HLA DP typing
CA1284931C (en) 1986-03-13 1991-06-18 Henry A. Erlich Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids
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US5322770A (en) 1989-12-22 1994-06-21 Hoffman-Laroche Inc. Reverse transcription with thermostable DNA polymerases - high temperature reverse transcription
US5561058A (en) 1986-08-22 1996-10-01 Hoffmann-La Roche Inc. Methods for coupled high temperatures reverse transcription and polymerase chain reactions
US5693517A (en) 1987-06-17 1997-12-02 Roche Molecular Systems, Inc. Reagents and methods for coupled high temperature reverse transcription and polymerase chain reactions
ATE111083T1 (de) 1986-10-22 1994-09-15 Abbott Lab Chemilumineszierende acridinium- und phenantridiniumsalze.
US5539082A (en) 1993-04-26 1996-07-23 Nielsen; Peter E. Peptide nucleic acids
DK51092D0 (da) 1991-05-24 1992-04-15 Ole Buchardt Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf
CA2081582A1 (en) 1991-11-05 1993-05-06 Teodorica Bugawan Methods and reagents for hla class i dna typing
TW393513B (en) 1991-11-26 2000-06-11 Isis Pharmaceuticals Inc Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines
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CA2122365C (en) 1991-11-26 2010-05-11 Brian Froehler Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines
US5502177A (en) 1993-09-17 1996-03-26 Gilead Sciences, Inc. Pyrimidine derivatives for labeled binding partners
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CN101423866A (zh) * 2007-10-31 2009-05-06 上海长海医院 检测K-ras基因突变的PNA、探针、引物及方法
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CN102304581B (zh) 2011-09-01 2013-10-30 广州好芝生物科技有限公司 用于检测kras基因突变的试剂盒及其检测方法
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023549569A (ja) * 2020-11-17 2023-11-27 シーワイ・モレキュラー・ディアグノスティクス・インコーポレイテッド 希少変異の高感度検出のための組成物および方法
JP7777879B2 (ja) 2020-11-17 2025-12-01 スパーク・モレキュラー・ディアグノスティクス・インコーポレイテッド 希少変異の高感度検出のための組成物および方法

Also Published As

Publication number Publication date
US20180171417A1 (en) 2018-06-21
US20150368725A1 (en) 2015-12-24
EP3161151A1 (en) 2017-05-03
CN106414738A (zh) 2017-02-15
US9909187B2 (en) 2018-03-06
WO2015200377A1 (en) 2015-12-30

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