CN101836117B - 用于检测生物靶点的快速和灵敏的方法 - Google Patents

用于检测生物靶点的快速和灵敏的方法 Download PDF

Info

Publication number
CN101836117B
CN101836117B CN200880112656.5A CN200880112656A CN101836117B CN 101836117 B CN101836117 B CN 101836117B CN 200880112656 A CN200880112656 A CN 200880112656A CN 101836117 B CN101836117 B CN 101836117B
Authority
CN
China
Prior art keywords
reporter
molecule
peroxidase
medium
probe
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN200880112656.5A
Other languages
English (en)
Chinese (zh)
Other versions
CN101836117A (zh
Inventor
J·洛泽
K·H·彼得森
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Agilent Technologies Inc
Original Assignee
Dako Denmark ApS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dako Denmark ApS filed Critical Dako Denmark ApS
Publication of CN101836117A publication Critical patent/CN101836117A/zh
Application granted granted Critical
Publication of CN101836117B publication Critical patent/CN101836117B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/581—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with enzyme label (including co-enzymes, co-factors, enzyme inhibitors or substrates)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C12Q1/28—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving peroxidase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/902—Oxidoreductases (1.)
    • G01N2333/908—Oxidoreductases (1.) acting on hydrogen peroxide as acceptor (1.11)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN200880112656.5A 2007-09-18 2008-09-16 用于检测生物靶点的快速和灵敏的方法 Active CN101836117B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US99420607P 2007-09-18 2007-09-18
US60/994,206 2007-09-18
PCT/DK2008/000327 WO2009036760A2 (en) 2007-09-18 2008-09-16 A rapid and sensitive method for detection of biological targets

Publications (2)

Publication Number Publication Date
CN101836117A CN101836117A (zh) 2010-09-15
CN101836117B true CN101836117B (zh) 2014-07-23

Family

ID=40121988

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200880112656.5A Active CN101836117B (zh) 2007-09-18 2008-09-16 用于检测生物靶点的快速和灵敏的方法

Country Status (7)

Country Link
US (2) US9377465B2 (enExample)
EP (1) EP2201058B1 (enExample)
JP (1) JP5639889B2 (enExample)
CN (1) CN101836117B (enExample)
CA (1) CA2698390C (enExample)
ES (1) ES2624450T3 (enExample)
WO (1) WO2009036760A2 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8435735B2 (en) 2009-02-19 2013-05-07 Dako Denmark A/S Methods and compounds for detection of molecular targets
CN104714007B (zh) * 2009-10-20 2017-04-12 丹麦达科有限公司 单个靶实体的免疫化学检测
WO2012005572A1 (en) 2010-07-06 2012-01-12 Interna Technologies Bv Mirna and its diagnostic and therapeutic uses in diseases or conditions associated with melanoma, or in diseases or conditions associated with activated braf pathway
US10180426B2 (en) 2010-11-08 2019-01-15 Dako Denmark A/S Quantification of single target molecules in histological samples
ES2629890T3 (es) 2010-11-17 2017-08-16 Interpace Diagnostics, Llc miARN como biomarcadores para distinguir entre neoplasias de tiroides benignas y malignas
US10718777B2 (en) 2010-12-06 2020-07-21 Agilent Technologies, Inc. Combined histological stain
CN102565411B (zh) * 2010-12-08 2014-05-28 中国科学院生物物理研究所 示踪磁性纳米颗粒的新方法
CA2832907C (en) 2011-04-19 2020-07-14 Dako Denmark A/S New method for enzyme-mediated signal amplification
EP2718348A4 (en) * 2011-06-07 2015-02-18 Diagnostic Innovations Llc COLOR-PRODUCING DIAGNOSTIC SYSTEMS AND REAGENTS AND METHODS THEREFOR
ES2613477T3 (es) * 2011-11-08 2017-05-24 Dako Denmark A/S Nuevo método para la evaluación de una diana en una muestra histológica
JP6101782B2 (ja) 2012-03-27 2017-03-22 ヴェンタナ メディカル システムズ， インク． シグナリングコンジュゲート及び使用法
EP3404116B1 (en) 2013-03-15 2022-10-19 The University of Chicago Methods and compositions related to t-cell activity
US9890417B2 (en) 2014-11-03 2018-02-13 Agilent Technologies, Inc. Signal amplification of fluorescence in situ hybridization
US10839509B2 (en) 2015-07-10 2020-11-17 3Scan Inc. Spatial multiplexing of histological stains
US11360098B2 (en) * 2015-09-28 2022-06-14 Quest Diagnostics Investments Llc Amyloid beta detection by mass spectrometry
US10526646B2 (en) 2015-12-18 2020-01-07 Agilent Technologies, Inc. Chromogenic peroxidase substrates
CN105987840B (zh) * 2016-06-03 2018-09-28 浙江世纪康大医疗科技股份有限公司 一种柠檬酸抗原修复液
CN105987839B (zh) * 2016-06-03 2018-09-28 浙江世纪康大医疗科技股份有限公司 一种edta-柠檬酸抗原修复液
CN109085338B (zh) * 2018-09-13 2021-07-13 武汉伊莱瑞特生物科技股份有限公司 Ecl底物液及其制备方法和应用
US11237170B2 (en) 2018-12-04 2022-02-01 Aat Bioquest, Inc. Styryl phenols, derivatives and their use in methods of analyte detection

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7183072B1 (en) * 2001-03-30 2007-02-27 Nanoprobes, Inc. Kit for detecting Her-2/neu gene by site-specific metal deposition
US7252955B2 (en) * 2000-05-10 2007-08-07 Loma Linda University Adventist Health Sciences Center Method of detecting colon cancer

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02500329A (ja) 1987-05-21 1990-02-08 クリエイテイブ・バイオマリキユールズ・インコーポレーテツド ターゲット化多機能蛋白質
DE768377T1 (de) 1988-09-02 1998-01-02 Dyax Corp Herstellung und Auswahl von Rekombinantproteinen mit verschiedenen Bindestellen
ATE102631T1 (de) 1988-11-11 1994-03-15 Medical Res Council Klonierung von immunglobulin sequenzen aus den variabelen domaenen.
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5196306A (en) 1989-03-29 1993-03-23 E. I. Du Pont De Nemours And Company Method for the detection or quantitation of an analyte using an analyte dependent enzyme activation system
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
US5688966A (en) 1996-07-26 1997-11-18 E. I. Du Pont De Nemours And Company Compounds and method for synthesizing sulfoindocyanine dyes
US5863748A (en) 1997-03-14 1999-01-26 New Life Science Products, Inc. p-Hydroxycinnamoyl-containing substrates for an analyte dependent enzyme activation system
IL123451A (en) 1998-02-25 2003-07-06 Ehud Keinan Method and kit for the detection of peroxide-based explosives
US6372937B1 (en) 1998-11-09 2002-04-16 Mark Norman Bobrow Enhanced catalyzed reporter deposition
US6617125B2 (en) * 2001-06-29 2003-09-09 Perkinelmer Life Sciences, Inc. Compositions for enhanced catalyzed reporter deposition
ATE501277T1 (de) 2005-07-01 2011-03-15 Dako Denmark As Monomere und polymere linker zur konjugierung von biologischen molekülen und anderen stoffen
US8435735B2 (en) * 2009-02-19 2013-05-07 Dako Denmark A/S Methods and compounds for detection of molecular targets
CN104714007B (zh) * 2009-10-20 2017-04-12 丹麦达科有限公司 单个靶实体的免疫化学检测

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7252955B2 (en) * 2000-05-10 2007-08-07 Loma Linda University Adventist Health Sciences Center Method of detecting colon cancer
US7183072B1 (en) * 2001-03-30 2007-02-27 Nanoprobes, Inc. Kit for detecting Her-2/neu gene by site-specific metal deposition

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Figueroa-Espinoza M C et al.Oxidative cross-linking of pentosans by a fungal laccase and horseradish peroxidase:mechanism of linkage between feruloylated arabinoxylans.《Cereal Chemistry》.1998,第75卷(第2期),259-265. *
Oxidative cross-linking of pentosans by a fungal laccase and horseradish peroxidase:mechanism of linkage between feruloylated arabinoxylans;Figueroa-Espinoza M C et al;《Cereal Chemistry》;19980331;第75卷(第2期);259-265 *
符婷.基于酶催化沉积信号放大和纳米功能界面的生物传感器研究.《中国优秀博硕士学位论文全文数据库(硕士)信息科技辑》.2006,全文. *

Also Published As

Publication number Publication date
CA2698390C (en) 2018-05-22
US20160370375A1 (en) 2016-12-22
JP5639889B2 (ja) 2014-12-10
ES2624450T3 (es) 2017-07-14
EP2201058B1 (en) 2017-04-12
CN101836117A (zh) 2010-09-15
JP2010539456A (ja) 2010-12-16
US10168335B2 (en) 2019-01-01
EP2201058A2 (en) 2010-06-30
WO2009036760A2 (en) 2009-03-26
US20100285467A1 (en) 2010-11-11
WO2009036760A3 (en) 2009-07-23
CA2698390A1 (en) 2009-03-26
US9377465B2 (en) 2016-06-28

Similar Documents

Publication Publication Date Title
CN101836117B (zh) 用于检测生物靶点的快速和灵敏的方法
JP5721639B2 (ja) 分子標的の検出のための方法と化合物
US20210222234A1 (en) Multiplexed imaging with enzyme mediated amplification
RU2566714C2 (ru) Иммунохимическое определение одиночных мишеней
CN103328979B (zh) 组合的组织学染色
US20140315204A1 (en) Immunohistochemistry Detection Method
US9958449B2 (en) Method for enzyme-mediated signal amplification
CN111491667A (zh) 肽核酸缀合物
US11079372B2 (en) Polymers and conjugates comprising the same

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CP03 Change of name, title or address
CP03 Change of name, title or address

Address after: Danish Glostrup

Patentee after: Denmark Dako Co.,Ltd.

Address before: Gloucester, Denmark

Patentee before: DAKO DENMARK A/S

TR01 Transfer of patent right
TR01 Transfer of patent right

Effective date of registration: 20200714

Address after: California, USA

Patentee after: Agilent Technologies, Inc.

Address before: Danish Glostrup

Patentee before: Denmark Dako Co.,Ltd.