ES2624450T3 - Método rápido y sensible para la detección de dianas biológicas - Google Patents
Método rápido y sensible para la detección de dianas biológicas Download PDFInfo
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- ES2624450T3 ES2624450T3 ES08801362.8T ES08801362T ES2624450T3 ES 2624450 T3 ES2624450 T3 ES 2624450T3 ES 08801362 T ES08801362 T ES 08801362T ES 2624450 T3 ES2624450 T3 ES 2624450T3
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- G01N33/581—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with enzyme label (including co-enzymes, co-factors, enzyme inhibitors or substrates)
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- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
- C12Q1/28—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving peroxidase
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- C—CHEMISTRY; METALLURGY
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- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/902—Oxidoreductases (1.)
- G01N2333/908—Oxidoreductases (1.) acting on hydrogen peroxide as acceptor (1.11)
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| US99420607P | 2007-09-18 | 2007-09-18 | |
| US994206P | 2007-09-18 | ||
| PCT/DK2008/000327 WO2009036760A2 (en) | 2007-09-18 | 2008-09-16 | A rapid and sensitive method for detection of biological targets |
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| ES2624450T3 true ES2624450T3 (es) | 2017-07-14 |
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| US8435735B2 (en) | 2009-02-19 | 2013-05-07 | Dako Denmark A/S | Methods and compounds for detection of molecular targets |
| BR112012009492A2 (pt) | 2009-10-20 | 2017-06-13 | Dako Denmark As | "métodos para visualização e detecção de unidades individuais simples de alvos e para avaliação quantitativa de um alvo imobilizado em uma amostra, bem como ensaio compreendendo uma etapa de detecção de unidades individuais de um alvo". |
| WO2012005572A1 (en) | 2010-07-06 | 2012-01-12 | Interna Technologies Bv | Mirna and its diagnostic and therapeutic uses in diseases or conditions associated with melanoma, or in diseases or conditions associated with activated braf pathway |
| WO2012062318A1 (en) | 2010-11-08 | 2012-05-18 | Dako Denmark A/S | Quantification of single target molecules in histological samples |
| US10150999B2 (en) | 2010-11-17 | 2018-12-11 | Interpace Diagnostics, Llc | miRNAs as biomarkers for distinguishing benign from malignant thyroid neoplasms |
| WO2012076010A1 (en) | 2010-12-06 | 2012-06-14 | Dako Denmark A/S | Combined histological stain |
| CN102565411B (zh) * | 2010-12-08 | 2014-05-28 | 中国科学院生物物理研究所 | 示踪磁性纳米颗粒的新方法 |
| US9366675B2 (en) | 2011-04-19 | 2016-06-14 | Dako Denmark A/S | Method for enzyme-mediated signal amplification |
| EP2718348A4 (en) * | 2011-06-07 | 2015-02-18 | Diagnostic Innovations Llc | COLOR-PRODUCING DIAGNOSTIC SYSTEMS AND REAGENTS AND METHODS THEREFOR |
| WO2013068011A1 (en) * | 2011-11-08 | 2013-05-16 | Dako Denmark A/S | New method for evaluation of target in histological sample |
| WO2013148498A1 (en) | 2012-03-27 | 2013-10-03 | Ventana Medical Systems, Inc. | Signaling conjugates and methods of use |
| ES2935257T3 (es) | 2013-03-15 | 2023-03-03 | Univ Chicago | Métodos y composiciones relacionadas con la actividad de las células T |
| US9890417B2 (en) | 2014-11-03 | 2018-02-13 | Agilent Technologies, Inc. | Signal amplification of fluorescence in situ hybridization |
| US10839509B2 (en) | 2015-07-10 | 2020-11-17 | 3Scan Inc. | Spatial multiplexing of histological stains |
| US11360098B2 (en) * | 2015-09-28 | 2022-06-14 | Quest Diagnostics Investments Llc | Amyloid beta detection by mass spectrometry |
| CN114315783B (zh) * | 2015-12-18 | 2025-06-06 | 安捷伦科技有限公司 | 生色过氧化物酶底物 |
| CN105987840B (zh) * | 2016-06-03 | 2018-09-28 | 浙江世纪康大医疗科技股份有限公司 | 一种柠檬酸抗原修复液 |
| CN105987839B (zh) * | 2016-06-03 | 2018-09-28 | 浙江世纪康大医疗科技股份有限公司 | 一种edta-柠檬酸抗原修复液 |
| CN109085338B (zh) * | 2018-09-13 | 2021-07-13 | 武汉伊莱瑞特生物科技股份有限公司 | Ecl底物液及其制备方法和应用 |
| US11237170B2 (en) | 2018-12-04 | 2022-02-01 | Aat Bioquest, Inc. | Styryl phenols, derivatives and their use in methods of analyte detection |
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| WO1988009344A1 (en) | 1987-05-21 | 1988-12-01 | Creative Biomolecules, Inc. | Targeted multifunctional proteins |
| EP0436597B1 (en) | 1988-09-02 | 1997-04-02 | Protein Engineering Corporation | Generation and selection of recombinant varied binding proteins |
| WO1990005144A1 (en) | 1988-11-11 | 1990-05-17 | Medical Research Council | Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5196306A (en) | 1989-03-29 | 1993-03-23 | E. I. Du Pont De Nemours And Company | Method for the detection or quantitation of an analyte using an analyte dependent enzyme activation system |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| US5688966A (en) | 1996-07-26 | 1997-11-18 | E. I. Du Pont De Nemours And Company | Compounds and method for synthesizing sulfoindocyanine dyes |
| US5863748A (en) | 1997-03-14 | 1999-01-26 | New Life Science Products, Inc. | p-Hydroxycinnamoyl-containing substrates for an analyte dependent enzyme activation system |
| IL123451A (en) | 1998-02-25 | 2003-07-06 | Ehud Keinan | Method and kit for the detection of peroxide-based explosives |
| US6372937B1 (en) | 1998-11-09 | 2002-04-16 | Mark Norman Bobrow | Enhanced catalyzed reporter deposition |
| US6531319B1 (en) | 2000-05-10 | 2003-03-11 | Keshab D. Pant | Method of detecting colon cancer |
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| US6617125B2 (en) | 2001-06-29 | 2003-09-09 | Perkinelmer Life Sciences, Inc. | Compositions for enhanced catalyzed reporter deposition |
| US8741566B2 (en) | 2005-07-01 | 2014-06-03 | Dako Denmark A/S | Immunohistochemistry and in situ hybridization detection method |
| US8435735B2 (en) * | 2009-02-19 | 2013-05-07 | Dako Denmark A/S | Methods and compounds for detection of molecular targets |
| BR112012009492A2 (pt) * | 2009-10-20 | 2017-06-13 | Dako Denmark As | "métodos para visualização e detecção de unidades individuais simples de alvos e para avaliação quantitativa de um alvo imobilizado em uma amostra, bem como ensaio compreendendo uma etapa de detecção de unidades individuais de um alvo". |
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| US20160370375A1 (en) | 2016-12-22 |
| CA2698390C (en) | 2018-05-22 |
| JP2010539456A (ja) | 2010-12-16 |
| US10168335B2 (en) | 2019-01-01 |
| WO2009036760A3 (en) | 2009-07-23 |
| US9377465B2 (en) | 2016-06-28 |
| EP2201058B1 (en) | 2017-04-12 |
| WO2009036760A2 (en) | 2009-03-26 |
| EP2201058A2 (en) | 2010-06-30 |
| JP5639889B2 (ja) | 2014-12-10 |
| CN101836117A (zh) | 2010-09-15 |
| CA2698390A1 (en) | 2009-03-26 |
| US20100285467A1 (en) | 2010-11-11 |
| CN101836117B (zh) | 2014-07-23 |
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