JP2013531801A5 - - Google Patents
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- JP2013531801A5 JP2013531801A5 JP2013518768A JP2013518768A JP2013531801A5 JP 2013531801 A5 JP2013531801 A5 JP 2013531801A5 JP 2013518768 A JP2013518768 A JP 2013518768A JP 2013518768 A JP2013518768 A JP 2013518768A JP 2013531801 A5 JP2013531801 A5 JP 2013531801A5
- Authority
- JP
- Japan
- Prior art keywords
- hapten
- peroxidase
- sample
- conjugate
- subsequent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000003992 Peroxidases Human genes 0.000 claims 13
- 108040007629 peroxidase activity proteins Proteins 0.000 claims 13
- DZGWFCGJZKJUFP-UHFFFAOYSA-N tyramine Chemical compound NCCC1=CC=C(O)C=C1 DZGWFCGJZKJUFP-UHFFFAOYSA-N 0.000 claims 9
- 125000003118 aryl group Chemical group 0.000 claims 5
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 4
- 229940127121 immunoconjugate Drugs 0.000 claims 4
- 150000002978 peroxides Chemical class 0.000 claims 4
- UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical compound NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 claims 4
- 230000003100 immobilizing effect Effects 0.000 claims 3
- 229960003732 tyramine Drugs 0.000 claims 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 2
- 125000001931 aliphatic group Chemical group 0.000 claims 2
- 150000001412 amines Chemical class 0.000 claims 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 2
- -1 dinitrophenyl Chemical group 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 239000001301 oxygen Substances 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 239000011593 sulfur Substances 0.000 claims 2
- SVUOLADPCWQTTE-UHFFFAOYSA-N 1h-1,2-benzodiazepine Chemical compound N1N=CC=CC2=CC=CC=C12 SVUOLADPCWQTTE-UHFFFAOYSA-N 0.000 claims 1
- AWBOSXFRPFZLOP-UHFFFAOYSA-N 2,1,3-benzoxadiazole Chemical compound C1=CC=CC2=NON=C21 AWBOSXFRPFZLOP-UHFFFAOYSA-N 0.000 claims 1
- 125000001894 2,4,6-trinitrophenyl group Chemical group [H]C1=C(C(*)=C(C([H])=C1[N+]([O-])=O)[N+]([O-])=O)[N+]([O-])=O 0.000 claims 1
- WHCPTFFIERCDSB-UHFFFAOYSA-N 7-(diethylamino)-2-oxochromene-3-carboxylic acid Chemical compound C1=C(C(O)=O)C(=O)OC2=CC(N(CC)CC)=CC=C21 WHCPTFFIERCDSB-UHFFFAOYSA-N 0.000 claims 1
- 102000002260 Alkaline Phosphatase Human genes 0.000 claims 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 claims 1
- SHIBSTMRCDJXLN-UHFFFAOYSA-N Digoxigenin Natural products C1CC(C2C(C3(C)CCC(O)CC3CC2)CC2O)(O)C2(C)C1C1=CC(=O)OC1 SHIBSTMRCDJXLN-UHFFFAOYSA-N 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 108010001336 Horseradish Peroxidase Proteins 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 claims 1
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 claims 1
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000002877 alkyl aryl group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- 229940049706 benzodiazepine Drugs 0.000 claims 1
- 239000004202 carbamide Substances 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- QONQRTHLHBTMGP-UHFFFAOYSA-N digitoxigenin Natural products CC12CCC(C3(CCC(O)CC3CC3)C)C3C11OC1CC2C1=CC(=O)OC1 QONQRTHLHBTMGP-UHFFFAOYSA-N 0.000 claims 1
- SHIBSTMRCDJXLN-KCZCNTNESA-N digoxigenin Chemical compound C1([C@@H]2[C@@]3([C@@](CC2)(O)[C@H]2[C@@H]([C@@]4(C)CC[C@H](O)C[C@H]4CC2)C[C@H]3O)C)=CC(=O)OC1 SHIBSTMRCDJXLN-KCZCNTNESA-N 0.000 claims 1
- 239000007850 fluorescent dye Substances 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 150000005363 heterobiaryls Chemical group 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 230000000415 inactivating effect Effects 0.000 claims 1
- 125000004999 nitroaryl group Chemical group 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 239000002096 quantum dot Substances 0.000 claims 1
- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 claims 1
- JUVIOZPCNVVQFO-HBGVWJBISA-N rotenone Chemical compound O([C@H](CC1=C2O3)C(C)=C)C1=CC=C2C(=O)[C@@H]1[C@H]3COC2=C1C=C(OC)C(OC)=C2 JUVIOZPCNVVQFO-HBGVWJBISA-N 0.000 claims 1
- 125000004962 sulfoxyl group Chemical group 0.000 claims 1
- 150000003648 triterpenes Chemical class 0.000 claims 1
- 0 CC(C1)C(CCNC(C(C)(C)CCOC(C)(C)CNC(C#*)=*)=S)=C*=C1O Chemical compound CC(C1)C(CCNC(C(C)(C)CCOC(C)(C)CNC(C#*)=*)=S)=C*=C1O 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39894610P | 2010-07-02 | 2010-07-02 | |
| US61/398,946 | 2010-07-02 | ||
| US201161464216P | 2011-02-28 | 2011-02-28 | |
| US61/464,216 | 2011-02-28 | ||
| PCT/US2011/042849 WO2012003476A2 (en) | 2010-07-02 | 2011-07-01 | Hapten conjugates for target detection |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013531801A JP2013531801A (ja) | 2013-08-08 |
| JP2013531801A5 true JP2013531801A5 (enExample) | 2014-07-17 |
Family
ID=44583735
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013518768A Pending JP2013531801A (ja) | 2010-07-02 | 2011-07-01 | 標的検出のためのハプテンコンジュゲート |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20130109019A1 (enExample) |
| EP (1) | EP2588443A2 (enExample) |
| JP (1) | JP2013531801A (enExample) |
| AU (1) | AU2011274369A1 (enExample) |
| CA (1) | CA2800936A1 (enExample) |
| WO (1) | WO2012003476A2 (enExample) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10267769B2 (en) | 2010-03-04 | 2019-04-23 | Ventana Medical Systems, Inc. | Processing system for processing specimens using acoustic energy |
| US10126216B2 (en) | 2011-02-17 | 2018-11-13 | Ventana Medical Systems, Inc. | Method for tissue sample fixation |
| US10539487B2 (en) | 2010-03-04 | 2020-01-21 | Ventana Medical Systems, Inc. | Systems and methods for monitoring tissue sample processing |
| ES2676183T3 (es) | 2010-07-02 | 2018-07-17 | Ventana Medical Systems, Inc. | Detección de dianas usando marcas de masa y espectrometría de masas |
| CA2867144C (en) * | 2012-03-27 | 2019-07-02 | Ventana Medical Systems, Inc. | Signaling conjugates and methods of use |
| WO2013167387A1 (en) | 2012-05-10 | 2013-11-14 | Ventana Medical Systems, Inc. | Uniquely specific probes for pten, pik3ca, met, top2a, and mdm2 |
| WO2014048942A1 (en) | 2012-09-25 | 2014-04-03 | Ventana Medical Systems, Inc. | Probes for pten, pik3ca, met, and top2a, and method for using the probes |
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| EP2971064B1 (en) * | 2013-03-12 | 2019-10-16 | Ventana Medical Systems, Inc. | Proximity assay for in situ detection of targets |
| WO2014140219A1 (en) * | 2013-03-15 | 2014-09-18 | Ventana Medical Systems, Inc. | Spectral unmixing |
| KR20250091304A (ko) | 2013-03-15 | 2025-06-20 | 제넨테크, 인크. | Pd-1 및 pd-l1 관련 상태를 치료하기 위한 바이오마커 및 방법 |
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| DK3063291T3 (da) * | 2013-10-11 | 2019-05-06 | Ventana Med Syst Inc | Multiplex her2 og østrogenreceptor co-farvnings-assays til påvisning af tumorheterogenitet |
| JP6825915B2 (ja) | 2014-02-24 | 2021-02-03 | ヴェンタナ メディカル システムズ， インク． | 標識された２’−ｏ−メチルｒｎａオリゴヌクレオチドプローブ及びシグナル増幅系を使用する自動ｒｎａ検出 |
| ES2753360T3 (es) | 2014-05-29 | 2020-04-08 | Spring Bioscience Corp | Anticuerpos contra PD-L1 y usos de los mismos |
| BR112017000497B1 (pt) | 2014-07-11 | 2023-12-26 | Ventana Medical Systems, Inc | Anticorpo isolado, célula hospedeira procariótica, imunoconjugado e método de detecção da presença ou do nível de expressão de pd-l1 |
| EP3254110B1 (en) | 2015-02-03 | 2020-03-18 | Ventana Medical Systems, Inc. | Histochemical assay for evaluating expression of programmed death ligand 1 (pd-l1) |
| WO2016147825A1 (ja) * | 2015-03-13 | 2016-09-22 | シスメックス株式会社 | 被検物質の検出方法およびその方法に用いられる試薬キット |
| RU2743169C2 (ru) | 2015-11-06 | 2021-02-15 | Вентана Медикал Системз, Инк. | Репрезентативная диагностика |
| ES2886600T3 (es) * | 2015-11-22 | 2021-12-20 | Ventana Med Syst Inc | Procedimientos de identificación de células inmunitarias en tejido tumoral positivo para PD-L1 |
| AU2017211236B2 (en) | 2016-01-26 | 2023-04-20 | Ventana Medical Systems, Inc. | Predictive diagnostic workflow for tumors using automated dissection, next generation sequencing, and automated slide stainers |
| JP6952706B2 (ja) | 2016-03-08 | 2021-10-20 | ヴェンタナ メディカル システムズ， インク． | エピトープタグを有する組換え抗体を使用する多重化免疫組織化学 |
| JP6736921B2 (ja) * | 2016-03-10 | 2020-08-05 | コニカミノルタ株式会社 | Ｆｉｓｈ染色方法 |
| WO2017175523A1 (ja) * | 2016-04-06 | 2017-10-12 | コニカミノルタ株式会社 | 蛍光免疫染色法 |
| WO2018002015A1 (en) | 2016-06-28 | 2018-01-04 | Ventana Medical Systems, Inc. | New colors for chromogenic ihc and ish staining with multi-dye quinone methide and tyramide conjugates |
| JP2019533149A (ja) | 2016-09-23 | 2019-11-14 | ヴェンタナ メディカル システムズ， インク． | 腫瘍試料中の細胞外マトリックスバイオマーカーをスコアリングするための方法及びシステム |
| EP3555622B1 (en) * | 2016-12-19 | 2023-02-22 | Ventana Medical Systems, Inc. | Methods and systems for quantitative immunohistochemistry |
| WO2019020556A1 (en) | 2017-07-24 | 2019-01-31 | Ventana Medical Systems, Inc. | METHODS AND SYSTEMS FOR ASSESSING INFILTRAT OF IMMUNE CELLS IN TUMOR SAMPLES |
| US11691141B2 (en) | 2017-11-13 | 2023-07-04 | Roche Sequencing Solutions, Inc. | Devices for sample analysis using epitachophoresis |
| DK3746790T3 (da) | 2018-01-31 | 2023-12-11 | Ventana Med Syst Inc | Fremgangsmåder og systemer til evaluering af immuncelleinfiltrat i kolorektal stadie III cancer |
| WO2019224153A1 (en) | 2018-05-21 | 2019-11-28 | Genentech, Inc. | Her2 heterogeneity as a biomarker in cancer |
| CN108957017A (zh) * | 2018-05-29 | 2018-12-07 | 郑州左安检测科技有限公司 | 一种检测苯二氮卓的试纸条及其制备方法和应用方法 |
| CN108918896A (zh) * | 2018-05-29 | 2018-11-30 | 郑州左安检测科技有限公司 | 一种检测苯二氮卓的fitc试纸条及其制备方法和应用方法 |
| WO2020016266A1 (en) | 2018-07-17 | 2020-01-23 | Ventana Medical Systems, Inc. | Materials and methods for detecting fusion proteins |
| CN112673258B (zh) | 2018-09-13 | 2025-07-25 | 文塔纳医疗系统公司 | 用于检测ntrk融合蛋白的组织化学和细胞化学方法 |
| JP7455816B2 (ja) * | 2018-09-20 | 2024-03-26 | ヴェンタナ メディカル システムズ， インク． | クマリン系架橋試薬 |
| WO2020072348A1 (en) | 2018-10-01 | 2020-04-09 | Ventana Medical Systems, Inc. | Methods and systems for predicting response to pd-1 axis directed therapeutics |
| WO2020074742A1 (en) | 2018-10-12 | 2020-04-16 | F. Hoffmann-La Roche Ag | Detection methods for epitachophoresis workflow automation |
| EP3884259A1 (en) | 2018-11-20 | 2021-09-29 | Ventana Medical Systems, Inc. | Methods and systems for preparing and analyzing cellular samples for morphological characteristics and biomarker expression |
| JP7411667B2 (ja) | 2019-02-05 | 2024-01-11 | ヴェンタナ メディカル システムズ， インク． | ステージｉｖの結腸直腸がんにおける免疫細胞浸潤の評価のための方法及びシステム |
| WO2020229437A1 (en) | 2019-05-14 | 2020-11-19 | F. Hoffmann-La Roche Ag | Devices and methods for sample analysis |
| US12252582B2 (en) | 2019-08-29 | 2025-03-18 | University Of Delaware | Biofunctional thiophene monomers and polymers thereof for electronic biomedical devices |
| CN115552248A (zh) | 2020-05-07 | 2022-12-30 | 文塔纳医疗系统公司 | 用于评价肿瘤样品中egfr和egfr配体表达的组织化学系统和方法 |
| CN115989221A (zh) * | 2020-08-28 | 2023-04-18 | 文塔纳医疗系统公司 | 包含可检测部分的缀合物 |
| JP2023544113A (ja) | 2020-09-22 | 2023-10-20 | エフ． ホフマン－ラ ロシュ アーゲー | α－１，６－コア－フコシル化ＰＳＡ及びそのフコシル化断片に特異的な抗体 |
| CN113552362B (zh) * | 2021-07-23 | 2024-08-09 | 湖北百奥斯生物科技有限公司 | 一种新型信号放大的免疫荧光试剂盒 |
| WO2023058624A1 (ja) * | 2021-10-08 | 2023-04-13 | コニカミノルタ株式会社 | 染色方法、評価方法および標本 |
| CN116444424B (zh) * | 2023-06-16 | 2023-09-08 | 广东省大湾区华南理工大学聚集诱导发光高等研究院 | 一种基于聚集诱导发光的酪酰胺荧光材料、免疫组化染色试剂盒及其应用 |
| WO2025014787A1 (en) | 2023-07-07 | 2025-01-16 | Ventana Medical Systems, Inc. | Brightfield triplex immunohistochemistry assay for evaluating the colocalization of the er, pr, and ki-67 biomarkers in cells |
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-
2011
- 2011-07-01 WO PCT/US2011/042849 patent/WO2012003476A2/en not_active Ceased
- 2011-07-01 EP EP11738526.0A patent/EP2588443A2/en not_active Withdrawn
- 2011-07-01 JP JP2013518768A patent/JP2013531801A/ja active Pending
- 2011-07-01 CA CA2800936A patent/CA2800936A1/en not_active Abandoned
- 2011-07-01 AU AU2011274369A patent/AU2011274369A1/en not_active Abandoned
- 2011-07-01 US US13/805,978 patent/US20130109019A1/en not_active Abandoned
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