CA2800936A1 - Hapten conjugates for target detection - Google Patents
Hapten conjugates for target detection Download PDFInfo
- Publication number
- CA2800936A1 CA2800936A1 CA2800936A CA2800936A CA2800936A1 CA 2800936 A1 CA2800936 A1 CA 2800936A1 CA 2800936 A CA2800936 A CA 2800936A CA 2800936 A CA2800936 A CA 2800936A CA 2800936 A1 CA2800936 A1 CA 2800936A1
- Authority
- CA
- Canada
- Prior art keywords
- hapten
- conjugate
- antibody
- peroxidase
- subsequent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/54—Nitrogen and either oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/50—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to ring nitrogen atoms
- C07D241/52—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/12—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/581—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with enzyme label (including co-enzymes, co-factors, enzyme inhibitors or substrates)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/902—Oxidoreductases (1.)
- G01N2333/908—Oxidoreductases (1.) acting on hydrogen peroxide as acceptor (1.11)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Public Health (AREA)
- Cell Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39894610P | 2010-07-02 | 2010-07-02 | |
| US61/398,946 | 2010-07-02 | ||
| US201161464216P | 2011-02-28 | 2011-02-28 | |
| US61/464,216 | 2011-02-28 | ||
| PCT/US2011/042849 WO2012003476A2 (en) | 2010-07-02 | 2011-07-01 | Hapten conjugates for target detection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2800936A1 true CA2800936A1 (en) | 2012-01-05 |
Family
ID=44583735
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2800936A Abandoned CA2800936A1 (en) | 2010-07-02 | 2011-07-01 | Hapten conjugates for target detection |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20130109019A1 (enExample) |
| EP (1) | EP2588443A2 (enExample) |
| JP (1) | JP2013531801A (enExample) |
| AU (1) | AU2011274369A1 (enExample) |
| CA (1) | CA2800936A1 (enExample) |
| WO (1) | WO2012003476A2 (enExample) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10126216B2 (en) | 2011-02-17 | 2018-11-13 | Ventana Medical Systems, Inc. | Method for tissue sample fixation |
| ES2759007T3 (es) | 2010-03-04 | 2020-05-07 | Ventana Med Syst Inc | Sistema de procesamiento para procesar muestras usando energía acústica |
| US10539487B2 (en) | 2010-03-04 | 2020-01-21 | Ventana Medical Systems, Inc. | Systems and methods for monitoring tissue sample processing |
| DK2588144T3 (en) | 2010-07-02 | 2018-07-23 | Ventana Med Syst Inc | Detection of targets using mass markers and mass spectrometry |
| ES2678211T3 (es) * | 2012-03-27 | 2018-08-09 | Ventana Medical Systems, Inc. | Conjugados de señalización y procedimientos de uso |
| WO2013167387A1 (en) | 2012-05-10 | 2013-11-14 | Ventana Medical Systems, Inc. | Uniquely specific probes for pten, pik3ca, met, top2a, and mdm2 |
| WO2014048942A1 (en) | 2012-09-25 | 2014-04-03 | Ventana Medical Systems, Inc. | Probes for pten, pik3ca, met, and top2a, and method for using the probes |
| CA2900842C (en) | 2013-03-12 | 2020-01-21 | Ventana Medical Systems, Inc. | Digitally enhanced microscopy for multiplexed histology |
| DK2971064T3 (da) * | 2013-03-12 | 2019-12-16 | Ventana Med Syst Inc | Nærhedsassay til in situ-påvisning af mål |
| KR20150131269A (ko) | 2013-03-15 | 2015-11-24 | 제넨테크, 인크. | Pd-1 및 pd-l1 관련 상태를 치료하기 위한 바이오마커 및 방법 |
| AU2014230469B2 (en) * | 2013-03-15 | 2017-07-13 | Ventana Medical Systems, Inc. | Spectral unmixing |
| KR102368591B1 (ko) | 2013-04-30 | 2022-02-25 | 캘리포니아 인스티튜트 오브 테크놀로지 | 순차적 하이브리드화 바코딩에 의한 분자의 멀티플렉스 표지화 |
| AU2014333815B2 (en) * | 2013-10-11 | 2020-07-09 | Nihon University School Of Medicine | Multiplex HER2 and estrogen receptor co-staining assays for detecting tumor heterogeneity |
| EP3110966A1 (en) | 2014-02-24 | 2017-01-04 | Ventana Medical Systems, Inc. | Automated rna detection using labeled 2'-o-methyl rna oligonucleotide probes and signal amplification systems |
| US9885721B2 (en) | 2014-05-29 | 2018-02-06 | Spring Bioscience Corporation | PD-L1 antibodies and uses thereof |
| CN106604933B (zh) | 2014-07-11 | 2021-08-10 | 文塔纳医疗系统公司 | 抗pd-l1抗体及其诊断用途 |
| EP3254110B1 (en) | 2015-02-03 | 2020-03-18 | Ventana Medical Systems, Inc. | Histochemical assay for evaluating expression of programmed death ligand 1 (pd-l1) |
| CN107430121B (zh) | 2015-03-13 | 2020-06-23 | 希森美康株式会社 | 受试物质的检测方法及在该方法中使用的试剂盒 |
| MX2018004838A (es) | 2015-11-06 | 2019-07-18 | Ventana Med Syst Inc | Diagnosticos representativos. |
| CA3005804C (en) | 2015-11-22 | 2022-03-29 | Ventana Medical Systems, Inc. | Methods of identifying immune cells in pd-l1 positive tumor tissue |
| WO2017132276A1 (en) | 2016-01-26 | 2017-08-03 | Ventana Medical Systems, Inc. | Predictive diagnostic workflow for tumors usnig automated dissection, next generation sequencing, and automated slide stainers |
| JP6952706B2 (ja) | 2016-03-08 | 2021-10-20 | ヴェンタナ メディカル システムズ， インク． | エピトープタグを有する組換え抗体を使用する多重化免疫組織化学 |
| JP6736921B2 (ja) * | 2016-03-10 | 2020-08-05 | コニカミノルタ株式会社 | Ｆｉｓｈ染色方法 |
| JPWO2017175523A1 (ja) * | 2016-04-06 | 2019-02-14 | コニカミノルタ株式会社 | 蛍光免疫染色法 |
| WO2018002015A1 (en) * | 2016-06-28 | 2018-01-04 | Ventana Medical Systems, Inc. | New colors for chromogenic ihc and ish staining with multi-dye quinone methide and tyramide conjugates |
| WO2018055014A1 (en) | 2016-09-23 | 2018-03-29 | Ventana Medical Systems, Inc. | Methods and systems for scoring extracellular matrix biomarkers in tumor samples |
| EP4220164B1 (en) | 2016-12-19 | 2024-08-21 | Ventana Medical Systems, Inc. | Methods and systems for quantitative immunohistochemistry |
| WO2019020556A1 (en) | 2017-07-24 | 2019-01-31 | Ventana Medical Systems, Inc. | METHODS AND SYSTEMS FOR ASSESSING INFILTRAT OF IMMUNE CELLS IN TUMOR SAMPLES |
| WO2019092269A1 (en) | 2017-11-13 | 2019-05-16 | F. Hoffmann-La Roche Ag | Devices for sample analysis using epitachophoresis |
| WO2019149817A1 (en) | 2018-01-31 | 2019-08-08 | Ventana Medical Systems, Inc. | Methods and systems for evaluation of immune cell infiltrate in stage iii colorectal cancer |
| EP3797296B1 (en) | 2018-05-21 | 2024-09-04 | Genentech, Inc. | Her2 heterogeneity as a biomarker in cancer |
| CN108918896A (zh) * | 2018-05-29 | 2018-11-30 | 郑州左安检测科技有限公司 | 一种检测苯二氮卓的fitc试纸条及其制备方法和应用方法 |
| CN108957017A (zh) * | 2018-05-29 | 2018-12-07 | 郑州左安检测科技有限公司 | 一种检测苯二氮卓的试纸条及其制备方法和应用方法 |
| WO2020016266A1 (en) | 2018-07-17 | 2020-01-23 | Ventana Medical Systems, Inc. | Materials and methods for detecting fusion proteins |
| CN112673258B (zh) | 2018-09-13 | 2025-07-25 | 文塔纳医疗系统公司 | 用于检测ntrk融合蛋白的组织化学和细胞化学方法 |
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| CN112789684B (zh) | 2018-10-01 | 2025-05-09 | 文塔纳医疗系统公司 | 用于预测对pd-1轴导向疗法的应答的方法和系统 |
| EP3864403A1 (en) | 2018-10-12 | 2021-08-18 | F. Hoffmann-La Roche AG | Detection methods for epitachophoresis workflow automation |
| JP7548903B2 (ja) | 2018-11-20 | 2024-09-10 | ヴェンタナ メディカル システムズ， インク． | 形態学的特徴およびバイオマーカー発現のために細胞サンプルを調製および分析するための方法およびシステム |
| WO2020161125A1 (en) | 2019-02-05 | 2020-08-13 | Ventana Medical Systems, Inc. | Methods and systems for evaluation of immune cell infiltrate in stage iv colorectal cancer |
| JP7441243B2 (ja) | 2019-05-14 | 2024-02-29 | エフ． ホフマン－ラ ロシュ アーゲー | 試料分析のための装置および方法 |
| US12252582B2 (en) | 2019-08-29 | 2025-03-18 | University Of Delaware | Biofunctional thiophene monomers and polymers thereof for electronic biomedical devices |
| CN115552248A (zh) | 2020-05-07 | 2022-12-30 | 文塔纳医疗系统公司 | 用于评价肿瘤样品中egfr和egfr配体表达的组织化学系统和方法 |
| EP4204398A2 (en) * | 2020-08-28 | 2023-07-05 | Ventana Medical Systems, Inc. | Conjugates including a detectable moiety |
| CN116323670A (zh) | 2020-09-22 | 2023-06-23 | 豪夫迈·罗氏有限公司 | 对α-1,6-核心-岩藻糖基化的PSA及其岩藻糖基化片段具有特异性的抗体 |
| CN113552362B (zh) * | 2021-07-23 | 2024-08-09 | 湖北百奥斯生物科技有限公司 | 一种新型信号放大的免疫荧光试剂盒 |
| WO2023058624A1 (ja) * | 2021-10-08 | 2023-04-13 | コニカミノルタ株式会社 | 染色方法、評価方法および標本 |
| CN116444424B (zh) * | 2023-06-16 | 2023-09-08 | 广东省大湾区华南理工大学聚集诱导发光高等研究院 | 一种基于聚集诱导发光的酪酰胺荧光材料、免疫组化染色试剂盒及其应用 |
| WO2025014787A1 (en) | 2023-07-07 | 2025-01-16 | Ventana Medical Systems, Inc. | Brightfield triplex immunohistochemistry assay for evaluating the colocalization of the er, pr, and ki-67 biomarkers in cells |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2320387A1 (de) * | 1973-04-21 | 1974-10-31 | Boehringer Mannheim Gmbh | Phenoxyalkylcarbonsaeurederivate und verfahren zur herstellung derselben |
| US4469797A (en) | 1982-09-23 | 1984-09-04 | Miles Laboratories, Inc. | Digoxigenin immunogens, antibodies, labeled conjugates, and related derivatives |
| DE3874206D1 (de) * | 1987-05-19 | 1992-10-08 | Fisons Plc | 2-(3-4-dihydroxyphenyl)-aethylamine, ihre herstellung und ihre verwendung als arzneimittel. |
| DE3836656A1 (de) | 1988-10-27 | 1990-05-03 | Boehringer Mannheim Gmbh | Neue digoxigenin-derivate und ihre verwendung |
| US5455143A (en) * | 1991-10-25 | 1995-10-03 | Minnesota Mining And Manufacturing Company | Aminoketone sensitizers for aqueous soluble photopolymer compositions |
| US6005079A (en) | 1992-08-21 | 1999-12-21 | Vrije Universiteit Brussels | Immunoglobulins devoid of light chains |
| DE69334275D1 (de) | 1992-08-21 | 2009-05-20 | Univ Bruxelles | Immunoglobuline ohne Leichtkette |
| EP0933355A1 (en) * | 1997-12-24 | 1999-08-04 | Universiteit Maastricht | Preparation of tyramide conjugates |
| US6437146B1 (en) * | 1998-09-25 | 2002-08-20 | Fujisawa Pharmaceutical Co., Ltd. | Oxazole compounds as prostaglandin e2 agonists or antagonists |
| US6372937B1 (en) | 1998-11-09 | 2002-04-16 | Mark Norman Bobrow | Enhanced catalyzed reporter deposition |
| US6387900B1 (en) * | 1999-08-12 | 2002-05-14 | Pharmacia & Upjohn S.P.A. | 3(5)-ureido-pyrazole derivatives process for their preparation and their use as antitumor agents |
| WO2001021610A1 (en) * | 1999-09-17 | 2001-03-29 | Nissan Chemical Industries, Ltd. | Benzopyran derivative |
| US6630469B2 (en) * | 2000-05-09 | 2003-10-07 | Bristol-Myers Squibb Company | 5-HT7 receptor antagonists |
| PT1282418E (pt) * | 2000-05-19 | 2005-10-31 | Applied Research Systems | Utilizacao de derivados pirazolo para o tratamento da infertilidade |
| US6649138B2 (en) | 2000-10-13 | 2003-11-18 | Quantum Dot Corporation | Surface-modified semiconductive and metallic nanoparticles having enhanced dispersibility in aqueous media |
| US20020083888A1 (en) | 2000-12-28 | 2002-07-04 | Zehnder Donald A. | Flow synthesis of quantum dot nanocrystals |
| EP2218762A3 (en) | 2001-07-20 | 2010-09-29 | Life Technologies Corporation | Luminescent nanoparticles and methods for their preparation |
| CA2471754A1 (en) * | 2001-12-28 | 2003-07-17 | Takeda Chemical Industries, Ltd. | Androgen receptor antagonist |
| EP1627420B1 (en) | 2003-05-07 | 2020-07-15 | Indiana University Research and Technology Corporation | Alloyed semiconductor quantum dots and concentration-gradient alloyed quantum dots, series comprising the same and methods related thereto |
| EP1651595A2 (en) * | 2003-05-30 | 2006-05-03 | Rigel Pharmaceuticals, Inc. | Ubiquitin ligase inhibitors |
| JP4411153B2 (ja) * | 2003-07-18 | 2010-02-10 | 富士フイルム株式会社 | ２光子吸収色素消色材料、３次元的屈折率変調材料、３次元吸収率変調材料及び３次元光記録材料 |
| KR100657891B1 (ko) | 2003-07-19 | 2006-12-14 | 삼성전자주식회사 | 반도체 나노결정 및 그 제조방법 |
| DE10348022A1 (de) * | 2003-10-15 | 2005-05-25 | Imtm Gmbh | Neue Dipeptidylpeptidase IV-Inhibitoren zur funktionellen Beeinflussung unterschiedlicher Zellen und zur Behandlung immunologischer, entzündlicher, neuronaler und anderer Erkrankungen |
| GB0324551D0 (en) * | 2003-10-21 | 2003-11-26 | Karobio Ab | Novel compounds |
| WO2005042530A1 (en) * | 2003-10-30 | 2005-05-12 | Boehringer Ingelheim (Canada) Ltd. | Rsv polymerase inhibitors |
| TW200533357A (en) * | 2004-01-08 | 2005-10-16 | Millennium Pharm Inc | 2-(amino-substituted)-4-aryl pyrimidines and related compounds useful for treating inflammatory diseases |
| US20060246423A1 (en) | 2005-02-10 | 2006-11-02 | Adelson Martin E | Method and kit for the collection and maintenance of the detectability of a plurality of microbiological species in a single gynecological sample |
| EP1893241A2 (en) | 2005-04-28 | 2008-03-05 | Ventana Medical Systems, Inc. | Fluorescent nanoparticles conjugated to antibodies via a peg linker |
| CN104090095B (zh) | 2005-11-23 | 2016-06-01 | 文塔纳医疗系统公司 | 分子缀合物 |
| EP3276349B1 (en) * | 2006-11-01 | 2019-08-07 | Ventana Medical Systems, Inc. | Haptens, hapten conjugates, compositions thereof and method for their preparation and use |
| JP2008228637A (ja) * | 2007-03-20 | 2008-10-02 | Tokushima Bunri Univ | 蛍光相関分光測定法を用いた過酸化水素量の測定方法及びその利用方法 |
| US20080299555A1 (en) * | 2007-05-30 | 2008-12-04 | Hiroaki Nitta | Multicolor chromogenic detection of biomarkers |
| CN102438988B (zh) * | 2009-04-21 | 2015-06-24 | 内尔维阿诺医学科学有限公司 | 作为hsp90抑制剂的间苯二酚衍生物 |
| DK2588144T3 (en) * | 2010-07-02 | 2018-07-23 | Ventana Med Syst Inc | Detection of targets using mass markers and mass spectrometry |
-
2011
- 2011-07-01 US US13/805,978 patent/US20130109019A1/en not_active Abandoned
- 2011-07-01 AU AU2011274369A patent/AU2011274369A1/en not_active Abandoned
- 2011-07-01 CA CA2800936A patent/CA2800936A1/en not_active Abandoned
- 2011-07-01 JP JP2013518768A patent/JP2013531801A/ja active Pending
- 2011-07-01 WO PCT/US2011/042849 patent/WO2012003476A2/en not_active Ceased
- 2011-07-01 EP EP11738526.0A patent/EP2588443A2/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| US20130109019A1 (en) | 2013-05-02 |
| JP2013531801A (ja) | 2013-08-08 |
| WO2012003476A2 (en) | 2012-01-05 |
| AU2011274369A1 (en) | 2012-12-06 |
| EP2588443A2 (en) | 2013-05-08 |
| WO2012003476A3 (en) | 2012-05-03 |
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| Date | Code | Title | Description |
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| FZDE | Discontinued |
Effective date: 20160704 |