JP2019519490A5 - - Google Patents

Download PDF

Info

Publication number
JP2019519490A5
JP2019519490A5 JP2018558655A JP2018558655A JP2019519490A5 JP 2019519490 A5 JP2019519490 A5 JP 2019519490A5 JP 2018558655 A JP2018558655 A JP 2018558655A JP 2018558655 A JP2018558655 A JP 2018558655A JP 2019519490 A5 JP2019519490 A5 JP 2019519490A5
Authority
JP
Japan
Prior art keywords
compound according
compound
linker
alkyl
independently
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2018558655A
Other languages
English (en)
Japanese (ja)
Other versions
JP7527537B2 (ja
JP2019519490A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2017/031919 external-priority patent/WO2017196954A1/en
Publication of JP2019519490A publication Critical patent/JP2019519490A/ja
Publication of JP2019519490A5 publication Critical patent/JP2019519490A5/ja
Application granted granted Critical
Publication of JP7527537B2 publication Critical patent/JP7527537B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2018558655A 2016-05-10 2017-05-10 ペプチド骨格を有する超明色ポリマー染料 Active JP7527537B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662334243P 2016-05-10 2016-05-10
US62/334,243 2016-05-10
PCT/US2017/031919 WO2017196954A1 (en) 2016-05-10 2017-05-10 Ultra bright polymeric dyes with peptide backbones

Publications (3)

Publication Number Publication Date
JP2019519490A JP2019519490A (ja) 2019-07-11
JP2019519490A5 true JP2019519490A5 (enExample) 2021-10-21
JP7527537B2 JP7527537B2 (ja) 2024-08-05

Family

ID=59034848

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2018558655A Active JP7527537B2 (ja) 2016-05-10 2017-05-10 ペプチド骨格を有する超明色ポリマー染料

Country Status (4)

Country Link
US (1) US11370922B2 (enExample)
EP (1) EP3455238A1 (enExample)
JP (1) JP7527537B2 (enExample)
WO (1) WO2017196954A1 (enExample)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3019559A4 (en) 2013-08-22 2017-04-05 Sony Corporation Water soluble fluorescent or colored dyes and methods for their use
CN107406353A (zh) 2015-02-26 2017-11-28 索尼公司 苯基乙炔基萘染料和用于它们用途的方法
KR102676814B1 (ko) 2015-02-26 2024-06-21 소니그룹주식회사 접합 그룹을 포함하는 수용성 형광 또는 착색 염료
WO2016183185A1 (en) 2015-05-11 2016-11-17 Sony Corporation Ultra bright dimeric or polymeric dyes
KR102525252B1 (ko) 2016-04-01 2023-04-26 소니그룹주식회사 강성 공간군을 갖는 매우 밝은 이량체성 또는 중합체성 염료
KR20250029292A (ko) 2016-04-01 2025-03-04 소니그룹주식회사 초휘도 이량체성 또는 중합체성 염료
RU2753706C2 (ru) 2016-04-06 2021-08-20 Сони Корпорейшн Ультраяркие димерные или полимерные красители со спейсерными линкерными группами
WO2017197014A2 (en) 2016-05-10 2017-11-16 Sony Corporation Compositions comprising a polymeric dye and a cyclodextrin and uses thereof
RU2018143594A (ru) 2016-05-11 2020-06-11 Сони Корпорейшн Ультраяркие димерные или полимерные красители
JP7068191B2 (ja) 2016-06-06 2022-05-16 ソニーグループ株式会社 蛍光または有色レポーター基を含むイオン性ポリマー
US12018159B2 (en) 2016-07-29 2024-06-25 Sony Group Corporation Ultra bright dimeric or polymeric dyes and methods for preparation of the same
CN116519642A (zh) 2017-06-16 2023-08-01 杜克大学 用于改善标记检测、计算、分析物感应和可调随机数生成的谐振器网络和方法
US12290571B2 (en) 2017-10-05 2025-05-06 Sony Group Corporation Programmable dendritic drugs
US12145956B2 (en) 2017-10-05 2024-11-19 Sony Group Corporation Programmable polymeric drugs
CN111836645A (zh) * 2017-11-16 2020-10-27 索尼公司 可编程的聚合药物
JP2021506788A (ja) * 2017-12-13 2021-02-22 ソニー株式会社 生物学的に活性な化合物を含むイオン性ポリマー
US12194104B2 (en) 2018-01-12 2025-01-14 Sony Group Corporation Phosphoalkyl ribose polymers comprising biologically active compounds
EP3737418B1 (en) 2018-01-12 2024-02-28 Sony Group Corporation Polymers with rigid spacing groups comprising biologically active compounds
EP4137818B1 (en) 2018-03-19 2025-12-10 Sony Group Corporation Use of divalent metals for enhancement of fluorescent signals
US12319817B2 (en) 2018-03-21 2025-06-03 Sony Group Corporation Polymeric tandem dyes with linker groups
WO2019191482A1 (en) 2018-03-30 2019-10-03 Becton, Dickinson And Company Water-soluble polymeric dyes having pendant chromophores
JP7580689B2 (ja) 2018-06-27 2024-11-12 ソニーグループ株式会社 デオキシリボースを含むリンカー基を有するポリマー色素
JP7239904B2 (ja) 2019-09-26 2023-03-15 ソニーグループ株式会社 リンカー基を有するポリマータンデム色素
US20240132725A1 (en) 2020-12-07 2024-04-25 Sony Group Corporation Spacing linker group design for brightness enhancement in dimeric or polymeric dyes
US12180401B2 (en) 2021-04-07 2024-12-31 Becton, Dickinson And Company Water-soluble fluorescent polymeric dyes

Family Cites Families (143)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4450305A (en) 1982-10-25 1984-05-22 American Cyanamid Company Poly(ethyleneoxy)-substituted-9,10-bis(phenylethynyl)anthracenes
US4476229A (en) 1982-11-08 1984-10-09 Abbott Laboratories Substituted carboxyfluoresceins
SU1121931A1 (ru) 1983-01-10 1988-04-15 Институт Биологической Химии Ан Бсср Конъюгаты тиреоидных гормонов с альбумином дл выработки антител к тиреоидным гормонам у животных
EP0355864A3 (en) 1984-03-15 1991-09-18 Wako Pure Chemical Industries, Ltd. Method of quantitatively measuring an oxidative substance by using triphenyl methane type leuco compounds as coloring matter
JPH0665677B2 (ja) 1985-03-09 1994-08-24 三菱化成株式会社 リン脂質類似構造を有するジオ−ルおよびその製造方法
US5268486A (en) 1986-04-18 1993-12-07 Carnegie-Mellon Unversity Method for labeling and detecting materials employing arylsulfonate cyanine dyes
US5053054A (en) 1988-09-12 1991-10-01 Ortho Pharmaceutical Corporation Methods and reagents for staining intracellular components
US5318894A (en) 1990-01-30 1994-06-07 Miles Inc. Composition, device and method of assaying for peroxidatively active substances
US6365730B1 (en) 1990-06-19 2002-04-02 Gene Shears Pty. Limited DNA-Armed ribozymes and minizymes
JPH04282391A (ja) 1991-03-08 1992-10-07 Fujisawa Pharmaceut Co Ltd エタノールアミン誘導体およびその製造法
EP0605655B1 (en) 1991-09-16 1997-05-07 Molecular Probes, Inc. Dimers of unsymmetrical cyanine dyes
CA2123133C (en) 1991-11-07 2005-01-04 Michael J. Heller Hybridization of polynucleotides conjugated with chromophores and fluorophores to generate donor-to-donor energy transfer system
ATE320001T1 (de) 1993-07-13 2006-03-15 Abbott Lab Durch fluoreszierenden polymer markierte konjugate und zwischen produkte
US6171859B1 (en) 1994-03-30 2001-01-09 Mitokor Method of targeting conjugate molecules to mitochondria
US5994143A (en) 1996-02-01 1999-11-30 Abbott Laboratories Polymeric fluorophores enhanced by moieties providing a hydrophobic and conformationally restrictive microenvironment
US6218108B1 (en) 1997-05-16 2001-04-17 Research Corporation Technologies, Inc. Nucleoside analogs with polycyclic aromatic groups attached, methods of synthesis and uses therefor
US6893868B2 (en) * 1997-02-20 2005-05-17 Onco Immunin, Inc. Homo-doubly labeled compositions for the detection of enzyme activity in biological samples
US5986030A (en) 1997-04-15 1999-11-16 Nalco Chemical Company Fluorescent water soluble polymers
DE19717904A1 (de) 1997-04-23 1998-10-29 Diagnostikforschung Inst Säurelabile und enzymatisch spaltbare Farbstoffkonstrukte zur Diagnostik mit Nahinfrarotlicht und zur Therapie
JP3078793B2 (ja) 1998-04-30 2000-08-21 株式会社分子バイオホトニクス研究所 ロタキサン構造を有する色素、ラベル化剤、およびラベル化方法
US7060708B2 (en) 1999-03-10 2006-06-13 New River Pharmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
US6716452B1 (en) 2000-08-22 2004-04-06 New River Pharmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
US6514700B1 (en) 1999-04-30 2003-02-04 Aclara Biosciences, Inc. Nucleic acid detection using degradation of a tagged sequence
US6627400B1 (en) 1999-04-30 2003-09-30 Aclara Biosciences, Inc. Multiplexed measurement of membrane protein populations
WO2001007430A1 (en) 1999-07-22 2001-02-01 Nalco Chemical Compant Fluorescent water-soluble polymers
US6479650B1 (en) 1999-12-14 2002-11-12 Research Corporation Technologies, Inc. Fluorescent nucleoside analogs and combinatorial fluorophore arrays comprising same
US20020012947A1 (en) 2000-03-14 2002-01-31 Bevers Susan Ann Biomarkers for the labeling, visual detection and quantification of biomolecules
ATE487136T1 (de) 2000-03-28 2010-11-15 Nanosphere Inc Nanopartikel mit gebundenen oligonukleotiden und verwendungen derselben
AU2001262994B2 (en) 2000-05-08 2005-09-15 Qtl Biosystems Llc Improvements to the fluorescent polymer-qtl approach to biosensing
US6852709B2 (en) 2000-05-31 2005-02-08 Johns Hopkins University Biologically useful polyphosphates
US20020099013A1 (en) 2000-11-14 2002-07-25 Thomas Piccariello Active agent delivery systems and methods for protecting and administering active agents
AU8911101A (en) 2000-09-11 2002-03-26 Univ Columbia Combinatorial fluorescence energy transfer tags and uses thereof
ATE315066T1 (de) 2000-09-19 2006-02-15 Li Cor Inc Cyaninfarbstoffe
US6448407B1 (en) 2000-11-01 2002-09-10 Pe Corporation (Ny) Atropisomers of asymmetric xanthene fluorescent dyes and methods of DNA sequencing and fragment analysis
US8394813B2 (en) 2000-11-14 2013-03-12 Shire Llc Active agent delivery systems and methods for protecting and administering active agents
GB2372256A (en) 2001-02-14 2002-08-21 Kalibrant Ltd Detectable entity comprising a plurality of detectable units releasably connected together by stimulus-cleavable linkers for use in fluorescence detection
US8323903B2 (en) 2001-10-12 2012-12-04 Life Technologies Corporation Antibody complexes and methods for immunolabeling
JP3813890B2 (ja) 2002-03-22 2006-08-23 富士写真フイルム株式会社 3層レジストプロセス用中間層材料組成物及びそれを用いたパターン形成方法
US7423133B2 (en) 2002-08-23 2008-09-09 The Board Of Trustees Of The Leland Stanford Junior University Fluorescent glycosides and methods for their use
CA2497152C (en) 2002-08-26 2016-06-07 The Regents Of The University Of California Methods and compositions for detection and analysis of polynucleotides using light harvesting multichromophores
US20040138467A1 (en) 2002-11-26 2004-07-15 French Roger Harquail Aromatic and aromatic/heteroaromatic molecular structures with controllable electron conducting properties
US7759459B2 (en) 2003-01-10 2010-07-20 Albert Einstein College Of Medicine Of Yeshiva University Fluorescent assays for protein kinases
US7238792B2 (en) 2003-03-18 2007-07-03 Washington State University Research Foundation Foldable polymers as probes
US7172907B2 (en) 2003-03-21 2007-02-06 Ge Healthcare Bio-Sciences Corp. Cyanine dye labelling reagents with meso-substitution
CA2535670A1 (en) * 2003-08-14 2005-02-24 Diatos Amino acid sequences facilitating penetration of a substance of interest into cells and/or cell nuclei
WO2005051967A2 (en) 2003-11-19 2005-06-09 Allelogic Biosciences Corp. Oligonucleotides labeled with a plurality of fluorophores
US20050123935A1 (en) 2003-12-09 2005-06-09 Richard Haugland Pyrenyloxysulfonic acid fluorescent agents
AU2005325262B2 (en) 2004-04-27 2011-08-11 Alnylam Pharmaceuticals, Inc. Single-stranded and double-stranded oligonucleotides comprising a 2-arylpropyl moiety
US20060035302A1 (en) * 2004-06-21 2006-02-16 Applera Corporation Kinase substrates with multiple phosphorylation sites
JP5214967B2 (ja) 2004-08-13 2013-06-19 エポック バイオサイエンシズ インコーポレーティッド ホスホン酸蛍光色素および複合体
EP1789794A1 (en) * 2004-09-14 2007-05-30 Applera Corporation, Applied Biosystems Group Multi-chromophoric quencher constructs for use in high sensitivity energy transfer probes
US8153706B2 (en) 2004-10-25 2012-04-10 Hewlett-Packard Development Company, L.P. Polymeric colorants having pigment and dye components and corresponding ink compositions
SI1655317T1 (sl) 2004-11-09 2007-10-31 Ipagsa Ind Sl Toplotno reaktivni infrardeäśi absorpcijski polimeri in njihova uporaba v litografskih ploĺ äśah, obäśutljivih na toploto
EP1838752B1 (en) 2005-01-10 2017-10-04 The Regents of The University of California Cationic conjugated polymers suitable for strand-specific polynucleotide detection in homogeneous and solid state assays
JP2008535945A (ja) 2005-03-09 2008-09-04 セファイド 極性色素
US20080227205A1 (en) * 2005-06-03 2008-09-18 Ambrx, Inc. Incorporation on Non-Naturally Encoded Amino Acids Into Proteins
US8227621B2 (en) 2005-06-30 2012-07-24 Li-Cor, Inc. Cyanine dyes and methods of use
EP1928822B1 (en) 2005-09-26 2013-02-27 Life Technologies Corporation Violet laser excitable dyes and their method of use
CN101287830B (zh) * 2005-10-12 2015-01-07 斯克利普斯研究院 噬菌体展示多肽的选择性翻译后修饰
WO2007061793A2 (en) 2005-11-18 2007-05-31 THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SCIENCES, CENTERS FOR DISEASE CONTROL AND PREVENTION Modified cardiolipin and uses therefor
JP5410760B2 (ja) 2005-12-12 2014-02-05 チバ ホールディング インコーポレーテッド 半導体素子、化合物、半導体素子の半導体層及び薄膜トランジスタ素子を作製する方法
US20070148094A1 (en) 2005-12-22 2007-06-28 Uzgiris Egidijus E Polymeric imaging agents and medical imaging methods
US8425915B2 (en) 2006-04-13 2013-04-23 Midatech Limited Nanoparticles for providing immune responses against infectious agents
US20100039684A1 (en) 2006-08-12 2010-02-18 Kolb Eric S Sensitizer dyes for photoacid generating systems using short visible wavelengths
CN101523631B (zh) 2006-10-12 2010-09-22 出光兴产株式会社 有机薄膜晶体管元件以及有机薄膜发光晶体管
EP2727965B1 (en) 2006-10-27 2019-03-06 Life Technologies Corporation FLUOROGENIC pH SENSITIVE DYES AND THEIR METHOD OF USE
US8053588B2 (en) 2007-03-07 2011-11-08 Kabushiki Kaisha Toyota Chuo Kenkyusho Organosilane compound and organosilica obtained therefrom
US9156865B2 (en) 2007-04-23 2015-10-13 Deliversir Ltd System for delivering therapeutic agents into living cells and cells nuclei
US9556210B2 (en) 2007-04-23 2017-01-31 Sabag-Rfa Ltd. System for delivering therapeutic agents into living cells and cells nuclei
PT2144633E (pt) 2007-04-23 2014-10-27 Deliversir Ltd Um sistema para a administração de agentes terapêuticos em células vivas e núcleos de células
WO2008138726A2 (en) 2007-05-11 2008-11-20 Basf Se Polymeric dyes
EP2014698A1 (en) 2007-07-12 2009-01-14 Crystax Pharmaceuticals S.L. Polymers and their use as fluorescent labels
TWI409280B (zh) 2007-07-31 2013-09-21 American Dye Source Inc 聚合物染料、塗覆層組合物及熱微影印刷板
GB2456298A (en) 2008-01-07 2009-07-15 Anthony Ian Newman Electroluminescent materials comprising oxidation resistant fluorenes
WO2009113645A1 (ja) 2008-03-10 2009-09-17 国立大学法人 東京大学 非荷電性親水性ブロック及び側鎖の一部に疎水性基が導入されカチオン性のポリアミノ酸ブロックを含んでなる共重合体、その使用
US9884070B2 (en) 2008-04-21 2018-02-06 Lawrence Livermore National Security, Llc Selective high-affinity polydentate ligands and methods of making such
KR101041446B1 (ko) 2008-07-21 2011-06-14 부산대학교 산학협력단 공액고분자 2단계 fret 시스템 및 바이오센서
WO2010026957A1 (ja) 2008-09-03 2010-03-11 国立大学法人 富山大学 水溶性ロタキサン型蛍光色素および蛍光性有機分子
JP4815015B2 (ja) 2008-11-14 2011-11-16 独立行政法人科学技術振興機構 オリゴヌクレオチド誘導体、ラベル化剤及びその利用
WO2010059051A2 (en) 2008-11-20 2010-05-27 Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno Rapid fret based pathogen diagnosis
CA2745307A1 (en) 2008-12-12 2010-06-17 University Of Massachusetts Polyesters with grafted zwitterions
CN106519588B (zh) 2009-11-09 2019-08-20 华盛顿大学商业化中心 官能化发色聚合物点及其生物共轭体
US9400273B1 (en) 2009-12-09 2016-07-26 Life Technologies Corporation 7-hydroxycoumarin-based cell-tracking reagents
WO2011088193A2 (en) 2010-01-13 2011-07-21 University Of Medicine And Dentistry Of New Jersey Fluorophore chelated lanthanide luminiscent probes with improved quantum efficiency
WO2011113020A1 (en) 2010-03-11 2011-09-15 Glumetrics, Inc. Measurement devices and methods for measuring analyte concentration incorporating temperature and ph correction
WO2011120053A1 (en) 2010-03-26 2011-09-29 Mersana Therapeutics, Inc. Modified polymers for delivery of polynucleotides, method of manufacture, and methods of use thereof
WO2011150079A1 (en) 2010-05-25 2011-12-01 Carnegie Mellon University Targeted probes of cellular physiology
JPWO2012005310A1 (ja) 2010-07-08 2013-09-05 旭硝子株式会社 含フッ素芳香族化合物、有機半導体材料および有機薄膜デバイス
EP3536695A1 (en) 2010-12-13 2019-09-11 QuiaPEG Pharmaceuticals AB Functionalized polymers
CN102174078A (zh) * 2011-01-10 2011-09-07 中国药科大学 肿瘤细胞选择性穿膜肽的应用
US9289516B2 (en) * 2011-03-09 2016-03-22 The General Hospital Corporation Imaging beta cell mass
US20130078671A1 (en) * 2011-03-25 2013-03-28 The Texas A&M University System Incorporation of two different noncanonical amino acids into a single protein
DK2769226T3 (en) 2011-07-15 2017-09-11 Medtronic Minimed Inc COMBINATIONS OF FLUORPHORES AND PYRIDINIUM BORIC ACID QUENCHERS FOR USE IN ANALYTICAL SENSORS
US20130059343A1 (en) 2011-09-06 2013-03-07 Li-Cor, Inc. Nucleotide derivatives
US9085761B1 (en) 2012-06-14 2015-07-21 Affymetrix, Inc. Methods and compositions for amplification of nucleic acids
CA2880290C (en) 2012-09-12 2020-10-27 Quark Pharmaceuticals, Inc. Double-stranded oligonucleotide molecules targeting p53 and methods of use thereof
WO2014055253A1 (en) * 2012-10-04 2014-04-10 The General Hospital Corporation Methods of synthesizing and using peg-like fluorochromes
CN104918639B (zh) 2012-10-22 2018-01-26 萨拜格Rfa公司 用于将治疗剂递送到活细胞和细胞核中的系统
WO2014102803A1 (en) 2012-12-31 2014-07-03 Yeda Research And Development Co. Ltd. Molecular sensor and methods of use thereof
US9545447B2 (en) 2013-01-04 2017-01-17 The Texas A&M University System Polymer-drug systems
US9714946B2 (en) 2013-03-14 2017-07-25 Dana-Farber Cancer Institute, Inc. Bromodomain binding reagents and uses thereof
CN105073761B (zh) 2013-03-15 2020-10-20 文森医学公司 用于体外和体内成像和检测的取代的硅杂蒽阳离子红至近红外荧光染料
WO2014147642A1 (en) 2013-03-19 2014-09-25 Council Of Scientific & Industrial Research Substituted fluoranthene-7-carbonitriles as fluorescent dyes for cell imaging applications
CN103319378B (zh) 2013-06-27 2015-06-10 中国科学院宁波材料技术与工程研究所 两性离子有机小分子太阳能电池阴极界面材料及其制法和用途
KR101572901B1 (ko) 2013-07-12 2015-12-15 부산대학교 산학협력단 2-단계 fret를 이용한 공액고분자 전해질 및 압타머 프로브 기반 표적 물질의 검출 방법 및 형광 센서
EP3019559A4 (en) 2013-08-22 2017-04-05 Sony Corporation Water soluble fluorescent or colored dyes and methods for their use
US10406246B2 (en) 2013-10-17 2019-09-10 Deutsches Kresbsforschungszentrum Double-labeled probe for molecular imaging and use thereof
JP5802865B1 (ja) 2013-11-11 2015-11-04 オリンパス株式会社 処置システム
EP3077454A1 (en) 2013-12-06 2016-10-12 Monosol, LLC Fluorescent tracer for water-soluble films, related methods, and related articles
WO2015109136A2 (en) 2014-01-16 2015-07-23 Sony Corporation Water soluble fluorescent or colored dyes and methods for their use
JP6374172B2 (ja) 2014-01-31 2018-08-15 富士フイルム株式会社 着色組成物、およびこれを用いた硬化膜、カラーフィルタ、パターン形成方法、カラーフィルタの製造方法、固体撮像素子、画像表示装置ならびに染料多量体
WO2015148915A1 (en) * 2014-03-27 2015-10-01 Academia Sinica Reactive labelling compounds and uses thereof
CN104072727A (zh) 2014-06-23 2014-10-01 华南理工大学 一种含磷脂酰胆碱基的2,7-芴的共轭聚合物及其制备方法与应用
WO2016077625A1 (en) 2014-11-12 2016-05-19 Stayton Patrick S Stabilized polymeric carriers for therapeutic agent delivery
CA2967077A1 (en) 2014-11-14 2016-05-19 Angiochem Inc. Conjugates including an antibody moiety, a polypeptide that traverses the blood-brain barrier, and a cytotoxin
KR102676814B1 (ko) 2015-02-26 2024-06-21 소니그룹주식회사 접합 그룹을 포함하는 수용성 형광 또는 착색 염료
CN107406353A (zh) 2015-02-26 2017-11-28 索尼公司 苯基乙炔基萘染料和用于它们用途的方法
WO2016144652A1 (en) 2015-03-12 2016-09-15 Becton, Dickinson And Company Polymeric bodipy dyes and methods for using the same
WO2016183185A1 (en) 2015-05-11 2016-11-17 Sony Corporation Ultra bright dimeric or polymeric dyes
US9670318B2 (en) 2015-05-28 2017-06-06 Miltenyi Biotec Gmbh Bright fluorochromes based on multimerization of fluorescent dyes
US9913992B2 (en) 2015-12-22 2018-03-13 Colgate-Palmolive Company Oral treatment device
KR102525252B1 (ko) 2016-04-01 2023-04-26 소니그룹주식회사 강성 공간군을 갖는 매우 밝은 이량체성 또는 중합체성 염료
KR20250029292A (ko) 2016-04-01 2025-03-04 소니그룹주식회사 초휘도 이량체성 또는 중합체성 염료
US10901940B2 (en) 2016-04-02 2021-01-26 Intel Corporation Processors, methods, systems, and instructions to atomically store to memory data wider than a natively supported data width
RU2753706C2 (ru) 2016-04-06 2021-08-20 Сони Корпорейшн Ультраяркие димерные или полимерные красители со спейсерными линкерными группами
WO2017197014A2 (en) 2016-05-10 2017-11-16 Sony Corporation Compositions comprising a polymeric dye and a cyclodextrin and uses thereof
RU2018143594A (ru) 2016-05-11 2020-06-11 Сони Корпорейшн Ультраяркие димерные или полимерные красители
JP7068191B2 (ja) 2016-06-06 2022-05-16 ソニーグループ株式会社 蛍光または有色レポーター基を含むイオン性ポリマー
US12018159B2 (en) 2016-07-29 2024-06-25 Sony Group Corporation Ultra bright dimeric or polymeric dyes and methods for preparation of the same
GB2554666B (en) 2016-09-30 2019-12-18 Sumitomo Chemical Co Composite Particle
CN106589005B (zh) 2016-11-01 2019-08-06 北京擎科生物科技有限公司 一种荧光信号放大探针中间体、荧光探针及其制备方法
US12290571B2 (en) 2017-10-05 2025-05-06 Sony Group Corporation Programmable dendritic drugs
US12145956B2 (en) 2017-10-05 2024-11-19 Sony Group Corporation Programmable polymeric drugs
CN111836645A (zh) 2017-11-16 2020-10-27 索尼公司 可编程的聚合药物
JP2021506788A (ja) 2017-12-13 2021-02-22 ソニー株式会社 生物学的に活性な化合物を含むイオン性ポリマー
EP3737418B1 (en) 2018-01-12 2024-02-28 Sony Group Corporation Polymers with rigid spacing groups comprising biologically active compounds
CN111565757A (zh) 2018-01-12 2020-08-21 索尼公司 包含生物活性化合物的磷酸烷基聚合物
US12194104B2 (en) 2018-01-12 2025-01-14 Sony Group Corporation Phosphoalkyl ribose polymers comprising biologically active compounds
EP4137818B1 (en) 2018-03-19 2025-12-10 Sony Group Corporation Use of divalent metals for enhancement of fluorescent signals
US12319817B2 (en) 2018-03-21 2025-06-03 Sony Group Corporation Polymeric tandem dyes with linker groups
CN112399996A (zh) 2018-07-13 2021-02-23 索尼公司 具有包含有机磷酸酯单元的主链的聚合的染料
JP7239904B2 (ja) 2019-09-26 2023-03-15 ソニーグループ株式会社 リンカー基を有するポリマータンデム色素
KR20220075399A (ko) 2019-09-30 2022-06-08 소니그룹주식회사 뉴클레오티드 프로브

Similar Documents

Publication Publication Date Title
JP2019519490A5 (enExample)
JP2019516821A5 (enExample)
DK1951316T3 (en) molecular conjugate
JP2019516812A5 (enExample)
JP2019516807A5 (enExample)
JP2018515628A5 (enExample)
AR110853A2 (es) Un método para preparar el conjugado de péptido insulinotrópico, y una composición farmacéutica que comprende a dicho conjugado de péptido insulinotrópico
JP2009536745A5 (enExample)
JP2011501747A (ja) 機能性脂質構築物
JPS6121227B2 (enExample)
JP6118560B2 (ja) 共役反応
JPH0535990B2 (enExample)
Rao et al. A tetrazine templated method for the synthesis of ternary conjugates
CN106470980B (zh) 靛红酸酐衍生物及其应用
CN104877982B (zh) 制备肽/蛋白缀合物的方法和试剂
JP2019536770A5 (enExample)
AU2004272465B2 (en) Size-controlled macromolecule
RU2202555C2 (ru) Биоконъюгационные комплексы, способы их получения (варианты), фенилборнокислые комплексообразующие реагенты, фенилборнокислые поперечно-сшивающие реагенты, набор средств или система, способ выделения требуемой популяции клеток
JP4120846B2 (ja) 活性化ペプチド類および接合体
JP2017083461A (ja) 共役反応
US20070010673A1 (en) Purification means
JP5062410B2 (ja) 非特異吸着防止剤ならびにプローブ結合粒子およびそれらの製造方法
JP2009510219A5 (enExample)
CN115215927A (zh) 一种含长链巯基臂的链霉亲和素及制备方法
KR20100103997A (ko) 양자점-앱타머 접합체를 이용한 생분석 방법