UA94594C2 - СПОСОБ ПОЛУЧЕНИЯ ПОЛИМЕРНЫХ КОНЪЮГАТОВ ДОКСОРУБИЦИНА С рН-КОНТРОЛИРОВАННЫМ ВЫСВОБОЖДЕНИЕМ ЛЕКАРСТВЕННОГО ВЕЩЕСТВА - Google Patents

СПОСОБ ПОЛУЧЕНИЯ ПОЛИМЕРНЫХ КОНЪЮГАТОВ ДОКСОРУБИЦИНА С рН-КОНТРОЛИРОВАННЫМ ВЫСВОБОЖДЕНИЕМ ЛЕКАРСТВЕННОГО ВЕЩЕСТВА

Info

Publication number
UA94594C2
UA94594C2 UAA200804282A UAA200804282A UA94594C2 UA 94594 C2 UA94594 C2 UA 94594C2 UA A200804282 A UAA200804282 A UA A200804282A UA A200804282 A UAA200804282 A UA A200804282A UA 94594 C2 UA94594 C2 UA 94594C2
Authority
UA
Ukraine
Prior art keywords
doxorubicin
preparation
drug
controlled release
polymeric conjugates
Prior art date
Application number
UAA200804282A
Other languages
English (en)
Ukrainian (uk)
Inventor
Томас Этрих
Петер Хитил
Мартин Студеновски
Михал Пехар
Карел Ульбрих
Бланка Ригова
Original Assignee
ЗЕНТИВА, а.с.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ЗЕНТИВА, а.с. filed Critical ЗЕНТИВА, а.с.
Publication of UA94594C2 publication Critical patent/UA94594C2/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
UAA200804282A 2005-09-05 2006-09-05 СПОСОБ ПОЛУЧЕНИЯ ПОЛИМЕРНЫХ КОНЪЮГАТОВ ДОКСОРУБИЦИНА С рН-КОНТРОЛИРОВАННЫМ ВЫСВОБОЖДЕНИЕМ ЛЕКАРСТВЕННОГО ВЕЩЕСТВА UA94594C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CZ20050558A CZ2005558A3 (cs) 2005-09-05 2005-09-05 Zpusob prípravy polymerních konjugátu doxorubicinu s pH-rízeným uvolnováním léciva

Publications (1)

Publication Number Publication Date
UA94594C2 true UA94594C2 (ru) 2011-05-25

Family

ID=37667174

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200804282A UA94594C2 (ru) 2005-09-05 2006-09-05 СПОСОБ ПОЛУЧЕНИЯ ПОЛИМЕРНЫХ КОНЪЮГАТОВ ДОКСОРУБИЦИНА С рН-КОНТРОЛИРОВАННЫМ ВЫСВОБОЖДЕНИЕМ ЛЕКАРСТВЕННОГО ВЕЩЕСТВА

Country Status (7)

Country Link
US (1) US20080318879A1 (ru)
EP (1) EP1922087B1 (ru)
AT (1) ATE520419T1 (ru)
CZ (1) CZ2005558A3 (ru)
EA (1) EA015091B1 (ru)
UA (1) UA94594C2 (ru)
WO (1) WO2007028347A2 (ru)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ2006505A3 (cs) * 2006-08-09 2008-04-09 Zentiva, A. S. Polymerní konjugáty doxorubicinu s pH-rízeným uvolnováním léciva a zpusob jejich prípravy
EP2503332A3 (en) * 2006-08-09 2013-11-13 Sumitomo Bakelite Company, Ltd. Sugar chain-capturing substance and use thereof
CZ298945B6 (cs) * 2006-09-18 2008-03-19 Zentiva, A. S. Polymerní lécivo a zpusob jeho výroby
WO2008139457A2 (en) * 2007-05-10 2008-11-20 Clear Direction Ltd. Methods and compositions for drug targeting
WO2010127271A1 (en) 2009-04-30 2010-11-04 Intezyne Technologies, Incorporated Polymer micelles containing anthracylines for the treatment of cancer
US8524784B2 (en) 2009-04-30 2013-09-03 Intezyne Technologies, Incorporated Polymer micelles containing anthracylines for the treatment of cancer
CN103936945B (zh) * 2013-01-23 2017-02-08 中国科学院化学研究所 一类高效抗肿瘤靶向药物载体及其制备方法
CN105727309B (zh) * 2016-03-31 2019-04-30 中国药科大学 双敏感两亲性多糖-阿霉素偶联物及其药学组合物的制备和应用
CN105963706B (zh) * 2016-04-15 2019-03-15 四川大学 一种支化hpma共聚物-dox偶联物及其制备方法和应用
CN105903031A (zh) * 2016-05-05 2016-08-31 上海交通大学 肿瘤微环境敏感的药物控释纳米体系的制备方法及其应用
GB2551979A (en) * 2016-06-30 2018-01-10 Rs Arastirma Egitim Danismanlik Llac Sanayi Ticaret Ltd Cleavable polymer drug conjugates
US20220008543A1 (en) * 2018-10-26 2022-01-13 Board Of Regents Of The University Of Nebraska Macromolecular prodrug-based thermosensitive injectable gel as a novel drug delivery platform

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6060518A (en) * 1996-08-16 2000-05-09 Supratek Pharma Inc. Polymer compositions for chemotherapy and methods of treatment using the same
DE19636889A1 (de) * 1996-09-11 1998-03-12 Felix Dr Kratz Antineoplastisch wirkende Transferrin- und Albuminkonjugate zytostatischer Verbindungen aus der Gruppe der Anthrazykline, Alkylantien, Antimetabolite und Cisplatin-Analoga und diese enthaltende Arzneimittel
CZ293787B6 (cs) * 2001-12-20 2004-07-14 Zentiva, A.S. pH senzitivní polymerní konjugáty antracyklinového kancerostatika pro cílenou terapii
AU2002953073A0 (en) * 2002-11-21 2003-01-16 Access Pharmaceuticals Australia Pty Limited Amplification of biotin-mediated targeting
CZ293886B6 (cs) * 2002-12-20 2004-08-18 Zentivaźáa@S pH senzitivní polymerní konjugáty antracyklinového kancerostatika pro cílenou terapii
CZ294996B6 (cs) * 2003-07-16 2005-04-13 Ústav Makromolekulární Chemie Av Čr Reaktivní polymery a kopolymery na bázi N-(2-hydroxypropyl)methakrylamidu, způsob jejich přípravy a jejich použití pro syntézu polymerních léčiv, pro modifikaci biologicky aktivních proteinů a přípravu systémů pro dopravu genů
WO2005117932A1 (en) * 2004-06-04 2005-12-15 The Board Of Governors For Higher Education, State Of Rhode Island And Providence Plantations Bisubstrate inhibitors of protein tyrosine kinases as therapeutic agents
GB0413613D0 (en) * 2004-06-17 2004-07-21 Univ London Small molecule carriers
US7968085B2 (en) * 2004-07-05 2011-06-28 Ascendis Pharma A/S Hydrogel formulations

Also Published As

Publication number Publication date
CZ297827B6 (cs) 2007-04-04
ATE520419T1 (de) 2011-09-15
CZ2005558A3 (cs) 2007-04-04
EA015091B1 (ru) 2011-06-30
US20080318879A1 (en) 2008-12-25
EP1922087B1 (en) 2011-08-17
WO2007028347A2 (en) 2007-03-15
WO2007028347A3 (en) 2007-05-10
EA200800756A1 (ru) 2008-06-30
EP1922087A2 (en) 2008-05-21

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