EA200800756A1 - СПОСОБ ПОЛУЧЕНИЯ ПОЛИМЕРНЫХ КОНЪЮГАТОВ ДОКСОРУБИЦИНА С КОНТРОЛИРУЕМЫМ pH ВЫСВОБОЖДЕНИЕМ ЛЕКАРСТВЕННОГО СРЕДСТВА - Google Patents

СПОСОБ ПОЛУЧЕНИЯ ПОЛИМЕРНЫХ КОНЪЮГАТОВ ДОКСОРУБИЦИНА С КОНТРОЛИРУЕМЫМ pH ВЫСВОБОЖДЕНИЕМ ЛЕКАРСТВЕННОГО СРЕДСТВА

Info

Publication number
EA200800756A1
EA200800756A1 EA200800756A EA200800756A EA200800756A1 EA 200800756 A1 EA200800756 A1 EA 200800756A1 EA 200800756 A EA200800756 A EA 200800756A EA 200800756 A EA200800756 A EA 200800756A EA 200800756 A1 EA200800756 A1 EA 200800756A1
Authority
EA
Eurasian Patent Office
Prior art keywords
doxorubicin
dispersification
medicines
controlled
polymeric conjugates
Prior art date
Application number
EA200800756A
Other languages
English (en)
Other versions
EA015091B1 (ru
Inventor
Томаш Этрих
Петр Хитиль
Мартин Студеновски
Михаль Пехар
Карел Ульбрих
Бланка Ригова
Original Assignee
Зентива А.С.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Зентива А.С. filed Critical Зентива А.С.
Publication of EA200800756A1 publication Critical patent/EA200800756A1/ru
Publication of EA015091B1 publication Critical patent/EA015091B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

Abstract

Способ получения полимерных конъюгатов N-(2-гидроксипропил)метакриламида и метакрилоиламиноацилгидразона доксорубицина с контролируемым рН высвобождением лекарственного средства, включающий следующие три стадии синтеза: (а) получение мономерного метакрилоиламиноацилгидразина, где аминоацил происходит из аминокислоты или олигопептида, путем реакции метакрилоилгалида с соответствующим пептидом, аминокислотой или производным указанных веществ, и последующий гидразинолиз; (б) синтез полимерного предшественника путем прямой сополимеризации N-(2-гидроксипропил)метакриламида и метакрилоиламиноацилгидразина; (в) связывание доксорубицина и полимерного предшественника путем реакции последнего с гидрохлоридом доксорубицина.
EA200800756A 2005-09-05 2006-09-05 СПОСОБ ПОЛУЧЕНИЯ ПОЛИМЕРНЫХ КОНЪЮГАТОВ ДОКСОРУБИЦИНА С КОНТРОЛИРУЕМЫМ pH ВЫСВОБОЖДЕНИЕМ ЛЕКАРСТВЕННОГО СРЕДСТВА EA015091B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CZ20050558A CZ297827B6 (cs) 2005-09-05 2005-09-05 Zpusob prípravy polymerních konjugátu doxorubicinu s pH-rízeným uvolnováním léciva
PCT/CZ2006/000056 WO2007028347A2 (en) 2005-09-05 2006-09-05 Method for the preparation of polymeric conjugates of doxorubicin with ph- controlled release of the drug

Publications (2)

Publication Number Publication Date
EA200800756A1 true EA200800756A1 (ru) 2008-06-30
EA015091B1 EA015091B1 (ru) 2011-06-30

Family

ID=37667174

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200800756A EA015091B1 (ru) 2005-09-05 2006-09-05 СПОСОБ ПОЛУЧЕНИЯ ПОЛИМЕРНЫХ КОНЪЮГАТОВ ДОКСОРУБИЦИНА С КОНТРОЛИРУЕМЫМ pH ВЫСВОБОЖДЕНИЕМ ЛЕКАРСТВЕННОГО СРЕДСТВА

Country Status (7)

Country Link
US (1) US20080318879A1 (ru)
EP (1) EP1922087B1 (ru)
AT (1) ATE520419T1 (ru)
CZ (1) CZ297827B6 (ru)
EA (1) EA015091B1 (ru)
UA (1) UA94594C2 (ru)
WO (1) WO2007028347A2 (ru)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2503332A3 (en) 2006-08-09 2013-11-13 Sumitomo Bakelite Company, Ltd. Sugar chain-capturing substance and use thereof
CZ299053B6 (cs) * 2006-08-09 2008-04-09 Zentiva, A. S. Polymerní konjugáty doxorubicinu s pH-rízeným uvolnováním léciva a zpusob jejich prípravy
CZ298945B6 (cs) * 2006-09-18 2008-03-19 Zentiva, A. S. Polymerní lécivo a zpusob jeho výroby
US20100316697A1 (en) * 2007-05-10 2010-12-16 Clear Direction Ltd. Methods and compositions for drug targeting
US8524783B2 (en) 2009-04-30 2013-09-03 Intezyne Technologies, Incorporated Polymer micelles containing anthracylines for the treatment of cancer
US8524784B2 (en) 2009-04-30 2013-09-03 Intezyne Technologies, Incorporated Polymer micelles containing anthracylines for the treatment of cancer
CN103936945B (zh) * 2013-01-23 2017-02-08 中国科学院化学研究所 一类高效抗肿瘤靶向药物载体及其制备方法
CN105727309B (zh) * 2016-03-31 2019-04-30 中国药科大学 双敏感两亲性多糖-阿霉素偶联物及其药学组合物的制备和应用
CN105963706B (zh) * 2016-04-15 2019-03-15 四川大学 一种支化hpma共聚物-dox偶联物及其制备方法和应用
CN105903031A (zh) * 2016-05-05 2016-08-31 上海交通大学 肿瘤微环境敏感的药物控释纳米体系的制备方法及其应用
GB2551979A (en) * 2016-06-30 2018-01-10 Rs Arastirma Egitim Danismanlik Llac Sanayi Ticaret Ltd Cleavable polymer drug conjugates

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6060518A (en) * 1996-08-16 2000-05-09 Supratek Pharma Inc. Polymer compositions for chemotherapy and methods of treatment using the same
DE19636889A1 (de) * 1996-09-11 1998-03-12 Felix Dr Kratz Antineoplastisch wirkende Transferrin- und Albuminkonjugate zytostatischer Verbindungen aus der Gruppe der Anthrazykline, Alkylantien, Antimetabolite und Cisplatin-Analoga und diese enthaltende Arzneimittel
CZ293787B6 (cs) * 2001-12-20 2004-07-14 Zentiva, A.S. pH senzitivní polymerní konjugáty antracyklinového kancerostatika pro cílenou terapii
AU2002953073A0 (en) * 2002-11-21 2003-01-16 Access Pharmaceuticals Australia Pty Limited Amplification of biotin-mediated targeting
CZ293886B6 (cs) * 2002-12-20 2004-08-18 Zentivaźáa@S pH senzitivní polymerní konjugáty antracyklinového kancerostatika pro cílenou terapii
CZ294996B6 (cs) * 2003-07-16 2005-04-13 Ústav Makromolekulární Chemie Av Čr Reaktivní polymery a kopolymery na bázi N-(2-hydroxypropyl)methakrylamidu, způsob jejich přípravy a jejich použití pro syntézu polymerních léčiv, pro modifikaci biologicky aktivních proteinů a přípravu systémů pro dopravu genů
WO2005117932A1 (en) * 2004-06-04 2005-12-15 The Board Of Governors For Higher Education, State Of Rhode Island And Providence Plantations Bisubstrate inhibitors of protein tyrosine kinases as therapeutic agents
GB0413613D0 (en) * 2004-06-17 2004-07-21 Univ London Small molecule carriers
US7968085B2 (en) * 2004-07-05 2011-06-28 Ascendis Pharma A/S Hydrogel formulations

Also Published As

Publication number Publication date
CZ2005558A3 (cs) 2007-04-04
EP1922087A2 (en) 2008-05-21
WO2007028347A2 (en) 2007-03-15
EP1922087B1 (en) 2011-08-17
WO2007028347A3 (en) 2007-05-10
US20080318879A1 (en) 2008-12-25
EA015091B1 (ru) 2011-06-30
UA94594C2 (ru) 2011-05-25
CZ297827B6 (cs) 2007-04-04
ATE520419T1 (de) 2011-09-15

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Legal Events

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM