ATE317850T1 - 2-((n-(2-amino-3-(heteroaryl- oder - aryl)propionyl)aminoacyl)amino)- alkylboronsäurederivate - Google Patents

2-((n-(2-amino-3-(heteroaryl- oder - aryl)propionyl)aminoacyl)amino)- alkylboronsäurederivate

Info

Publication number
ATE317850T1
ATE317850T1 AT02743128T AT02743128T ATE317850T1 AT E317850 T1 ATE317850 T1 AT E317850T1 AT 02743128 T AT02743128 T AT 02743128T AT 02743128 T AT02743128 T AT 02743128T AT E317850 T1 ATE317850 T1 AT E317850T1
Authority
AT
Austria
Prior art keywords
amino
aminoacyl
propionyl
heteroaryl
aryl
Prior art date
Application number
AT02743128T
Other languages
English (en)
Inventor
Pascal Furet
Vito Guagnano
Patricia Imbach
Marc Lang
Original Assignee
Novartis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0113096A external-priority patent/GB0113096D0/en
Priority claimed from GB0129394A external-priority patent/GB0129394D0/en
Application filed by Novartis Pharma Gmbh filed Critical Novartis Pharma Gmbh
Application granted granted Critical
Publication of ATE317850T1 publication Critical patent/ATE317850T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
AT02743128T 2001-05-30 2002-05-29 2-((n-(2-amino-3-(heteroaryl- oder - aryl)propionyl)aminoacyl)amino)- alkylboronsäurederivate ATE317850T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0113096A GB0113096D0 (en) 2001-05-30 2001-05-30 Organic compounds
GB0129394A GB0129394D0 (en) 2001-12-07 2001-12-07 Organic compounds

Publications (1)

Publication Number Publication Date
ATE317850T1 true ATE317850T1 (de) 2006-03-15

Family

ID=26246132

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02743128T ATE317850T1 (de) 2001-05-30 2002-05-29 2-((n-(2-amino-3-(heteroaryl- oder - aryl)propionyl)aminoacyl)amino)- alkylboronsäurederivate

Country Status (11)

Country Link
US (2) US6933290B2 (de)
EP (1) EP1399468B1 (de)
JP (1) JP4416501B2 (de)
CN (1) CN100415770C (de)
AT (1) ATE317850T1 (de)
BR (1) BR0210112A (de)
CA (1) CA2446282A1 (de)
DE (1) DE60209227T2 (de)
ES (1) ES2258149T3 (de)
PT (1) PT1399468E (de)
WO (1) WO2002096933A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6933290B2 (en) * 2001-05-30 2005-08-23 Novartis Ag 2-{N-(2-amino-3-(heteroaryl or aryl)propionyl)-aminoacyl}-amino}-alkylboronic acid derivatives
US7524883B2 (en) 2002-01-08 2009-04-28 Eisai R&D Management Co., Ltd. Eponemycin and epoxomicin analogs and uses thereof
CA2505361A1 (en) * 2002-11-11 2004-05-27 Bayer Healthcare Ag Phenyl or heteroaryl amino alkane derivatives as ip receptor antagonist
US7576206B2 (en) 2003-08-14 2009-08-18 Cephalon, Inc. Proteasome inhibitors and methods of using the same
US7223745B2 (en) 2003-08-14 2007-05-29 Cephalon, Inc. Proteasome inhibitors and methods of using the same
US7468383B2 (en) 2005-02-11 2008-12-23 Cephalon, Inc. Proteasome inhibitors and methods of using the same
EP1940843A4 (de) 2005-08-11 2010-09-15 Ariad Pharma Inc Ungesättigte heterocyclische derivate
EP1962839A4 (de) 2005-11-14 2010-08-25 Ariad Pharma Inc Verabreichung von mntor-inhibitoren zur behandlung von krebspatienten
AU2006331673B2 (en) 2005-12-23 2013-02-28 Ariad Pharmaceuticals, Inc. Bicyclic heteroaryl compounds
EA028622B1 (ru) 2007-08-06 2017-12-29 Милленниум Фармасьютикалз, Инк. Ингибиторы протеасом
DK2300013T3 (en) 2008-05-21 2017-12-04 Ariad Pharma Inc PHOSPHORUS DERIVATIVES AS KINASE INHIBITORS
SI2318419T1 (sl) 2008-06-17 2015-07-31 Millennium Pharmaceuticals, Inc. Spojine boronat estra in njihovi farmacevtski sestavki
AR075090A1 (es) 2008-09-29 2011-03-09 Millennium Pharm Inc Derivados de acido 1-amino-2-ciclobutiletilboronico inhibidores de proteosoma,utiles como agentes anticancerigenos, y composiciones farmaceuticas que los comprenden.
US8846664B2 (en) 2008-11-12 2014-09-30 Ariad Pharmaceuticals, Inc. Pyrazinopyrazines and derivatives as kinase inhibitors
EP2399129B1 (de) 2009-02-20 2015-11-25 Michael P. Lisanti Verfahren zur diagnose bzw. prognose eines neoplasmas einschliesslich der bestimmung des expressionsgrads eines proteins in stromazellen neben dem neoplasma
WO2011087822A1 (en) 2009-12-22 2011-07-21 Cephalon, Inc. Proteasome inhibitors and processes for their preparation, purification and use
JP6042724B2 (ja) * 2010-03-01 2016-12-14 オニキス セラピューティクス， インク．Ｏｎｙｘ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． イムノプロテアソーム阻害のための化合物
JP5801378B2 (ja) 2010-04-19 2015-10-28 ニーキ ファーマ インコーポレイテッド プロテアソーム阻害剤およびガリウム錯体を用いた併用療法
GB2523211B (en) 2012-01-27 2020-03-18 Univ Jefferson MCT protein inhibitor-related prognostic and therapeutic methods
CN103421032B (zh) * 2012-05-17 2016-01-20 上海创诺制药有限公司 一种硼替佐米中间体及其制备方法和应用
EP2986290A4 (de) 2013-04-19 2017-01-04 Thomas Jefferson University Caveolin-1-verwandte verfahren zur behandlung von glioblastom mit temozolomid
UA121389C2 (uk) 2014-05-20 2020-05-25 Мілленніум Фармасьютікалз, Інк. Борвмісні інгібітори протеасом для застосування після первинної протиракової терапії
CN110526912B (zh) 2014-06-19 2023-02-14 武田药品工业株式会社 用于激酶抑制的杂芳基化合物
MA41505A (fr) 2015-02-11 2017-12-19 Millennium Pharm Inc Nouvelle forme cristalline d'un inhibiteur de protéasome
PT3472149T (pt) 2016-06-21 2023-11-23 Orion Opthalmology Llc Derivados de prolinamida heterocíclicos
WO2017222914A1 (en) 2016-06-21 2017-12-28 Inception 4, Inc. Carbocyclic prolinamide derivatives

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4499082A (en) 1983-12-05 1985-02-12 E. I. Du Pont De Nemours And Company α-Aminoboronic acid peptides
EP0315574A3 (de) 1987-11-05 1990-08-22 Hoechst Aktiengesellschaft Renin-Inhibitoren
US5106948A (en) * 1988-05-27 1992-04-21 Mao Foundation For Medical Education And Research Cytotoxic boronic acid peptide analogs
GB9017694D0 (en) 1990-08-13 1990-09-26 Sandoz Ltd Improvements in or relating to organic chemistry
US5384410A (en) 1993-03-24 1995-01-24 The Du Pont Merck Pharmaceutical Company Removal of boronic acid protecting groups by transesterification
IL109319A0 (en) 1993-04-27 1994-07-31 Du Pont Merck Pharma Amidino and guanidino substituted boronic acid compounds
US5658885A (en) 1993-04-27 1997-08-19 The Dupont Merck Pharmaceutical Company Amidino and guanidino substituted boronic acid inhibitors of trypsin-like enzymes
FR2721611B1 (fr) * 1994-06-22 1996-09-27 Adir Nouveaux dérivés peptidiques de l'acide boronique, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent .
US6083903A (en) 1994-10-28 2000-07-04 Leukosite, Inc. Boronic ester and acid compounds, synthesis and uses
US5550262A (en) 1994-11-14 1996-08-27 Cephalon, Inc. Multicatalytic protease inhibitors
US5614649A (en) 1994-11-14 1997-03-25 Cephalon, Inc. Multicatalytic protease inhibitors
CN1282242A (zh) 1997-12-16 2001-01-31 赛福伦公司 多相催化蛋白酶抑制剂用作抗肿瘤剂
US6933290B2 (en) * 2001-05-30 2005-08-23 Novartis Ag 2-{N-(2-amino-3-(heteroaryl or aryl)propionyl)-aminoacyl}-amino}-alkylboronic acid derivatives

Also Published As

Publication number Publication date
CA2446282A1 (en) 2002-12-05
US20040167337A1 (en) 2004-08-26
BR0210112A (pt) 2004-06-08
EP1399468A1 (de) 2004-03-24
DE60209227T2 (de) 2006-08-17
CN1512999A (zh) 2004-07-14
JP2005501005A (ja) 2005-01-13
ES2258149T3 (es) 2006-08-16
CN100415770C (zh) 2008-09-03
PT1399468E (pt) 2006-05-31
EP1399468B1 (de) 2006-02-15
US6933290B2 (en) 2005-08-23
WO2002096933A1 (en) 2002-12-05
US20050239716A1 (en) 2005-10-27
DE60209227D1 (de) 2006-04-20
JP4416501B2 (ja) 2010-02-17

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