BR0210112A - Derivados do ácido 2-{[n-(2-amino-3-(heteroarila ou arila)propionil)-aminoacil]-amino}-alquilborÈnico - Google Patents
Derivados do ácido 2-{[n-(2-amino-3-(heteroarila ou arila)propionil)-aminoacil]-amino}-alquilborÈnicoInfo
- Publication number
- BR0210112A BR0210112A BR0210112-2A BR0210112A BR0210112A BR 0210112 A BR0210112 A BR 0210112A BR 0210112 A BR0210112 A BR 0210112A BR 0210112 A BR0210112 A BR 0210112A
- Authority
- BR
- Brazil
- Prior art keywords
- amino
- aminoacyl
- propionyl
- heteroaryl
- aryl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
"DERIVADOS DO áCIDO 2-{[N-(2-AMINO-3-(HETERO-ARILA OU ARILA)PROPIONIL)-AMINOACIL]-AMINO}-ALQUILBORÈNICO". A presente invenção refere-se a compostos de fórmula I em que os substituintes são conforme definidos na descrição, a processos para a preparação dos mesmos, a preparações farmacêuticas compreendendo aqueles compostos e ao uso dos mesmos na preparação de composições farmacêuticas, para o tratamento terapêutico de animais de sangue quente, inclusive seres humanos.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0113096A GB0113096D0 (en) | 2001-05-30 | 2001-05-30 | Organic compounds |
GB0129394A GB0129394D0 (en) | 2001-12-07 | 2001-12-07 | Organic compounds |
PCT/EP2002/005937 WO2002096933A1 (en) | 2001-05-30 | 2002-05-29 | 2-{[n-(2-amino-3-(heteroaryl or aryl)propionyl)-aminoacyl]-amino}-alkylboronic acid derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0210112A true BR0210112A (pt) | 2004-06-08 |
Family
ID=26246132
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0210112-2A BR0210112A (pt) | 2001-05-30 | 2002-05-29 | Derivados do ácido 2-{[n-(2-amino-3-(heteroarila ou arila)propionil)-aminoacil]-amino}-alquilborÈnico |
Country Status (11)
Country | Link |
---|---|
US (2) | US6933290B2 (pt) |
EP (1) | EP1399468B1 (pt) |
JP (1) | JP4416501B2 (pt) |
CN (1) | CN100415770C (pt) |
AT (1) | ATE317850T1 (pt) |
BR (1) | BR0210112A (pt) |
CA (1) | CA2446282A1 (pt) |
DE (1) | DE60209227T2 (pt) |
ES (1) | ES2258149T3 (pt) |
PT (1) | PT1399468E (pt) |
WO (1) | WO2002096933A1 (pt) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT1399468E (pt) * | 2001-05-30 | 2006-05-31 | Novartis Ag | Derivados do acido 2-{[n-(2-amino-3-(heteroaril ou aril)propionil)-aminoacil]-amino}-alquilboronico |
US7524883B2 (en) | 2002-01-08 | 2009-04-28 | Eisai R&D Management Co., Ltd. | Eponemycin and epoxomicin analogs and uses thereof |
JP2006514110A (ja) * | 2002-11-11 | 2006-04-27 | バイエル・ヘルスケア・アクチェンゲゼルシャフト | Ip受容体アンタゴニストとしてのフェニルまたはヘテロアリールアミノアルカン誘導体 |
US7223745B2 (en) | 2003-08-14 | 2007-05-29 | Cephalon, Inc. | Proteasome inhibitors and methods of using the same |
US7576206B2 (en) | 2003-08-14 | 2009-08-18 | Cephalon, Inc. | Proteasome inhibitors and methods of using the same |
US7468383B2 (en) | 2005-02-11 | 2008-12-23 | Cephalon, Inc. | Proteasome inhibitors and methods of using the same |
JP5321061B2 (ja) | 2005-08-11 | 2013-10-23 | アリアド・ファーマシューティカルズ・インコーポレイテッド | 不飽和複素環誘導体 |
CN101360495B (zh) | 2005-11-14 | 2012-03-14 | 阿里亚德医药股份有限公司 | 对癌症病人给药mTOR抑制剂 |
MX2008008152A (es) | 2005-12-23 | 2008-09-12 | Ariad Pharma Inc | Compuestos heterociclicos biciclicos. |
WO2009020448A1 (en) | 2007-08-06 | 2009-02-12 | Millennium Pharmaceuticals, Inc. | Proteasome inhibitors |
DK2300013T3 (en) | 2008-05-21 | 2017-12-04 | Ariad Pharma Inc | PHOSPHORUS DERIVATIVES AS KINASE INHIBITORS |
MX349769B (es) | 2008-06-17 | 2017-08-11 | Millennium Pharm Inc | Compuestos de éster boronato y composiciones farmacéuticas de los mismos. |
AR075090A1 (es) | 2008-09-29 | 2011-03-09 | Millennium Pharm Inc | Derivados de acido 1-amino-2-ciclobutiletilboronico inhibidores de proteosoma,utiles como agentes anticancerigenos, y composiciones farmaceuticas que los comprenden. |
EP2365809B8 (en) | 2008-11-12 | 2018-10-10 | Ariad Pharmaceuticals, Inc. | Pyrazinopyrazines and derivatives as kinase inhibitors |
EP3021120A1 (en) | 2009-02-20 | 2016-05-18 | Michael P. Lisanti | Diagnosis, prognosis, therapeutics and methods for treating neoplastic deiseases comprising determining the level of caveolin-1 in a stromal cell sample |
CN102725300B (zh) | 2009-12-22 | 2015-03-11 | 赛福伦公司 | 蛋白酶体抑制剂及其制备、纯化、和应用的方法 |
US9359398B2 (en) * | 2010-03-01 | 2016-06-07 | Onyx Therapeutics, Inc. | Compounds for immunoproteasome inhibition |
CN102946879B (zh) | 2010-04-19 | 2015-04-22 | 尼基制药公司 | 一种蛋白酶体抑制剂和镓络合物在制备治疗增殖性疾病的药物中的应用 |
GB2523211B (en) | 2012-01-27 | 2020-03-18 | Univ Jefferson | MCT protein inhibitor-related prognostic and therapeutic methods |
CN103421032B (zh) * | 2012-05-17 | 2016-01-20 | 上海创诺制药有限公司 | 一种硼替佐米中间体及其制备方法和应用 |
US10022372B2 (en) | 2013-04-19 | 2018-07-17 | Thomas Jefferson University | Caveolin-1 related methods for treating glioblastoma with temozolomide |
JP2017524652A (ja) | 2014-05-20 | 2017-08-31 | ミレニアム ファーマシューティカルズ, インコーポレイテッドMillennium Pharmaceuticals, Inc. | 一次癌療法後に使用するためのホウ素含有プロテアソーム阻害剤 |
BR112016029662B1 (pt) | 2014-06-19 | 2023-10-24 | Takeda Pharmaceutical Company Limited | COMPOSTO DE FÓRMULA Bf OU UMA FORMA FARMACEUTICAMENTE ACEITÁVEL DO MESMO, COMPOSIÇÃO FARMACÊUTICA COMPREENDENDO O MESMO E SEU USO |
MA41505A (fr) | 2015-02-11 | 2017-12-19 | Millennium Pharm Inc | Nouvelle forme cristalline d'un inhibiteur de protéasome |
AU2017282651B2 (en) | 2016-06-21 | 2021-08-12 | Orion Ophthalmology LLC | Heterocyclic prolinamide derivatives |
EP3472151A4 (en) | 2016-06-21 | 2020-03-04 | Orion Ophthalmology LLC | CARBOCYCLIC PROLINAMIDE DERIVATIVES |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4499082A (en) | 1983-12-05 | 1985-02-12 | E. I. Du Pont De Nemours And Company | α-Aminoboronic acid peptides |
EP0315574A3 (de) | 1987-11-05 | 1990-08-22 | Hoechst Aktiengesellschaft | Renin-Inhibitoren |
US5106948A (en) * | 1988-05-27 | 1992-04-21 | Mao Foundation For Medical Education And Research | Cytotoxic boronic acid peptide analogs |
GB9017694D0 (en) | 1990-08-13 | 1990-09-26 | Sandoz Ltd | Improvements in or relating to organic chemistry |
US5384410A (en) | 1993-03-24 | 1995-01-24 | The Du Pont Merck Pharmaceutical Company | Removal of boronic acid protecting groups by transesterification |
IL109319A0 (en) | 1993-04-27 | 1994-07-31 | Du Pont Merck Pharma | Amidino and guanidino substituted boronic acid compounds |
US5658885A (en) | 1993-04-27 | 1997-08-19 | The Dupont Merck Pharmaceutical Company | Amidino and guanidino substituted boronic acid inhibitors of trypsin-like enzymes |
FR2721611B1 (fr) * | 1994-06-22 | 1996-09-27 | Adir | Nouveaux dérivés peptidiques de l'acide boronique, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent . |
US6083903A (en) | 1994-10-28 | 2000-07-04 | Leukosite, Inc. | Boronic ester and acid compounds, synthesis and uses |
US5550262A (en) | 1994-11-14 | 1996-08-27 | Cephalon, Inc. | Multicatalytic protease inhibitors |
US5614649A (en) | 1994-11-14 | 1997-03-25 | Cephalon, Inc. | Multicatalytic protease inhibitors |
AU735685B2 (en) | 1997-12-16 | 2001-07-12 | Cephalon, Inc. | Multicatalytic protease inhibitors for use as anti-tumor agents |
PT1399468E (pt) * | 2001-05-30 | 2006-05-31 | Novartis Ag | Derivados do acido 2-{[n-(2-amino-3-(heteroaril ou aril)propionil)-aminoacil]-amino}-alquilboronico |
-
2002
- 2002-05-29 PT PT02743128T patent/PT1399468E/pt unknown
- 2002-05-29 CA CA002446282A patent/CA2446282A1/en not_active Abandoned
- 2002-05-29 BR BR0210112-2A patent/BR0210112A/pt not_active IP Right Cessation
- 2002-05-29 US US10/478,794 patent/US6933290B2/en not_active Expired - Fee Related
- 2002-05-29 CN CNB028108132A patent/CN100415770C/zh not_active Expired - Fee Related
- 2002-05-29 WO PCT/EP2002/005937 patent/WO2002096933A1/en active IP Right Grant
- 2002-05-29 AT AT02743128T patent/ATE317850T1/de not_active IP Right Cessation
- 2002-05-29 ES ES02743128T patent/ES2258149T3/es not_active Expired - Lifetime
- 2002-05-29 EP EP02743128A patent/EP1399468B1/en not_active Expired - Lifetime
- 2002-05-29 JP JP2003500112A patent/JP4416501B2/ja not_active Expired - Fee Related
- 2002-05-29 DE DE60209227T patent/DE60209227T2/de not_active Expired - Fee Related
-
2005
- 2005-06-30 US US11/172,146 patent/US20050239716A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CA2446282A1 (en) | 2002-12-05 |
CN100415770C (zh) | 2008-09-03 |
US20050239716A1 (en) | 2005-10-27 |
US20040167337A1 (en) | 2004-08-26 |
WO2002096933A1 (en) | 2002-12-05 |
DE60209227D1 (de) | 2006-04-20 |
JP2005501005A (ja) | 2005-01-13 |
US6933290B2 (en) | 2005-08-23 |
CN1512999A (zh) | 2004-07-14 |
EP1399468B1 (en) | 2006-02-15 |
DE60209227T2 (de) | 2006-08-17 |
EP1399468A1 (en) | 2004-03-24 |
PT1399468E (pt) | 2006-05-31 |
JP4416501B2 (ja) | 2010-02-17 |
ES2258149T3 (es) | 2006-08-16 |
ATE317850T1 (de) | 2006-03-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 9A ANUIDADE(S). |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2108 DE 31/05/2011. |