BR0210112A - Derivados do ácido 2-{[n-(2-amino-3-(heteroarila ou arila)propionil)-aminoacil]-amino}-alquilborÈnico - Google Patents

Derivados do ácido 2-{[n-(2-amino-3-(heteroarila ou arila)propionil)-aminoacil]-amino}-alquilborÈnico

Info

Publication number
BR0210112A
BR0210112A BR0210112-2A BR0210112A BR0210112A BR 0210112 A BR0210112 A BR 0210112A BR 0210112 A BR0210112 A BR 0210112A BR 0210112 A BR0210112 A BR 0210112A
Authority
BR
Brazil
Prior art keywords
amino
aminoacyl
propionyl
heteroaryl
aryl
Prior art date
Application number
BR0210112-2A
Other languages
English (en)
Inventor
Pascal Furet
Vito Guagnano
Patricia Imbach
Marc Lang
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0113096A external-priority patent/GB0113096D0/en
Priority claimed from GB0129394A external-priority patent/GB0129394D0/en
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BR0210112A publication Critical patent/BR0210112A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

"DERIVADOS DO áCIDO 2-{[N-(2-AMINO-3-(HETERO-ARILA OU ARILA)PROPIONIL)-AMINOACIL]-AMINO}-ALQUILBORÈNICO". A presente invenção refere-se a compostos de fórmula I em que os substituintes são conforme definidos na descrição, a processos para a preparação dos mesmos, a preparações farmacêuticas compreendendo aqueles compostos e ao uso dos mesmos na preparação de composições farmacêuticas, para o tratamento terapêutico de animais de sangue quente, inclusive seres humanos.
BR0210112-2A 2001-05-30 2002-05-29 Derivados do ácido 2-{[n-(2-amino-3-(heteroarila ou arila)propionil)-aminoacil]-amino}-alquilborÈnico BR0210112A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0113096A GB0113096D0 (en) 2001-05-30 2001-05-30 Organic compounds
GB0129394A GB0129394D0 (en) 2001-12-07 2001-12-07 Organic compounds
PCT/EP2002/005937 WO2002096933A1 (en) 2001-05-30 2002-05-29 2-{[n-(2-amino-3-(heteroaryl or aryl)propionyl)-aminoacyl]-amino}-alkylboronic acid derivatives

Publications (1)

Publication Number Publication Date
BR0210112A true BR0210112A (pt) 2004-06-08

Family

ID=26246132

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0210112-2A BR0210112A (pt) 2001-05-30 2002-05-29 Derivados do ácido 2-{[n-(2-amino-3-(heteroarila ou arila)propionil)-aminoacil]-amino}-alquilborÈnico

Country Status (11)

Country Link
US (2) US6933290B2 (pt)
EP (1) EP1399468B1 (pt)
JP (1) JP4416501B2 (pt)
CN (1) CN100415770C (pt)
AT (1) ATE317850T1 (pt)
BR (1) BR0210112A (pt)
CA (1) CA2446282A1 (pt)
DE (1) DE60209227T2 (pt)
ES (1) ES2258149T3 (pt)
PT (1) PT1399468E (pt)
WO (1) WO2002096933A1 (pt)

Families Citing this family (26)

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CN100415770C (zh) * 2001-05-30 2008-09-03 诺瓦提斯公司 2－{[n－(2－氨基－3－(杂芳基或芳基)丙酰基)－氨基酰基]－氨基}－烷基硼酸衍生物
US7524883B2 (en) 2002-01-08 2009-04-28 Eisai R&D Management Co., Ltd. Eponemycin and epoxomicin analogs and uses thereof
AU2003276201A1 (en) * 2002-11-11 2004-06-03 Bayer Healthcare Ag Phenyl or heteroaryl amino alkane derivatives as ip receptor antagonist
US7223745B2 (en) 2003-08-14 2007-05-29 Cephalon, Inc. Proteasome inhibitors and methods of using the same
US7576206B2 (en) 2003-08-14 2009-08-18 Cephalon, Inc. Proteasome inhibitors and methods of using the same
US7468383B2 (en) 2005-02-11 2008-12-23 Cephalon, Inc. Proteasome inhibitors and methods of using the same
WO2007021937A2 (en) 2005-08-11 2007-02-22 Ariad Pharmaceuticals, Inc. Unsaturated heterocyclic derivatives
JP5709354B2 (ja) 2005-11-14 2015-04-30 アリアド・ファーマシューティカルズ・インコーポレイテッド ｍＴＯＲ阻害剤投与によるがん患者の治療
PL2495016T3 (pl) 2005-12-23 2020-06-01 Ariad Pharmaceuticals, Inc. Bicykliczne związki heteroarylowe
PT2178888E (pt) 2007-08-06 2012-10-04 Millennium Pharm Inc Inibidores do proteassoma
MX2010012703A (es) 2008-05-21 2010-12-21 Ariad Pharma Inc Derivados fosforosos como inhibidores de cinasa.
CN103450241A (zh) 2008-06-17 2013-12-18 米伦纽姆医药公司 硼酸酯化合物及其医药组合物
AR075090A1 (es) 2008-09-29 2011-03-09 Millennium Pharm Inc Derivados de acido 1-amino-2-ciclobutiletilboronico inhibidores de proteosoma,utiles como agentes anticancerigenos, y composiciones farmaceuticas que los comprenden.
WO2010056311A1 (en) 2008-11-12 2010-05-20 Ariad Pharmaceuticals, Inc. Pyrazinopyrazines and derivatives as kinase inhibitors
EP2399129B1 (en) 2009-02-20 2015-11-25 Michael P. Lisanti A method of diagnosis or prognosis of a neoplasm comprising determining the level of expression of a protein in stromal cells adjacent to the neoplasm
EP2516449A1 (en) 2009-12-22 2012-10-31 Cephalon, Inc. Proteasome inhibitors and processes for their preparation, purification and use
US9359398B2 (en) * 2010-03-01 2016-06-07 Onyx Therapeutics, Inc. Compounds for immunoproteasome inhibition
EP2560647B1 (en) 2010-04-19 2016-04-13 Niiki Pharma Inc. Combination therapy with a proteasome inhibitor and a gallium complex
WO2013112881A1 (en) 2012-01-27 2013-08-01 Thomas Jefferson University Mct protein inhibitor-related prognostic and therapeutic methods
CN103421032B (zh) * 2012-05-17 2016-01-20 上海创诺制药有限公司 一种硼替佐米中间体及其制备方法和应用
EP2986290A4 (en) 2013-04-19 2017-01-04 Thomas Jefferson University Caveolin-1 related methods for treating glioblastoma with temozolomide
UY36132A (es) 2014-05-20 2015-11-30 Millennium Pharm Inc Métodos para terapia de cáncer
MA40240B1 (fr) 2014-06-19 2019-03-29 Ariad Pharma Inc Composés hétéroaryle d'inhibition de la kinase
MA41505A (fr) 2015-02-11 2017-12-19 Millennium Pharm Inc Nouvelle forme cristalline d'un inhibiteur de protéasome
EP4257191A3 (en) 2016-06-21 2023-11-22 Orion Ophthalmology LLC Heterocyclic prolinamide derivatives
JP7164521B2 (ja) 2016-06-21 2022-11-01 オリオン・オフサルモロジー・エルエルシー 炭素環式プロリンアミド誘導体

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4499082A (en) 1983-12-05 1985-02-12 E. I. Du Pont De Nemours And Company α-Aminoboronic acid peptides
EP0315574A3 (de) 1987-11-05 1990-08-22 Hoechst Aktiengesellschaft Renin-Inhibitoren
US5106948A (en) * 1988-05-27 1992-04-21 Mao Foundation For Medical Education And Research Cytotoxic boronic acid peptide analogs
GB9017694D0 (en) 1990-08-13 1990-09-26 Sandoz Ltd Improvements in or relating to organic chemistry
US5384410A (en) 1993-03-24 1995-01-24 The Du Pont Merck Pharmaceutical Company Removal of boronic acid protecting groups by transesterification
US5658885A (en) 1993-04-27 1997-08-19 The Dupont Merck Pharmaceutical Company Amidino and guanidino substituted boronic acid inhibitors of trypsin-like enzymes
IL109319A0 (en) 1993-04-27 1994-07-31 Du Pont Merck Pharma Amidino and guanidino substituted boronic acid compounds
FR2721611B1 (fr) * 1994-06-22 1996-09-27 Adir Nouveaux dérivés peptidiques de l'acide boronique, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent .
US6083903A (en) 1994-10-28 2000-07-04 Leukosite, Inc. Boronic ester and acid compounds, synthesis and uses
US5550262A (en) 1994-11-14 1996-08-27 Cephalon, Inc. Multicatalytic protease inhibitors
US5614649A (en) 1994-11-14 1997-03-25 Cephalon, Inc. Multicatalytic protease inhibitors
KR20010033150A (ko) 1997-12-16 2001-04-25 세파론, 인코포레이티드 항종양제용 다촉매 프로테아제 억제제
CN100415770C (zh) * 2001-05-30 2008-09-03 诺瓦提斯公司 2－{[n－(2－氨基－3－(杂芳基或芳基)丙酰基)－氨基酰基]－氨基}－烷基硼酸衍生物

Also Published As

Publication number Publication date
JP4416501B2 (ja) 2010-02-17
CN1512999A (zh) 2004-07-14
ES2258149T3 (es) 2006-08-16
EP1399468B1 (en) 2006-02-15
CN100415770C (zh) 2008-09-03
ATE317850T1 (de) 2006-03-15
US20040167337A1 (en) 2004-08-26
JP2005501005A (ja) 2005-01-13
CA2446282A1 (en) 2002-12-05
DE60209227T2 (de) 2006-08-17
EP1399468A1 (en) 2004-03-24
DE60209227D1 (de) 2006-04-20
WO2002096933A1 (en) 2002-12-05
PT1399468E (pt) 2006-05-31
US20050239716A1 (en) 2005-10-27
US6933290B2 (en) 2005-08-23

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Legal Events

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 9A ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2108 DE 31/05/2011.