NO20080970L - Glykopegylert faktor VII og faktor VIIA - Google Patents
Glykopegylert faktor VII og faktor VIIAInfo
- Publication number
- NO20080970L NO20080970L NO20080970A NO20080970A NO20080970L NO 20080970 L NO20080970 L NO 20080970L NO 20080970 A NO20080970 A NO 20080970A NO 20080970 A NO20080970 A NO 20080970A NO 20080970 L NO20080970 L NO 20080970L
- Authority
- NO
- Norway
- Prior art keywords
- conjugates
- factor
- peptide
- glycopegylated
- glycosyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
Abstract
Foreliggende oppfinnelse tilveiebringer konjugater mellom Faktor VII- eller Faktor VIIa-peptider og PEG-grupper. Konjugatene er bundet via en intakt glykosylbindende gruppe som er innskutt mellom, og kovalent bundet til, peptidet og den modifiserende gruppe. Konjugatene blir dannet av både glykosylerte og ikke-glykosylerte peptider ved innvirkning av en glykosyltransferase. Glykosyltransferasen ligerer en modifisert sukkergruppe på enten en aminosyre- eller glykosylrest på peptidet. Det er også tilveiebrakt farmasøytiske formuleringer innbefattende konjugatene. Metoder for fremstilling av konjugatene er også innenfor oppfinnelsens omfang.
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US70998305P | 2005-08-19 | 2005-08-19 | |
US72589405P | 2005-10-11 | 2005-10-11 | |
US73060705P | 2005-10-26 | 2005-10-26 | |
US73364905P | 2005-11-04 | 2005-11-04 | |
US75644306P | 2006-01-05 | 2006-01-05 | |
US74686806P | 2006-05-09 | 2006-05-09 | |
PCT/US2006/032649 WO2007022512A2 (en) | 2005-08-19 | 2006-08-21 | Glycopegylated factor vii and factor viia |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20080970L true NO20080970L (no) | 2008-05-19 |
Family
ID=37758493
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20080970A NO20080970L (no) | 2005-08-19 | 2008-02-26 | Glykopegylert faktor VII og faktor VIIA |
Country Status (12)
Country | Link |
---|---|
US (2) | US20090305967A1 (no) |
EP (1) | EP1937719A4 (no) |
JP (1) | JP2009515508A (no) |
KR (1) | KR20080080081A (no) |
CN (1) | CN102719508A (no) |
AU (1) | AU2006280932A1 (no) |
BR (1) | BRPI0614839A2 (no) |
CA (1) | CA2619969A1 (no) |
IL (1) | IL189586A0 (no) |
MX (1) | MX2008002395A (no) |
NO (1) | NO20080970L (no) |
WO (1) | WO2007022512A2 (no) |
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-
2006
- 2006-08-21 AU AU2006280932A patent/AU2006280932A1/en not_active Withdrawn
- 2006-08-21 BR BRPI0614839-5A patent/BRPI0614839A2/pt not_active Application Discontinuation
- 2006-08-21 CN CN2012102432833A patent/CN102719508A/zh not_active Withdrawn
- 2006-08-21 CA CA002619969A patent/CA2619969A1/en not_active Abandoned
- 2006-08-21 KR KR1020087006691A patent/KR20080080081A/ko not_active Application Discontinuation
- 2006-08-21 WO PCT/US2006/032649 patent/WO2007022512A2/en active Application Filing
- 2006-08-21 US US12/064,012 patent/US20090305967A1/en not_active Abandoned
- 2006-08-21 JP JP2008527212A patent/JP2009515508A/ja active Pending
- 2006-08-21 MX MX2008002395A patent/MX2008002395A/es unknown
- 2006-08-21 EP EP06802028A patent/EP1937719A4/en not_active Withdrawn
-
2008
- 2008-02-18 IL IL189586A patent/IL189586A0/en unknown
- 2008-02-26 NO NO20080970A patent/NO20080970L/no unknown
-
2009
- 2009-10-23 US US12/605,041 patent/US20100113743A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
KR20080080081A (ko) | 2008-09-02 |
BRPI0614839A2 (pt) | 2009-05-19 |
US20090305967A1 (en) | 2009-12-10 |
EP1937719A4 (en) | 2010-11-24 |
AU2006280932A1 (en) | 2007-02-22 |
CA2619969A1 (en) | 2007-02-22 |
IL189586A0 (en) | 2008-08-07 |
WO2007022512A2 (en) | 2007-02-22 |
JP2009515508A (ja) | 2009-04-16 |
WO2007022512A3 (en) | 2007-10-04 |
US20100113743A1 (en) | 2010-05-06 |
EP1937719A2 (en) | 2008-07-02 |
MX2008002395A (es) | 2008-03-18 |
CN102719508A (zh) | 2012-10-10 |
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