UA91575C2 - Дендример-пег с четырьмя ветвями для коньюгирования с белками и пептидами - Google Patents
Дендример-пег с четырьмя ветвями для коньюгирования с белками и пептидамиInfo
- Publication number
- UA91575C2 UA91575C2 UAA200808587A UAA200808587A UA91575C2 UA 91575 C2 UA91575 C2 UA 91575C2 UA A200808587 A UAA200808587 A UA A200808587A UA A200808587 A UAA200808587 A UA A200808587A UA 91575 C2 UA91575 C2 UA 91575C2
- Authority
- UA
- Ukraine
- Prior art keywords
- conjugation
- peptides
- peg
- proteins
- dendrimer
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/26—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/321—Polymers modified by chemical after-treatment with inorganic compounds
- C08G65/325—Polymers modified by chemical after-treatment with inorganic compounds containing nitrogen
Abstract
Полимерная дендримероподобная структура с четырьмя ветвями из монометоксиполиэтиленгликоля, которая может быть представлена как:.Карбоксильную группу предыдущей структуры можно функционально активировать для получения коньюгатов, которые представляют интерес в фармацевтике.Связывание этого дендримероподобного полиэтиленгликоля с терапевтическими белками улучшает их стабильность in vitro и in vivo.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CU20050241A CU23556A1 (es) | 2005-11-30 | 2005-11-30 | Estructura polimérica semejante a dendrímero para la obtención de conjugados de interés farmacéutico |
Publications (1)
Publication Number | Publication Date |
---|---|
UA91575C2 true UA91575C2 (ru) | 2010-08-10 |
Family
ID=37672068
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA200808587A UA91575C2 (ru) | 2005-11-30 | 2006-11-20 | Дендример-пег с четырьмя ветвями для коньюгирования с белками и пептидами |
Country Status (17)
Country | Link |
---|---|
US (1) | US8703893B2 (ru) |
EP (1) | EP1967212B1 (ru) |
JP (1) | JP5123201B2 (ru) |
KR (1) | KR101134983B1 (ru) |
CN (2) | CN101389354A (ru) |
AR (1) | AR058841A1 (ru) |
AU (1) | AU2006319636B2 (ru) |
BR (1) | BRPI0604313A (ru) |
CA (1) | CA2631335C (ru) |
CU (1) | CU23556A1 (ru) |
EG (1) | EG26619A (ru) |
MY (1) | MY150739A (ru) |
RU (1) | RU2409389C2 (ru) |
UA (1) | UA91575C2 (ru) |
UY (1) | UY29981A1 (ru) |
WO (1) | WO2007062610A2 (ru) |
ZA (1) | ZA200804694B (ru) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104524596B (zh) * | 2006-01-20 | 2018-10-09 | 星药股份有限公司 | 经修饰的大分子 |
WO2009151687A2 (en) * | 2008-03-12 | 2009-12-17 | The Regents Of The University Of Michigan | Dendrimer conjugates |
US8889635B2 (en) * | 2008-09-30 | 2014-11-18 | The Regents Of The University Of Michigan | Dendrimer conjugates |
WO2010054321A2 (en) | 2008-11-07 | 2010-05-14 | The Regents Of The University Of Michigan | Methods of treating autoimmune disorders and/or inflammatory disorders |
US20100158850A1 (en) * | 2008-12-23 | 2010-06-24 | The Regents Of The University Of Michigan | Dendrimer based modular platforms |
US8945508B2 (en) | 2009-10-13 | 2015-02-03 | The Regents Of The University Of Michigan | Dendrimer compositions and methods of synthesis |
WO2011059586A2 (en) | 2009-10-30 | 2011-05-19 | The Regents Of The University Of Michigan | Multifunctional small molecules |
WO2013085718A1 (en) | 2011-12-08 | 2013-06-13 | The Regents Of The University Of Michigan | Multifunctional small molecules |
CN107652438B (zh) | 2011-12-21 | 2021-10-12 | 加利福尼亚大学董事会 | 药物递送增强的末端树枝状聚合物 |
US9642916B2 (en) | 2012-12-12 | 2017-05-09 | The Regents Of The University Of California | Porphyrin modified telodendrimers |
RU2677796C9 (ru) * | 2013-03-05 | 2019-03-15 | Ханми Фарм. Ко., Лтд. | Улучшенный способ получения конъюгата физиологически активного полипептида с высоким выходом |
EP2786766A1 (en) * | 2013-04-05 | 2014-10-08 | Ufpeptides S.r.l. | Supramolecular aggregates comprising maleimido cores |
WO2014207769A1 (en) | 2013-06-27 | 2014-12-31 | Mylan Laboratories Ltd | Process for the preparation of nepafenac |
CU20140003A7 (es) * | 2014-01-08 | 2015-08-27 | Ct De Inmunología Molecular Biofarmacuba | Conjugado que comprende eritropoyetina y una estructura polimérica ramificada |
ES2824028T3 (es) | 2014-08-19 | 2021-05-11 | Biogen Ma Inc | Método de PEGilación |
RU2018100425A (ru) * | 2015-06-11 | 2019-07-15 | АмБио Фармасьютикалс, ЭлЭлСи | Пегилированный гранулоцитарный колониестимулирующий фактор (гксф) |
EP3385383B1 (en) | 2015-12-04 | 2021-04-07 | Zenyaku Kogyo Co., Ltd. | Anti-il-17 aptamer having improved retention in blood |
US11389510B2 (en) | 2016-01-08 | 2022-07-19 | Ascendis Pharma Growth Disorders A/S | Controlled-release CNP agonists with low initial NPR-B activity |
AU2017205690B2 (en) | 2016-01-08 | 2022-04-28 | Ascendis Pharma Growth Disorders A/S | Controlled-release CNP agonists with increased NEP stability |
IL259658B1 (en) | 2016-01-08 | 2024-02-01 | Ascendis Pharma Growth Disorders As | Controlled-release CNP agonists with reduced side effects |
PL3400019T3 (pl) | 2016-01-08 | 2023-01-23 | Ascendis Pharma Growth Disorders A/S | Proleki cnp z przyłączeniem nośnika w ugrupowaniu pierścieniowy |
WO2017118693A1 (en) | 2016-01-08 | 2017-07-13 | Ascendis Pharma Growth Disorders A/S | Cnp prodrugs with large carrier moieties |
KR102518217B1 (ko) | 2016-01-08 | 2023-04-04 | 아센디스 파마 그로우쓰 디스오더스 에이/에스 | 낮은 npr-c 결합을 갖는 제어 방출성 cnp 작용제 |
CN110392583B (zh) | 2016-09-15 | 2023-01-03 | 加利福尼亚大学董事会 | 改进的杂化的末端树枝状聚合物 |
EP4223309A1 (en) | 2016-09-29 | 2023-08-09 | Ascendis Pharma Growth Disorders A/S | Combination therapy with controlled-release cnp agonists |
CN109134282B (zh) * | 2017-06-28 | 2021-03-16 | 北京键凯科技股份有限公司 | 一种树状多缩乙二醇衍生物及其制备方法和应用 |
WO2019001473A1 (zh) * | 2017-06-28 | 2019-01-03 | 北京键凯科技股份有限公司 | 一种树状多缩乙二醇衍生物及其制备方法和应用 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4732863A (en) | 1984-12-31 | 1988-03-22 | University Of New Mexico | PEG-modified antibody with reduced affinity for cell surface Fc receptors |
US5951974A (en) * | 1993-11-10 | 1999-09-14 | Enzon, Inc. | Interferon polymer conjugates |
US5932462A (en) | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
US5985263A (en) * | 1997-12-19 | 1999-11-16 | Enzon, Inc. | Substantially pure histidine-linked protein polymer conjugates |
ATE421535T1 (de) | 2000-10-16 | 2009-02-15 | Chugai Pharmaceutical Co Ltd | Peg-modifiziertes erythropoietin |
JP4758608B2 (ja) * | 2001-11-07 | 2011-08-31 | ネクター セラピューティックス | 分枝ポリマーおよびそれらの結合体 |
US7144978B2 (en) * | 2002-01-15 | 2006-12-05 | Pan Asia Bio Co., Ltd. | Multidrop tree branching functional polyethylene glycol, methods of preparing and using same |
CN1176137C (zh) * | 2002-01-15 | 2004-11-17 | 泛亚生物技术有限公司 | 多臂树杈型功能化聚乙二醇制备方法及它在药物中的应用 |
CN1569892A (zh) * | 2004-04-30 | 2005-01-26 | 新峰生物科技(上海)有限公司 | 多臂树杈型聚乙二醇与蛋白质或多肽的结合物及其制备方法 |
ITMI20020951A1 (it) | 2002-05-06 | 2003-11-06 | Univ Degli Studi Trieste | Derivati multifunzionali del polietilenglicole loro preparazione ed impiego |
NZ541374A (en) * | 2003-05-23 | 2008-09-26 | Nektar Therapeutics Al Corp | PEG derivatives having an amidocarbonate linkage |
EP1654004A2 (en) * | 2003-08-08 | 2006-05-10 | Novo Nordisk A/S | Synthesis and application of new structural well defined branched polymers as conjugating agents for peptides |
CA2552892C (en) * | 2004-01-08 | 2014-08-05 | Neose Technologies, Inc. | O-linked glycosylation of peptides |
JP2008506704A (ja) | 2004-07-16 | 2008-03-06 | ネクター セラピューティクス アラバマ,コーポレイション | Gm−csf成分およびポリマーの複合体 |
US7714114B2 (en) | 2005-02-16 | 2010-05-11 | Nektar Therapeutics | Conjugates of an EPO moiety and a polymer |
KR20070108180A (ko) * | 2005-02-16 | 2007-11-08 | 노보 노르디스크 에이/에스 | 구조적으로 잘 정의된 분지형 중합체와 콘쥬게이트된인슐린분비제 유도체 |
-
2005
- 2005-11-30 CU CU20050241A patent/CU23556A1/es active IP Right Grant
-
2006
- 2006-10-19 BR BRPI0604313-5A patent/BRPI0604313A/pt not_active Application Discontinuation
- 2006-11-20 AU AU2006319636A patent/AU2006319636B2/en not_active Ceased
- 2006-11-20 CN CNA2006800491651A patent/CN101389354A/zh active Pending
- 2006-11-20 CA CA2631335A patent/CA2631335C/en not_active Expired - Fee Related
- 2006-11-20 UA UAA200808587A patent/UA91575C2/ru unknown
- 2006-11-20 MY MYPI20081872 patent/MY150739A/en unknown
- 2006-11-20 US US12/095,335 patent/US8703893B2/en not_active Expired - Fee Related
- 2006-11-20 CN CN201510340715.6A patent/CN104906594B/zh not_active Expired - Fee Related
- 2006-11-20 EP EP06817995.1A patent/EP1967212B1/en active Active
- 2006-11-20 JP JP2008542584A patent/JP5123201B2/ja not_active Expired - Fee Related
- 2006-11-20 KR KR1020087015901A patent/KR101134983B1/ko active IP Right Grant
- 2006-11-20 WO PCT/CU2006/000014 patent/WO2007062610A2/es active Search and Examination
- 2006-11-20 RU RU2008126209/05A patent/RU2409389C2/ru not_active IP Right Cessation
- 2006-11-28 AR ARP060105233A patent/AR058841A1/es not_active Application Discontinuation
- 2006-11-30 UY UY29981A patent/UY29981A1/es not_active Application Discontinuation
-
2008
- 2008-05-29 ZA ZA200804694A patent/ZA200804694B/xx unknown
- 2008-06-01 EG EG2008060905A patent/EG26619A/en active
Also Published As
Publication number | Publication date |
---|---|
AU2006319636A1 (en) | 2007-06-07 |
WO2007062610A2 (es) | 2007-06-07 |
RU2008126209A (ru) | 2010-01-10 |
CN104906594B (zh) | 2016-12-28 |
EP1967212B1 (en) | 2016-09-21 |
BRPI0604313A (pt) | 2007-01-30 |
WO2007062610A3 (es) | 2007-09-20 |
CA2631335A1 (en) | 2007-06-07 |
JP5123201B2 (ja) | 2013-01-23 |
AR058841A1 (es) | 2008-02-27 |
US20090082537A1 (en) | 2009-03-26 |
MY150739A (en) | 2014-02-28 |
CA2631335C (en) | 2013-07-16 |
UY29981A1 (es) | 2007-06-29 |
EP1967212A2 (en) | 2008-09-10 |
US8703893B2 (en) | 2014-04-22 |
CN101389354A (zh) | 2009-03-18 |
KR101134983B1 (ko) | 2012-04-09 |
AU2006319636B2 (en) | 2012-10-18 |
EG26619A (en) | 2014-04-08 |
CU23556A1 (es) | 2010-07-20 |
KR20080072960A (ko) | 2008-08-07 |
ZA200804694B (en) | 2009-03-25 |
CN104906594A (zh) | 2015-09-16 |
JP2009517414A (ja) | 2009-04-30 |
RU2409389C2 (ru) | 2011-01-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
UA91575C2 (ru) | Дендример-пег с четырьмя ветвями для коньюгирования с белками и пептидами | |
WO2007100902A3 (en) | Acryloyloxyethylphosphorylcholine containing polymer conjugates and their preparation | |
EP3406347A3 (en) | Xten conjugate compositions and methods of making same | |
MX2020006187A (es) | Conjugados polimericos del factor viii. | |
WO2006017619A3 (en) | Receptor-binding cyclic peptides and methods of use | |
WO2008073162A3 (en) | Lysine acetylation sites | |
WO2008103693A3 (en) | Chemical linkers with single amino acids and conjugates thereof | |
WO2010033220A3 (en) | Modified therapeutics peptides, methods of their preparation and use | |
WO2006127896A3 (en) | Glycopegylated factor ix | |
NZ589086A (en) | Human serum albumin (HSA) linkers and conjugates thereof | |
WO2010069532A8 (en) | Antibodies against human angiopoietin 2 | |
EP3831380A3 (en) | Psma binding ligand-linker conjugates and methods for using | |
WO2006012527A8 (en) | Bivalent linkers and conjugates thereof | |
WO2010065709A3 (en) | Hydroxamic acid derivatives, preparation and therapeutic uses thereof | |
DK1180121T3 (da) | Langtidsvirkende insulinotrope peptider | |
WO2006096207A3 (en) | Methods for preparing multivalent constructs for therapeutic and diagnostic applications | |
WO2007047834A3 (en) | Oral peptide conjugates for metabolic diseases | |
WO2007102149A3 (en) | Hydrazido derivatives of hyaluronic acid | |
WO2008079973A3 (en) | Egfr binding peptides and uses thereof | |
HK1118011A1 (zh) | 透明質酸的抗腫瘤生物結合物或以化學接合方法間接地取得的衍生物,以及其製藥用途 | |
GB0718957D0 (en) | Optical imaging agents | |
EP3381445A3 (en) | Aqueous formulation of antibody stablised by antioxidants for parenteral administration | |
WO2010023670A3 (en) | Methods for covalently attaching a polymer to a methionine residue in proteins and peptides | |
WO2006050930A3 (en) | Conjugates with enhanced cell uptake activity | |
MX2009006410A (es) | Conjugados de polimero-oligonucleotido, proteina y/o peptido. |