ATE421535T1 - Peg-modifiziertes erythropoietin - Google Patents
Peg-modifiziertes erythropoietinInfo
- Publication number
- ATE421535T1 ATE421535T1 AT01970285T AT01970285T ATE421535T1 AT E421535 T1 ATE421535 T1 AT E421535T1 AT 01970285 T AT01970285 T AT 01970285T AT 01970285 T AT01970285 T AT 01970285T AT E421535 T1 ATE421535 T1 AT E421535T1
- Authority
- AT
- Austria
- Prior art keywords
- peg
- epo
- conjugated
- native
- erythropoietin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/505—Erythropoietin [EPO]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1816—Erythropoietin [EPO]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2000315421 | 2000-10-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE421535T1 true ATE421535T1 (de) | 2009-02-15 |
Family
ID=18794529
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT01970285T ATE421535T1 (de) | 2000-10-16 | 2001-09-28 | Peg-modifiziertes erythropoietin |
Country Status (8)
Country | Link |
---|---|
US (2) | US20040082765A1 (de) |
EP (1) | EP1333036B1 (de) |
JP (1) | JP5170931B2 (de) |
AT (1) | ATE421535T1 (de) |
AU (1) | AU2001290312A1 (de) |
DE (1) | DE60137525D1 (de) |
ES (1) | ES2320101T3 (de) |
WO (1) | WO2002032957A1 (de) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EA008866B1 (ru) * | 2002-12-26 | 2007-08-31 | Маунтин Вью Фамэсьютикэлс, Инк. | ПОЛИМЕРНЫЙ КОНЪЮГАТ МОДИФИКАЦИЙ ИНТЕРФЕРОНА-β, ФАРМАЦЕВТИЧЕСКИЕ ПРОДУКТЫ НА ЕГО ОСНОВЕ И СПОСОБ ИХ ПОЛУЧЕНИЯ |
US7655618B2 (en) | 2002-12-27 | 2010-02-02 | Diobex, Inc. | Compositions and methods for the prevention and control of insulin-induced hypoglycemia |
CA2509755A1 (en) | 2002-12-27 | 2004-07-22 | Diobex, Inc. | Compositions and methods for the prevention and control of insulin-induced hypoglycemia |
CA2458085A1 (en) | 2003-03-21 | 2004-09-21 | F. Hoffmann-La Roche Ag | Transcriptional activity assay |
EP1471153A3 (de) * | 2003-03-21 | 2005-06-15 | F. Hoffmann-La Roche Ag | Transkriptionsaktivitätsassay |
KR20060032140A (ko) * | 2003-05-30 | 2006-04-14 | 센토코 인코포레이티드 | 트랜스글루타미나아제를 이용한 신규 에리트로포이에틴접합체의 형성 |
WO2005058366A2 (en) * | 2003-12-10 | 2005-06-30 | Nektar Therapeutics Al, Corporation | Compositions comprising two different populations of polymer-active agent conjugates |
DK1699915T3 (da) * | 2003-12-30 | 2010-09-13 | Augustinus Bader | Anvendelse af erythropoietin til levervævsregenerering |
EP1848461A2 (de) * | 2005-02-16 | 2007-10-31 | Nektar Therapeutics Al, Corporation | Konjugate einer epo-gruppierung und eines polymers |
CA2611836A1 (en) * | 2005-06-13 | 2006-12-21 | Nastech Pharmaceutical Company Inc. | Transmucosal delivery of peptide derivatives |
IL169377A (en) | 2005-06-23 | 2012-09-24 | Avigdor Shafferman | Uniformly conjugated serine hydrolases |
WO2007026772A1 (ja) * | 2005-08-31 | 2007-03-08 | Kaneka Corporation | ネコ由来タンパク質のコード配列を含む外来性遺伝子を含むトランスジェニック鳥類およびその作製法 |
US20080171696A1 (en) * | 2005-10-21 | 2008-07-17 | Avigenics, Inc. | Pharmacodynamically enhanced therapeutic proteins |
CU23556A1 (es) * | 2005-11-30 | 2010-07-20 | Ct Ingenieria Genetica Biotech | Estructura polimérica semejante a dendrímero para la obtención de conjugados de interés farmacéutico |
US7982010B2 (en) | 2006-03-31 | 2011-07-19 | Baxter International Inc. | Factor VIII polymer conjugates |
US7985839B2 (en) | 2006-03-31 | 2011-07-26 | Baxter International Inc. | Factor VIII polymer conjugates |
US7645860B2 (en) | 2006-03-31 | 2010-01-12 | Baxter Healthcare S.A. | Factor VIII polymer conjugates |
JP2009532351A (ja) | 2006-03-31 | 2009-09-10 | バクスター・インターナショナル・インコーポレイテッド | ペグ化第viii因子 |
CN101511391B (zh) * | 2006-07-25 | 2013-03-13 | 利普生技术有限公司 | N末端聚唾液酸化 |
GB0615067D0 (en) * | 2006-07-28 | 2006-09-06 | Ttp Communications Ltd | Reconfigurable signal processing scheme |
JP5723528B2 (ja) * | 2006-08-04 | 2015-05-27 | プロロング ファーマシューティカルズ エルエルシー | 修飾されたエリスロポエチン |
PT2101821E (pt) | 2006-12-15 | 2014-10-03 | Baxter Int | Fator conjugado viia-ácido (poli)siálico com prolongamento do tempo de meia vida in vivo |
US8110651B2 (en) | 2008-01-11 | 2012-02-07 | Serina Therapeutics, Inc. | Multifunctional forms of polyoxazoline copolymers and drug compositions comprising the same |
US8101706B2 (en) | 2008-01-11 | 2012-01-24 | Serina Therapeutics, Inc. | Multifunctional forms of polyoxazoline copolymers and drug compositions comprising the same |
GB0922354D0 (en) | 2009-12-21 | 2010-02-03 | Polytherics Ltd | Novel polymer conjugates |
EP3175863B1 (de) | 2009-05-20 | 2021-12-01 | BioMarin Pharmaceutical Inc. | Varianten des natriuretischen peptids typ c |
CA2773596C (en) | 2009-09-15 | 2017-11-28 | Kaneka Corporation | Modified erythropoietin to which water-soluble long-chain molecule is added |
US10188739B2 (en) | 2014-02-27 | 2019-01-29 | Xenetic Biosciences, Inc. | Compositions and methods for administering insulin or insulin-like protein to the brain |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4179337A (en) * | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
US5100664A (en) * | 1985-09-20 | 1992-03-31 | Cetus Corporation | Human IL-2 as a vaccine adjuvant |
US4904584A (en) * | 1987-12-23 | 1990-02-27 | Genetics Institute, Inc. | Site-specific homogeneous modification of polypeptides |
JP2502646B2 (ja) | 1988-01-19 | 1996-05-29 | 松下電器産業株式会社 | バ―ナ |
JPH029900A (ja) * | 1988-04-12 | 1990-01-12 | Kirin Amgen Inc | 修飾エリスロポエチン |
US5382657A (en) * | 1992-08-26 | 1995-01-17 | Hoffmann-La Roche Inc. | Peg-interferon conjugates |
NO934477L (no) * | 1992-12-09 | 1994-06-10 | Ortho Pharma Corp | PEG hydrazon- og PEG oksim-bindingdannende reagenser og proteinderivater derav |
NZ250375A (en) * | 1992-12-09 | 1995-07-26 | Ortho Pharma Corp | Peg hydrazone and peg oxime linkage forming reagents and protein derivatives |
GB9317618D0 (en) | 1993-08-24 | 1993-10-06 | Royal Free Hosp School Med | Polymer modifications |
US5643575A (en) | 1993-10-27 | 1997-07-01 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
US5747446A (en) * | 1994-03-22 | 1998-05-05 | Beth Israel Deaconess Medical Center | Modified polypeptides with increased biological activity |
US5824784A (en) * | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
WO1996028475A1 (fr) * | 1995-03-10 | 1996-09-19 | Nakamura, Toshikazu | Facteur de croissance des hepatocytes modifie a l'aide de polyethylene glycol |
US5767078A (en) * | 1995-06-07 | 1998-06-16 | Johnson; Dana L. | Agonist peptide dimers |
JP4410852B2 (ja) * | 1996-08-02 | 2010-02-03 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | 単一の共有結合n末端水溶性ポリマーを有するポリペプチド |
JP2001508783A (ja) * | 1997-01-29 | 2001-07-03 | ポリマスク・ファーマシューティカルズ・パブリック・リミテッド・カンパニー | Peg化法 |
BR9812267B1 (pt) * | 1997-07-14 | 2013-11-26 | Hormônio de crescimento recombinante. | |
JP2002531089A (ja) * | 1998-11-30 | 2002-09-24 | イーライ・リリー・アンド・カンパニー | 赤血球産生性化合物 |
EP1144613B2 (de) * | 1999-01-14 | 2020-05-06 | Bolder Biotechnology, Inc. | Verfahren zur herstellung von proteinen mit freien cysteinresten |
EA004685B1 (ru) | 1999-01-29 | 2004-06-24 | Эмджен Инк. | Конъюгаты гксф |
CZ299516B6 (cs) * | 1999-07-02 | 2008-08-20 | F. Hoffmann-La Roche Ag | Konjugát erythropoetinového glykoproteinu, zpusobjeho výroby a použití a farmaceutická kompozice sjeho obsahem |
PE20010288A1 (es) * | 1999-07-02 | 2001-03-07 | Hoffmann La Roche | Derivados de eritropoyetina |
-
2001
- 2001-09-28 AT AT01970285T patent/ATE421535T1/de active
- 2001-09-28 JP JP2002536338A patent/JP5170931B2/ja not_active Expired - Lifetime
- 2001-09-28 US US10/399,254 patent/US20040082765A1/en not_active Abandoned
- 2001-09-28 AU AU2001290312A patent/AU2001290312A1/en not_active Abandoned
- 2001-09-28 WO PCT/JP2001/008539 patent/WO2002032957A1/ja active Application Filing
- 2001-09-28 EP EP01970285A patent/EP1333036B1/de not_active Expired - Lifetime
- 2001-09-28 ES ES01970285T patent/ES2320101T3/es not_active Expired - Lifetime
- 2001-09-28 DE DE60137525T patent/DE60137525D1/de not_active Expired - Lifetime
-
2006
- 2006-08-03 US US11/498,053 patent/US8022191B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US20060276634A1 (en) | 2006-12-07 |
EP1333036A1 (de) | 2003-08-06 |
US20040082765A1 (en) | 2004-04-29 |
US8022191B2 (en) | 2011-09-20 |
AU2001290312A1 (en) | 2002-04-29 |
JPWO2002032957A1 (ja) | 2004-02-26 |
ES2320101T3 (es) | 2009-05-19 |
JP5170931B2 (ja) | 2013-03-27 |
EP1333036B1 (de) | 2009-01-21 |
WO2002032957A1 (fr) | 2002-04-25 |
EP1333036A4 (de) | 2004-09-29 |
DE60137525D1 (de) | 2009-03-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE421535T1 (de) | Peg-modifiziertes erythropoietin | |
DE60006100D1 (de) | Lang wirkende insulinotrope peptide | |
ATE463260T1 (de) | Ortspezifische duale pegylation von proteine | |
ATE551362T1 (de) | Peptide, die den blutzuckergehalt senken | |
BR0010757A (pt) | Inibidores de peptìdeo de fusão de longa duração de infecção viral | |
ATE550041T1 (de) | Transglutaminase-vermittelte konjugation von peptiden | |
ATE364654T1 (de) | Polyamideketten von genauer länge und deren konjugate mit proteinen | |
ATE542137T1 (de) | Immunocytokine mit modulierter selektivität | |
AU2001296962A1 (en) | Pegylated interleukin-10 | |
ATE89743T1 (de) | Conjugate dichter sterne. | |
EA200400067A1 (ru) | Конъюгаты гксф | |
CO5190661A1 (es) | Derivados de la eritropoyetina | |
DK0973819T3 (da) | Ikke-antigene forgrenede polymerkonjugater | |
DK1274728T3 (da) | Fremgangsmåder og sammensætninger til forebyggelse og behandling af anæmi | |
ATE505204T1 (de) | Konjugate von erythropoietin (epo) mit polyethylenglykol (peg) | |
DE69432141D1 (de) | Taxane mit furyl-oder thienyl substituierten seitenketten | |
DE60236796D1 (de) | Verzweigte polyalkylenglykole | |
DK0557199T3 (da) | Polyethylenglycol-hirudin-konjugater, fremgangsmåde til fremstilling deraf og anvendelse deraf til behandling af tromboser | |
CA2373252A1 (en) | Long lasting anti-angiogenic peptides | |
TR200200599T2 (tr) | İnsan insülini monomerik analogları. | |
WO2004014951A3 (en) | Binding molecules | |
CY1115962T1 (el) | Πεπτιδια που μειωνουν τα επιπεδα της γλυκοζης στο αιμα | |
TH52654A (th) | แอนตี-แอนจิโอจินิก เปปไทด์ ที่มีอายุยาวนาน | |
YU29492A (sh) | Konjugati proteina sa polietilenom | |
ITAR930014A1 (it) | Snodo rotante per collane e bracciali tubolari |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification |
Ref document number: 1333036 Country of ref document: EP |