CU20140003A7 - Conjugado que comprende eritropoyetina y una estructura polimérica ramificada - Google Patents

Conjugado que comprende eritropoyetina y una estructura polimérica ramificada

Info

Publication number
CU20140003A7
CU20140003A7 CUP2014000003A CU20140003A CU20140003A7 CU 20140003 A7 CU20140003 A7 CU 20140003A7 CU P2014000003 A CUP2014000003 A CU P2014000003A CU 20140003 A CU20140003 A CU 20140003A CU 20140003 A7 CU20140003 A7 CU 20140003A7
Authority
CU
Cuba
Prior art keywords
conjugate
kda
mpeg
erythropoyetin
understanding
Prior art date
Application number
CUP2014000003A
Other languages
English (en)
Inventor
Meireles Rolando Páez
González Daniel Enrique Amaro
Odio Fidel Raúl Castro
Valdés Yenisel Hernández
Estrada Gladys Amalia Ruiz
Original Assignee
Ct De Inmunología Molecular Biofarmacuba
Ct De Ingeniería Genética Y Biotecnología Biocubafarma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ct De Inmunología Molecular Biofarmacuba, Ct De Ingeniería Genética Y Biotecnología Biocubafarma filed Critical Ct De Inmunología Molecular Biofarmacuba
Priority to CUP2014000003A priority Critical patent/CU20140003A7/es
Priority to TW104100285A priority patent/TWI561245B/zh
Priority to SG11201604984TA priority patent/SG11201604984TA/en
Priority to ARP150100036A priority patent/AR099045A1/es
Priority to CN201580004018.1A priority patent/CN106163541A/zh
Priority to KR1020167018696A priority patent/KR20160105811A/ko
Priority to AU2015205774A priority patent/AU2015205774B2/en
Priority to EP15705897.5A priority patent/EP3093024A1/en
Priority to EA201691386A priority patent/EA201691386A1/ru
Priority to NZ722092A priority patent/NZ722092A/en
Priority to JP2016545283A priority patent/JP6367952B2/ja
Priority to PCT/CU2015/000001 priority patent/WO2015104008A1/es
Priority to US15/108,862 priority patent/US20160317674A1/en
Priority to CA2935306A priority patent/CA2935306A1/en
Priority to MX2016008928A priority patent/MX2016008928A/es
Publication of CU20140003A7 publication Critical patent/CU20140003A7/es
Priority to IL246526A priority patent/IL246526A0/en
Priority to ZA2016/04636A priority patent/ZA201604636B/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • A61K38/1816Erythropoietin [EPO]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polyethers (AREA)

Abstract

La presente invención revela un conjugado que comprende eritropoyetina (EPO) y una estructura polimérica ramificada asimétrica que comprende dos ramas de monometoxipolietilenglicol (mPEG) donde la masa molecular de una de estas ramas de mPEG está entre 10 kDa y 23 kDa, y la masa molecular de la otra rama de mPEG está entre 17 kDa y 23kDa, así como las composiciones farmacéuticas que lo contienen. La invención también provee un método para la obtención de EPO peguilada que se caracteriza porque dicha proteína se conjuga a una estructura polimérica ramificada asimétrica, con dos ramas de mPEG que poseen las masas moleculares antes descritas.
CUP2014000003A 2014-01-08 2014-01-08 Conjugado que comprende eritropoyetina y una estructura polimérica ramificada CU20140003A7 (es)

Priority Applications (17)

Application Number Priority Date Filing Date Title
CUP2014000003A CU20140003A7 (es) 2014-01-08 2014-01-08 Conjugado que comprende eritropoyetina y una estructura polimérica ramificada
TW104100285A TWI561245B (en) 2014-01-08 2015-01-06 Conjugate comprising erythropoietin and a branched polymeric structure
EP15705897.5A EP3093024A1 (en) 2014-01-08 2015-01-08 Conjugate comprising erythropoietin and a branched polymer structure
NZ722092A NZ722092A (en) 2014-01-08 2015-01-08 Conjugate comprising erythropoietin and a branched polymer structure
CN201580004018.1A CN106163541A (zh) 2014-01-08 2015-01-08 包含促红细胞生成素和支化聚合物结构的缀合物
KR1020167018696A KR20160105811A (ko) 2014-01-08 2015-01-08 에리트로포이에틴을 포함하는 컨쥬게이트 및 분지형 폴리머 구조
AU2015205774A AU2015205774B2 (en) 2014-01-08 2015-01-08 Conjugate comprising erythropoietin and a branched polymer structure
SG11201604984TA SG11201604984TA (en) 2014-01-08 2015-01-08 Conjugate comprising erythropoietin and a branched polymer structure
EA201691386A EA201691386A1 (ru) 2014-01-08 2015-01-08 Конъюгат, включающий эритропоэтин и разветвленную полимерную структуру
ARP150100036A AR099045A1 (es) 2014-01-08 2015-01-08 Conjugado que comprende eritropoyetina y una estructura polimérica ramificada
JP2016545283A JP6367952B2 (ja) 2014-01-08 2015-01-08 エリスロポエチンおよび分枝ポリマー構造を含む複合体
PCT/CU2015/000001 WO2015104008A1 (es) 2014-01-08 2015-01-08 Conjugado que comprende eritropoyetina y una estructura polimérica ramificada
US15/108,862 US20160317674A1 (en) 2014-01-08 2015-01-08 Conjugate comprising erythropoietin and a branched polymer structure
CA2935306A CA2935306A1 (en) 2014-01-08 2015-01-08 Conjugate comprising erythropoietin and a branched polymer structure
MX2016008928A MX2016008928A (es) 2014-01-08 2015-01-08 Conjugado que comprende eritropoyetina y una estructura polimerica ramificada.
IL246526A IL246526A0 (en) 2014-01-08 2016-06-29 A bracelet containing erythropoietin and a branched polymer structure
ZA2016/04636A ZA201604636B (en) 2014-01-08 2016-07-07 Conjugate comprising erythropoietin and a branched polymeric structure

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CUP2014000003A CU20140003A7 (es) 2014-01-08 2014-01-08 Conjugado que comprende eritropoyetina y una estructura polimérica ramificada

Publications (1)

Publication Number Publication Date
CU20140003A7 true CU20140003A7 (es) 2015-08-27

Family

ID=52573994

Family Applications (1)

Application Number Title Priority Date Filing Date
CUP2014000003A CU20140003A7 (es) 2014-01-08 2014-01-08 Conjugado que comprende eritropoyetina y una estructura polimérica ramificada

Country Status (17)

Country Link
US (1) US20160317674A1 (es)
EP (1) EP3093024A1 (es)
JP (1) JP6367952B2 (es)
KR (1) KR20160105811A (es)
CN (1) CN106163541A (es)
AR (1) AR099045A1 (es)
AU (1) AU2015205774B2 (es)
CA (1) CA2935306A1 (es)
CU (1) CU20140003A7 (es)
EA (1) EA201691386A1 (es)
IL (1) IL246526A0 (es)
MX (1) MX2016008928A (es)
NZ (1) NZ722092A (es)
SG (1) SG11201604984TA (es)
TW (1) TWI561245B (es)
WO (1) WO2015104008A1 (es)
ZA (1) ZA201604636B (es)

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6514533B1 (en) 1992-06-11 2003-02-04 Alkermas Controlled Therapeutics, Inc. Device for the sustained release of aggregation-stabilized, biologically active agent
US5932462A (en) * 1995-01-10 1999-08-03 Shearwater Polymers, Inc. Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
DK1311285T4 (en) 2000-05-15 2017-07-24 Hoffmann La Roche Liquid pharmaceutical composition containing an erythropoietin derivative
CN1176137C (zh) * 2002-01-15 2004-11-17 泛亚生物技术有限公司 多臂树杈型功能化聚乙二醇制备方法及它在药物中的应用
PL396711A1 (pl) * 2002-12-26 2011-12-19 Mountain View Pharmaceuticals, Inc. Koniugaty polimerów z cytokinami, chemokinami, czynnikami wzrostu, hormonami polipeptydowymi i ich antagonistami, kompozycja farmaceutyczna i sposób zapobiegania, diagnozowania lub leczenia
WO2006061853A2 (en) * 2004-12-10 2006-06-15 Serum Institute Of India Limited Novel erythropoietic compounds and a process for producing erythropoietic compounds
CU23556A1 (es) * 2005-11-30 2010-07-20 Ct Ingenieria Genetica Biotech Estructura polimérica semejante a dendrímero para la obtención de conjugados de interés farmacéutico
PL2054074T3 (pl) * 2006-08-04 2015-03-31 Prolong Pharmaceuticals Llc Zmodyfikowana erytropoetyna
US8188222B2 (en) * 2006-11-08 2012-05-29 Nippon Kayaku Kabushiki Kaisha High molecular weight derivative of nucleic acid antimetabolite
CN101376676B (zh) * 2008-10-09 2012-04-25 天津派格生物技术有限公司 聚乙二醇化红细胞生成素蛋白长效制剂

Also Published As

Publication number Publication date
KR20160105811A (ko) 2016-09-07
US20160317674A1 (en) 2016-11-03
SG11201604984TA (en) 2016-07-28
IL246526A0 (en) 2016-08-31
JP2017506619A (ja) 2017-03-09
TW201538168A (zh) 2015-10-16
WO2015104008A8 (es) 2016-08-25
AU2015205774B2 (en) 2017-11-30
AU2015205774A1 (en) 2016-07-28
CN106163541A (zh) 2016-11-23
EP3093024A1 (en) 2016-11-16
TWI561245B (en) 2016-12-11
MX2016008928A (es) 2016-10-04
ZA201604636B (en) 2018-05-30
EA201691386A1 (ru) 2016-11-30
CA2935306A1 (en) 2015-07-16
AR099045A1 (es) 2016-06-22
JP6367952B2 (ja) 2018-08-01
NZ722092A (en) 2017-11-24
WO2015104008A1 (es) 2015-07-16

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