NO20080249L - Transglutaminaseformidlet konjugasjon av veksthormon - Google Patents

Transglutaminaseformidlet konjugasjon av veksthormon

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Publication number
NO20080249L
NO20080249L NO20080249A NO20080249A NO20080249L NO 20080249 L NO20080249 L NO 20080249L NO 20080249 A NO20080249 A NO 20080249A NO 20080249 A NO20080249 A NO 20080249A NO 20080249 L NO20080249 L NO 20080249L
Authority
NO
Norway
Prior art keywords
growth hormone
transglutaminase
conjugation
mediated growth
functional group
Prior art date
Application number
NO20080249A
Other languages
English (en)
Inventor
Florencio Zaragoza Dorwald
Niels Langeland Johansen
Lars Fogh Iversen
Original Assignee
Novo Nordisk Healthcare Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk Healthcare Ag filed Critical Novo Nordisk Healthcare Ag
Publication of NO20080249L publication Critical patent/NO20080249L/no

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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/104—Aminoacyltransferases (2.3.2)
    • C12N9/1044—Protein-glutamine gamma-glutamyltransferase (2.3.2.13), i.e. transglutaminase or factor XIII
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    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/02—Aminoacyltransferases (2.3.2)
    • C12Y203/02013—Protein-glutamine gamma-glutamyltransferase (2.3.2.13), i.e. transglutaminase or factor XIII

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  • Hematology (AREA)
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Abstract

Fremgangsmåte for PEGylering av veksthormon, hvor fremgangsmåten omfatter å omsette veksthormon med en aminomfattende nukleofil, som videre omfatter en første funksjonell gruppe, i nærvær av TGase for å danne et transaminert veksthormon, etterfulgt av en omsetning av det transaminerte veksthormon med en PEG som er blitt funksjonalisert med en andre funksjonell gruppe, hvor den første og den andre funksjonelle gruppen er valgt slik at de reagerer, hvorved det dannes en kovalent binding.
NO20080249A 2005-06-15 2008-01-14 Transglutaminaseformidlet konjugasjon av veksthormon NO20080249L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05105256 2005-06-15
EP05109667 2005-10-18
PCT/EP2006/063246 WO2006134148A2 (en) 2005-06-15 2006-06-15 Transglutaminase mediated conjugation of growth hormone

Publications (1)

Publication Number Publication Date
NO20080249L true NO20080249L (no) 2008-03-17

Family

ID=37031113

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20080249A NO20080249L (no) 2005-06-15 2008-01-14 Transglutaminaseformidlet konjugasjon av veksthormon

Country Status (13)

Country Link
US (1) US20100197573A1 (no)
EP (1) EP1893239A2 (no)
JP (1) JP2008543297A (no)
KR (1) KR20080016674A (no)
AU (1) AU2006259080A1 (no)
BR (1) BRPI0611570A2 (no)
CA (1) CA2612794A1 (no)
IL (1) IL187630A0 (no)
MX (1) MX2007015676A (no)
NO (1) NO20080249L (no)
RU (1) RU2007145085A (no)
TW (1) TW200716179A (no)
WO (1) WO2006134148A2 (no)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2008105545A (ru) 2005-08-30 2009-10-10 Ново Нордиск Хелс Кеа Аг (Ch) Жидкие препараты пэгилированного гормона роста
CN101495155A (zh) 2006-07-07 2009-07-29 诺沃-诺迪斯克保健股份有限公司 新的蛋白结合物及其制备方法
CA2672651C (en) 2006-12-15 2014-03-11 Lifebond Ltd. Gelatin-transglutaminase hemostatic dressings and sealants
CA2678669A1 (en) * 2007-02-22 2008-08-28 Novo Nordisk Health Care Ag Transglutaminase variants with improved specificity
US9272048B2 (en) * 2008-04-29 2016-03-01 Ascendis Pharma Growth Disorders Division A/S PEGylated recombinant human growth hormone compounds
US8367388B2 (en) 2008-06-18 2013-02-05 Lifebond Ltd. Cross-linked compositions
WO2010029107A1 (en) * 2008-09-09 2010-03-18 Novo Nordisk Health Care Ag Growth hormone conjugate with increased stability
EP2427215A1 (en) * 2009-05-07 2012-03-14 Novo Nordisk Health Care AG Stable pharmaceutical compositions of peptide derivatized using an oxime linker
CN102612376A (zh) * 2009-08-06 2012-07-25 诺沃-诺迪斯克保健股份有限公司 具有延长的体内功效的生长激素
JP5796860B2 (ja) 2009-12-22 2015-10-21 ライフボンド リミテッドＬｉｆｅｂｏｎｄ Ｌｔｄ 架橋マトリックスの特性を調節するための酵素的架橋剤の改変
CN106139158A (zh) 2010-01-22 2016-11-23 诺沃—诺迪斯克保健股份有限公司 体内功效延长的生长激素
JP5914363B2 (ja) 2010-02-16 2016-05-11 ノヴォ ノルディスク アー／エス 低減されたｖｗｆ結合を有する因子ｖｉｉｉ分子
ITPD20100155A1 (it) 2010-05-19 2011-11-20 Univ Padova Metodo per la preparazione di coniugati mediante transglutaminasi
CA2807012A1 (en) 2010-08-05 2012-02-09 Lifebond Ltd. Dry composition wound dressings and adhesives
MX2013009862A (es) 2011-03-02 2013-10-25 Novo Nordisk As Factor de coagulacion dirigido al transcripto 1 tipo trem (tlt-1) en plaquetas activadas.
TWI596110B (zh) 2011-09-23 2017-08-21 諾佛 儂迪克股份有限公司 新穎升糖素類似物
US9650331B2 (en) 2012-06-18 2017-05-16 Polytherics Limited Conjugation reagents
CN105209497B (zh) 2013-03-15 2021-09-07 诺和诺德股份有限公司 能够特异性结合组织因子途径抑制物上的两个表位的抗体
US11045523B2 (en) 2013-04-05 2021-06-29 Novo Nordisk Healthcare Ag Formulation of growth hormone albumin-binder conjugate
WO2014170496A1 (en) 2013-04-18 2014-10-23 Novo Nordisk A/S Stable, protracted glp-1/glucagon receptor co-agonists for medical use
ES2756526T3 (es) * 2013-07-11 2020-04-27 Novartis Ag Modificaciones de proteínas quimioenzimáticas específicas para lisina utilizando transglutaminasa microbiana
CN106536547A (zh) 2014-06-04 2017-03-22 诺和诺德股份有限公司 用于医疗用途的glp‑1/胰高血糖素受体共激动剂
JP2021502068A (ja) 2017-11-07 2021-01-28 コデクシス， インコーポレイテッド トランスグルタミナーゼバリアント

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179337A (en) * 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
WO1996010089A1 (fr) 1994-09-29 1996-04-04 Ajinomoto Co., Inc. Modification d'un peptide et d'une proteine
US6620916B1 (en) 1996-09-26 2003-09-16 Ajinomoto Co., Inc. Modified physiologically active proteins and medicinal compositions containing the same
EP1352062A2 (en) * 2001-01-11 2003-10-15 Maxygen Aps Improved growth hormone molecules
KR20060032140A (ko) * 2003-05-30 2006-04-14 센토코 인코포레이티드 트랜스글루타미나아제를 이용한 신규 에리트로포이에틴접합체의 형성
CN1243022C (zh) * 2003-10-17 2006-02-22 华东师范大学 生物修饰重组人生长激素复合物及其制备方法
ES2397241T3 (es) * 2004-01-21 2013-03-05 Novo Nordisk Health Care Ag Conjugación de péptidos mediante transglutaminasa
ATE542920T1 (de) * 2004-12-22 2012-02-15 Ambrx Inc Modifiziertes menschliches wachstumshormon
RU2008105545A (ru) * 2005-08-30 2009-10-10 Ново Нордиск Хелс Кеа Аг (Ch) Жидкие препараты пэгилированного гормона роста

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Publication number Publication date
WO2006134148A2 (en) 2006-12-21
MX2007015676A (es) 2008-02-20
RU2007145085A (ru) 2009-07-20
EP1893239A2 (en) 2008-03-05
IL187630A0 (en) 2008-03-20
KR20080016674A (ko) 2008-02-21
US20100197573A1 (en) 2010-08-05
CA2612794A1 (en) 2006-12-21
WO2006134148A3 (en) 2007-12-21
JP2008543297A (ja) 2008-12-04
AU2006259080A1 (en) 2006-12-21
TW200716179A (en) 2007-05-01
BRPI0611570A2 (pt) 2011-02-22

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