JP2015529197A5 - - Google Patents
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- Publication number
- JP2015529197A5 JP2015529197A5 JP2015528570A JP2015528570A JP2015529197A5 JP 2015529197 A5 JP2015529197 A5 JP 2015529197A5 JP 2015528570 A JP2015528570 A JP 2015528570A JP 2015528570 A JP2015528570 A JP 2015528570A JP 2015529197 A5 JP2015529197 A5 JP 2015529197A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- compound
- ovalbumin
- keyhole limpet
- limpet hemocyanin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000004169 proteins and genes Human genes 0.000 claims description 36
- 108090000623 proteins and genes Proteins 0.000 claims description 36
- 150000001875 compounds Chemical class 0.000 claims description 25
- 101000800130 Bos taurus Thyroglobulin Proteins 0.000 claims description 18
- 108010058846 Ovalbumin Proteins 0.000 claims description 18
- 108010045069 keyhole-limpet hemocyanin Proteins 0.000 claims description 18
- 229940092253 ovalbumin Drugs 0.000 claims description 18
- 230000002163 immunogen Effects 0.000 claims description 16
- 238000000034 method Methods 0.000 claims description 12
- PMXMIIMHBWHSKN-UHFFFAOYSA-N 3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-9-hydroxy-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one Chemical compound FC1=CC=C2C(C3CCN(CC3)CCC=3C(=O)N4CCCC(O)C4=NC=3C)=NOC2=C1 PMXMIIMHBWHSKN-UHFFFAOYSA-N 0.000 description 5
- 229960001057 paliperidone Drugs 0.000 description 5
- 229960001534 risperidone Drugs 0.000 description 3
- RAPZEAPATHNIPO-UHFFFAOYSA-N risperidone Chemical compound FC1=CC=C2C(C3CCN(CC3)CCC=3C(=O)N4CCCCC4=NC=3C)=NOC2=C1 RAPZEAPATHNIPO-UHFFFAOYSA-N 0.000 description 3
- 239000012491 analyte Substances 0.000 description 2
- 238000003556 assay Methods 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 238000002967 competitive immunoassay Methods 0.000 description 1
- 239000013068 control sample Substances 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261691459P | 2012-08-21 | 2012-08-21 | |
| US61/691,459 | 2012-08-21 | ||
| PCT/US2013/055712 WO2014031595A1 (en) | 2012-08-21 | 2013-08-20 | Haptens of paliperidone |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018017796A Division JP6491371B2 (ja) | 2012-08-21 | 2018-02-05 | パリペリドンのハプテン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015529197A JP2015529197A (ja) | 2015-10-05 |
| JP2015529197A5 true JP2015529197A5 (enExample) | 2016-04-14 |
| JP6286429B2 JP6286429B2 (ja) | 2018-02-28 |
Family
ID=49081008
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015528570A Expired - Fee Related JP6286429B2 (ja) | 2012-08-21 | 2013-08-20 | パリペリドンのハプテン |
| JP2018017796A Expired - Fee Related JP6491371B2 (ja) | 2012-08-21 | 2018-02-05 | パリペリドンのハプテン |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018017796A Expired - Fee Related JP6491371B2 (ja) | 2012-08-21 | 2018-02-05 | パリペリドンのハプテン |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9394354B2 (enExample) |
| EP (2) | EP3556759B1 (enExample) |
| JP (2) | JP6286429B2 (enExample) |
| CN (2) | CN110003201A (enExample) |
| AU (2) | AU2013305930B2 (enExample) |
| CA (1) | CA2882555C (enExample) |
| ES (2) | ES2739383T3 (enExample) |
| PL (1) | PL2888258T3 (enExample) |
| PT (1) | PT2888258T (enExample) |
| TR (1) | TR201911272T4 (enExample) |
| WO (1) | WO2014031595A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104755093B (zh) | 2012-08-21 | 2018-11-16 | 詹森药业有限公司 | 奥氮平半抗原的抗体及其用途 |
| AU2013305965B2 (en) | 2012-08-21 | 2017-08-24 | Saladax Biomedical Inc. | Antibodies to paliperidone and use thereof |
| ES2978909T3 (es) | 2012-08-21 | 2024-09-23 | Janssen Pharmaceutica Nv | Anticuerpos contra haptenos de aripiprazol y uso de los mismos |
| WO2014031668A2 (en) | 2012-08-21 | 2014-02-27 | Ortho-Clinical Diagnostics, Inc | Antibodies to quetiapine and use thereof |
| EP3556759B1 (en) * | 2012-08-21 | 2023-11-29 | Janssen Pharmaceutica NV | Haptens of paliperidone |
| TR201816416T4 (tr) | 2012-08-21 | 2018-11-21 | Janssen Pharmaceutica Nv | Risperidona yönelik antikorlar ve bunların kullanımı. |
| JP6374387B2 (ja) | 2012-08-21 | 2018-08-15 | ヤンセン ファーマシューティカ エヌ．ベー． | リスペリドンハプテンへの抗体及びその使用 |
| CN104755928B (zh) | 2012-08-21 | 2017-05-10 | 詹森药业有限公司 | 奥氮平的抗体及其用途 |
| PT3663317T (pt) | 2012-08-21 | 2023-01-23 | Janssen Pharmaceutica Nv | Anticorpos para haptenos de quetiapina e sua utilização |
| CA2882489A1 (en) | 2012-08-21 | 2014-02-27 | Ortho-Clinical Diagnostics, Inc. | Antibodies to paliperidone haptens and use thereof |
| ES2762105T3 (es) | 2012-08-21 | 2020-05-22 | Janssen Pharmaceutica Nv | Anticuerpos para aripiprazol y uso de los mismos |
| ES2822914T3 (es) | 2012-08-21 | 2021-05-05 | Janssen Pharmaceutica Nv | Haptenos de aripiprazol y su uso en inmunoensayos |
| AU2016370853A1 (en) | 2015-12-17 | 2018-06-07 | Saladax Biomedical Inc. | Antibodies to quetiapine and use thereof |
| CN108431040B (zh) | 2015-12-17 | 2022-07-26 | 詹森药业有限公司 | 利培酮的抗体及其用途 |
| CN111751535B (zh) * | 2020-07-02 | 2023-07-11 | 北京勤邦科技股份有限公司 | 一种检测硫丹的试纸条及其应用 |
| AU2021406283A1 (en) * | 2020-12-22 | 2023-06-22 | Intervet International B.V. | Conjugated zearalenone to protect against mycotoxicosis |
| CN116003404B (zh) * | 2022-12-14 | 2024-10-01 | 杭州同舟生物技术有限公司 | 一种利培酮人工半抗原、人工抗原及其制备方法和应用 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4166452A (en) | 1976-05-03 | 1979-09-04 | Generales Constantine D J Jr | Apparatus for testing human responses to stimuli |
| US5284948A (en) * | 1991-06-07 | 1994-02-08 | Eastman Kodak Company | Drug hapten analogues for immunoassays |
| US6034078A (en) | 1992-05-29 | 2000-03-07 | Eli Lilly And Company Limited | Thienobenzodiazepine compounds |
| EP0582368B1 (en) | 1992-05-29 | 2001-01-24 | Eli Lilly And Company Limited | Thienobenzodiazepine derivatives for treatment of CNS disorders |
| US5395933A (en) | 1992-08-07 | 1995-03-07 | Eastman Kodak Company | Carbamazepine hapten analogues |
| US6958156B2 (en) | 2000-12-15 | 2005-10-25 | Vyrex Corporation | Isoflavone derivatives |
| US7193065B2 (en) * | 2001-07-13 | 2007-03-20 | Roche Diagnostics Operations, Inc. | Protease inhibitor conjugates and antibodies useful in immunoassay |
| ATE492565T1 (de) * | 2002-01-31 | 2011-01-15 | Randox Lab Ltd | Immunogene, antikörper und konjugate für ketamin und dessen metaboliten |
| ATE380818T1 (de) | 2002-03-28 | 2007-12-15 | Lilly Co Eli | Piperazine-substituierte aryl-benzodiazepinen und ihre verwendung als dopaminrezeptor-antagonisten zur behandlung von psychose |
| ES2285227T3 (es) | 2002-08-05 | 2007-11-16 | Eli Lilly And Company | Arilbenzodiazepinas sustituidas con piperazina. |
| EP1664007B1 (en) | 2003-09-23 | 2009-12-23 | Fermion Oy | Preparation of quetiapine |
| TW200616604A (en) | 2004-08-26 | 2006-06-01 | Nicholas Piramal India Ltd | Nitric oxide releasing prodrugs containing bio-cleavable linker |
| FR2878850B1 (fr) * | 2004-12-02 | 2008-10-31 | Cis Bio Internat Sa | Derives de l'inositol-1-phosphate |
| MX2010003259A (es) | 2007-09-27 | 2010-04-12 | Novartis Ag | Ensayo de monitoreo de farmacos. |
| US20100069356A1 (en) | 2008-09-17 | 2010-03-18 | Auspex Pharmaceuticals, Inc. | Dibenzothiazepine modulators of dopamine, alpha adrenergic, and serotonin receptors |
| WO2010043893A1 (en) | 2008-10-14 | 2010-04-22 | Astrazeneca Ab | Fused, spirocyclic heteroaromatic compounds for the treatment of bacterial infections |
| EP2194048A1 (en) | 2008-12-02 | 2010-06-09 | Dirk Sartor | Nitrate esters for the treatment of vascular and metabolic diseases |
| ES2833035T3 (es) * | 2009-07-31 | 2021-06-14 | Ascendis Pharma As | Hidrogeles biodegradables insolubles en agua a base de polietilenglicol |
| EP2485767A1 (en) * | 2009-10-06 | 2012-08-15 | Ascendis Pharma A/S | Carrier linked paliperidone prodrugs |
| EP2343296A1 (en) * | 2009-12-01 | 2011-07-13 | Chemo Ibérica, S.A. | A process for the purification of paliperidone |
| CA2785846C (en) | 2009-12-31 | 2015-07-07 | Kempharm, Inc. | Amino acid conjugates of quetiapine, process for making and using the same |
| SI2544536T1 (sl) | 2010-03-11 | 2019-03-29 | Kempharm, Inc. | Maščobno kislinski konjugati kvetiapina proces za njih izdelavo in uporabo |
| US8088594B2 (en) | 2010-03-16 | 2012-01-03 | Saladax Biomedical Inc. | Risperidone immunoassay |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| US8623324B2 (en) | 2010-07-21 | 2014-01-07 | Aat Bioquest Inc. | Luminescent dyes with a water-soluble intramolecular bridge and their biological conjugates |
| JP5757497B2 (ja) * | 2010-10-06 | 2015-07-29 | 公立大学法人大阪府立大学 | シガトキシン類ｃｔｘ１ｂおよび５４−デオキシ−ｃｔｘ１ｂを認識するモノクローナル抗体およびそれを用いるシガトキシン類検出キット |
| EP2741779A1 (en) | 2011-08-12 | 2014-06-18 | Ascendis Pharma A/S | High-loading water-soluble carrier-linked prodrugs |
| WO2013024048A1 (en) | 2011-08-12 | 2013-02-21 | Ascendis Pharma A/S | Polymeric hyperbranched carrier-linked prodrugs |
| WO2013088255A1 (en) | 2011-12-15 | 2013-06-20 | Alkermes Pharma Ireland Limited | Prodrugs of secondary amine compounds |
| TR201816416T4 (tr) | 2012-08-21 | 2018-11-21 | Janssen Pharmaceutica Nv | Risperidona yönelik antikorlar ve bunların kullanımı. |
| WO2014031668A2 (en) | 2012-08-21 | 2014-02-27 | Ortho-Clinical Diagnostics, Inc | Antibodies to quetiapine and use thereof |
| JP6374387B2 (ja) | 2012-08-21 | 2018-08-15 | ヤンセン ファーマシューティカ エヌ．ベー． | リスペリドンハプテンへの抗体及びその使用 |
| EP3556759B1 (en) * | 2012-08-21 | 2023-11-29 | Janssen Pharmaceutica NV | Haptens of paliperidone |
-
2013
- 2013-08-20 EP EP19177909.9A patent/EP3556759B1/en active Active
- 2013-08-20 ES ES13753775T patent/ES2739383T3/es active Active
- 2013-08-20 PT PT13753775T patent/PT2888258T/pt unknown
- 2013-08-20 CN CN201910140503.1A patent/CN110003201A/zh active Pending
- 2013-08-20 CA CA2882555A patent/CA2882555C/en active Active
- 2013-08-20 ES ES19177909T patent/ES2971506T3/es active Active
- 2013-08-20 AU AU2013305930A patent/AU2013305930B2/en not_active Ceased
- 2013-08-20 CN CN201380054994.9A patent/CN104837838A/zh active Pending
- 2013-08-20 WO PCT/US2013/055712 patent/WO2014031595A1/en not_active Ceased
- 2013-08-20 EP EP13753775.9A patent/EP2888258B1/en active Active
- 2013-08-20 JP JP2015528570A patent/JP6286429B2/ja not_active Expired - Fee Related
- 2013-08-20 US US13/970,660 patent/US9394354B2/en not_active Expired - Fee Related
- 2013-08-20 PL PL13753775T patent/PL2888258T3/pl unknown
- 2013-08-20 TR TR2019/11272T patent/TR201911272T4/tr unknown
-
2017
- 2017-11-20 AU AU2017264978A patent/AU2017264978B2/en not_active Ceased
-
2018
- 2018-02-05 JP JP2018017796A patent/JP6491371B2/ja not_active Expired - Fee Related
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