JP2002523783A5 - - Google Patents
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- Publication number
- JP2002523783A5 JP2002523783A5 JP2000567958A JP2000567958A JP2002523783A5 JP 2002523783 A5 JP2002523783 A5 JP 2002523783A5 JP 2000567958 A JP2000567958 A JP 2000567958A JP 2000567958 A JP2000567958 A JP 2000567958A JP 2002523783 A5 JP2002523783 A5 JP 2002523783A5
- Authority
- JP
- Japan
- Prior art keywords
- dye
- energy transfer
- group
- fam
- phe
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000975 dye Substances 0.000 description 65
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 16
- 230000027455 binding Effects 0.000 description 16
- 125000004429 atom Chemical group 0.000 description 13
- 125000000524 functional group Chemical group 0.000 description 12
- 238000000034 method Methods 0.000 description 12
- -1 deoxy Proteins 0.000 description 9
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 8
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 8
- 229910052799 carbon Inorganic materials 0.000 description 8
- 229910052757 nitrogen Inorganic materials 0.000 description 8
- 229910052760 oxygen Inorganic materials 0.000 description 8
- 239000001301 oxygen Substances 0.000 description 8
- 239000000049 pigment Substances 0.000 description 8
- 108020004414 DNA Proteins 0.000 description 7
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 7
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 7
- 229910052698 phosphorus Inorganic materials 0.000 description 7
- 239000011574 phosphorus Substances 0.000 description 7
- 239000011593 sulfur Substances 0.000 description 7
- 229910052717 sulfur Inorganic materials 0.000 description 7
- ANRHNWWPFJCPAZ-UHFFFAOYSA-M thionine Chemical compound [Cl-].C1=CC(N)=CC2=[S+]C3=CC(N)=CC=C3N=C21 ANRHNWWPFJCPAZ-UHFFFAOYSA-M 0.000 description 7
- 229940037201 oris Drugs 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 239000002699 waste material Substances 0.000 description 6
- 238000006243 chemical reaction Methods 0.000 description 5
- 102000053602 DNA Human genes 0.000 description 3
- 125000003118 aryl group Chemical group 0.000 description 3
- 239000012620 biological material Substances 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 238000010168 coupling process Methods 0.000 description 3
- 238000005859 coupling reaction Methods 0.000 description 3
- 125000005647 linker group Chemical group 0.000 description 3
- 239000002773 nucleotide Substances 0.000 description 3
- 125000003729 nucleotide group Chemical group 0.000 description 3
- VYMDGNCVAMGZFE-UHFFFAOYSA-N phenylbutazonum Chemical compound O=C1C(CCCC)C(=O)N(C=2C=CC=CC=2)N1C1=CC=CC=C1 VYMDGNCVAMGZFE-UHFFFAOYSA-N 0.000 description 3
- 239000004215 Carbon black (E152) Substances 0.000 description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
- PEEHTFAAVSWFBL-UHFFFAOYSA-N Maleimide Chemical compound O=C1NC(=O)C=C1 PEEHTFAAVSWFBL-UHFFFAOYSA-N 0.000 description 2
- 238000003457 Shi epoxidation reaction Methods 0.000 description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
- 239000012876 carrier material Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 229930195733 hydrocarbon Natural products 0.000 description 2
- 150000002430 hydrocarbons Chemical class 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 150000002540 isothiocyanates Chemical class 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 2
- 150000008300 phosphoramidites Chemical class 0.000 description 2
- 239000001022 rhodamine dye Substances 0.000 description 2
- 239000013076 target substance Substances 0.000 description 2
- NJYVEMPWNAYQQN-UHFFFAOYSA-N 5-carboxyfluorescein Chemical compound C12=CC=C(O)C=C2OC2=CC(O)=CC=C2C21OC(=O)C1=CC(C(=O)O)=CC=C21 NJYVEMPWNAYQQN-UHFFFAOYSA-N 0.000 description 1
- LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical compound O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 description 1
- 241000684958 Abuta Species 0.000 description 1
- OTXOHOIOFJSIFX-POYBYMJQSA-N [[(2s,5r)-5-(2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate Chemical compound O1[C@H](COP(O)(=O)OP(O)(=O)OP(O)(=O)O)CC[C@@H]1N1C(=O)NC(=O)C=C1 OTXOHOIOFJSIFX-POYBYMJQSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000000295 emission spectrum Methods 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 125000001475 halogen functional group Chemical group 0.000 description 1
- 125000001072 heteroaryl group Chemical group 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 description 1
- 108091033319 polynucleotide Proteins 0.000 description 1
- 102000040430 polynucleotide Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9846998P | 1998-08-31 | 1998-08-31 | |
| US60/098,469 | 1998-08-31 | ||
| PCT/US1999/019739 WO2000013026A1 (en) | 1998-08-31 | 1999-08-30 | Energy transfer dyes |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002523783A JP2002523783A (ja) | 2002-07-30 |
| JP2002523783A5 true JP2002523783A5 (enExample) | 2009-12-17 |
| JP4659213B2 JP4659213B2 (ja) | 2011-03-30 |
Family
ID=22269416
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000567958A Expired - Fee Related JP4659213B2 (ja) | 1998-08-31 | 1999-08-30 | エネルギー転移色素 |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1110088B1 (enExample) |
| JP (1) | JP4659213B2 (enExample) |
| AT (1) | ATE252239T1 (enExample) |
| AU (1) | AU767840B2 (enExample) |
| CA (1) | CA2341520C (enExample) |
| DE (2) | DE69912139T2 (enExample) |
| ES (1) | ES2209492T3 (enExample) |
| GB (1) | GB2341189B (enExample) |
| WO (1) | WO2000013026A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6967250B1 (en) * | 1998-08-31 | 2005-11-22 | Amersham Biosciences Corp | Energy transfer dyes |
| CA2382063A1 (en) * | 1999-09-17 | 2001-03-22 | Shiv Kumar | Charge-modified nucleic acid terminators |
| GB0024351D0 (en) * | 2000-10-04 | 2000-11-22 | Amersham Pharm Biotech Uk Ltd | Dye-labelled peptide and method |
| AT410601B (de) * | 2000-12-29 | 2003-06-25 | Hoffmann La Roche | Sensor zur lumineszenz-optischen bestimmung eines analyten sowie reagens, das nach dem fret-prinzip arbeitet |
| CA2490961A1 (en) * | 2002-07-01 | 2004-01-08 | Guava Technologies, Inc. | Fluorescent dyes, energy transfer couples and methods |
| EP1439210B1 (en) | 2002-07-18 | 2007-09-05 | Protein Express Co., Ltd. | aminoacyl-tRNA bound to labelled p-aminophenylalanine or tyrosine |
| ITPZ20030002A1 (it) * | 2003-08-12 | 2005-02-13 | Giuseppe Caputo | Composti del tipo cianina aventi un braccio di legame alchinilico |
| US7417726B2 (en) | 2003-09-19 | 2008-08-26 | Applied Biosystems Inc. | Normalization of data using controls |
| US7667024B2 (en) | 2003-11-19 | 2010-02-23 | Allelogic Biosciences Corp. | Oligonucleotides labeled with a plurality of fluorophores |
| CA2581174A1 (en) | 2004-09-16 | 2006-03-30 | Applera Corporation | Fluorescent dye compounds, conjugates and uses thereof |
| EP1886145A2 (en) | 2005-05-03 | 2008-02-13 | Applera Corporation | Fluorescent detection system and dye set for use therewith |
| JP2011506673A (ja) | 2007-12-14 | 2011-03-03 | バイオティウム， インコーポレイテッド | 蛍光性化合物 |
| US8658434B2 (en) | 2009-10-28 | 2014-02-25 | Biotium, Inc. | Fluorescent pyrene compounds |
| US9579402B2 (en) | 2009-12-04 | 2017-02-28 | Biotium, Inc. | Heterocycle-substituted xanthene dyes |
| JP5540867B2 (ja) * | 2010-04-26 | 2014-07-02 | コニカミノルタ株式会社 | 有機蛍光色素内包シリカナノ粒子、その製造方法、それを用いた生体物質標識剤 |
| WO2013056841A1 (en) | 2011-10-19 | 2013-04-25 | Inra (Institut National De La Recherche Agronomique) | A method for diagnosing tse |
| WO2019002295A1 (en) * | 2017-06-27 | 2019-01-03 | Coriolis Pharma Research GmbH | QUANTITATIVE DETERMINATION OF POLYSORBATE |
| MX2023012081A (es) * | 2021-04-13 | 2023-10-25 | Somalogic Operating Co Inc | Nucleosidos modificados. |
| CN119462681B (zh) * | 2024-10-16 | 2025-09-30 | 聊城柏莱斯生物科技有限公司 | 一种荧光定量pcr参比染料及其制备方法与应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE397360B (sv) * | 1970-10-13 | 1977-10-31 | Kanzaki Paper Mfg Co Ltd | Fluoranforeningar, speciellt bensfluoranforeningar, till anvendning som fergmaterial i registrerings- och kopieringssystem och sett att framstella dessa nya foreningar |
| JP3260884B2 (ja) * | 1993-02-05 | 2002-02-25 | キヤノン株式会社 | 標識複合体、それを用いる分析法、生体関連物質の検出および定量の方法 |
| US6008373A (en) * | 1995-06-07 | 1999-12-28 | Carnegie Mellon University | Fluorescent labeling complexes with large stokes shift formed by coupling together cyanine and other fluorochromes capable of resonance energy transfer |
| US5728528A (en) * | 1995-09-20 | 1998-03-17 | The Regents Of The University Of California | Universal spacer/energy transfer dyes |
| US5800996A (en) * | 1996-05-03 | 1998-09-01 | The Perkin Elmer Corporation | Energy transfer dyes with enchanced fluorescence |
| US5853992A (en) * | 1996-10-04 | 1998-12-29 | The Regents Of The University Of California | Cyanine dyes with high-absorbance cross section as donor chromophores in energy transfer labels |
| US5804386A (en) * | 1997-01-15 | 1998-09-08 | Incyte Pharmaceuticals, Inc. | Sets of labeled energy transfer fluorescent primers and their use in multi component analysis |
| US6165800A (en) * | 1997-05-30 | 2000-12-26 | Bayer Corporation | Chemiluminescent energy transfer conjugates and their uses as labels in binding assays |
-
1999
- 1999-08-25 GB GB9920022A patent/GB2341189B/en not_active Revoked
- 1999-08-30 AT AT99943985T patent/ATE252239T1/de not_active IP Right Cessation
- 1999-08-30 EP EP99943985A patent/EP1110088B1/en not_active Expired - Lifetime
- 1999-08-30 ES ES99943985T patent/ES2209492T3/es not_active Expired - Lifetime
- 1999-08-30 JP JP2000567958A patent/JP4659213B2/ja not_active Expired - Fee Related
- 1999-08-30 CA CA2341520A patent/CA2341520C/en not_active Expired - Fee Related
- 1999-08-30 DE DE69912139T patent/DE69912139T2/de not_active Expired - Lifetime
- 1999-08-30 AU AU56970/99A patent/AU767840B2/en not_active Ceased
- 1999-08-30 WO PCT/US1999/019739 patent/WO2000013026A1/en not_active Ceased
- 1999-08-30 DE DE29915165U patent/DE29915165U1/de not_active Expired - Lifetime
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