JP2015508500A5 - - Google Patents

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JP2015508500A5
JP2015508500A5 JP2014551418A JP2014551418A JP2015508500A5 JP 2015508500 A5 JP2015508500 A5 JP 2015508500A5 JP 2014551418 A JP2014551418 A JP 2014551418A JP 2014551418 A JP2014551418 A JP 2014551418A JP 2015508500 A5 JP2015508500 A5 JP 2015508500A5
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Japan
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peroxide
enzyme
eam
binding ligand
complex
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JP2014551418A
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JP6276706B2 (ja
JP2015508500A (ja
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Priority claimed from PCT/US2013/020836 external-priority patent/WO2013106434A1/en
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JP2014551418A 2012-01-09 2013-01-09 Ｅ−ｔｒａｃｅアッセイシグナル増幅の酵素カスケード方法 Expired - Fee Related JP6276706B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261584563P 2012-01-09 2012-01-09
US61/584,563 2012-01-09
PCT/US2013/020836 WO2013106434A1 (en) 2012-01-09 2013-01-09 Enzyme cascade methods for e-trace assay signal amplification

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JP2015508500A JP2015508500A (ja) 2015-03-19
JP2015508500A5 true JP2015508500A5 (enExample) 2016-02-25
JP6276706B2 JP6276706B2 (ja) 2018-02-07

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JP2014551418A Expired - Fee Related JP6276706B2 (ja) 2012-01-09 2013-01-09 Ｅ−ｔｒａｃｅアッセイシグナル増幅の酵素カスケード方法

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US (2) US9250203B2 (enExample)
EP (1) EP2802669A1 (enExample)
JP (1) JP6276706B2 (enExample)
CA (1) CA2860739A1 (enExample)
WO (1) WO2013106434A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9250234B2 (en) 2011-01-19 2016-02-02 Ohmx Corporation Enzyme triggered redox altering chemical elimination (E-TRACE) immunoassay
JP5352742B2 (ja) 2009-08-07 2013-11-27 オームクス コーポレーション 酵素による酸化還元変化化学的脱離（ｅ−ｔｒａｃｅ）免疫学的検定法
WO2012012537A1 (en) 2010-07-20 2012-01-26 Ohmx Corporation Novel chemistry used in biosensors
JP6203183B2 (ja) 2011-10-17 2017-09-27 オームクス コーポレイション 酵素誘発レドックス変化化学的脱離（ｅ−ｔｒａｃｅ）イムノアッセイを使用する、ヘモグロビンａ１ｃのパーセンテージの単回直接検出
EP2773650A1 (en) 2011-11-04 2014-09-10 Ohmx Corporation Novel chemistry used in biosensors
JP2015529809A (ja) 2012-07-27 2015-10-08 オームクス コーポレイション 酵素及び他の標的分析物の存在及び活性の切断前検出後の単分子層の電気測定
US9404883B2 (en) 2012-07-27 2016-08-02 Ohmx Corporation Electronic measurements of monolayers following homogeneous reactions of their components

Family Cites Families (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US407828A (en) 1889-07-30 Tire-tightener
US332565A (en) 1885-12-15 Self-binding grain-harvester
US4247533A (en) 1978-05-01 1981-01-27 The Rockefeller University Hemoglobin A1c radioimmunoassay
DE3061860D1 (en) 1979-04-24 1983-03-17 Marcel Jozefonvicz Process for the determination of proteases and antiproteases
US4469863A (en) 1980-11-12 1984-09-04 Ts O Paul O P Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof
US4727036A (en) 1985-08-08 1988-02-23 Molecular Diagnostics, Inc. Antibodies for use in determining hemoglobin A1c
US5235033A (en) 1985-03-15 1993-08-10 Anti-Gene Development Group Alpha-morpholino ribonucleoside derivatives and polymers thereof
US5034506A (en) 1985-03-15 1991-07-23 Anti-Gene Development Group Uncharged morpholino-based polymers having achiral intersubunit linkages
US5206144A (en) 1985-03-29 1993-04-27 Novo Industri A/S Determination of glycated (glycosylated) hemoglobin in blood
US4806468A (en) 1987-02-05 1989-02-21 Becton, Dickinson And Company Measurement of glycosylated hemoglobin by immunoassay
JPS63254998A (ja) * 1987-04-10 1988-10-21 Imuno Baion:Kk 微量のピリジンヌクレオチド補酵素分析法
US5216141A (en) 1988-06-06 1993-06-01 Benner Steven A Oligonucleotide analogs containing sulfur linkages
AU633507B2 (en) 1988-08-02 1993-02-04 London Biotechnology Limited An amplification assay for hydrolase enzymes
US5173373A (en) 1989-09-14 1992-12-22 Yamaha Hatsudoki Kabushiki Kaisha Gasket for fuel cell
US5637459A (en) 1990-06-11 1997-06-10 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: chimeric selex
US5270163A (en) 1990-06-11 1993-12-14 University Research Corporation Methods for identifying nucleic acid ligands
KR970002255B1 (ko) 1990-06-11 1997-02-26 넥스스타 파아마슈티컬드, 인크. 핵산 리간드
US5496938A (en) 1990-06-11 1996-03-05 Nexstar Pharmaceuticals, Inc. Nucleic acid ligands to HIV-RT and HIV-1 rev
US5705337A (en) 1990-06-11 1998-01-06 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: chemi-SELEX
US5683867A (en) 1990-06-11 1997-11-04 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: blended SELEX
US5567588A (en) 1990-06-11 1996-10-22 University Research Corporation Systematic evolution of ligands by exponential enrichment: Solution SELEX
US5386023A (en) 1990-07-27 1995-01-31 Isis Pharmaceuticals Backbone modified oligonucleotide analogs and preparation thereof through reductive coupling
US5602240A (en) 1990-07-27 1997-02-11 Ciba Geigy Ag. Backbone modified oligonucleotide analogs
JPH06509646A (ja) 1991-07-26 1994-10-27 デイド・ケミストリイ・システムズ・インコーポレーテツド 懸濁された固体支持体の存在下でのシグナル検出アッセイ
US5644048A (en) 1992-01-10 1997-07-01 Isis Pharmaceuticals, Inc. Process for preparing phosphorothioate oligonucleotides
US5637684A (en) 1994-02-23 1997-06-10 Isis Pharmaceuticals, Inc. Phosphoramidate and phosphorothioamidate oligomeric compounds
DE4430023A1 (de) 1994-08-24 1996-02-29 Boehringer Mannheim Gmbh Elektrochemischer Sensor
US5620850A (en) 1994-09-26 1997-04-15 President And Fellows Of Harvard College Molecular recognition at surfaces derivatized with self-assembled monolayers
WO1997029366A1 (en) 1996-02-08 1997-08-14 Australian Membrane And Biotechnology Research Institute Enzyme detection biosensors
US7393645B2 (en) 1996-11-05 2008-07-01 Clinical Micro Sensors, Inc. Compositions for the electronic detection of analytes utilizing monolayers
US7045285B1 (en) 1996-11-05 2006-05-16 Clinical Micro Sensors, Inc. Electronic transfer moieties attached to peptide nucleic acids
WO1998020162A2 (en) 1996-11-05 1998-05-14 Clinical Micro Sensors Electrodes linked via conductive oligomers to nucleic acids
US7160678B1 (en) 1996-11-05 2007-01-09 Clinical Micro Sensors, Inc. Compositions for the electronic detection of analytes utilizing monolayers
US6162645A (en) 1997-03-13 2000-12-19 Abbott Laboratories Determination of % glycated hemoglobin
US6013459A (en) 1997-06-12 2000-01-11 Clinical Micro Sensors, Inc. Detection of analytes using reorganization energy
US7560237B2 (en) 1997-06-12 2009-07-14 Osmetech Technology Inc. Electronics method for the detection of analytes
US6134461A (en) 1998-03-04 2000-10-17 E. Heller & Company Electrochemical analyte
WO1999057317A1 (en) 1998-05-06 1999-11-11 Clinical Micro Sensors, Inc. Electronic methods for the detection of analytes utilizing monolayers
RU2161653C2 (ru) 1998-08-24 2001-01-10 ФАРМАКОВСКИЙ Дмитрий Александрович Способ количественного электрохимического анализа биомолекул
US6281006B1 (en) 1998-08-24 2001-08-28 Therasense, Inc. Electrochemical affinity assay
US6740518B1 (en) 1998-09-17 2004-05-25 Clinical Micro Sensors, Inc. Signal detection techniques for the detection of analytes
AU1241000A (en) 1998-10-27 2000-05-15 Clinical Micro Sensors, Inc. Detection of target analytes using particles and electrodes
US6432723B1 (en) 1999-01-22 2002-08-13 Clinical Micro Sensors, Inc. Biosensors utilizing ligand induced conformation changes
US6495336B1 (en) 1999-02-23 2002-12-17 Pentapharm Ag Oligopeptide derivatives for the electrochemical measurement of protease activity
US7312087B2 (en) 2000-01-11 2007-12-25 Clinical Micro Sensors, Inc. Devices and methods for biochip multiplexing
US6942771B1 (en) 1999-04-21 2005-09-13 Clinical Micro Sensors, Inc. Microfluidic systems in the electrochemical detection of target analytes
US7234414B2 (en) 1999-11-18 2007-06-26 Sensortec Limited Mastitis detection
GB0002201D0 (en) 2000-01-31 2000-03-22 Imperial College Process
US6753143B2 (en) * 2000-05-01 2004-06-22 Clinical Micro Sensors, Inc. Target analyte detection using asymmetrical self-assembled monolayers
DE10024314A1 (de) 2000-05-17 2001-11-22 Basf Ag Verfahren, umfassend die indirekte elektrochemische Regeneration von NAD(P)H
EP1243276A1 (en) 2001-03-23 2002-09-25 Franciscus Marinus Hendrikus De Groot Elongated and multiple spacers containing activatible prodrugs
RU2301997C2 (ru) 2001-08-24 2007-06-27 Сенсор-Тек Лимитед Способ получения высокочувствительных потенциометрических датчиков
US6562581B2 (en) 2001-08-31 2003-05-13 Portascience Method for quantitative determination of glycated hemoglobin
KR100407822B1 (ko) 2001-12-04 2003-12-01 한국전자통신연구원 전기화학식 면역 센서와 이를 이용한 생화학 시료검출장치 및 방법
CA2506080A1 (en) 2002-11-14 2004-05-27 Syntarga B.V. Prodrugs built as multiple self-elimination-release spacers
US7214528B1 (en) 2002-12-31 2007-05-08 Oregon Health & Sciences University Device for direct electrical detection of molecules and molecule-molecule interactions
US8425745B2 (en) 2006-10-06 2013-04-23 Nanomix, Inc. Electrochemical nanosensors for biomolecule detection
AU2003903504A0 (en) 2003-07-08 2003-07-24 Johnson, Daniel Improvements in sensor chips
GB0316075D0 (en) 2003-07-09 2003-08-13 Molecular Sensing Plc Protease detection assay
FR2859524B1 (fr) * 2003-09-04 2005-12-16 Jaubjaub Consulting Gabarit de controle demontable de la geometrie d'un profile forme
AU2005216251B2 (en) 2004-02-23 2011-03-10 Genentech, Inc. Heterocyclic self-immolative linkers and conjugates
TWI245894B (en) 2004-02-26 2005-12-21 Univ Tamkang Method and chemical sensor for determining concentrations of hydrogen peroxide and its precursor in a solution
US7511142B2 (en) 2004-07-28 2009-03-31 Agency For Science, Technology And Research Mediator-modified redox biomolecules for use in electrochemical determination of analyte
MX2007001770A (es) 2004-08-13 2007-08-07 Egomedical Technologies Ag Sistema de prueba de analitos para determinar la concentracion de un analito en un fluido fisiologico o acuoso.
GB2420180A (en) 2004-11-11 2006-05-17 Sensor Tech Ltd Method of electrochemical analysis of an analyte
WO2007025281A2 (en) 2005-08-24 2007-03-01 Applera Corporation A method to quantify sirnas, mirnas and polymorphic mirnas
TWI412367B (zh) 2006-12-28 2013-10-21 Medarex Llc 化學鏈接劑與可裂解基質以及其之綴合物
JP2011502245A (ja) 2007-10-17 2011-01-20 オームクス コーポレーション 酵素検出のための電気化学的検定方法
US8673646B2 (en) 2008-05-13 2014-03-18 General Atomics Electrochemical biosensor for direct determination of percentage of glycated hemoglobin
WO2010142037A1 (en) 2009-06-08 2010-12-16 The University Of Western Ontario An electrochemical method and apparatus of identifying the presence of a target
JP5352742B2 (ja) 2009-08-07 2013-11-27 オームクス コーポレーション 酵素による酸化還元変化化学的脱離（ｅ−ｔｒａｃｅ）免疫学的検定法
US9250234B2 (en) 2011-01-19 2016-02-02 Ohmx Corporation Enzyme triggered redox altering chemical elimination (E-TRACE) immunoassay
WO2011041586A1 (en) 2009-09-30 2011-04-07 Virogenomics, Inc. Electromagnetic detection of analytes
WO2011146143A2 (en) 2010-05-21 2011-11-24 Ohmx Corporation Detection of cancer by assaying psa enzymatic activity
US20140134658A1 (en) 2010-05-21 2014-05-15 Notrhwestern University, An Illinois Not For Profit Corporation Psa enzymatic activity: a new biomarker for assessing prostate cancer aggressiveness
CA2800257C (en) 2010-05-26 2019-03-05 The Board Of Trustees Of The University Of Illinois Personal glucose meters for detection and quantification of a broad range of analytes
WO2012012537A1 (en) 2010-07-20 2012-01-26 Ohmx Corporation Novel chemistry used in biosensors
JP6203183B2 (ja) 2011-10-17 2017-09-27 オームクス コーポレイション 酵素誘発レドックス変化化学的脱離（ｅ−ｔｒａｃｅ）イムノアッセイを使用する、ヘモグロビンａ１ｃのパーセンテージの単回直接検出
EP2773650A1 (en) 2011-11-04 2014-09-10 Ohmx Corporation Novel chemistry used in biosensors
JP2015529809A (ja) 2012-07-27 2015-10-08 オームクス コーポレイション 酵素及び他の標的分析物の存在及び活性の切断前検出後の単分子層の電気測定
US9404883B2 (en) 2012-07-27 2016-08-02 Ohmx Corporation Electronic measurements of monolayers following homogeneous reactions of their components
US9659398B2 (en) 2013-03-15 2017-05-23 Dreamworks Animation Llc Multiple visual representations of lighting effects in a computer animation scene

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