JP2015508500A5 - - Google Patents

Download PDF

Info

Publication number
JP2015508500A5
JP2015508500A5 JP2014551418A JP2014551418A JP2015508500A5 JP 2015508500 A5 JP2015508500 A5 JP 2015508500A5 JP 2014551418 A JP2014551418 A JP 2014551418A JP 2014551418 A JP2014551418 A JP 2014551418A JP 2015508500 A5 JP2015508500 A5 JP 2015508500A5
Authority
JP
Japan
Prior art keywords
peroxide
enzyme
eam
binding ligand
complex
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2014551418A
Other languages
English (en)
Japanese (ja)
Other versions
JP2015508500A (ja
JP6276706B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2013/020836 external-priority patent/WO2013106434A1/en
Publication of JP2015508500A publication Critical patent/JP2015508500A/ja
Publication of JP2015508500A5 publication Critical patent/JP2015508500A5/ja
Application granted granted Critical
Publication of JP6276706B2 publication Critical patent/JP6276706B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2014551418A 2012-01-09 2013-01-09 Ｅ−ｔｒａｃｅアッセイシグナル増幅の酵素カスケード方法 Expired - Fee Related JP6276706B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261584563P 2012-01-09 2012-01-09
US61/584,563 2012-01-09
PCT/US2013/020836 WO2013106434A1 (en) 2012-01-09 2013-01-09 Enzyme cascade methods for e-trace assay signal amplification

Publications (3)

Publication Number Publication Date
JP2015508500A JP2015508500A (ja) 2015-03-19
JP2015508500A5 true JP2015508500A5 (enExample) 2016-02-25
JP6276706B2 JP6276706B2 (ja) 2018-02-07

Family

ID=47559760

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014551418A Expired - Fee Related JP6276706B2 (ja) 2012-01-09 2013-01-09 Ｅ−ｔｒａｃｅアッセイシグナル増幅の酵素カスケード方法

Country Status (5)

Country Link
US (2) US9250203B2 (enExample)
EP (1) EP2802669A1 (enExample)
JP (1) JP6276706B2 (enExample)
CA (1) CA2860739A1 (enExample)
WO (1) WO2013106434A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8951400B2 (en) 2007-10-17 2015-02-10 Ohmx Corporation Chemistry used in biosensors
US9250234B2 (en) 2011-01-19 2016-02-02 Ohmx Corporation Enzyme triggered redox altering chemical elimination (E-TRACE) immunoassay
EP2462238B1 (en) 2009-08-07 2013-07-17 Ohmx Corporation Enzyme triggered redox altering chemical elimination (e-trace) immunoassay
EP2768967B1 (en) 2011-10-17 2017-12-06 Ohmx Corporation Single, direct detection of hemoglobin a1c percentage using enzyme triggered redox altering chemical elimination (e-trace) immunoassay
JP2014532720A (ja) 2011-11-04 2014-12-08 オームクス コーポレイション バイオセンサーにおいて使用される新規化学
US9416390B2 (en) 2012-07-27 2016-08-16 Ohmx Corporation Electric measurement of monolayers following pro-cleave detection of presence and activity of enzymes and other target analytes
EP3121288A1 (en) 2012-07-27 2017-01-25 Ohmx Corporation Electronic measurements of monolayers following homogeneous reactions of their components

Family Cites Families (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US332565A (en) 1885-12-15 Self-binding grain-harvester
US407828A (en) 1889-07-30 Tire-tightener
US4247533A (en) 1978-05-01 1981-01-27 The Rockefeller University Hemoglobin A1c radioimmunoassay
EP0018002B1 (de) 1979-04-24 1983-02-09 Marcel Jozefonvicz Neues Bestimmungsverfahren für Proteasen und Antiproteasen
US4469863A (en) 1980-11-12 1984-09-04 Ts O Paul O P Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof
US4727036A (en) 1985-08-08 1988-02-23 Molecular Diagnostics, Inc. Antibodies for use in determining hemoglobin A1c
US5034506A (en) 1985-03-15 1991-07-23 Anti-Gene Development Group Uncharged morpholino-based polymers having achiral intersubunit linkages
US5235033A (en) 1985-03-15 1993-08-10 Anti-Gene Development Group Alpha-morpholino ribonucleoside derivatives and polymers thereof
US5206144A (en) 1985-03-29 1993-04-27 Novo Industri A/S Determination of glycated (glycosylated) hemoglobin in blood
US4806468A (en) 1987-02-05 1989-02-21 Becton, Dickinson And Company Measurement of glycosylated hemoglobin by immunoassay
JPS63254998A (ja) * 1987-04-10 1988-10-21 Imuno Baion:Kk 微量のピリジンヌクレオチド補酵素分析法
US5216141A (en) 1988-06-06 1993-06-01 Benner Steven A Oligonucleotide analogs containing sulfur linkages
AU633507B2 (en) 1988-08-02 1993-02-04 London Biotechnology Limited An amplification assay for hydrolase enzymes
US5173373A (en) 1989-09-14 1992-12-22 Yamaha Hatsudoki Kabushiki Kaisha Gasket for fuel cell
US5705337A (en) 1990-06-11 1998-01-06 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: chemi-SELEX
US5683867A (en) 1990-06-11 1997-11-04 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: blended SELEX
EP0533838B1 (en) 1990-06-11 1997-12-03 NeXstar Pharmaceuticals, Inc. Nucleic acid ligands
US5270163A (en) 1990-06-11 1993-12-14 University Research Corporation Methods for identifying nucleic acid ligands
US5637459A (en) 1990-06-11 1997-06-10 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: chimeric selex
US5567588A (en) 1990-06-11 1996-10-22 University Research Corporation Systematic evolution of ligands by exponential enrichment: Solution SELEX
US5496938A (en) 1990-06-11 1996-03-05 Nexstar Pharmaceuticals, Inc. Nucleic acid ligands to HIV-RT and HIV-1 rev
US5602240A (en) 1990-07-27 1997-02-11 Ciba Geigy Ag. Backbone modified oligonucleotide analogs
US5386023A (en) 1990-07-27 1995-01-31 Isis Pharmaceuticals Backbone modified oligonucleotide analogs and preparation thereof through reductive coupling
EP0597951B1 (en) 1991-07-26 1999-03-31 Dade Chemistry Systems Inc. An assay with signal detection in the presence of a suspended solid support
US5644048A (en) 1992-01-10 1997-07-01 Isis Pharmaceuticals, Inc. Process for preparing phosphorothioate oligonucleotides
US5637684A (en) 1994-02-23 1997-06-10 Isis Pharmaceuticals, Inc. Phosphoramidate and phosphorothioamidate oligomeric compounds
DE4430023A1 (de) 1994-08-24 1996-02-29 Boehringer Mannheim Gmbh Elektrochemischer Sensor
US5620850A (en) 1994-09-26 1997-04-15 President And Fellows Of Harvard College Molecular recognition at surfaces derivatized with self-assembled monolayers
EP0879412A4 (en) 1996-02-08 2004-08-11 Ambri Ltd BIOSENSOR TO DETECT ENZYMS
US7393645B2 (en) 1996-11-05 2008-07-01 Clinical Micro Sensors, Inc. Compositions for the electronic detection of analytes utilizing monolayers
US7045285B1 (en) 1996-11-05 2006-05-16 Clinical Micro Sensors, Inc. Electronic transfer moieties attached to peptide nucleic acids
WO1998020162A2 (en) 1996-11-05 1998-05-14 Clinical Micro Sensors Electrodes linked via conductive oligomers to nucleic acids
US7160678B1 (en) 1996-11-05 2007-01-09 Clinical Micro Sensors, Inc. Compositions for the electronic detection of analytes utilizing monolayers
US6162645A (en) 1997-03-13 2000-12-19 Abbott Laboratories Determination of % glycated hemoglobin
AU744503B2 (en) 1997-06-12 2002-02-28 Clinical Micro Sensors, Inc. Electronic methods for the detection of analytes
US6013459A (en) 1997-06-12 2000-01-11 Clinical Micro Sensors, Inc. Detection of analytes using reorganization energy
US6134461A (en) 1998-03-04 2000-10-17 E. Heller & Company Electrochemical analyte
ATE407220T1 (de) 1998-05-06 2008-09-15 Clinical Micro Sensors Inc Elekronische verfahren zur erkennung von analyten mit hilfe von einfachschichten
RU2161653C2 (ru) 1998-08-24 2001-01-10 ФАРМАКОВСКИЙ Дмитрий Александрович Способ количественного электрохимического анализа биомолекул
US6281006B1 (en) * 1998-08-24 2001-08-28 Therasense, Inc. Electrochemical affinity assay
US6740518B1 (en) 1998-09-17 2004-05-25 Clinical Micro Sensors, Inc. Signal detection techniques for the detection of analytes
US6541617B1 (en) 1998-10-27 2003-04-01 Clinical Micro Sensors, Inc. Detection of target analytes using particles and electrodes
US6432723B1 (en) 1999-01-22 2002-08-13 Clinical Micro Sensors, Inc. Biosensors utilizing ligand induced conformation changes
US6495336B1 (en) 1999-02-23 2002-12-17 Pentapharm Ag Oligopeptide derivatives for the electrochemical measurement of protease activity
US6942771B1 (en) 1999-04-21 2005-09-13 Clinical Micro Sensors, Inc. Microfluidic systems in the electrochemical detection of target analytes
US7312087B2 (en) 2000-01-11 2007-12-25 Clinical Micro Sensors, Inc. Devices and methods for biochip multiplexing
US7234414B2 (en) 1999-11-18 2007-06-26 Sensortec Limited Mastitis detection
GB0002201D0 (en) 2000-01-31 2000-03-22 Imperial College Process
US6753143B2 (en) 2000-05-01 2004-06-22 Clinical Micro Sensors, Inc. Target analyte detection using asymmetrical self-assembled monolayers
DE10024314A1 (de) 2000-05-17 2001-11-22 Basf Ag Verfahren, umfassend die indirekte elektrochemische Regeneration von NAD(P)H
EP1243276A1 (en) 2001-03-23 2002-09-25 Franciscus Marinus Hendrikus De Groot Elongated and multiple spacers containing activatible prodrugs
RU2301997C2 (ru) 2001-08-24 2007-06-27 Сенсор-Тек Лимитед Способ получения высокочувствительных потенциометрических датчиков
US6562581B2 (en) 2001-08-31 2003-05-13 Portascience Method for quantitative determination of glycated hemoglobin
KR100407822B1 (ko) 2001-12-04 2003-12-01 한국전자통신연구원 전기화학식 면역 센서와 이를 이용한 생화학 시료검출장치 및 방법
WO2004043493A1 (en) 2002-11-14 2004-05-27 Syntarga B.V. Prodrugs built as multiple self-elimination-release spacers
US7214528B1 (en) 2002-12-31 2007-05-08 Oregon Health & Sciences University Device for direct electrical detection of molecules and molecule-molecule interactions
AU2003903504A0 (en) 2003-07-08 2003-07-24 Johnson, Daniel Improvements in sensor chips
GB0316075D0 (en) 2003-07-09 2003-08-13 Molecular Sensing Plc Protease detection assay
FR2859524B1 (fr) * 2003-09-04 2005-12-16 Jaubjaub Consulting Gabarit de controle demontable de la geometrie d'un profile forme
JP5064037B2 (ja) 2004-02-23 2012-10-31 ジェネンテック， インコーポレイテッド 複素環式自壊的リンカーおよび結合体
TWI245894B (en) 2004-02-26 2005-12-21 Univ Tamkang Method and chemical sensor for determining concentrations of hydrogen peroxide and its precursor in a solution
US7511142B2 (en) 2004-07-28 2009-03-31 Agency For Science, Technology And Research Mediator-modified redox biomolecules for use in electrochemical determination of analyte
ATE445020T1 (de) 2004-08-13 2009-10-15 Egomedical Technologies Ag Analyttestsystem zur bestimmung der konzentration eines analyten in einer physiologischen oder wässrigen flüssigkeit
GB2420180A (en) 2004-11-11 2006-05-17 Sensor Tech Ltd Method of electrochemical analysis of an analyte
WO2007025281A2 (en) 2005-08-24 2007-03-01 Applera Corporation A method to quantify sirnas, mirnas and polymorphic mirnas
WO2008045799A2 (en) 2006-10-06 2008-04-17 Nanomix, Inc. Electrochemical nanosensors for biomolecule detection
TWI412367B (zh) 2006-12-28 2013-10-21 Medarex Llc 化學鏈接劑與可裂解基質以及其之綴合物
US8951400B2 (en) 2007-10-17 2015-02-10 Ohmx Corporation Chemistry used in biosensors
JP2011501161A (ja) 2007-10-17 2011-01-06 オームクス コーポレーション バイオセンサーに用いる新しい化学
WO2009140343A1 (en) 2008-05-13 2009-11-19 General Atomics Electrochemical biosensor for direct determination of percentage of glycated hemoglobin
CN102460139B (zh) 2009-06-08 2014-04-30 西安大略大学 鉴别靶存在情况的电化学方法和装置
EP2462238B1 (en) 2009-08-07 2013-07-17 Ohmx Corporation Enzyme triggered redox altering chemical elimination (e-trace) immunoassay
US9250234B2 (en) 2011-01-19 2016-02-02 Ohmx Corporation Enzyme triggered redox altering chemical elimination (E-TRACE) immunoassay
WO2011041586A1 (en) 2009-09-30 2011-04-07 Virogenomics, Inc. Electromagnetic detection of analytes
US20120034638A1 (en) 2010-05-21 2012-02-09 Michael Ahrens Electrochemical assay for the detection of enzymatically active PSA
US20140134658A1 (en) 2010-05-21 2014-05-15 Notrhwestern University, An Illinois Not For Profit Corporation Psa enzymatic activity: a new biomarker for assessing prostate cancer aggressiveness
EP2576806B1 (en) 2010-05-26 2017-03-08 The Board of Trustees of the University of Illionis Personal glucose meters for detection and quantification of a broad range of analytes
EP2768967B1 (en) 2011-10-17 2017-12-06 Ohmx Corporation Single, direct detection of hemoglobin a1c percentage using enzyme triggered redox altering chemical elimination (e-trace) immunoassay
JP2014532720A (ja) 2011-11-04 2014-12-08 オームクス コーポレイション バイオセンサーにおいて使用される新規化学
EP3121288A1 (en) 2012-07-27 2017-01-25 Ohmx Corporation Electronic measurements of monolayers following homogeneous reactions of their components
US9416390B2 (en) 2012-07-27 2016-08-16 Ohmx Corporation Electric measurement of monolayers following pro-cleave detection of presence and activity of enzymes and other target analytes
US9659398B2 (en) 2013-03-15 2017-05-23 Dreamworks Animation Llc Multiple visual representations of lighting effects in a computer animation scene

Similar Documents

Publication Publication Date Title
Qu et al. Ultrasensitive ELISA using enzyme-loaded nanospherical brushes as labels
JP2015508500A5 (enExample)
Wang et al. Competitive immunoassays for the detection of small molecules using single molecule arrays
Akter et al. A highly sensitive quartz crystal microbalance immunosensor based on magnetic bead-supported bienzymes catalyzed mass enhancement strategy
Aissa et al. Magnetic molecularly imprinted polymer for the isolation and detection of biotin and biotinylated biomolecules
Zhang et al. Electrochemical immunosensor for interferon-γ based on disposable ITO detector and HRP-antibody-conjugated nano gold as signal tag
Alves et al. Oriented antibody immobilization by site-specific UV photocrosslinking of biotin at the conserved nucleotide binding site for enhanced antigen detection
Chen et al. An ultra-sensitive chemiluminescence immunosensor of carcinoembryonic antigen using HRP-functionalized mesoporous silica nanoparticles as labels
Corgier et al. A versatile method for direct and covalent immobilization of DNA and proteins on biochips
JP2015529809A5 (enExample)
Zhao et al. Carbon nanotubes multifunctionalized by rolling circle amplification and their application for highly sensitive detection of cancer markers
JP5171958B2 (ja) カスケード酵素免疫測定法
Niu et al. Highly amplified electrochemiluminescence of peroxydisulfate using bienzyme functionalized palladium nanoparticles as labels for ultrasensitive immunoassay
Liu et al. Covalent functionalization of gold nanoparticles as electronic bridges and signal amplifiers towards an electrochemical immunosensor for botulinum neurotoxin type A
JP5675782B2 (ja) 標識化プローブ−水溶性担体複合体
Han et al. Electrochemical immunoassay for thyroxine detection using cascade catalysis as signal amplified enhancer and multi-functionalized magnetic graphene sphere as signal tag
Lee et al. Ultrasensitive ImmunoMag-CRISPR lateral flow assay for point-of-care testing of urinary biomarkers
Guo et al. Advanced electrochemical biosensing toward Staphylococcus aureus based on the RPA-CRISPR/Cas12a system and conductive nanocomposite
Tong et al. ELISA–PLA: A novel hybrid platform for the rapid, highly sensitive and specific quantification of proteins and post-translational modifications
WO2012007903A3 (en) A method of detecting surrogate markers for active tuberculosis in a serum sample
Mattarozzi et al. Aptamer-based assays: strategies in the use of aptamers conjugated to magnetic micro-and nanobeads as recognition elements in food control
Xu et al. Micro/nano technology for next‐generation diagnostics
Yao et al. Core-shell Au@ PdNPs based colorimetric enhanced lateral flow immunoassay for C-reactive protein detection
JP2017026631A5 (enExample)
Wu et al. Electrochemical‐and Fluorescent‐Mediated Signal Amplifications for Rapid Detection of Low‐Abundance Circulating Tumor Cells on a Paper‐Based Microfluidic Immunodevice