JP2015529809A5 - - Google Patents
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- JP2015529809A5 JP2015529809A5 JP2015524473A JP2015524473A JP2015529809A5 JP 2015529809 A5 JP2015529809 A5 JP 2015529809A5 JP 2015524473 A JP2015524473 A JP 2015524473A JP 2015524473 A JP2015524473 A JP 2015524473A JP 2015529809 A5 JP2015529809 A5 JP 2015529809A5
- Authority
- JP
- Japan
- Prior art keywords
- eam
- erm
- electrode
- target analyte
- test sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000012491 analyte Substances 0.000 claims 20
- 239000000203 mixture Substances 0.000 claims 15
- 239000002094 self assembled monolayer Substances 0.000 claims 15
- 239000013545 self-assembled monolayer Substances 0.000 claims 15
- 102000004190 Enzymes Human genes 0.000 claims 14
- 108090000790 Enzymes Proteins 0.000 claims 14
- 229910052723 transition metal Inorganic materials 0.000 claims 13
- 150000003624 transition metals Chemical class 0.000 claims 13
- 239000007787 solid Substances 0.000 claims 12
- 238000000034 method Methods 0.000 claims 7
- 238000003556 assay Methods 0.000 claims 6
- 239000003446 ligand Substances 0.000 claims 6
- VVJKKWFAADXIJK-UHFFFAOYSA-N Allylamine Chemical compound NCC=C VVJKKWFAADXIJK-UHFFFAOYSA-N 0.000 claims 4
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical group [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 4
- 102000035195 Peptidases Human genes 0.000 claims 4
- 108091005804 Peptidases Proteins 0.000 claims 4
- 239000002202 Polyethylene glycol Substances 0.000 claims 4
- KTWOOEGAPBSYNW-UHFFFAOYSA-N ferrocene Chemical compound [Fe+2].C=1C=C[CH-]C=1.C=1C=C[CH-]C=1 KTWOOEGAPBSYNW-UHFFFAOYSA-N 0.000 claims 4
- 230000002209 hydrophobic effect Effects 0.000 claims 4
- 229920001223 polyethylene glycol Polymers 0.000 claims 4
- 125000000524 functional group Chemical group 0.000 claims 3
- IMSODMZESSGVBE-UHFFFAOYSA-N 2-Oxazoline Chemical compound C1CN=CO1 IMSODMZESSGVBE-UHFFFAOYSA-N 0.000 claims 2
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims 2
- NOWKCMXCCJGMRR-UHFFFAOYSA-N Aziridine Chemical compound C1CN1 NOWKCMXCCJGMRR-UHFFFAOYSA-N 0.000 claims 2
- 102000004157 Hydrolases Human genes 0.000 claims 2
- 108090000604 Hydrolases Proteins 0.000 claims 2
- 102000004195 Isomerases Human genes 0.000 claims 2
- 108090000769 Isomerases Proteins 0.000 claims 2
- 102000003960 Ligases Human genes 0.000 claims 2
- 108090000364 Ligases Proteins 0.000 claims 2
- 102000004317 Lyases Human genes 0.000 claims 2
- 108090000856 Lyases Proteins 0.000 claims 2
- 102000004316 Oxidoreductases Human genes 0.000 claims 2
- 108090000854 Oxidoreductases Proteins 0.000 claims 2
- 102000045595 Phosphoprotein Phosphatases Human genes 0.000 claims 2
- 108700019535 Phosphoprotein Phosphatases Proteins 0.000 claims 2
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 2
- 102000007066 Prostate-Specific Antigen Human genes 0.000 claims 2
- 108010072866 Prostate-Specific Antigen Proteins 0.000 claims 2
- 239000004365 Protease Substances 0.000 claims 2
- KJTLSVCANCCWHF-UHFFFAOYSA-N Ruthenium Chemical compound [Ru] KJTLSVCANCCWHF-UHFFFAOYSA-N 0.000 claims 2
- 229920002125 Sokalan® Polymers 0.000 claims 2
- 102000004357 Transferases Human genes 0.000 claims 2
- 108090000992 Transferases Proteins 0.000 claims 2
- 230000003993 interaction Effects 0.000 claims 2
- 229910052742 iron Inorganic materials 0.000 claims 2
- 230000008520 organization Effects 0.000 claims 2
- 229910052762 osmium Inorganic materials 0.000 claims 2
- SYQBFIAQOQZEGI-UHFFFAOYSA-N osmium atom Chemical compound [Os] SYQBFIAQOQZEGI-UHFFFAOYSA-N 0.000 claims 2
- 239000004584 polyacrylic acid Substances 0.000 claims 2
- 229920000193 polymethacrylate Polymers 0.000 claims 2
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 2
- 229920002717 polyvinylpyridine Polymers 0.000 claims 2
- 235000019833 protease Nutrition 0.000 claims 2
- 235000019419 proteases Nutrition 0.000 claims 2
- 229910052707 ruthenium Inorganic materials 0.000 claims 2
- 238000005406 washing Methods 0.000 claims 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 235000014633 carbohydrates Nutrition 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 238000006911 enzymatic reaction Methods 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims 1
- 239000011976 maleic acid Substances 0.000 claims 1
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 claims 1
- 235000021317 phosphate Nutrition 0.000 claims 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261676641P | 2012-07-27 | 2012-07-27 | |
| US61/676,641 | 2012-07-27 | ||
| US201261677593P | 2012-07-31 | 2012-07-31 | |
| US61/677,593 | 2012-07-31 | ||
| US201261708301P | 2012-10-01 | 2012-10-01 | |
| US61/708,301 | 2012-10-01 | ||
| PCT/US2013/052340 WO2014018899A1 (en) | 2012-07-27 | 2013-07-26 | Electric measurement of monolayers following pro-cleave detection of presence and activity of enzymes and other target analytes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015529809A JP2015529809A (ja) | 2015-10-08 |
| JP2015529809A5 true JP2015529809A5 (enExample) | 2016-09-08 |
Family
ID=48918486
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015524473A Pending JP2015529809A (ja) | 2012-07-27 | 2013-07-26 | 酵素及び他の標的分析物の存在及び活性の切断前検出後の単分子層の電気測定 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US9416390B2 (enExample) |
| EP (1) | EP2877851A1 (enExample) |
| JP (1) | JP2015529809A (enExample) |
| CA (1) | CA2880104A1 (enExample) |
| WO (1) | WO2014018899A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8951400B2 (en) | 2007-10-17 | 2015-02-10 | Ohmx Corporation | Chemistry used in biosensors |
| JP5352742B2 (ja) | 2009-08-07 | 2013-11-27 | オームクス コーポレーション | 酵素による酸化還元変化化学的脱離（ｅ−ｔｒａｃｅ）免疫学的検定法 |
| WO2012100078A1 (en) | 2011-01-19 | 2012-07-26 | Ohmx Corporation | Enzyme triggered redox altering chemical elimination (e-trace) immmunoassay |
| JP6203183B2 (ja) | 2011-10-17 | 2017-09-27 | オームクス コーポレイション | 酵素誘発レドックス変化化学的脱離（ｅ−ｔｒａｃｅ）イムノアッセイを使用する、ヘモグロビンａ１ｃのパーセンテージの単回直接検出 |
| WO2013067349A1 (en) | 2011-11-04 | 2013-05-10 | Ohmx Corporation | Novel chemistry used in biosensors |
| EP2802669A1 (en) | 2012-01-09 | 2014-11-19 | Ohmx Corporation | Enzyme cascade methods for e-trace assay signal amplification |
| EP2877592B1 (en) | 2012-07-27 | 2016-09-21 | Ohmx Corporation | Electronic measurements of monolayers following homogeneous reactions of their components |
| US9880121B2 (en) | 2014-04-29 | 2018-01-30 | Ohmx Corporation | Bioelectronic binding assay using peak profiling |
| US20160041118A1 (en) | 2014-08-11 | 2016-02-11 | Ohmx Corporation | Enzyme triggered redox altering chemical elimination (e-trace) assay with multiplexing capabilities |
| WO2016061590A1 (en) | 2014-10-17 | 2016-04-21 | Wardell Mark R | Method for detecting proteases and active infection in biological fluids and tissues |
| US20160178562A1 (en) * | 2014-12-19 | 2016-06-23 | Ohmx Corporation | Competitive enzymatic assay |
| EP3362785A4 (en) * | 2015-10-14 | 2019-06-12 | University Health Network (UHN) | ELECTROCHEMICAL TEST FOR A PROTEIN ANALYTE |
| US10323331B2 (en) | 2016-12-29 | 2019-06-18 | Industrial Technology Research Institute | Valuable metal selectively adsorbing electrode and method for selectively recovering valuable metals |
| CN112881492A (zh) * | 2021-02-26 | 2021-06-01 | 长沙市信励致和科技有限责任公司 | 基于人绒毛膜促性腺激素肽适配体的丝网印刷电极体系及其制备方法 |
| KR102661260B1 (ko) * | 2021-08-27 | 2024-04-29 | 고려대학교 산학협력단 | 전자전달 능력이 향상된 효소기반 전극, 그 제조방법 및 그 응용 |
| CN114414642B (zh) * | 2022-01-07 | 2023-06-02 | 重庆医科大学 | 用于人乳头瘤病毒16型e6癌蛋白检测的电化学传感器 |
| CN115950933B (zh) * | 2022-11-29 | 2025-02-07 | 常州先趋医疗科技有限公司 | 自组装单分子膜修饰电极及其制备方法和用途 |
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| JP2013528379A (ja) | 2010-05-21 | 2013-07-11 | オームクス コーポレーション | Ｐｓａ酵素活性アッセイによる癌の検出 |
| US8945943B2 (en) | 2010-05-26 | 2015-02-03 | The Board Of Trustees Of The University Of Illinois | Personal glucose meters for detection and quantification of a broad range of analytes |
| KR101702837B1 (ko) * | 2010-07-22 | 2017-02-07 | 삼성전자주식회사 | 필름형 전자회로를 구비하는 전자제품의 케이스 구조물 및 그 제조방법 |
| WO2012100078A1 (en) | 2011-01-19 | 2012-07-26 | Ohmx Corporation | Enzyme triggered redox altering chemical elimination (e-trace) immmunoassay |
| JP6203183B2 (ja) | 2011-10-17 | 2017-09-27 | オームクス コーポレイション | 酵素誘発レドックス変化化学的脱離（ｅ−ｔｒａｃｅ）イムノアッセイを使用する、ヘモグロビンａ１ｃのパーセンテージの単回直接検出 |
| WO2013067349A1 (en) | 2011-11-04 | 2013-05-10 | Ohmx Corporation | Novel chemistry used in biosensors |
| EP2802669A1 (en) | 2012-01-09 | 2014-11-19 | Ohmx Corporation | Enzyme cascade methods for e-trace assay signal amplification |
| EP2877592B1 (en) | 2012-07-27 | 2016-09-21 | Ohmx Corporation | Electronic measurements of monolayers following homogeneous reactions of their components |
| US9659398B2 (en) | 2013-03-15 | 2017-05-23 | Dreamworks Animation Llc | Multiple visual representations of lighting effects in a computer animation scene |
| US9880121B2 (en) | 2014-04-29 | 2018-01-30 | Ohmx Corporation | Bioelectronic binding assay using peak profiling |
-
2013
- 2013-07-26 WO PCT/US2013/052340 patent/WO2014018899A1/en not_active Ceased
- 2013-07-26 US US13/952,345 patent/US9416390B2/en not_active Expired - Fee Related
- 2013-07-26 JP JP2015524473A patent/JP2015529809A/ja active Pending
- 2013-07-26 CA CA2880104A patent/CA2880104A1/en not_active Abandoned
- 2013-07-26 EP EP13745769.3A patent/EP2877851A1/en not_active Withdrawn
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