JP2015529809A - 酵素及び他の標的分析物の存在及び活性の切断前検出後の単分子層の電気測定 - Google Patents

酵素及び他の標的分析物の存在及び活性の切断前検出後の単分子層の電気測定 Download PDF

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JP2015529809A
JP2015529809A JP2015524473A JP2015524473A JP2015529809A JP 2015529809 A JP2015529809 A JP 2015529809A JP 2015524473 A JP2015524473 A JP 2015524473A JP 2015524473 A JP2015524473 A JP 2015524473A JP 2015529809 A JP2015529809 A JP 2015529809A
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JP2015529809A5 (enExample
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アダム ジー． ガウスタッド
アダム ジー． ガウスタッド
マイケル ジェイ． アーレンス
マイケル ジェイ． アーレンス
ポール エー． バーティン
ポール エー． バーティン
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オームクス コーポレイション
オームクス コーポレイション
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/005—Enzyme electrodes involving specific analytes or enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2610/00—Assays involving self-assembled monolayers [SAMs]

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
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  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Enzymes And Modification Thereof (AREA)
JP2015524473A 2012-07-27 2013-07-26 酵素及び他の標的分析物の存在及び活性の切断前検出後の単分子層の電気測定 Pending JP2015529809A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201261676641P 2012-07-27 2012-07-27
US61/676,641 2012-07-27
US201261677593P 2012-07-31 2012-07-31
US61/677,593 2012-07-31
US201261708301P 2012-10-01 2012-10-01
US61/708,301 2012-10-01
PCT/US2013/052340 WO2014018899A1 (en) 2012-07-27 2013-07-26 Electric measurement of monolayers following pro-cleave detection of presence and activity of enzymes and other target analytes

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JP2015529809A true JP2015529809A (ja) 2015-10-08
JP2015529809A5 JP2015529809A5 (enExample) 2016-09-08

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US (1) US9416390B2 (enExample)
EP (1) EP2877851A1 (enExample)
JP (1) JP2015529809A (enExample)
CA (1) CA2880104A1 (enExample)
WO (1) WO2014018899A1 (enExample)

Cited By (1)

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KR20230031516A (ko) * 2021-08-27 2023-03-07 고려대학교 산학협력단 효소기반 전극, 그 제조방법 및 그 응용

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JP5352742B2 (ja) 2009-08-07 2013-11-27 オームクス コーポレーション 酵素による酸化還元変化化学的脱離（ｅ−ｔｒａｃｅ）免疫学的検定法
US9250234B2 (en) 2011-01-19 2016-02-02 Ohmx Corporation Enzyme triggered redox altering chemical elimination (E-TRACE) immunoassay
WO2012012537A1 (en) 2010-07-20 2012-01-26 Ohmx Corporation Novel chemistry used in biosensors
JP6203183B2 (ja) 2011-10-17 2017-09-27 オームクス コーポレイション 酵素誘発レドックス変化化学的脱離（ｅ−ｔｒａｃｅ）イムノアッセイを使用する、ヘモグロビンａ１ｃのパーセンテージの単回直接検出
EP2773650A1 (en) 2011-11-04 2014-09-10 Ohmx Corporation Novel chemistry used in biosensors
US9250203B2 (en) 2012-01-09 2016-02-02 Ohmx Corporation Enzyme cascade methods for E-TRACE assay signal amplification
US9404883B2 (en) 2012-07-27 2016-08-02 Ohmx Corporation Electronic measurements of monolayers following homogeneous reactions of their components
US9880121B2 (en) 2014-04-29 2018-01-30 Ohmx Corporation Bioelectronic binding assay using peak profiling
US20160041118A1 (en) 2014-08-11 2016-02-11 Ohmx Corporation Enzyme triggered redox altering chemical elimination (e-trace) assay with multiplexing capabilities
WO2016061590A1 (en) 2014-10-17 2016-04-21 Wardell Mark R Method for detecting proteases and active infection in biological fluids and tissues
US20160178562A1 (en) * 2014-12-19 2016-06-23 Ohmx Corporation Competitive enzymatic assay
US20180299399A1 (en) * 2015-10-14 2018-10-18 University Health Network Electrochemical assay for a protein analyte
US10323331B2 (en) 2016-12-29 2019-06-18 Industrial Technology Research Institute Valuable metal selectively adsorbing electrode and method for selectively recovering valuable metals
CN112881492A (zh) * 2021-02-26 2021-06-01 长沙市信励致和科技有限责任公司 基于人绒毛膜促性腺激素肽适配体的丝网印刷电极体系及其制备方法
CN114414642B (zh) * 2022-01-07 2023-06-02 重庆医科大学 用于人乳头瘤病毒16型e6癌蛋白检测的电化学传感器
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KR20230031516A (ko) * 2021-08-27 2023-03-07 고려대학교 산학협력단 효소기반 전극, 그 제조방법 및 그 응용
KR102661260B1 (ko) 2021-08-27 2024-04-29 고려대학교 산학협력단 전자전달 능력이 향상된 효소기반 전극, 그 제조방법 및 그 응용

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WO2014018899A1 (en) 2014-01-30
US20140027310A1 (en) 2014-01-30
CA2880104A1 (en) 2014-01-30
WO2014018899A9 (en) 2014-03-06
EP2877851A1 (en) 2015-06-03
US9416390B2 (en) 2016-08-16

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