JP2013532974A5 - - Google Patents
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- JP2013532974A5 JP2013532974A5 JP2013516714A JP2013516714A JP2013532974A5 JP 2013532974 A5 JP2013532974 A5 JP 2013532974A5 JP 2013516714 A JP2013516714 A JP 2013516714A JP 2013516714 A JP2013516714 A JP 2013516714A JP 2013532974 A5 JP2013532974 A5 JP 2013532974A5
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- JP
- Japan
- Prior art keywords
- mouse
- human
- light chain
- gene
- endogenous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108090000623 proteins and genes Proteins 0.000 claims description 33
- 108060003951 Immunoglobulin Proteins 0.000 claims description 17
- 102000018358 immunoglobulin Human genes 0.000 claims description 17
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 9
- 239000000427 antigen Substances 0.000 claims description 9
- 108091007433 antigens Proteins 0.000 claims description 9
- 102000036639 antigens Human genes 0.000 claims description 9
- 210000004027 cell Anatomy 0.000 claims description 9
- 150000007523 nucleic acids Chemical group 0.000 claims description 9
- 210000003719 b-lymphocyte Anatomy 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 108700028369 Alleles Proteins 0.000 claims 15
- 108091008053 gene clusters Proteins 0.000 claims 4
- 238000012217 deletion Methods 0.000 claims 2
- 230000037430 deletion Effects 0.000 claims 2
- 210000004408 hybridoma Anatomy 0.000 claims 2
- 101100060131 Mus musculus Cdk5rap2 gene Proteins 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 210000001161 mammalian embryo Anatomy 0.000 claims 1
- 108700026220 vif Genes Proteins 0.000 claims 1
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 description 19
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 description 19
- 239000012634 fragment Substances 0.000 description 6
- 102000025171 antigen binding proteins Human genes 0.000 description 3
- 108091000831 antigen binding proteins Proteins 0.000 description 3
- 101001008255 Homo sapiens Immunoglobulin kappa variable 1D-8 Proteins 0.000 description 1
- 101001047628 Homo sapiens Immunoglobulin kappa variable 2-29 Proteins 0.000 description 1
- 101001008321 Homo sapiens Immunoglobulin kappa variable 2D-26 Proteins 0.000 description 1
- 101001047619 Homo sapiens Immunoglobulin kappa variable 3-20 Proteins 0.000 description 1
- 101001008263 Homo sapiens Immunoglobulin kappa variable 3D-15 Proteins 0.000 description 1
- 241001529936 Murinae Species 0.000 description 1
- 210000004602 germ cell Anatomy 0.000 description 1
- 229940099472 immunoglobulin a Drugs 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35731410P | 2010-06-22 | 2010-06-22 | |
| US35731710P | 2010-06-22 | 2010-06-22 | |
| US61/357,317 | 2010-06-22 | ||
| US61/357,314 | 2010-06-22 | ||
| PCT/US2011/041366 WO2011163311A1 (en) | 2010-06-22 | 2011-06-22 | Mice expressing alight chain with human lambda variable and mouse constant regions |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015205321A Division JP6243384B2 (ja) | 2010-06-22 | 2015-10-19 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013532974A JP2013532974A (ja) | 2013-08-22 |
| JP2013532974A5 true JP2013532974A5 (cg-RX-API-DMAC7.html) | 2014-07-17 |
| JP5988969B2 JP5988969B2 (ja) | 2016-09-07 |
Family
ID=44509861
Family Applications (16)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013516714A Active JP5988969B2 (ja) | 2010-06-22 | 2011-06-22 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2013516716A Active JP6009441B2 (ja) | 2010-06-22 | 2011-06-22 | ハイブリッド軽鎖マウス |
| JP2015205439A Active JP6073441B2 (ja) | 2010-06-22 | 2015-10-19 | ハイブリッド軽鎖マウス |
| JP2015205321A Active JP6243384B2 (ja) | 2010-06-22 | 2015-10-19 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2016204854A Withdrawn JP2017006152A (ja) | 2010-06-22 | 2016-10-19 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2016208582A Active JP6341972B2 (ja) | 2010-06-22 | 2016-10-25 | ハイブリッド軽鎖マウス |
| JP2017222512A Active JP6545773B2 (ja) | 2010-06-22 | 2017-11-20 | ハイブリッド軽鎖マウス |
| JP2018188847A Pending JP2018201528A (ja) | 2010-06-22 | 2018-10-04 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2018188846A Pending JP2018201527A (ja) | 2010-06-22 | 2018-10-04 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2018228851A Active JP6963542B2 (ja) | 2010-06-22 | 2018-12-06 | ハイブリッド軽鎖マウス |
| JP2020015538A Withdrawn JP2020062061A (ja) | 2010-06-22 | 2020-01-31 | ハイブリッド軽鎖マウス |
| JP2020098480A Active JP7236409B2 (ja) | 2010-06-22 | 2020-06-05 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2021009451A Withdrawn JP2021061863A (ja) | 2010-06-22 | 2021-01-25 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2022034415A Withdrawn JP2022066449A (ja) | 2010-06-22 | 2022-03-07 | ハイブリッド軽鎖マウス |
| JP2023127047A Pending JP2023133554A (ja) | 2010-06-22 | 2023-08-03 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2024214653A Pending JP2025027148A (ja) | 2010-06-22 | 2024-12-09 | ハイブリッド軽鎖マウス |
Family Applications After (15)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013516716A Active JP6009441B2 (ja) | 2010-06-22 | 2011-06-22 | ハイブリッド軽鎖マウス |
| JP2015205439A Active JP6073441B2 (ja) | 2010-06-22 | 2015-10-19 | ハイブリッド軽鎖マウス |
| JP2015205321A Active JP6243384B2 (ja) | 2010-06-22 | 2015-10-19 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2016204854A Withdrawn JP2017006152A (ja) | 2010-06-22 | 2016-10-19 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2016208582A Active JP6341972B2 (ja) | 2010-06-22 | 2016-10-25 | ハイブリッド軽鎖マウス |
| JP2017222512A Active JP6545773B2 (ja) | 2010-06-22 | 2017-11-20 | ハイブリッド軽鎖マウス |
| JP2018188847A Pending JP2018201528A (ja) | 2010-06-22 | 2018-10-04 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2018188846A Pending JP2018201527A (ja) | 2010-06-22 | 2018-10-04 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2018228851A Active JP6963542B2 (ja) | 2010-06-22 | 2018-12-06 | ハイブリッド軽鎖マウス |
| JP2020015538A Withdrawn JP2020062061A (ja) | 2010-06-22 | 2020-01-31 | ハイブリッド軽鎖マウス |
| JP2020098480A Active JP7236409B2 (ja) | 2010-06-22 | 2020-06-05 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2021009451A Withdrawn JP2021061863A (ja) | 2010-06-22 | 2021-01-25 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2022034415A Withdrawn JP2022066449A (ja) | 2010-06-22 | 2022-03-07 | ハイブリッド軽鎖マウス |
| JP2023127047A Pending JP2023133554A (ja) | 2010-06-22 | 2023-08-03 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2024214653A Pending JP2025027148A (ja) | 2010-06-22 | 2024-12-09 | ハイブリッド軽鎖マウス |
Country Status (30)
Families Citing this family (93)
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| US20110314563A1 (en) | 2008-12-18 | 2011-12-22 | Kingdon Craig R | Antibody production |
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| US20130045492A1 (en) | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
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| EP2761008A1 (en) | 2011-09-26 | 2014-08-06 | Kymab Limited | Chimaeric surrogate light chains (slc) comprising human vpreb |
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