|
JP5864546B2
(ja)
|
2010-05-07 |
2016-02-17 |
グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーＧｌａｘｏＳｍｉｔｈＫｌｉｎｅ ＬＬＣ |
インダゾール
|
|
WO2011160206A1
(en)
|
2010-06-23 |
2011-12-29 |
Morin Ryan D |
Biomarkers for non-hodgkin lymphomas and uses thereof
|
|
US9175331B2
(en)
|
2010-09-10 |
2015-11-03 |
Epizyme, Inc. |
Inhibitors of human EZH2, and methods of use thereof
|
|
BR112013005806B1
(pt)
|
2010-09-10 |
2022-05-10 |
Epizyme, Inc |
Métodos para detectar se um indivíduo é um candidato para o tratamento com ou responsivo a um inibidor de ezh2 e usos terapêuticos do dito inibidor de ezh2
|
|
EP2646020B1
(en)
*
|
2010-12-01 |
2016-09-21 |
Glaxosmithkline LLC |
Indoles
|
|
WO2012118812A2
(en)
*
|
2011-02-28 |
2012-09-07 |
Epizyme, Inc. |
Substituted 6,5-fused bicyclic heteroaryl compounds
|
|
JO3363B1
(ar)
|
2011-04-13 |
2019-03-13 |
Epizyme Inc |
مركبات بنزين مستبدلة بأريل أو أريل غير متجانس
|
|
TW201733984A
(zh)
|
2011-04-13 |
2017-10-01 |
雅酶股份有限公司 |
經取代之苯化合物
|
|
AU2013203641B2
(en)
*
|
2011-04-13 |
2014-08-21 |
Epizyme, Inc. |
Aryl-or heteroaryl-substituted benzene compounds
|
|
CA2850570A1
(en)
*
|
2011-09-30 |
2013-04-04 |
Glaxosmithkline Llc |
Methods of treating cancer
|
|
CN104039956A
(zh)
*
|
2011-11-04 |
2014-09-10 |
葛兰素史密斯克莱知识产权（第2号）有限公司 |
治疗方法
|
|
EP2780014A4
(en)
*
|
2011-11-18 |
2015-07-01 |
Constellation Pharmaceuticals Inc |
MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF
|
|
US9051269B2
(en)
|
2011-11-18 |
2015-06-09 |
Constellation Pharmaceuticals, Inc. |
Modulators of methyl modifying enzymes, compositions and uses thereof
|
|
BR112014015197A8
(pt)
|
2011-12-21 |
2017-06-13 |
Novira Therapeutics Inc |
agentes antivirais de hepatite b
|
|
JP5989805B2
(ja)
|
2012-02-10 |
2016-09-07 |
コンステレーション・ファーマシューティカルズ・インコーポレイテッドＣｏｎｓｔｅｌｌａｔｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． |
メチル基変更酵素の調節物質、組成物及びその使用
|
|
RU2704445C2
(ru)
|
2012-03-12 |
2019-10-28 |
Эпизайм, Инк. |
Ингибиторы ezh2 человека и способы их применения
|
|
AU2013237226A1
(en)
|
2012-03-19 |
2014-10-09 |
Emory University |
Quinazoline compounds and their use in therapy
|
|
US9394283B2
(en)
*
|
2012-04-13 |
2016-07-19 |
Epizyme, Inc. |
Salt form of a human histone methyltransferase EZH2 inhibitor
|
|
US9562041B2
(en)
|
2012-05-16 |
2017-02-07 |
Glaxosmithkline Llc |
Enhancer of zeste homolog 2 inhibitors
|
|
CN104769428A
(zh)
|
2012-06-14 |
2015-07-08 |
怀特海德生物医学研究所 |
评价化学实体与其靶标分子之间的相互作用的全基因组方法
|
|
KR102271574B1
(ko)
|
2012-08-28 |
2021-07-01 |
얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 |
설파모일-아릴아미드 및 b형 간염 치료제로서의 그 용도
|
|
CA2884848C
(en)
|
2012-09-28 |
2017-08-22 |
Pfizer Inc. |
Benzamide and heterobenzamide compounds
|
|
PE20150887A1
(es)
|
2012-10-15 |
2015-06-04 |
Epizyme Inc |
Compuestos de benceno sustituidos
|
|
CA2887243C
(en)
|
2012-10-15 |
2024-04-09 |
Epizyme, Inc. |
Methods of treating cancer
|
|
KR20150095779A
(ko)
*
|
2012-12-13 |
2015-08-21 |
글락소스미스클라인 엘엘씨 |
제스트 인핸서 상동체 2 억제제
|
|
US20150313906A1
(en)
*
|
2012-12-19 |
2015-11-05 |
Glaxosmithkline Llc |
Combination
|
|
CA2894222A1
(en)
*
|
2012-12-21 |
2014-06-26 |
Epizyme, Inc. |
1,4-pyridone bicyclic heteroaryl compounds
|
|
UA111305C2
(uk)
|
2012-12-21 |
2016-04-11 |
Пфайзер Інк. |
Конденсовані лактами арилу та гетероарилу
|
|
MA38341B1
(fr)
*
|
2013-02-11 |
2018-11-30 |
Constellation Pharmaceuticals Inc |
Modulateurs d'enzymes de modification par méthylation, compositions et utilisations associées
|
|
WO2014131847A1
(en)
|
2013-02-28 |
2014-09-04 |
Janssen R&D Ireland |
Sulfamoyl-arylamides and the use thereof as medicaments for the treatment of hepatitis b
|
|
US8993771B2
(en)
|
2013-03-12 |
2015-03-31 |
Novira Therapeutics, Inc. |
Hepatitis B antiviral agents
|
|
EP2970137A1
(en)
|
2013-03-14 |
2016-01-20 |
Epizyme, Inc. |
Pyrazole derivatives as arginine methyltransferase inhibitors and uses thereof
|
|
EP2970135B1
(en)
|
2013-03-14 |
2018-07-18 |
Epizyme, Inc. |
Pyrazole derivatives as prmt1 inhibitors and uses thereof
|
|
WO2014153172A1
(en)
|
2013-03-14 |
2014-09-25 |
Epizyme, Inc. |
Pyrazole derivatives as prmt1 inhibitors and uses thereof
|
|
WO2014153208A1
(en)
|
2013-03-14 |
2014-09-25 |
Epizyme, Inc. |
Arginine methyltransferase inhibitors and uses thereof
|
|
WO2014153214A1
(en)
|
2013-03-14 |
2014-09-25 |
Epizyme, Inc. |
Arginine methyl transferase inhibtors and uses thereof
|
|
KR102028793B1
(ko)
|
2013-03-14 |
2019-10-07 |
에피자임, 인코포레이티드 |
아르기닌 메틸기 전이효소 억제제 및 이의 용도
|
|
JP2016516046A
(ja)
|
2013-03-14 |
2016-06-02 |
ジェネンテック， インコーポレイテッド |
がんの治療方法及びがん薬物耐性を阻止する方法
|
|
WO2014153100A2
(en)
|
2013-03-14 |
2014-09-25 |
Epizyme, Inc. |
Arginine methyltransferase inhibitors and uses thereof
|
|
US9765035B2
(en)
|
2013-03-14 |
2017-09-19 |
Epizyme, Inc. |
Arginine methyltransferase inhibitors and uses thereof
|
|
JP2016518336A
(ja)
|
2013-03-14 |
2016-06-23 |
エピザイム，インコーポレイティド |
Ｐｒｍｔ１阻害剤としてのピラゾール誘導体およびその使用
|
|
US9120757B2
(en)
|
2013-03-14 |
2015-09-01 |
Epizyme, Inc. |
Arginine methyltransferase inhibitors and uses thereof
|
|
US9745305B2
(en)
|
2013-03-15 |
2017-08-29 |
Constellation Pharmaceuticals, Inc. |
Modulators of methyl modifying enzymes, compositions and uses thereof
|
|
WO2014155301A1
(en)
*
|
2013-03-26 |
2014-10-02 |
Piramal Enterprises Limited |
Substituted bicyclic compounds as inhibitors of ezh2
|
|
MX353412B
(es)
|
2013-04-03 |
2018-01-10 |
Janssen Sciences Ireland Uc |
Derivados de n-fenil-carboxamida y su uso como medicamentos para el tratamiento de la hepatitis b.
|
|
WO2014177982A1
(en)
|
2013-04-30 |
2014-11-06 |
Glaxosmithkline Intellectual Property (No.2) Limited |
Enhancer of zeste homolog 2 inhibitors
|
|
DK2997019T3
(en)
|
2013-05-17 |
2018-12-03 |
Janssen Sciences Ireland Uc |
SULFAMOYLTHIOPHENAMIDE DERIVATIVES AND USE THEREOF AS MEDICINES FOR TREATING HEPATITIS B
|
|
TWI733288B
(zh)
|
2013-05-17 |
2021-07-11 |
愛爾蘭商健生科學愛爾蘭無限公司 |
胺磺醯基吡咯醯胺衍生物及其作為用於治療ｂ型肝炎藥物的用途
|
|
EP3004096A1
(en)
*
|
2013-06-06 |
2016-04-13 |
Glaxosmithkline Intellectual Property (No. 2) Limited |
Enhancer of zeste homolog 2 inhibitors
|
|
AU2014288839B2
(en)
|
2013-07-10 |
2017-02-02 |
Glaxosmithkline Intellectual Property (No.2) Limited |
Enhancer of Zeste Homolog 2 inhibitors
|
|
HRP20180791T1
(hr)
|
2013-07-25 |
2018-09-07 |
Janssen Sciences Ireland Uc |
Glioksamid supstituirani derivati pirolamida i njihova uporaba kao lijekova za liječenje hepatitisa b
|
|
US9969716B2
(en)
|
2013-08-15 |
2018-05-15 |
Constellation Pharmaceuticals, Inc. |
Indole derivatives as modulators of methyl modifying enzymes, compositions and uses thereof
|
|
KR102142177B1
(ko)
|
2013-10-16 |
2020-08-07 |
에피자임, 인코포레이티드 |
Ezh2 억제용 하이드로클로라이드 염 형태
|
|
CA2923712C
(en)
|
2013-10-23 |
2021-11-02 |
Janssen Sciences Ireland Uc |
Carboxamide derivatives and the use thereof as medicaments for the treatment of hepatitis b
|
|
US9822103B2
(en)
|
2013-11-22 |
2017-11-21 |
Bristol-Myers Squibb Company |
Inhibitors of lysine methyl transferase
|
|
US10392349B2
(en)
|
2014-01-16 |
2019-08-27 |
Novira Therapeutics, Inc. |
Azepane derivatives and methods of treating hepatitis B infections
|
|
US9169212B2
(en)
|
2014-01-16 |
2015-10-27 |
Novira Therapeutics, Inc. |
Azepane derivatives and methods of treating hepatitis B infections
|
|
CA2936947A1
(en)
|
2014-02-05 |
2015-08-13 |
Novira Therapeutics, Inc. |
Combination therapy for treatment of hbv infections
|
|
TW201620893A
(zh)
|
2014-02-06 |
2016-06-16 |
健生科學愛爾蘭無限公司 |
磺醯胺基吡咯醯胺衍生物及其用作治療ｂ型肝炎之醫藥品的用途
|
|
WO2015120372A2
(en)
*
|
2014-02-10 |
2015-08-13 |
University Of Rochester |
Compositions and methods to inhibit ezh2 for the treatment of cardiovascular diseases
|
|
US20160361309A1
(en)
|
2014-02-26 |
2016-12-15 |
Glaxosmithkline Intellectual Property (No.2) Limited |
Methods of treating cancer patients responding to ezh2 inhibitor gsk126
|
|
WO2015143424A2
(en)
*
|
2014-03-21 |
2015-09-24 |
Glaxosmithkline Intellectual Property (No. 2) Limited |
Methods of treating cancer
|
|
CN105037360B
(zh)
*
|
2014-04-28 |
2016-08-17 |
四川大学 |
吡啶酮衍生物及其制备方法和用途
|
|
CN105017221B
(zh)
*
|
2014-04-30 |
2019-05-28 |
中国医学科学院药物研究所 |
苯并咪唑衍生物及其制法和药物组合物与用途
|
|
TN2016000529A1
(en)
|
2014-06-17 |
2018-04-04 |
Pfizer |
Substituted dihydroisoquinolinone compounds
|
|
US20170217941A1
(en)
*
|
2014-06-25 |
2017-08-03 |
Epizyme, Inc. |
Substituted benzene and 6,5-fused bicyclic heteroaryl compounds
|
|
BR112017008840A2
(pt)
*
|
2014-10-28 |
2017-12-19 |
Glaxosmithkline Ip No 2 Ltd |
intensificador de inibidores do homólogo 2 de zeste
|
|
WO2016073956A1
(en)
|
2014-11-06 |
2016-05-12 |
Dana-Farber Cancer Institute, Inc. |
Ezh2 inhibitors and uses thereof
|
|
AR102767A1
(es)
|
2014-12-05 |
2017-03-22 |
Lilly Co Eli |
Inhibidores de ezh2
|
|
WO2016102493A1
(en)
*
|
2014-12-22 |
2016-06-30 |
Bayer Pharma Aktiengesellschaft |
Imidazopyridine ezh2 inhibitors
|
|
EP3236962A2
(en)
|
2014-12-23 |
2017-11-01 |
University of Copenhagen |
Treatment of cancer by inhibiting ezh2 activity
|
|
UY36462A
(es)
*
|
2014-12-23 |
2016-07-29 |
Novartis Ag |
Compuestos de triazolopirimidina y usos de los mismos
|
|
JP2018510159A
(ja)
|
2015-03-19 |
2018-04-12 |
ノヴィラ・セラピューティクス・インコーポレイテッド |
アゾカン及びアゾナン誘導体及びｂ型肝炎感染症の治療法
|
|
US10961532B2
(en)
|
2015-04-07 |
2021-03-30 |
The General Hospital Corporation |
Methods for reactivating genes on the inactive X chromosome
|
|
EP3307713A4
(en)
*
|
2015-06-10 |
2019-01-23 |
Epizyme, Inc. |
EZH2 INHIBITOR FOR THE TREATMENT OF LYMPHOMA
|
|
US10875876B2
(en)
|
2015-07-02 |
2020-12-29 |
Janssen Sciences Ireland Uc |
Cyclized sulfamoylarylamide derivatives and the use thereof as medicaments for the treatment of hepatitis B
|
|
KR20180042356A
(ko)
|
2015-08-24 |
2018-04-25 |
에피자임, 인코포레이티드 |
암 치료 방법
|
|
TW201718598A
(zh)
|
2015-08-27 |
2017-06-01 |
美國禮來大藥廠 |
Ｅｚｈ２抑制劑
|
|
US10577350B2
(en)
|
2015-08-28 |
2020-03-03 |
Constellation Pharmaceuticals, Inc. |
Crystalline forms of (R)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide
|
|
TW201718496A
(zh)
|
2015-09-29 |
2017-06-01 |
諾維拉治療公司 |
B型肝炎抗病毒劑之晶型
|
|
MX394355B
(es)
|
2015-10-06 |
2025-03-24 |
Epizyme Inc |
Método de tratamiento de meduloblastoma con un inhibidor de ezh2.
|
|
EP3371601A1
(en)
|
2015-11-05 |
2018-09-12 |
Epizyme Inc |
Flow cytometry for monitoring histone h3 methylation status
|
|
RS59763B1
(sr)
*
|
2015-11-19 |
2020-02-28 |
Jiangsu Hengrui Medicine Co |
Derivati benzofurana, postupci njihove pripreme i njihova upotreba u medicini
|
|
WO2017132518A1
(en)
|
2016-01-29 |
2017-08-03 |
Epizyme, Inc. |
Combination therapy for treating cancer
|
|
JP7174408B2
(ja)
|
2016-02-10 |
2022-11-17 |
ウェイク・フォレスト・ユニヴァーシティ・ヘルス・サイエンシズ |
肝線維症のモデル系ならびにその作製および使用方法
|
|
ES3057783T3
(en)
|
2016-03-15 |
2026-03-04 |
Oryzon Genomics Sa |
Combinations of lsd1 inhibitors for use in the treatment of neoplastic diseases
|
|
AU2017248828A1
(en)
|
2016-04-15 |
2018-11-01 |
Janssen Sciences Ireland Uc |
Combinations and methods comprising a capsid assembly inhibitor
|
|
JP7493304B2
(ja)
|
2016-04-22 |
2024-05-31 |
ダナ－ファーバー キャンサー インスティテュート， インコーポレイテッド |
Ｅｚｈ２インヒビターおよびそれらの使用
|
|
CN105777718B
(zh)
*
|
2016-04-27 |
2019-03-19 |
上海应用技术学院 |
潜在ezh2小分子抑制剂及其合成方法
|
|
WO2017192290A1
(en)
|
2016-05-04 |
2017-11-09 |
The Wistar Institute Of Anatomy And Biology |
Methods of treating cancers overexpressing carm1 with ezh2 inhibitors and platinum-based antineoplastic drugs
|
|
EP3471830A4
(en)
|
2016-06-17 |
2020-02-26 |
Epizyme Inc |
EZH2 INHIBITORS TO TREAT CANCER
|
|
WO2017221092A1
(en)
*
|
2016-06-20 |
2017-12-28 |
Novartis Ag |
Triazolopyridine compounds and uses thereof
|
|
CN107573327B
(zh)
*
|
2016-07-05 |
2020-03-31 |
四川大学 |
吲唑-甲酰胺-吡啶酮衍生物及其制备方法和用途
|
|
CN107573336B
(zh)
*
|
2016-07-05 |
2021-01-19 |
四川大学 |
苯并杂环-甲酰胺-吡啶酮衍生物及其制备方法和用途
|
|
CN109843870A
(zh)
|
2016-10-19 |
2019-06-04 |
星座制药公司 |
Ezh2抑制剂的合成
|
|
WO2018086590A1
(zh)
*
|
2016-11-11 |
2018-05-17 |
上海海雁医药科技有限公司 |
砜基取代的苯并杂环衍生物、其制法与医药上的用途
|
|
CN108699002B
(zh)
*
|
2016-11-11 |
2021-11-09 |
上海海雁医药科技有限公司 |
1,5,7-三取代的异喹啉衍生物、其制法与医药上的用途
|
|
EP3548032A2
(en)
|
2016-12-02 |
2019-10-09 |
Epizyme, Inc. |
Combination therapy for treating cancer
|
|
TW201831181A
(zh)
|
2017-01-19 |
2018-09-01 |
日商第一三共股份有限公司 |
用以用於治療ｈｔｌｖ－１相關脊髓病之醫藥組成物
|
|
US10266542B2
(en)
|
2017-03-15 |
2019-04-23 |
Mirati Therapeutics, Inc. |
EZH2 inhibitors
|
|
US11642346B2
(en)
|
2017-03-31 |
2023-05-09 |
Epizyme, Inc. |
Combination therapy for treating cancer
|
|
US20230201212A1
(en)
|
2017-06-13 |
2023-06-29 |
Epizyme, Inc. |
Inhibitors of ezh2 and methods of use thereof
|
|
BR112020008325A2
(pt)
|
2017-11-14 |
2020-10-20 |
Pfizer Inc. |
terapias de combinação com o inibidor de ezh2
|
|
MX2020007974A
(es)
|
2018-01-31 |
2020-09-07 |
Mirati Therapeutics Inc |
Inhibidores de complejo represivo polycomb 2 (prc2).
|
|
CN110229151B
(zh)
*
|
2018-03-06 |
2021-09-10 |
上海海和药物研究开发股份有限公司 |
吲嗪类化合物、其制备方法及用途
|
|
MX2020009531A
(es)
|
2018-03-14 |
2020-10-05 |
Janssen Sciences Ireland Unlimited Co |
Regimen posologico del modulador del ensamblaje de la capside.
|
|
HRP20240793T1
(hr)
|
2018-04-18 |
2024-09-13 |
Constellation Pharmaceuticals, Inc. |
Modulatori enzima koji modificiraju metil, njihovi pripravci i upotreba
|
|
EP3823671B1
(en)
|
2018-07-09 |
2024-02-07 |
Fondation Asile Des Aveugles |
Inhibition of prc2 subunits to treat eye disorders
|
|
EP3831822A4
(en)
*
|
2018-07-27 |
2022-03-23 |
Suzhou Sinovent Pharmaceuticals Co., Ltd. |
POLY-SUBSTITUTED BENZENE COMPOUND, PROCESS OF MANUFACTURE AND USE THEREOF
|
|
WO2020169784A1
(en)
|
2019-02-22 |
2020-08-27 |
Janssen Sciences Ireland Unlimited Company |
Amide derivatives useful in the treatment of hbv infection or hbv-induced diseases
|
|
CN109761960B
(zh)
*
|
2019-02-25 |
2021-08-31 |
江苏豪森药业集团有限公司 |
抗耐药抗肿瘤egfr抑制剂的制备方法
|
|
US12421228B2
(en)
|
2019-04-22 |
2025-09-23 |
Mirati Therapeutics, Inc. |
Naphthyridine derivatives as PRC2 inhibitors
|
|
AR119732A1
(es)
|
2019-05-06 |
2022-01-05 |
Janssen Sciences Ireland Unlimited Co |
Derivados de amida útiles en el tratamiento de la infección por vhb o de enfermedades inducidas por vhb
|
|
EP3980422A1
(en)
|
2019-06-05 |
2022-04-13 |
Mirati Therapeutics, Inc. |
Imidazo[1,2-c]pyrimidine derivatives as prc2 inhibitors for treating cancer
|
|
LT4003532T
(lt)
|
2019-07-24 |
2024-11-11 |
Constellation Pharmaceuticals, Inc. |
7-chlor-2- (4-(3-metoksiazetidin-1-il)cikloheksil)-2,4-dimetil-n-((6-metil-4-(metiltio)-2-okso-1,2-dihidropiridin-3-il)metil)benzo[d][1,3]dioksol-5-karboksamido kristalinės formos
|
|
CN114555112A
(zh)
|
2019-08-22 |
2022-05-27 |
朱诺治疗学股份有限公司 |
T细胞疗法和zeste增强子同源物2(ezh2)抑制剂的组合疗法及相关方法
|
|
US12006232B2
(en)
|
2020-06-09 |
2024-06-11 |
Rapid Water Technology LLC |
Water processing apparatus
|
|
JP2023554393A
(ja)
*
|
2020-12-16 |
2023-12-27 |
アイエフエム デュー インコーポレイテッド |
Ｓｔｉｎｇ活性に関連する状態を治療するための化合物および組成物
|
|
CN113307765A
(zh)
*
|
2021-05-24 |
2021-08-27 |
上海泰坦科技股份有限公司 |
吡啶甲胺类化合物及其制备方法
|
|
EP4392034A1
(en)
|
2021-08-25 |
2024-07-03 |
Institut National de la Santé et de la Recherche Médicale (INSERM) |
Use of ezh2 inhibitors for the treatment of aortic valve stenosis
|
|
US20250049802A1
(en)
|
2021-12-14 |
2025-02-13 |
Pfizer Inc. |
Combination therapies and uses for treating cancer
|
|
EP4514391A1
(en)
|
2022-04-27 |
2025-03-05 |
Daiichi Sankyo Company, Limited |
Combination of antibody-drug conjugate with ezh1 and/or ezh2 inhibitor
|
|
CN117088810A
(zh)
*
|
2023-06-27 |
2023-11-21 |
海南医学院 |
3-氰基吡啶酮化合物的串联合成方法
|
|
CN117362277B
(zh)
*
|
2023-10-13 |
2025-02-11 |
沈阳药科大学 |
含咪唑啉酮结构的苯甲酰胺类化合物及其制备方法和应用
|
|
CN118745144A
(zh)
*
|
2024-06-21 |
2024-10-08 |
辽宁大学 |
新型ezh2抑制剂化合物及其制备方法和应用
|