RS59763B1 - Derivati benzofurana, postupci njihove pripreme i njihova upotreba u medicini - Google Patents
Derivati benzofurana, postupci njihove pripreme i njihova upotreba u mediciniInfo
- Publication number
- RS59763B1 RS59763B1 RS20191628A RSP20191628A RS59763B1 RS 59763 B1 RS59763 B1 RS 59763B1 RS 20191628 A RS20191628 A RS 20191628A RS P20191628 A RSP20191628 A RS P20191628A RS 59763 B1 RS59763 B1 RS 59763B1
- Authority
- RS
- Serbia
- Prior art keywords
- medicine
- preparation
- benzofuran derivative
- benzofuran
- derivative
- Prior art date
Links
- 150000001907 coumarones Chemical class 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Furan Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510800975 | 2015-11-19 | ||
| PCT/CN2016/104318 WO2017084494A1 (zh) | 2015-11-19 | 2016-11-02 | 苯并呋喃类衍生物、其制备方法及其在医药上的应用 |
| EP16865671.8A EP3378859B1 (en) | 2015-11-19 | 2016-11-02 | Benzofuran derivative, preparation method thereof and use thereof in medicine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RS59763B1 true RS59763B1 (sr) | 2020-02-28 |
Family
ID=58717310
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RS20191628A RS59763B1 (sr) | 2015-11-19 | 2016-11-02 | Derivati benzofurana, postupci njihove pripreme i njihova upotreba u medicini |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US10759787B2 (sr) |
| EP (1) | EP3378859B1 (sr) |
| JP (1) | JP6828229B2 (sr) |
| KR (1) | KR20180081587A (sr) |
| CN (1) | CN107428742B (sr) |
| AU (1) | AU2016357900B2 (sr) |
| BR (1) | BR112018007876B1 (sr) |
| CA (1) | CA3002436A1 (sr) |
| DK (1) | DK3378859T3 (sr) |
| ES (1) | ES2760510T3 (sr) |
| HK (1) | HK1243414A1 (sr) |
| HR (1) | HRP20192209T1 (sr) |
| HU (1) | HUE047785T2 (sr) |
| LT (1) | LT3378859T (sr) |
| MX (1) | MX2018005019A (sr) |
| PL (1) | PL3378859T3 (sr) |
| PT (1) | PT3378859T (sr) |
| RS (1) | RS59763B1 (sr) |
| RU (1) | RU2727198C2 (sr) |
| SI (1) | SI3378859T1 (sr) |
| TW (1) | TWI718207B (sr) |
| WO (1) | WO2017084494A1 (sr) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10266542B2 (en) | 2017-03-15 | 2019-04-23 | Mirati Therapeutics, Inc. | EZH2 inhibitors |
| US11155537B2 (en) | 2017-05-18 | 2021-10-26 | Jiangsu Hengrui Medicine Co., Ltd. | Crystal of benzofuran derivative free base and preparation method |
| MY201580A (en) * | 2017-05-18 | 2024-03-02 | Jiangsu Hengrui Medicine Co | Use of ezh2 inhibitor combined with btk inhibitor in preparing drug for treating tumor |
| TWI717656B (zh) * | 2017-11-10 | 2021-02-01 | 大陸商江蘇恒瑞醫藥股份有限公司 | 苯並呋喃衍生物的製備方法 |
| DK4043466T3 (da) | 2018-01-31 | 2024-09-30 | Mirati Therapeutics Inc | PRC2-inhibitorer |
| CN110179796B (zh) * | 2018-02-23 | 2023-01-24 | 江苏恒瑞医药股份有限公司 | 一种苯并呋喃类衍生物的组合物及制备方法 |
| EP3781561B1 (en) * | 2018-04-18 | 2024-03-13 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
| CN110563722A (zh) * | 2018-06-06 | 2019-12-13 | 上海青煜医药科技有限公司 | 吡啶或哒嗪并环化合物及其应用 |
| TW202027787A (zh) * | 2018-09-29 | 2020-08-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | Ｅｚｈ２抑制劑與免疫檢查點抑制劑聯合在製備治療腫瘤的藥物中的用途 |
| WO2020192650A1 (zh) | 2019-03-25 | 2020-10-01 | 上海华汇拓医药科技有限公司 | 酰胺类化合物制备方法及其在医药领域的应用 |
| CN113302185B (zh) * | 2019-04-29 | 2024-04-09 | 上海和誉生物医药科技有限公司 | 苯并呋喃-6-甲酰胺衍生物、其制备方法和药学上的应用 |
| WO2020228591A1 (zh) * | 2019-05-10 | 2020-11-19 | 江苏恒瑞医药股份有限公司 | 一种6-取代氨基苯并呋喃化合物的制备方法 |
| CN110003187B (zh) * | 2019-05-10 | 2021-11-05 | 南京工业大学 | 一种多氟烷基取代苯并呋喃类化合物及其制备方法 |
| CN112007162B (zh) * | 2019-05-30 | 2023-05-12 | 江苏恒瑞医药股份有限公司 | Ezh2抑制剂与免疫检查点抑制剂、vegfr抑制剂联合在制备治疗肿瘤药物中的用途 |
| CN110172448B (zh) * | 2019-05-30 | 2020-07-28 | 中南大学湘雅二医院 | 一种滑膜肉瘤细胞系hSS-005R及其子代细胞系 |
| WO2020259667A1 (zh) * | 2019-06-28 | 2020-12-30 | 江苏恒瑞医药股份有限公司 | Tlr激动剂与抗ox40抗体或其抗原结合片段联合在制备治疗肿瘤的药物中的用途 |
| US20220257577A1 (en) | 2019-07-24 | 2022-08-18 | Constellation Pharmaceuticals, Inc. | Ezh2 inhibition in combination therapies for the treatment of cancers |
| WO2021063332A1 (zh) * | 2019-09-30 | 2021-04-08 | 江苏恒瑞医药股份有限公司 | 一种ezh2抑制剂与cdk4/6抑制剂联合在制备治疗肿瘤药物中的用途 |
| WO2021063340A1 (zh) * | 2019-09-30 | 2021-04-08 | 江苏恒瑞医药股份有限公司 | Ezh2抑制剂与免疫检查点抑制剂、酪氨酸激酶抑制剂联合在制备治疗肿瘤药物中的用途 |
| WO2021063331A1 (zh) * | 2019-09-30 | 2021-04-08 | 江苏恒瑞医药股份有限公司 | EZH2抑制剂与含有TGF-β受体的融合蛋白联合在制备治疗肿瘤的药物中的用途 |
| CN112870365A (zh) * | 2019-11-29 | 2021-06-01 | 江苏恒瑞医药股份有限公司 | Ezh2抑制剂和/或parp抑制剂与化疗药物联合在制备治疗肿瘤药物中的用途 |
| MX2024002538A (es) | 2021-08-30 | 2024-03-19 | Jiangsu Hengrui Pharmaceuticals Co Ltd | Uso de un inhibidor de la ezh2 en la preparacion de farmacos para el tratamiento del linfoma de linfocitos t. |
| AU2022365986A1 (en) | 2021-10-15 | 2024-05-09 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Method for preparing benzofuran derivative |
| TW202415655A (zh) | 2022-06-13 | 2024-04-16 | 美商樹線生物科學公司 | １，８—萘啶—２—酮異雙功能ｂｃｌ６降解劑 |
| WO2023244918A1 (en) | 2022-06-13 | 2023-12-21 | Treeline Biosciences, Inc. | Quinolone bcl6 bifunctional degraders |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110275630A1 (en) | 2003-06-02 | 2011-11-10 | Abbott Laboratories | Isoindolinone kinase inhibitors |
| AU2009214194B2 (en) * | 2008-02-14 | 2012-05-17 | F. Hoffmann-La Roche Ag | Heterocyclic antiviral compounds |
| WO2012005805A1 (en) * | 2010-05-07 | 2012-01-12 | Glaxosmithkline Llc | Azaindazoles |
| ES2534804T3 (es) | 2010-05-07 | 2015-04-28 | Glaxosmithkline Llc | Indazoles |
| PT2566327T (pt) * | 2010-05-07 | 2017-05-26 | Glaxosmithkline Llc | Indoles |
| EP2410171A1 (en) | 2010-07-23 | 2012-01-25 | Ewt Ip B.V. | Wind turbine having a rotor with hub |
| SG180031A1 (en) | 2010-10-15 | 2012-05-30 | Agency Science Tech & Res | Combination treatment of cancer |
| WO2012118812A2 (en) * | 2011-02-28 | 2012-09-07 | Epizyme, Inc. | Substituted 6,5-fused bicyclic heteroaryl compounds |
| TW201733984A (zh) * | 2011-04-13 | 2017-10-01 | 雅酶股份有限公司 | 經取代之苯化合物 |
| JO3438B1 (ar) | 2011-04-13 | 2019-10-20 | Epizyme Inc | مركبات بنزين مستبدلة بأريل أو أريل غير متجانس |
| WO2013039988A1 (en) * | 2011-09-13 | 2013-03-21 | Glax0Smithkline Llc | Azaindazoles |
| KR20140082742A (ko) * | 2011-09-30 | 2014-07-02 | 글락소스미스클라인 엘엘씨 | 암을 치료하는 방법 |
| WO2013067300A1 (en) | 2011-11-04 | 2013-05-10 | Glaxosmithkline Intellectual Property (No. 2) Limited | Method of treatment |
| WO2013173441A2 (en) | 2012-05-16 | 2013-11-21 | Glaxosmithkline Llc | Enhancer of zeste homolog 2 inhibitors |
| UA111305C2 (uk) | 2012-12-21 | 2016-04-11 | Пфайзер Інк. | Конденсовані лактами арилу та гетероарилу |
| EP2991980B1 (en) | 2013-04-30 | 2019-01-02 | Glaxosmithkline Intellectual Property (No. 2) Limited | Enhancer of zeste homolog 2 inhibitors |
| WO2015077194A1 (en) * | 2013-11-22 | 2015-05-28 | Bristol-Myers Squibb Company | Inhibitors of lysine methyl transferase |
| RU2679131C2 (ru) * | 2014-03-17 | 2019-02-06 | Дайити Санкио Компани, Лимитед | Производное 1,3-бензодиоксола |
-
2016
- 2016-11-02 BR BR112018007876-0A patent/BR112018007876B1/pt active IP Right Grant
- 2016-11-02 EP EP16865671.8A patent/EP3378859B1/en active Active
- 2016-11-02 RU RU2018119173A patent/RU2727198C2/ru active
- 2016-11-02 JP JP2018523005A patent/JP6828229B2/ja active Active
- 2016-11-02 US US15/775,958 patent/US10759787B2/en active Active
- 2016-11-02 PL PL16865671T patent/PL3378859T3/pl unknown
- 2016-11-02 PT PT168656718T patent/PT3378859T/pt unknown
- 2016-11-02 SI SI201630514T patent/SI3378859T1/sl unknown
- 2016-11-02 CN CN201680013259.7A patent/CN107428742B/zh active Active
- 2016-11-02 HU HUE16865671A patent/HUE047785T2/hu unknown
- 2016-11-02 MX MX2018005019A patent/MX2018005019A/es unknown
- 2016-11-02 ES ES16865671T patent/ES2760510T3/es active Active
- 2016-11-02 RS RS20191628A patent/RS59763B1/sr unknown
- 2016-11-02 KR KR1020187016692A patent/KR20180081587A/ko not_active Application Discontinuation
- 2016-11-02 AU AU2016357900A patent/AU2016357900B2/en active Active
- 2016-11-02 DK DK16865671.8T patent/DK3378859T3/da active
- 2016-11-02 LT LTEP16865671.8T patent/LT3378859T/lt unknown
- 2016-11-02 WO PCT/CN2016/104318 patent/WO2017084494A1/zh active Application Filing
- 2016-11-02 CA CA3002436A patent/CA3002436A1/en active Pending
- 2016-11-16 TW TW105137422A patent/TWI718207B/zh active
-
2018
- 2018-03-01 HK HK18102969.3A patent/HK1243414A1/zh unknown
-
2019
- 2019-12-09 HR HRP20192209TT patent/HRP20192209T1/hr unknown
-
2020
- 2020-07-22 US US16/935,407 patent/US11059811B2/en active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HK1243414A1 (zh) | 苯並呋喃類衍生物、其製備方法及其在醫藥上的應用 | |
| HUE054964T2 (hu) | Pirazol-heteroaril készítmény, az elõállítás módja és gyógyászati felhasználása | |
| HK1255566A1 (zh) | 氧代吡啶酰胺類衍生物、其製備方法及其在醫藥上的應用 | |
| HK1251551A1 (zh) | 氮雜環丁烷衍生物、其製備方法及用途 | |
| PL3214081T3 (pl) | Pochodna izoindoliny, półprodukt, sposób wytwarzania, kompozycja farmaceutyczna i ich zastosowanie | |
| PL3181560T3 (pl) | Pochodna pirydynoamidopirymidyny, sposób jej otrzymywania i zastosowanie | |
| HK1244808A1 (zh) | 苯並哌啶類衍生物、其製備方法及其在醫藥上的應用 | |
| EP3395366C0 (en) | METHOD FOR DESIGNING A DRUG, DRUG OBTAINED AND ASSOCIATED APPLICATION | |
| ZA201908091B (en) | Indole-formamide derivative, preparation method therefor and use thereof in medicine | |
| IL252397A0 (en) | Pharmaceutical preparations, their preparation and uses | |
| IL290114A (en) | Pharmaceutical preparations, their preparation and uses | |
| EP3020478A4 (en) | HIGH PERFORMANCE POLYOXOMETALATE CATALYST AND PROCESS FOR PREPARING THE SAME | |
| LT3229843T (lt) | Farmacinė kompozicija, jos paruošimo būdas ir naudojimas | |
| PL3360863T3 (pl) | Pochodna i związek pośredni etomidatu, sposób przygotowania i zastosowanie | |
| HK1214767A1 (zh) | 片劑形式的藥物組合物及其製造方法 | |
| EP3078659A4 (en) | 3-FURYL-2-CYANO-2-ACRYLAMIDE DERIVATIVE, PROCESS FOR PREPARING THE SAME, PHARMACEUTICAL COMPOSITION AND USE THEREOF | |
| IL237283A0 (en) | Dldh and its derivatives, and preparations containing them for medical use | |
| HRP20182167T1 (hr) | Derivati benzilhidroksida, njihova priprava i njihova terapeutska uporaba |