HUE054964T2 - Pirazol-heteroaril készítmény, az elõállítás módja és gyógyászati felhasználása - Google Patents
Pirazol-heteroaril készítmény, az elõállítás módja és gyógyászati felhasználásaInfo
- Publication number
- HUE054964T2 HUE054964T2 HUE17874091A HUE17874091A HUE054964T2 HU E054964 T2 HUE054964 T2 HU E054964T2 HU E17874091 A HUE17874091 A HU E17874091A HU E17874091 A HUE17874091 A HU E17874091A HU E054964 T2 HUE054964 T2 HU E054964T2
- Authority
- HU
- Hungary
- Prior art keywords
- pyrazolo
- preparation
- medical use
- heteroaryl derivative
- heteroaryl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201611066071 | 2016-11-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
HUE054964T2 true HUE054964T2 (hu) | 2021-10-28 |
Family
ID=62194797
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HUE17874091A HUE054964T2 (hu) | 2016-11-28 | 2017-11-27 | Pirazol-heteroaril készítmény, az elõállítás módja és gyógyászati felhasználása |
Country Status (16)
Country | Link |
---|---|
US (2) | US11117898B2 (hu) |
EP (1) | EP3546457B1 (hu) |
JP (1) | JP7145854B2 (hu) |
KR (1) | KR20190084991A (hu) |
CN (1) | CN108884092B (hu) |
AU (1) | AU2017366621B2 (hu) |
BR (1) | BR112019010182A2 (hu) |
CA (1) | CA3044903A1 (hu) |
ES (1) | ES2886973T3 (hu) |
HU (1) | HUE054964T2 (hu) |
MX (1) | MX2019005379A (hu) |
MY (1) | MY192084A (hu) |
PT (1) | PT3546457T (hu) |
RU (1) | RU2748833C2 (hu) |
TW (1) | TWI760390B (hu) |
WO (1) | WO2018095426A1 (hu) |
Families Citing this family (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2017342536A1 (en) | 2016-10-14 | 2019-05-02 | Precision Biosciences, Inc. | Engineered meganucleases specific for recognition sequences in the Hepatitis B virus genome |
AU2018392212B9 (en) | 2017-12-20 | 2021-03-18 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 2'3' cyclic dinucleotides with phosphonate bond activating the STING adaptor protein |
KR102492187B1 (ko) | 2017-12-20 | 2023-01-27 | 인스티튜트 오브 오가닉 케미스트리 앤드 바이오케미스트리 에이에스 씨알 브이.브이.아이. | Sting 어댑터 단백질을 활성화하는 포스포네이트 결합을 가진 3'3' 사이클릭 다이뉴클레오티드 |
CN111788204B (zh) | 2018-02-26 | 2023-05-05 | 吉利德科学公司 | 作为hbv复制抑制剂的取代吡咯嗪化合物 |
WO2019195181A1 (en) | 2018-04-05 | 2019-10-10 | Gilead Sciences, Inc. | Antibodies and fragments thereof that bind hepatitis b virus protein x |
KR20200140867A (ko) | 2018-04-06 | 2020-12-16 | 인스티튜트 오브 오가닉 케미스트리 앤드 바이오케미스트리 에이에스 씨알 브이.브이.아이. | 3'3'-사이클릭 다이뉴클레오티드 |
TW202005654A (zh) | 2018-04-06 | 2020-02-01 | 捷克科學院有機化學與生物化學研究所 | 2,2,─環二核苷酸 |
TWI818007B (zh) | 2018-04-06 | 2023-10-11 | 捷克科學院有機化學與生物化學研究所 | 2'3'-環二核苷酸 |
TW201945388A (zh) | 2018-04-12 | 2019-12-01 | 美商精密生物科學公司 | 對b型肝炎病毒基因體中之識別序列具有特異性之最佳化之經工程化巨核酸酶 |
US11485741B2 (en) | 2018-04-24 | 2022-11-01 | Bristol-Myers Squibb Company | Macrocyclic toll-like receptor 7 (TLR7) agonists |
US20190359645A1 (en) | 2018-05-03 | 2019-11-28 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 2'3'-cyclic dinucleotides comprising carbocyclic nucleotide |
CN110526918B (zh) * | 2018-05-25 | 2021-09-03 | 江苏恒瑞医药股份有限公司 | 一种吡唑并杂芳基类衍生物的晶型及制备方法 |
CN110526917B (zh) * | 2018-05-25 | 2021-09-03 | 江苏恒瑞医药股份有限公司 | 一种吡唑并杂芳基类衍生物的可药用盐、晶型及其制备方法 |
CN111819178B (zh) * | 2018-05-25 | 2022-04-12 | 江苏恒瑞医药股份有限公司 | 一种吡唑并杂芳基类衍生物盐酸盐的晶型及制备方法 |
WO2020028097A1 (en) | 2018-08-01 | 2020-02-06 | Gilead Sciences, Inc. | Solid forms of (r)-11-(methoxymethyl)-12-(3-methoxypropoxy)-3,3-dimethyl-8-0x0-2,3,8,13b-tetrahydro-1h-pyrido[2,1-a]pyrrolo[1,2-c] phthalazine-7-c arboxylic acid |
US11554120B2 (en) | 2018-08-03 | 2023-01-17 | Bristol-Myers Squibb Company | 1H-pyrazolo[4,3-d]pyrimidine compounds as toll-like receptor 7 (TLR7) agonists and methods and uses therefor |
WO2020063858A1 (zh) * | 2018-09-29 | 2020-04-02 | 江苏恒瑞医药股份有限公司 | Tlr激动剂与免疫检查点抑制剂联合在制备治疗肿瘤的药物中的用途 |
CN112513039B (zh) * | 2018-10-11 | 2023-01-24 | 江苏恒瑞医药股份有限公司 | 一种tlr7激动剂前药、其制备方法及其在医药上的应用 |
WO2020092528A1 (en) | 2018-10-31 | 2020-05-07 | Gilead Sciences, Inc. | Substituted 6-azabenzimidazole compounds having hpk1 inhibitory activity |
MX2021005047A (es) | 2018-10-31 | 2021-09-08 | Gilead Sciences Inc | Compuestos de 6-azabenzimidazol sustituidos como inhibidores de hpk1. |
WO2020162705A1 (ko) | 2019-02-08 | 2020-08-13 | 성균관대학교산학협력단 | 톨-유사 수용체 7 또는 8 작용자와 콜레스테롤의 결합체 및 그 용도 |
US11766447B2 (en) | 2019-03-07 | 2023-09-26 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 3′3′-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide as sting modulator |
EP3935066A1 (en) | 2019-03-07 | 2022-01-12 | Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. | 3'3'-cyclic dinucleotides and prodrugs thereof |
CN113543851A (zh) | 2019-03-07 | 2021-10-22 | 捷克共和国有机化学与生物化学研究所 | 2’3’-环二核苷酸及其前药 |
TWI751517B (zh) | 2019-04-17 | 2022-01-01 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
TW202210480A (zh) | 2019-04-17 | 2022-03-16 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
EP3972695A1 (en) | 2019-05-23 | 2022-03-30 | Gilead Sciences, Inc. | Substituted exo-methylene-oxindoles which are hpk1/map4k1 inhibitors |
CN112007034B (zh) * | 2019-05-31 | 2022-05-24 | 江苏恒瑞医药股份有限公司 | Tlr激动剂与免疫检查点抑制剂、vegfr抑制剂联合在制备治疗肿瘤药物中的用途 |
CN114040776A (zh) * | 2019-06-28 | 2022-02-11 | 江苏恒瑞医药股份有限公司 | Tlr激动剂与抗ox40抗体或其抗原结合片段联合在制备治疗肿瘤的药物中的用途 |
EP4017476A1 (en) | 2019-08-19 | 2022-06-29 | Gilead Sciences, Inc. | Pharmaceutical formulations of tenofovir alafenamide |
WO2021067181A1 (en) | 2019-09-30 | 2021-04-08 | Gilead Sciences, Inc. | Hbv vaccines and methods treating hbv |
CN112830929B (zh) * | 2019-11-22 | 2022-09-16 | 江苏恒瑞医药股份有限公司 | 吡唑并杂芳基类化合物的制备方法 |
US20230031465A1 (en) | 2019-12-06 | 2023-02-02 | Precision Biosciences, Inc. | Optimized engineered meganucleases having specificity for a recognition sequence in the hepatitis b virus genome |
WO2021154661A1 (en) * | 2020-01-27 | 2021-08-05 | Bristol-Myers Squibb Company | 1H-PYRAZOLO[4,3-d]PYRIMIDINE COMPOUNDS AS TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS |
EP4097105A1 (en) * | 2020-01-27 | 2022-12-07 | Bristol-Myers Squibb Company | 1h-pyrazolo[4,3-d]pyrimidine compounds as toll-like receptor 7 (tlr7) agonists |
US20230130516A1 (en) * | 2020-01-27 | 2023-04-27 | Bristol-Myers Squibb Company | 1H-PYRAZOLO[4,3-d]PYRIMIDINE COMPOUNDS AS TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS |
US20230122249A1 (en) | 2020-01-27 | 2023-04-20 | Bristol-Myers Squibb Company | 1H-PYRAZOLO[4,3-d]PYRIMIDINE COMPOUNDS AS TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS |
EP4097106A1 (en) | 2020-01-27 | 2022-12-07 | Bristol-Myers Squibb Company | 1h-pyrazolo[4,3-d]pyrimidine compounds as toll-like receptor 7 (tlr7) agonists |
KR20220132595A (ko) | 2020-01-27 | 2022-09-30 | 브리스톨-마이어스 스큅 컴퍼니 | 톨-유사 수용체 7 (TLR7) 효능제로서의 C3-치환된 1H-피라졸로[4,3-d]피리미딘 화합물 |
US20230144824A1 (en) * | 2020-01-27 | 2023-05-11 | Bristol-Myers Squibb Company | 1H-PYRAZOLO[4,3-d]PYRIMIDINE COMPOUNDS AS TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS |
EP4097100A1 (en) * | 2020-01-27 | 2022-12-07 | Bristol-Myers Squibb Company | 1h-pyrazolo[4,3-d]pyrimidine compounds as toll-like receptor 7 (tlr7) agonists |
US20230140430A1 (en) * | 2020-01-27 | 2023-05-04 | Bristol-Myers Squibb Company | 1H-PYRAZOLO[4,3-d]PYRIMIDINE COMPOUNDS AS TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS |
US20230100429A1 (en) | 2020-03-02 | 2023-03-30 | Progeneer Inc. | Live-pathogen-mimetic nanoparticles based on pathogen cell wall skeleton, and production method thereof |
JP2023518433A (ja) | 2020-03-20 | 2023-05-01 | ギリアード サイエンシーズ, インコーポレイテッド | 4’-c-置換-2-ハロ-2’-デオキシアデノシンヌクレオシドのプロドラッグ並びにその製造法及び使用法 |
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JP2023536945A (ja) | 2020-08-04 | 2023-08-30 | プロジェニア インコーポレイテッド | 動力学的に作用するアジュバントアンサンブル |
CN116322751A (zh) | 2020-08-04 | 2023-06-23 | 蛋白科技先锋 | 包含能够动力学控制的佐剂的mRNA疫苗 |
JP2023536954A (ja) | 2020-08-04 | 2023-08-30 | プロジェニア インコーポレイテッド | 活性化部位が一時的に不活性化したトール様受容体7または8作用薬と機能性薬物の結合体およびその用途 |
CN114276351B (zh) * | 2020-09-27 | 2023-06-16 | 江苏恒瑞医药股份有限公司 | 含氮杂环类衍生物、其制备方法及其在医药上的应用 |
CN114621230B (zh) * | 2020-12-10 | 2023-06-16 | 江苏恒瑞医药股份有限公司 | 含氮杂环化合物、其制备方法及其在医药上的应用 |
WO2022241134A1 (en) | 2021-05-13 | 2022-11-17 | Gilead Sciences, Inc. | COMBINATION OF A TLR8 MODULATING COMPOUND AND ANTI-HBV siRNA THERAPEUTICS |
WO2022271684A1 (en) | 2021-06-23 | 2022-12-29 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
IL309378A (en) | 2021-06-23 | 2024-02-01 | Gilead Sciences Inc | DIACYLGLYERCOL KINASE MODULATING COMPOUNDS |
EP4359411A1 (en) | 2021-06-23 | 2024-05-01 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
CN117396478A (zh) | 2021-06-23 | 2024-01-12 | 吉利德科学公司 | 二酰基甘油激酶调节化合物 |
WO2023104165A1 (zh) * | 2021-12-08 | 2023-06-15 | 上海维申医药有限公司 | 作为TLR7/8激动剂的吡啶[4,3-d]嘧啶类化合物 |
WO2024055879A1 (zh) * | 2022-09-16 | 2024-03-21 | 四川科伦博泰生物医药股份有限公司 | 一类双并环化合物、其制备方法及用途 |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6638967B2 (en) | 2000-08-08 | 2003-10-28 | Ortho-Mcneil Phamraceutical, Inc. | Thiophene of furan pyrrolidine compounds |
NZ545536A (en) | 2003-09-05 | 2010-04-30 | Anadys Pharmaceuticals Inc | TLR7 ligands for the treatment of hepatitis C |
EP1877407A1 (en) * | 2005-04-25 | 2008-01-16 | Novartis AG | Imidazo(1,2-a)pyridine derivatives useful as peptide deformylase (pdf) inhibitors |
ES2374455T3 (es) | 2006-02-17 | 2012-02-16 | Pfizer Limited | Derivados de 3-deazapurinza como moduladores de tlr7. |
DE602007012881D1 (en) | 2006-07-18 | 2011-04-14 | Anadys Pharmaceuticals Inc | Carbonat- und carbamat-prodrugs von thiazolo ä4,5-dü-pyrimidinen |
EP2132209B8 (en) * | 2007-03-19 | 2014-04-16 | AstraZeneca AB | 9-substituted-8-oxo-adenine compounds as toll-like receptor (tlr7 ) modulators |
PE20081887A1 (es) * | 2007-03-20 | 2009-01-16 | Dainippon Sumitomo Pharma Co | Nuevo compuesto de adenina |
WO2009034547A2 (en) * | 2007-09-14 | 2009-03-19 | Università Degli Studi Di Siena | New 4-substituted derivatives of pyrazolo[3,4-d pyrimidine and pyrrolo[2,3-d]pyrimidine and uses thereof |
BRPI0820342A2 (pt) | 2007-11-07 | 2015-05-26 | Foldrx Pharmaceuticals Inc | Modulação de tráfego de proteína |
WO2009091032A1 (ja) | 2008-01-17 | 2009-07-23 | Dainippon Sumitomo Pharma Co., Ltd. | アデニン化合物の製造方法 |
NZ612380A (en) * | 2008-12-09 | 2015-01-30 | Gilead Sciences Inc | Modulators of toll-like receptors |
GB0908772D0 (en) | 2009-05-21 | 2009-07-01 | Astrazeneca Ab | New salts 756 |
ES2661850T3 (es) | 2009-09-14 | 2018-04-04 | Gilead Sciences, Inc. | Moduladores de receptores del tipo toll |
PL2491035T3 (pl) * | 2009-10-22 | 2018-01-31 | Gilead Sciences Inc | Pochodne puryny lub deazapuryny przydatne do leczenia (między innymi) infekcji wirusowych |
WO2012080730A1 (en) | 2010-12-17 | 2012-06-21 | Astrazeneca Ab | Purine derivatives |
KR101379808B1 (ko) * | 2012-04-03 | 2014-04-24 | 울산대학교 산학협력단 | 산화질소 생성 억제용 피라졸로피리미딘 유도체 화합물 |
EP3049086A4 (en) * | 2013-09-27 | 2017-02-22 | Nimbus Iris, Inc. | Irak inhibitors and uses thereof |
EP3116876A4 (en) * | 2014-03-13 | 2017-10-25 | Agency For Science, Technology And Research | Fused pyrimidine-based hydroxamate derivatives |
MX2016013689A (es) | 2014-04-22 | 2017-01-20 | Hoffmann La Roche | Compuestos 4-amino-imidazoquinolina. |
CN110938076B (zh) * | 2014-08-15 | 2021-08-10 | 正大天晴药业集团股份有限公司 | 作为tlr7激动剂的吡咯并嘧啶化合物 |
CN105367576A (zh) * | 2014-08-15 | 2016-03-02 | 正大天晴药业集团股份有限公司 | 作为tlr7激动剂的吡咯并嘧啶化合物 |
ES2688194T3 (es) | 2014-09-11 | 2018-10-31 | Bristol-Myers Squibb Company | Inhibidores de mieloperoxidasa de triazolopirimidina y triazolopiridina de tioéter |
-
2017
- 2017-11-27 AU AU2017366621A patent/AU2017366621B2/en active Active
- 2017-11-27 MX MX2019005379A patent/MX2019005379A/es unknown
- 2017-11-27 MY MYPI2019002775A patent/MY192084A/en unknown
- 2017-11-27 KR KR1020197014586A patent/KR20190084991A/ko not_active Application Discontinuation
- 2017-11-27 PT PT178740916T patent/PT3546457T/pt unknown
- 2017-11-27 ES ES17874091T patent/ES2886973T3/es active Active
- 2017-11-27 JP JP2019527146A patent/JP7145854B2/ja active Active
- 2017-11-27 WO PCT/CN2017/113007 patent/WO2018095426A1/zh active Application Filing
- 2017-11-27 RU RU2019118390A patent/RU2748833C2/ru active
- 2017-11-27 EP EP17874091.6A patent/EP3546457B1/en active Active
- 2017-11-27 BR BR112019010182A patent/BR112019010182A2/pt unknown
- 2017-11-27 US US16/464,341 patent/US11117898B2/en active Active
- 2017-11-27 TW TW106141159A patent/TWI760390B/zh not_active IP Right Cessation
- 2017-11-27 HU HUE17874091A patent/HUE054964T2/hu unknown
- 2017-11-27 CN CN201780017416.6A patent/CN108884092B/zh active Active
- 2017-11-27 CA CA3044903A patent/CA3044903A1/en active Pending
-
2021
- 2021-08-17 US US17/404,281 patent/US20210380593A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
RU2019118390A3 (hu) | 2020-12-28 |
AU2017366621A1 (en) | 2019-05-23 |
CN108884092B (zh) | 2021-06-29 |
CA3044903A1 (en) | 2018-05-31 |
ES2886973T3 (es) | 2021-12-21 |
EP3546457B1 (en) | 2021-07-14 |
PT3546457T (pt) | 2021-08-06 |
US20210380593A1 (en) | 2021-12-09 |
AU2017366621B2 (en) | 2021-07-29 |
WO2018095426A1 (zh) | 2018-05-31 |
TW201819387A (zh) | 2018-06-01 |
RU2019118390A (ru) | 2020-12-28 |
JP2019535730A (ja) | 2019-12-12 |
MX2019005379A (es) | 2019-09-04 |
TWI760390B (zh) | 2022-04-11 |
EP3546457A4 (en) | 2020-05-20 |
US20210115046A1 (en) | 2021-04-22 |
RU2748833C2 (ru) | 2021-05-31 |
JP7145854B2 (ja) | 2022-10-03 |
US11117898B2 (en) | 2021-09-14 |
EP3546457A1 (en) | 2019-10-02 |
BR112019010182A2 (pt) | 2019-09-17 |
KR20190084991A (ko) | 2019-07-17 |
MY192084A (en) | 2022-07-26 |
CN108884092A (zh) | 2018-11-23 |
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