|
CN1946417A
(zh)
|
2003-12-05 |
2007-04-11 |
阿德内克休斯治疗公司 |
2型血管内皮生长因子受体的抑制剂
|
|
CA2670471A1
(en)
|
2006-11-22 |
2008-06-05 |
Adnexus, A Bristol-Myers Squibb R&D Company (A Delaware Corporation) |
Targeted therapeutics based on engineered proteins for tyrosine kinases receptors, including igf-ir
|
|
CN102007145A
(zh)
|
2008-02-14 |
2011-04-06 |
百时美施贵宝公司 |
基于结合egfr的工程化蛋白质的靶向治疗剂
|
|
PE20091931A1
(es)
|
2008-05-22 |
2009-12-31 |
Bristol Myers Squibb Co |
Proteinas de dominio de armazon basadas en fibronectina multivalentes
|
|
TWI496582B
(zh)
|
2008-11-24 |
2015-08-21 |
必治妥美雅史谷比公司 |
雙重專一性之ｅｇｆｒ／ｉｇｆｉｒ結合分子
|
|
CA2795325A1
(en)
*
|
2010-04-13 |
2011-10-20 |
Medimmune, Llc |
Fibronectin type iii domain-based multimeric scaffolds
|
|
TW201138808A
(en)
|
2010-05-03 |
2011-11-16 |
Bristol Myers Squibb Co |
Serum albumin binding molecules
|
|
ES2573108T3
(es)
|
2010-05-26 |
2016-06-06 |
Bristol-Myers Squibb Company |
Proteínas de armazón a base de fibronectina que tienen estabilidad mejorada
|
|
RS55609B1
(sr)
|
2011-04-13 |
2017-06-30 |
Bristol Myers Squibb Co |
Fc fuzioni proteini koji sadrže nove linkere ili aranžmane
|
|
EP3318880B1
(en)
|
2011-05-17 |
2020-12-16 |
Bristol-Myers Squibb Company |
Improved methods for the selection of binding proteins
|
|
EP2709669A1
(en)
|
2011-05-17 |
2014-03-26 |
Bristol-Myers Squibb Company |
Methods for maintaining pegylation of polypeptides
|
|
AU2012323316B2
(en)
|
2011-10-11 |
2017-08-10 |
Viela Bio, Inc. |
CD40L-specific Tn3-derived scaffolds and methods of use thereof
|
|
EP2773659A2
(en)
|
2011-10-31 |
2014-09-10 |
Bristol-Myers Squibb Company |
Fibronectin binding domains with reduced immunogenicity
|
|
CA2854806A1
(en)
|
2011-11-07 |
2013-05-16 |
Medimmune, Llc |
Multispecific and multivalent binding proteins and uses thereof
|
|
CN104136457A
(zh)
|
2011-11-08 |
2014-11-05 |
Umc乌德勒支控股有限公司 |
包括白细胞介素10和白细胞介素4的融合蛋白
|
|
TWI633117B
(zh)
|
2012-09-13 |
2018-08-21 |
必治妥美雅史谷比公司 |
結合至肌肉生長抑制素（ｍｙｏｓｔａｔｉｎ）以纖維連接蛋白爲主之支架結構域蛋白質
|
|
US9695228B2
(en)
*
|
2012-11-21 |
2017-07-04 |
Janssen Biotech, Inc. |
EGFR and c-Met fibronectin type III domain binding molecules
|
|
EP2951206A2
(en)
|
2013-02-01 |
2015-12-09 |
Bristol-Myers Squibb Company |
Fibronectin based scaffold proteins
|
|
ES2689372T3
(es)
|
2013-02-06 |
2018-11-13 |
Bristol-Myers Squibb Company |
Proteínas de dominio de fibronectina tipo III con solubilidad mejorada
|
|
ES2870802T3
(es)
|
2013-02-12 |
2021-10-27 |
Bristol Myers Squibb Co |
Métodos de replegado de proteínas a elevado pH
|
|
EP3744728A1
(en)
|
2013-02-12 |
2020-12-02 |
Bristol-Myers Squibb Company |
Tangential flow filtration based protein refolding methods
|
|
US20160152686A1
(en)
|
2013-03-13 |
2016-06-02 |
Bristol-Myers Squibb Company |
Fibronectin based scaffold domains linked to serum albumin or moiety binding thereto
|
|
ES2812208T3
(es)
|
2013-03-14 |
2021-03-16 |
Bristol Myers Squibb Co |
Combinación de un agonista de DR5 y un antagonista de anti-PD-1 y métodos de uso
|
|
US10392611B2
(en)
|
2013-05-30 |
2019-08-27 |
Duke University |
Polymer conjugates having reduced antigenicity and methods of using the same
|
|
US10364451B2
(en)
|
2013-05-30 |
2019-07-30 |
Duke University |
Polymer conjugates having reduced antigenicity and methods of using the same
|
|
CN105899226B
(zh)
|
2013-10-14 |
2020-05-12 |
詹森生物科技公司 |
半胱氨酸工程化iii型纤连蛋白域结合分子
|
|
US11299528B2
(en)
|
2014-03-11 |
2022-04-12 |
D&D Pharmatech Inc. |
Long acting TRAIL receptor agonists for treatment of autoimmune diseases
|
|
CN106795214B
(zh)
|
2014-03-20 |
2022-09-02 |
百时美施贵宝公司 |
稳定化的基于纤连蛋白的支架分子
|
|
EP3129401B1
(en)
|
2014-03-20 |
2019-06-12 |
Bristol-Myers Squibb Company |
Serum albumin-binding fibronectin type iii domains
|
|
WO2015148269A2
(en)
*
|
2014-03-24 |
2015-10-01 |
Medimmune, Llc |
Stabilized tnfn3 scaffold proteins
|
|
NO2776305T3
(https=)
|
2014-04-23 |
2018-01-27 |
|
|
|
US10562946B2
(en)
*
|
2014-06-20 |
2020-02-18 |
Genentech, Inc. |
Chagasin-based scaffold compositions, methods, and uses
|
|
JP6863888B2
(ja)
|
2014-10-01 |
2021-04-21 |
メディミューン，エルエルシー |
ポリペプチドをコンジュゲートさせる方法
|
|
MX385081B
(es)
|
2014-11-25 |
2025-03-14 |
Bristol Myers Squibb Co |
Métodos y composiciones para radioetiquetado con 18f de productos biológicos.
|
|
EP3842451A1
(en)
|
2015-03-12 |
2021-06-30 |
MedImmune, LLC |
Method of purifying albumin-fusion proteins
|
|
US10385115B2
(en)
|
2015-03-26 |
2019-08-20 |
Duke University |
Fibronectin type III domain-based fusion proteins
|
|
US10844122B2
(en)
*
|
2015-05-06 |
2020-11-24 |
Janssen Biotech, Inc. |
Prostate specific membrane antigen (PSMA) bispecific binding agents and uses thereof
|
|
JP6882782B2
(ja)
|
2015-08-04 |
2021-06-02 |
デューク ユニバーシティ |
遺伝子コードされた本質的に無秩序な送達用ステルスポリマーおよびその使用方法
|
|
WO2017048709A1
(en)
|
2015-09-14 |
2017-03-23 |
Arizona Board Of Regents On Behalf Of Arizona State University |
Generating recominant affinity reagents with arrayed targets
|
|
EP3708580B1
(en)
|
2015-09-23 |
2023-11-01 |
Bristol-Myers Squibb Company |
Fast-off rate serum albumin binding fibronectin type iii domains
|
|
ES2809125T3
(es)
|
2015-09-23 |
2021-03-03 |
Bristol Myers Squibb Co |
Moléculas de armazón a base de fibronectina de unión a glipicano-3
|
|
JP7174627B2
(ja)
*
|
2015-10-23 |
2022-11-17 |
ウニフェルシタイト・トゥヴェンテ |
インテグリン結合ペプチド及びその使用
|
|
WO2017106627A1
(en)
|
2015-12-17 |
2017-06-22 |
The Johns Hopkins University |
Ameliorating systemic sclerosis with death receptor agonists
|
|
US11752213B2
(en)
|
2015-12-21 |
2023-09-12 |
Duke University |
Surfaces having reduced non-specific binding and antigenicity
|
|
KR102508650B1
(ko)
|
2016-04-07 |
2023-03-13 |
더 존스 홉킨스 유니버시티 |
사멸 수용체 작용제로써 췌장암 및 통증을 치료하기 위한 조성물 및 방법
|
|
AR108377A1
(es)
|
2016-05-06 |
2018-08-15 |
Medimmune Llc |
Proteínas de unión biespecíficas y sus usos
|
|
CN105802970A
(zh)
*
|
2016-05-30 |
2016-07-27 |
东北师范大学 |
靶向沉默Gβ1的shRNA
|
|
US10994033B2
(en)
|
2016-06-01 |
2021-05-04 |
Bristol-Myers Squibb Company |
Imaging methods using 18F-radiolabeled biologics
|
|
WO2017210476A1
(en)
|
2016-06-01 |
2017-12-07 |
Duke University |
Nonfouling biosensors
|
|
JP2019527540A
(ja)
|
2016-06-21 |
2019-10-03 |
ヤンセン バイオテツク，インコーポレーテツド |
システイン操作フィブロネクチンｉｉｉ型ドメイン結合分子
|
|
RU2019110848A
(ru)
|
2016-09-14 |
2020-10-15 |
Дьюк Юниверсити |
Наночастицы на основе триблочных полипептидов для доставки гидрофильных лекарственных средств
|
|
EP3515928B1
(en)
|
2016-09-23 |
2026-01-28 |
Duke University |
Unstructured non-repetitive polypeptides having lcst behavior
|
|
US10611823B2
(en)
|
2016-12-14 |
2020-04-07 |
Hanssen Biotech, Inc |
CD137 binding fibronectin type III domains
|
|
NZ754187A
(en)
|
2016-12-14 |
2026-02-27 |
Janssen Biotech Inc |
Cd8a-binding fibronectin type iii domains
|
|
WO2018111976A1
(en)
|
2016-12-14 |
2018-06-21 |
Janssen Biotech, Inc. |
Pd-l1 binding fibronectin type iii domains
|
|
WO2018132732A1
(en)
|
2017-01-12 |
2018-07-19 |
Duke University |
Genetically encoded lipid-polypeptide hybrid biomaterials that exhibit temperature triggered hierarchical self-assembly
|
|
US10787499B2
(en)
*
|
2017-02-13 |
2020-09-29 |
Regents Of The University Of Minnesota |
EpCAM targeted polypeptides, conjugates thereof, and methods of use thereof
|
|
WO2018213320A1
(en)
|
2017-05-15 |
2018-11-22 |
Duke University |
Recombinant production of hybrid lipid-biopolymer materials that self-assemble and encapsulate agents
|
|
AR111963A1
(es)
|
2017-05-26 |
2019-09-04 |
Univ California |
Método y moléculas
|
|
WO2019006374A1
(en)
|
2017-06-30 |
2019-01-03 |
Duke University |
ORDER AND DISORDER AS A DESIGN PRINCIPLE FOR STIMULI-SENSITIVE BIOPOLYMER NETWORKS
|
|
US12296018B2
(en)
|
2018-01-26 |
2025-05-13 |
Duke University |
Albumin binding peptide-drug (AlBiPeD) conjugates and methods of making and using same
|
|
US11491206B1
(en)
|
2018-02-13 |
2022-11-08 |
Duke University |
Compositions and methods for the treatment of trail-resistant cancer
|
|
US11680091B2
(en)
|
2018-02-23 |
2023-06-20 |
The University Of Chicago |
Methods and composition involving thermophilic fibronectin type III (FN3) monobodies
|
|
EP3788343B1
(en)
|
2018-04-30 |
2024-03-27 |
Duke University |
Stimuli-responsive peg-like polymer-based drug delivery platform
|
|
UY38251A
(es)
|
2018-06-01 |
2019-12-31 |
Novartis Ag |
Moléculas de unión contra bcma y usos de las mismas
|
|
CN110724198B
(zh)
*
|
2018-07-17 |
2023-05-26 |
上海一宸医药科技有限公司 |
长效纤连蛋白iii型结构域融合蛋白
|
|
EP3829622A4
(en)
|
2018-08-02 |
2022-05-11 |
Duke University |
DOUBLE AGONIST FUSION PROTEINS
|
|
WO2020051541A1
(en)
|
2018-09-07 |
2020-03-12 |
Duke University |
Nanoparticulate drug delivery systems
|
|
EP3715376A1
(en)
|
2019-03-23 |
2020-09-30 |
Ablevia biotech GmbH |
Compound for the prevention or treatment of myasthenia gravis
|
|
US11986536B2
(en)
|
2019-03-23 |
2024-05-21 |
Ablevia Biotech Gmbh |
Compound for the sequestration of undesirable antibodies in a patient
|
|
EP3715374A1
(en)
|
2019-03-23 |
2020-09-30 |
Ablevia biotech GmbH |
Compound for the sequestration of undesirable antibodies in a patient
|
|
JP7641912B2
(ja)
|
2019-04-19 |
2025-03-07 |
シナーキン・ファーマ・ベスローテン・フエンノートシャップ |
Ｉｌ１３を含む融合タンパク質
|
|
CN118994397A
(zh)
|
2019-05-21 |
2024-11-22 |
诺华股份有限公司 |
针对bcma的三特异性结合分子及其用途
|
|
PE20220568A1
(es)
|
2019-05-21 |
2022-04-20 |
Novartis Ag |
Moleculas de union a cd19 y usos de las mismas
|
|
EP3972993A1
(en)
|
2019-05-21 |
2022-03-30 |
Novartis AG |
Variant cd58 domains and uses thereof
|
|
US11512314B2
(en)
|
2019-07-12 |
2022-11-29 |
Duke University |
Amphiphilic polynucleotides
|
|
EP3999091A1
(en)
|
2019-07-15 |
2022-05-25 |
MedImmune Limited |
Tripartite systems for protein dimerization and methods of use
|
|
WO2021076543A1
(en)
|
2019-10-14 |
2021-04-22 |
Aro Biotherapeutics Company |
Epcam binding fibronectin type iii domains
|
|
WO2021076574A2
(en)
|
2019-10-14 |
2021-04-22 |
Aro Biotherapeutics Company |
Fn3 domain-sirna conjugates and uses thereof
|
|
CN114786682B
(zh)
|
2019-10-14 |
2024-07-16 |
Aro生物疗法公司 |
结合cd71的纤维粘连蛋白iii型结构域
|
|
CN111217903B
(zh)
*
|
2020-02-25 |
2022-11-15 |
芜湖天明生物技术有限公司 |
一种重组人纤连蛋白ⅲ1-c及其制备方法和应用
|
|
JP2023515633A
(ja)
|
2020-02-28 |
2023-04-13 |
ブリストル－マイヤーズ スクイブ カンパニー |
放射性標識されたフィブロネクチンに基づく足場および抗体ならびにそのセラノスティクス的使用
|
|
CN116249549A
(zh)
|
2020-03-27 |
2023-06-09 |
诺华股份有限公司 |
用于治疗增殖性疾病和自身免疫病症的双特异性组合疗法
|
|
US11767353B2
(en)
|
2020-06-05 |
2023-09-26 |
Theraly Fibrosis, Inc. |
Trail compositions with reduced immunogenicity
|
|
CN111944204B
(zh)
*
|
2020-07-24 |
2022-03-08 |
南京理工大学 |
一种Fe3O4磁性细菌纤维素及其制备方法
|
|
EP4216990A1
(en)
|
2020-09-23 |
2023-08-02 |
Ablevia biotech GmbH |
Compound for the sequestration of undesirable antibodies in a patient
|
|
IL301332A
(en)
|
2020-09-23 |
2023-05-01 |
Ablevia Biotech Gmbh |
Compound for the prevention or treatment of autoantibody-mediated conditions
|
|
CA3192753A1
(en)
|
2020-09-23 |
2022-03-31 |
Oskar SMRZKA |
Compound for increasing the efficacy of factor viii replacement therapy
|
|
BR112023005246A2
(pt)
|
2020-09-23 |
2023-04-25 |
Ablevia Biotech Gmbh |
Composto para o sequestro de anticorpos anti-peg indesejáveis em um paciente
|
|
JP2023542390A
(ja)
|
2020-09-23 |
2023-10-06 |
アブレヴィア バイオテック ゲーエムベーハー |
ウイルスベクターの有効性を増強するための化合物
|
|
EP4217401A1
(en)
|
2020-09-24 |
2023-08-02 |
Ablevia biotech GmbH |
Compound for the prevention or treatment of myasthenia gravis
|
|
US20250215081A1
(en)
|
2020-11-06 |
2025-07-03 |
Novartis Ag |
Anti-cd19 agent and b cell targeting agent combination therapy for treating b cell malignancies
|
|
US20240025993A1
(en)
|
2020-11-06 |
2024-01-25 |
Novartis Ag |
Cd19 binding molecules and uses thereof
|
|
CA3214552A1
(en)
|
2021-04-14 |
2022-10-20 |
Russell C. Addis |
Cd71 binding fibronectin type iii domains
|
|
BR112023021318A2
(pt)
|
2021-04-14 |
2023-12-19 |
Aro Biotherapeutics Company |
Conjugados de domínio fn3-sirna e usos dos mesmos
|
|
AU2023238299A1
(en)
|
2022-03-24 |
2024-11-07 |
Ablevia Biotech Gmbh |
Compound for increasing efficacy of oncolytic viruses
|
|
KR102459313B1
(ko)
*
|
2022-04-11 |
2022-10-26 |
주식회사 대영방재산업 |
내구성이 개선된 소방용 수격 흡수기
|
|
CN121752717A
(zh)
|
2023-06-23 |
2026-03-27 |
阿斯利康(瑞典)有限公司 |
分子开关
|
|
WO2025125630A1
(en)
|
2023-12-15 |
2025-06-19 |
Medimmune Limited |
Method for bioprotac design
|