|
US7314632B1
(en)
*
|
1997-07-11 |
2008-01-01 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Pseudomonas exotoxin A-like chimeric immunogens
|
|
US20030054012A1
(en)
*
|
2000-05-12 |
2003-03-20 |
Fitzgerald David J. |
Pseudomonas exotoxin a-like chimeric immunogens for eliciting a secretory iga-mediated immune response
|
|
DK1000163T3
(da)
*
|
1997-07-11 |
2006-02-06 |
Us Gov Health & Human Serv |
Pseudomonas-exotoksin A-lignende kimære immunogener
|
|
US6809184B1
(en)
*
|
1997-12-01 |
2004-10-26 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Antibodies, including FV molecules, and immunoconjugates having high binding affinity for mesothelin and methods for their use
|
|
US7745159B2
(en)
*
|
1999-02-26 |
2010-06-29 |
Nathalie B Scholler |
Methods and compositions for diagnosing carcinomas
|
|
CA2369433A1
(en)
*
|
1999-02-26 |
2000-08-31 |
Pacific Northwest Research Institute |
Methods and compositions for diagnosing carcinomas
|
|
US6770445B1
(en)
*
|
1999-02-26 |
2004-08-03 |
Pacific Northwest Research Institute |
Methods and compositions for diagnosing carcinomas
|
|
EP2011801A1
(en)
*
|
1999-05-27 |
2009-01-07 |
Government of the United States as represented by the Secretary, Department of Health and Human Services |
Immunoconjugates having high binding affinity
|
|
GB9924351D0
(en)
|
1999-10-14 |
1999-12-15 |
Brennan Frank |
Immunomodulation methods and compositions
|
|
US6987024B1
(en)
*
|
2000-04-10 |
2006-01-17 |
Raven Biotechnologies, Inc. |
Human ovarian mesothelial cells and methods of isolation and uses thereof
|
|
US20030104402A1
(en)
*
|
2001-01-23 |
2003-06-05 |
University Of Rochester |
Methods of producing or identifying intrabodies in eukaryotic cells
|
|
ES2502366T3
(es)
*
|
2001-03-09 |
2014-10-03 |
Board Of Regents, The University Of Texas System |
Inducción de inmunidad tumoral por variantes de proteína de unión a folato
|
|
US9200036B2
(en)
|
2002-07-12 |
2015-12-01 |
The Johns Hopkins University |
Mesothelin vaccines and model systems
|
|
US20090110702A1
(en)
|
2002-07-12 |
2009-04-30 |
The Johns Hopkins University |
Mesothelin Vaccines and Model Systems and Control of Tumors
|
|
CA2492160A1
(en)
*
|
2002-07-12 |
2004-01-22 |
The Johns Hopkins University |
Mesothelin vaccines and model systems
|
|
KR101173871B1
(ko)
*
|
2003-02-06 |
2012-08-16 |
앤저 테라퓨틱스 인코퍼레이티드 |
변형된 독립생존 미생물, 백신 조성물 및 그것의 사용방법
|
|
KR101192652B1
(ko)
*
|
2003-02-06 |
2012-10-19 |
앤저 테라퓨틱스 인코퍼레이티드 |
비포식 세포로의 침투가 약화된 리스테리아, 리스테리아를 포함하는 백신, 및 그것의 사용방법
|
|
US7695725B2
(en)
*
|
2003-02-06 |
2010-04-13 |
Aduro Biotech |
Modified free-living microbes, vaccine compositions and methods of use thereof
|
|
US20040180387A1
(en)
*
|
2003-03-13 |
2004-09-16 |
Fujirebio Diagnostics, Inc. |
Detection of urinary mesothelin-/megakaryocyte potentiating factor-related peptides for assessment of ovarian cancer
|
|
WO2005014652A1
(en)
*
|
2003-08-05 |
2005-02-17 |
Morphotek, Inc. |
A variant cell surface molecule associated with cancer
|
|
US7399793B2
(en)
*
|
2003-10-31 |
2008-07-15 |
Basf Corporation |
Coating composition curable with ultraviolet radiation
|
|
EP2478912B1
(en)
|
2003-11-06 |
2016-08-31 |
Seattle Genetics, Inc. |
Auristatin conjugates with anti-HER2 or anti-CD22 antibodies and their use in therapy
|
|
US7842289B2
(en)
|
2003-12-24 |
2010-11-30 |
Aduro Biotech |
Recombinant nucleic acid molecules, expression cassettes, and bacteria, and methods of use thereof
|
|
WO2005072263A2
(en)
*
|
2004-01-21 |
2005-08-11 |
Fujirebio America, Inc. |
Detection of urinary mesothelin-/megakaryocyte potentiating factor-related peptides for assessment of mesothelioma
|
|
EP2444805A3
(en)
|
2004-01-21 |
2012-06-20 |
Fujirebio America, Inc. |
Detection of mesothelin-/megakaryocyte potentiating factor-related peptides in peritoneal fluid for assessment of the peritoneum and the peritoneal cavity
|
|
EP3101034A1
(en)
|
2004-02-12 |
2016-12-07 |
Morphotek, Inc. |
Monoclonal antibodies that specifically bind to folate receptor alpha
|
|
EP1861425B1
(en)
|
2005-03-10 |
2012-05-16 |
Morphotek, Inc. |
Anti-mesothelin antibodies
|
|
CA2607444C
(en)
|
2005-04-22 |
2015-03-10 |
Morphotek, Inc. |
Antibodies with immune effector activity and that internalize in folate receptor alpha-positive cells
|
|
US7935804B2
(en)
|
2006-03-01 |
2011-05-03 |
Aduro Biotech |
Engineered Listeria and methods of use thereof
|
|
US20070207171A1
(en)
*
|
2006-03-01 |
2007-09-06 |
Cerus Corporation |
Engineered listeria and methods of use thereof
|
|
EP2860253B1
(en)
|
2006-03-01 |
2018-08-01 |
Aduro Biotech, Inc. |
Engineered listeria and methods of use thereof
|
|
US20090047673A1
(en)
*
|
2006-08-22 |
2009-02-19 |
Cary Robert B |
Miniaturized lateral flow device for rapid and sensitive detection of proteins or nucleic acids
|
|
CN101784655A
(zh)
*
|
2007-04-27 |
2010-07-21 |
菲尼克斯股份有限公司 |
可溶性重组二十面体病毒样颗粒的改良生成和体内装配
|
|
PE20090943A1
(es)
|
2007-07-16 |
2009-08-05 |
Genentech Inc |
Anticuerpos anti-cd79b e inmunoconjugados
|
|
EP2176295B1
(en)
|
2007-07-16 |
2014-11-19 |
Genentech, Inc. |
Humanized anti-cd79b antibodies and immunoconjugates and methods of use
|
|
JP2009028871A
(ja)
|
2007-07-30 |
2009-02-12 |
Denso Wave Inc |
ロボット制御装置
|
|
ES2526355T3
(es)
|
2007-10-01 |
2015-01-09 |
Bristol-Myers Squibb Company |
Anticuerpos humanos que se adhieren a mesotelina, y usos de los mismos
|
|
MX2010005603A
(es)
|
2007-11-26 |
2010-08-02 |
Bayer Schering Pharma Ag |
Anticuerpos antimesotelina y usos de los mismos.
|
|
KR101607346B1
(ko)
|
2008-01-31 |
2016-03-29 |
제넨테크, 인크. |
항-ｃｄ７９ｂ 항체 및 면역접합체 및 사용 방법
|
|
CA2718321A1
(en)
*
|
2008-03-27 |
2009-10-01 |
Dimiter S. Dimitrov |
Human anti-mesothelin monoclonal antibodies
|
|
US8785134B2
(en)
*
|
2008-11-10 |
2014-07-22 |
The Mitre Corporation |
Glycoprotein vesicles and their methods of use
|
|
AR076284A1
(es)
|
2009-04-29 |
2011-06-01 |
Bayer Schering Pharma Ag |
Inmunoconjugados de antimesotelina y usos de los mismos
|
|
WO2011031441A1
(en)
|
2009-08-28 |
2011-03-17 |
The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Therapy with a chimeric molecule and a pro-apoptotic agent
|
|
ES2544805T3
(es)
|
2009-09-11 |
2015-09-04 |
The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Exotoxina A de Pseudomonas mejorada con inmunogenicidad reducida
|
|
CN102781963B
(zh)
*
|
2009-10-27 |
2018-02-16 |
Ucb医药有限公司 |
功能修饰性NAv1.7抗体
|
|
WO2011100455A1
(en)
|
2010-02-12 |
2011-08-18 |
The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Inhibition of antibody responses to foreign proteins
|
|
BR112013014527A2
(pt)
|
2010-12-20 |
2017-03-07 |
Genentech Inc |
anticorpo isolado, ácido nucleico isolado, célula hospedeira, método para produzir um anticorpo, imunoconjugado, formulação farmacêutica, uso do imunoconjugado, método para tratamento de um indivíduo que tem um câncer positivo para mesotelina, para inibição de proliferação de uma célula positiva para mesotelina, para detecção de mesotelina humana em uma amostra biológica e para detectar um câncer positivo para mesotelina
|
|
CN103608467B
(zh)
|
2011-04-20 |
2017-07-21 |
美飒生物技术公司 |
用于核酸的振荡扩增反应
|
|
SG194787A1
(en)
|
2011-05-06 |
2013-12-30 |
Us Gov Health & Human Serv |
Recombinant immunotoxin targeting mesothelin
|
|
CA2843200A1
(en)
*
|
2011-07-27 |
2013-01-31 |
Baylor Research Institute |
Dendritic cell (dc)-vaccine therapy for pancreatic cancer
|
|
US9127081B2
(en)
|
2012-05-10 |
2015-09-08 |
Washington University |
Tumor targeted TNF-related apoptosis inducing ligand fusion polypeptide and nucleic acids encoding the same
|
|
WO2014004549A2
(en)
|
2012-06-27 |
2014-01-03 |
Amgen Inc. |
Anti-mesothelin binding proteins
|
|
EP3327037B1
(en)
|
2012-08-21 |
2019-10-09 |
The U.S.A. as represented by the Secretary, Department of Health and Human Services |
Mesothelin domain-specific monoclonal antibodies and use thereof
|
|
CN104955845B
(zh)
|
2012-09-27 |
2018-11-16 |
美国政府(由卫生和人类服务部的部长所代表) |
间皮素抗体和引起有效的抗肿瘤活性的方法
|
|
WO2014182532A1
(en)
|
2013-05-07 |
2014-11-13 |
The Usa, As Represented By The Secretary, Dept. Of Health And Human Services |
Mesothelin-specific immunocytokine and use thereof
|
|
HUE049175T2
(hu)
|
2014-09-23 |
2020-09-28 |
Hoffmann La Roche |
Eljárás anti-CD79b immunkonjugátumok alkalmazására
|
|
WO2016126608A1
(en)
|
2015-02-02 |
2016-08-11 |
Novartis Ag |
Car-expressing cells against multiple tumor antigens and uses thereof
|
|
EP3286546B1
(en)
|
2015-04-24 |
2023-07-19 |
Mesa Biotech, Inc. |
Fluidic test cassette
|
|
WO2016196506A1
(en)
|
2015-05-29 |
2016-12-08 |
Galena Biopharma, Inc. |
PEPTIDE VACCINE THERAPY FOR TREATMENT OF FRα-EXPRESSING TUMORS
|
|
EP4643874A3
(en)
|
2015-12-22 |
2026-02-11 |
Novartis AG |
Mesothelin chimeric antigen receptor (car) and antibody against pd-l1 inhibitor for combined use in anticancer therapy
|
|
RU2018127657A
(ru)
|
2015-12-30 |
2020-01-31 |
Новартис Аг |
Виды терапии на основе иммуноэффекторных клеток с улучшенной эффективностью
|
|
MX2018008797A
(es)
|
2016-01-19 |
2018-11-29 |
Pfizer |
Vacunas contra el cancer.
|
|
KR20180118175A
(ko)
|
2016-03-04 |
2018-10-30 |
노파르티스 아게 |
다중 키메라 항원 수용체 (car) 분자를 발현하는 세포 및 그에 따른 용도
|
|
EP3432924A1
(en)
|
2016-03-23 |
2019-01-30 |
Novartis AG |
Cell secreted minibodies and uses thereof
|
|
CN109715808A
(zh)
|
2016-04-15 |
2019-05-03 |
诺华股份有限公司 |
用于选择性蛋白质表达的组合物和方法
|
|
EP3463438B1
(en)
|
2016-05-31 |
2022-04-06 |
The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. |
Vaccine therapy for treatment of endometrial and ovarian cancer
|
|
BR112019002035A2
(pt)
|
2016-08-01 |
2019-05-14 |
Novartis Ag |
tratamento de câncer usando um receptor de antígeno quimérico em combinação com um inibidor de uma molécula pró-macrófago m2
|
|
GB201616699D0
(en)
|
2016-09-30 |
2016-11-16 |
Mab Designs Ltd |
Antibodies
|
|
ES2912408T3
(es)
|
2017-01-26 |
2022-05-25 |
Novartis Ag |
Composiciones de CD28 y métodos para terapia con receptores quiméricos para antígenos
|
|
WO2019005208A1
(en)
|
2017-06-30 |
2019-01-03 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
ANTIBODIES TO HUMAN MESOTHELIN AND USES IN ANTICANCER THERAPY
|
|
CN111683962B
(zh)
|
2017-11-10 |
2025-05-16 |
美国政府(由卫生和人类服务部的部长所代表) |
靶向肿瘤抗原的嵌合抗原受体
|
|
WO2019210153A1
(en)
|
2018-04-27 |
2019-10-31 |
Novartis Ag |
Car t cell therapies with enhanced efficacy
|
|
EP3788369A1
(en)
|
2018-05-01 |
2021-03-10 |
Novartis Ag |
Biomarkers for evaluating car-t cells to predict clinical outcome
|
|
EP3801769A1
(en)
|
2018-05-25 |
2021-04-14 |
Novartis AG |
Combination therapy with chimeric antigen receptor (car) therapies
|
|
WO2019237035A1
(en)
|
2018-06-08 |
2019-12-12 |
Intellia Therapeutics, Inc. |
Compositions and methods for immunooncology
|
|
AR116109A1
(es)
|
2018-07-10 |
2021-03-31 |
Novartis Ag |
Derivados de 3-(5-amino-1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos
|
|
KR20210106437A
(ko)
|
2018-12-20 |
2021-08-30 |
노파르티스 아게 |
3-(1-옥소이소인돌린-2-일)피페리딘-2,6-디온 유도체를 포함하는 투약 요법 및 약학적 조합물
|
|
CA3125484A1
(en)
|
2019-01-08 |
2020-07-16 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Cross-species single domain antibodies targeting mesothelin for treating solid tumors
|
|
CN113490528B
(zh)
|
2019-02-15 |
2024-12-03 |
诺华股份有限公司 |
3-(1-氧代-5-(哌啶-4-基)异吲哚啉-2-基)哌啶-2,6-二酮衍生物及其用途
|
|
CA3123519A1
(en)
|
2019-02-15 |
2020-08-20 |
Novartis Ag |
Substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof
|
|
BR112022011902A2
(pt)
|
2019-12-20 |
2022-09-06 |
Novartis Ag |
Terapias de combinação
|
|
JP2023529211A
(ja)
|
2020-06-11 |
2023-07-07 |
ノバルティス アーゲー |
Ｚｂｔｂ３２阻害剤及びその使用
|
|
KR20230027056A
(ko)
|
2020-06-23 |
2023-02-27 |
노파르티스 아게 |
3-(1-옥소이소인돌린-2-일)피페리딘-2,6-디온 유도체를 포함하는 투약 요법
|
|
JP7819176B2
(ja)
|
2020-08-03 |
2026-02-24 |
ノバルティス アーゲー |
ヘテロアリール置換３－（１－オキソイソインドリン－２－イル）ピペリジン－２，６－ジオン誘導体及びその使用
|
|
TW202304979A
(zh)
|
2021-04-07 |
2023-02-01 |
瑞士商諾華公司 |
抗ＴＧＦβ抗體及其他治療劑用於治療增殖性疾病之用途
|
|
TW202321296A
(zh)
|
2021-10-06 |
2023-06-01 |
美商鏈接免疫療法公司 |
抗間皮素抗原結合分子及其用途
|
|
WO2023214325A1
(en)
|
2022-05-05 |
2023-11-09 |
Novartis Ag |
Pyrazolopyrimidine derivatives and uses thereof as tet2 inhibitors
|
|
WO2025171238A1
(en)
|
2024-02-07 |
2025-08-14 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Monoclonal antibodies that bind the juxta-membrane region of mesothelin and uses thereof
|
|
WO2025240496A1
(en)
|
2024-05-14 |
2025-11-20 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Natural killer cells expressing a mesothelin-targeted chimeric antigen receptor and interleukin-15 for the treatment of solid tumors
|