ATE254931T1 - Mesothelinantigen, verfahren und testsatz zur targetierung - Google Patents
Mesothelinantigen, verfahren und testsatz zur targetierungInfo
- Publication number
- ATE254931T1 ATE254931T1 AT97902853T AT97902853T ATE254931T1 AT E254931 T1 ATE254931 T1 AT E254931T1 AT 97902853 T AT97902853 T AT 97902853T AT 97902853 T AT97902853 T AT 97902853T AT E254931 T1 ATE254931 T1 AT E254931T1
- Authority
- AT
- Austria
- Prior art keywords
- mesothelin
- targeting
- test kit
- antigen
- methods
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
- A61K51/1072—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants the tumor cell being from the reproductive system, e.g. ovaria, uterus, testes or prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
- A61K47/6869—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from a cell of the reproductive system: ovaria, uterus, testes, prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Cell Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Reproductive Health (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Genetics & Genomics (AREA)
- Urology & Nephrology (AREA)
- Toxicology (AREA)
- Rheumatology (AREA)
- Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1016696P | 1996-01-05 | 1996-01-05 | |
PCT/US1997/000224 WO1997025068A2 (en) | 1996-01-05 | 1997-01-03 | Mesothelin antigen and methods and kits for targeting it |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE254931T1 true ATE254931T1 (de) | 2003-12-15 |
Family
ID=21744267
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT97902853T ATE254931T1 (de) | 1996-01-05 | 1997-01-03 | Mesothelinantigen, verfahren und testsatz zur targetierung |
Country Status (9)
Country | Link |
---|---|
US (2) | US6083502A (de) |
EP (1) | EP0871492B1 (de) |
JP (2) | JP2000505787A (de) |
AT (1) | ATE254931T1 (de) |
AU (1) | AU703769B2 (de) |
CA (1) | CA2241604C (de) |
DE (1) | DE69726404T2 (de) |
ES (1) | ES2212071T3 (de) |
WO (1) | WO1997025068A2 (de) |
Families Citing this family (85)
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US20030054012A1 (en) * | 2000-05-12 | 2003-03-20 | Fitzgerald David J. | Pseudomonas exotoxin a-like chimeric immunogens for eliciting a secretory iga-mediated immune response |
ATE307208T1 (de) * | 1997-07-11 | 2005-11-15 | Us Gov Health & Human Serv | Pseudomonas exotoxin-a-ähnliche chimerische immunogene |
US7314632B1 (en) * | 1997-07-11 | 2008-01-01 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Pseudomonas exotoxin A-like chimeric immunogens |
US6809184B1 (en) * | 1997-12-01 | 2004-10-26 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Antibodies, including FV molecules, and immunoconjugates having high binding affinity for mesothelin and methods for their use |
US6770445B1 (en) * | 1999-02-26 | 2004-08-03 | Pacific Northwest Research Institute | Methods and compositions for diagnosing carcinomas |
AU3007200A (en) * | 1999-02-26 | 2000-09-14 | Pacific Northwest Research Institute | Methods and compositions for diagnosing carcinomas |
US7745159B2 (en) | 1999-02-26 | 2010-06-29 | Nathalie B Scholler | Methods and compositions for diagnosing carcinomas |
CA2374398C (en) | 1999-05-27 | 2011-03-15 | Ira Pastan | Immunoconjugates having high binding affinity |
GB9924351D0 (en) | 1999-10-14 | 1999-12-15 | Brennan Frank | Immunomodulation methods and compositions |
US6987024B1 (en) * | 2000-04-10 | 2006-01-17 | Raven Biotechnologies, Inc. | Human ovarian mesothelial cells and methods of isolation and uses thereof |
WO2002086096A2 (en) * | 2001-01-23 | 2002-10-31 | University Of Rochester Medical Center | Methods of producing or identifying intrabodies in eukaryotic cells |
WO2002072766A2 (en) * | 2001-03-09 | 2002-09-19 | Board Of Regents, Universitx Of Texas System | Induction of tumor immunity by variants of folate binding protein |
US9200036B2 (en) | 2002-07-12 | 2015-12-01 | The Johns Hopkins University | Mesothelin vaccines and model systems |
AU2003259109A1 (en) | 2002-07-12 | 2004-02-02 | The Johns Hopkins University | Mesothelin vaccines and model systems |
US20090110702A1 (en) | 2002-07-12 | 2009-04-30 | The Johns Hopkins University | Mesothelin Vaccines and Model Systems and Control of Tumors |
EP1592441B1 (de) * | 2003-02-06 | 2012-04-11 | Aduro Biotech | Listerien deren eindringen in nicht-phagozytische zellen abgeschwächt ist, impfstoffe, die diese listerien enthalten und deren verwendungen |
US7695725B2 (en) | 2003-02-06 | 2010-04-13 | Aduro Biotech | Modified free-living microbes, vaccine compositions and methods of use thereof |
WO2004084936A2 (en) * | 2003-02-06 | 2004-10-07 | Cerus Corporation | Modified free-living microbes, vaccine compositions and methods of use thereof |
US20040180387A1 (en) * | 2003-03-13 | 2004-09-16 | Fujirebio Diagnostics, Inc. | Detection of urinary mesothelin-/megakaryocyte potentiating factor-related peptides for assessment of ovarian cancer |
WO2005014652A1 (en) * | 2003-08-05 | 2005-02-17 | Morphotek, Inc. | A variant cell surface molecule associated with cancer |
US7399793B2 (en) * | 2003-10-31 | 2008-07-15 | Basf Corporation | Coating composition curable with ultraviolet radiation |
KR101192496B1 (ko) | 2003-11-06 | 2012-10-18 | 시애틀 지네틱스, 인크. | 리간드에 접합될 수 있는 모노메틸발린 화합물 |
US7842289B2 (en) | 2003-12-24 | 2010-11-30 | Aduro Biotech | Recombinant nucleic acid molecules, expression cassettes, and bacteria, and methods of use thereof |
WO2005072263A2 (en) * | 2004-01-21 | 2005-08-11 | Fujirebio America, Inc. | Detection of urinary mesothelin-/megakaryocyte potentiating factor-related peptides for assessment of mesothelioma |
WO2005072341A2 (en) * | 2004-01-21 | 2005-08-11 | Fujirebio America, Inc. | Detection of mesothelin-/megakaryocyte potentiating factor-related peptides in peritoneal fluid for assessment of the peritoneum and the peritoneal cavity |
JP4805848B2 (ja) | 2004-02-12 | 2011-11-02 | モルフォテック、インク. | 腫瘍抗原の生物活性を特異的に阻止するモノクローナル抗体 |
US7592426B2 (en) * | 2005-03-10 | 2009-09-22 | Morphotek, Inc. | Anti-mesothelin antibodies |
EP1879922A2 (de) | 2005-04-22 | 2008-01-23 | Morphotek, Inc. | Antikörper mit immuneffektoraktivität, die in alpha-positive folatrezeptorzellen internalisiert werden |
ES2532942T3 (es) | 2006-03-01 | 2015-04-06 | Aduro Biotech | Listeria obtenida por ingeniería genética y métodos de uso de la misma |
US20070207171A1 (en) * | 2006-03-01 | 2007-09-06 | Cerus Corporation | Engineered listeria and methods of use thereof |
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WO2008105814A2 (en) * | 2006-08-22 | 2008-09-04 | Los Alamos National Security, Llc | Miniturized lateral flow device for rapid and sensitive detection of proteins or nucleic acids |
US20090093019A1 (en) * | 2007-04-27 | 2009-04-09 | Phelps Jamie P | Production and in vivo assembly of soluble recombinant icosahedral virus-like particles |
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DK2195017T3 (en) | 2007-10-01 | 2015-01-19 | Bristol Myers Squibb Co | Human antibodies that bind mesothelin, and uses thereof |
CN104151429B (zh) | 2007-11-26 | 2018-07-10 | 拜耳知识产权有限责任公司 | 抗-间皮素抗体及其用途 |
EP2657253B1 (de) | 2008-01-31 | 2017-07-19 | Genentech, Inc. | Anti-CD79b-Antikörper und Immunokonjugate sowie Verwendungsverfahren |
WO2009120769A1 (en) | 2008-03-27 | 2009-10-01 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Human anti-mesothelin monoclonal antibodies |
US8785134B2 (en) * | 2008-11-10 | 2014-07-22 | The Mitre Corporation | Glycoprotein vesicles and their methods of use |
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US8734798B2 (en) * | 2009-10-27 | 2014-05-27 | Ucb Pharma S.A. | Function modifying NAv 1.7 antibodies |
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SG191294A1 (en) | 2010-12-20 | 2013-07-31 | Genentech Inc | Anti-mesothelin antibodies and immunoconjugates |
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US9127081B2 (en) | 2012-05-10 | 2015-09-08 | Washington University | Tumor targeted TNF-related apoptosis inducing ligand fusion polypeptide and nucleic acids encoding the same |
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HUE049175T2 (hu) | 2014-09-23 | 2020-09-28 | Hoffmann La Roche | Eljárás anti-CD79b immunkonjugátumok alkalmazására |
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JP2022520448A (ja) | 2019-02-15 | 2022-03-30 | ノバルティス アーゲー | 置換3-(1-オキソイソインドリン-2-イル)ピペリジン-2,6-ジオン誘導体及びその使用 |
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CA3165399A1 (en) | 2019-12-20 | 2021-06-24 | Novartis Ag | Uses of anti-tgf-beta antibodies and checkpoint inhibitors for the treatment of proliferative diseases |
AU2021288224A1 (en) | 2020-06-11 | 2023-01-05 | Novartis Ag | ZBTB32 inhibitors and uses thereof |
IL298262A (en) | 2020-06-23 | 2023-01-01 | Novartis Ag | A dosage regimen that includes derivatives of 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione |
EP4188549A1 (de) | 2020-08-03 | 2023-06-07 | Novartis AG | Heteroarylsubstituierte 3-(1-oxoisoindolin-2-yl)piperidin-2,6-dionderivate und verwendungen davon |
TW202304979A (zh) | 2021-04-07 | 2023-02-01 | 瑞士商諾華公司 | 抗TGFβ抗體及其他治療劑用於治療增殖性疾病之用途 |
WO2023214325A1 (en) | 2022-05-05 | 2023-11-09 | Novartis Ag | Pyrazolopyrimidine derivatives and uses thereof as tet2 inhibitors |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH02504517A (ja) * | 1987-08-19 | 1990-12-20 | セントカー・インコーポレーテツド | ヒト卵巣ガン腫に会合する抗原 |
US5608039A (en) * | 1990-10-12 | 1997-03-04 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Single chain B3 antibody fusion proteins and their uses |
EP0554356B1 (de) * | 1990-10-12 | 1998-09-16 | THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce | Monoklonaler antikörper |
JP3328341B2 (ja) * | 1991-12-27 | 2002-09-24 | 中外製薬株式会社 | 新規な巨核球増幅因子 |
IL107366A (en) * | 1992-10-23 | 2003-03-12 | Chugai Pharmaceutical Co Ltd | Genes coding for megakaryocyte potentiator |
JP3490125B2 (ja) * | 1992-10-23 | 2004-01-26 | 中外製薬株式会社 | 巨核球増幅因子をコードする遺伝子 |
-
1997
- 1997-01-03 ES ES97902853T patent/ES2212071T3/es not_active Expired - Lifetime
- 1997-01-03 CA CA2241604A patent/CA2241604C/en not_active Expired - Lifetime
- 1997-01-03 EP EP97902853A patent/EP0871492B1/de not_active Expired - Lifetime
- 1997-01-03 AU AU16927/97A patent/AU703769B2/en not_active Expired
- 1997-01-03 JP JP9525355A patent/JP2000505787A/ja not_active Withdrawn
- 1997-01-03 WO PCT/US1997/000224 patent/WO1997025068A2/en active IP Right Grant
- 1997-01-03 AT AT97902853T patent/ATE254931T1/de not_active IP Right Cessation
- 1997-01-03 DE DE69726404T patent/DE69726404T2/de not_active Expired - Lifetime
- 1997-01-03 US US08/776,271 patent/US6083502A/en not_active Expired - Lifetime
-
1998
- 1998-12-17 US US09/215,035 patent/US6153430A/en not_active Expired - Lifetime
-
2007
- 2007-01-10 JP JP2007002808A patent/JP2007197439A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
WO1997025068A3 (en) | 1997-10-23 |
US6153430A (en) | 2000-11-28 |
EP0871492B1 (de) | 2003-11-26 |
AU1692797A (en) | 1997-08-01 |
CA2241604A1 (en) | 1997-07-17 |
AU703769B2 (en) | 1999-04-01 |
EP0871492A2 (de) | 1998-10-21 |
ES2212071T3 (es) | 2004-07-16 |
DE69726404D1 (de) | 2004-01-08 |
US6083502A (en) | 2000-07-04 |
JP2000505787A (ja) | 2000-05-16 |
JP2007197439A (ja) | 2007-08-09 |
CA2241604C (en) | 2010-03-30 |
DE69726404T2 (de) | 2004-09-09 |
WO1997025068A2 (en) | 1997-07-17 |
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