DE69834032D1 - Verfahren zur erkennung von nucleinsäuremolekülen codierend für (poly)peptide, welche mit zielmolekülen interagieren - Google Patents
Verfahren zur erkennung von nucleinsäuremolekülen codierend für (poly)peptide, welche mit zielmolekülen interagierenInfo
- Publication number
- DE69834032D1 DE69834032D1 DE69834032T DE69834032T DE69834032D1 DE 69834032 D1 DE69834032 D1 DE 69834032D1 DE 69834032 T DE69834032 T DE 69834032T DE 69834032 T DE69834032 T DE 69834032T DE 69834032 D1 DE69834032 D1 DE 69834032D1
- Authority
- DE
- Germany
- Prior art keywords
- peptides
- interact
- poly
- nucleic acid
- copying
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1041—Ribosome/Polysome display, e.g. SPERT, ARM
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Immunology (AREA)
- Plant Pathology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP97106753 | 1997-04-23 | ||
EP97106753 | 1997-04-23 | ||
PCT/EP1998/002420 WO1998048008A1 (en) | 1997-04-23 | 1998-04-23 | Methods for identifying nucleic acid molecules encoding (poly)peptides that interact with target molecules |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69834032D1 true DE69834032D1 (de) | 2006-05-18 |
DE69834032T2 DE69834032T2 (de) | 2006-12-07 |
Family
ID=8226724
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69834032T Expired - Lifetime DE69834032T2 (de) | 1997-04-23 | 1998-04-23 | Verfahren zur erkennung von nucleinsäuremolekülen codierend für (poly)peptide, welche mit zielmolekülen interagieren |
Country Status (7)
Country | Link |
---|---|
US (2) | US6348315B1 (de) |
EP (1) | EP0975748B1 (de) |
JP (1) | JP4086325B2 (de) |
AT (1) | ATE321849T1 (de) |
CA (1) | CA2289691C (de) |
DE (1) | DE69834032T2 (de) |
WO (1) | WO1998048008A1 (de) |
Families Citing this family (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE321849T1 (de) * | 1997-04-23 | 2006-04-15 | Univ Zuerich | Verfahren zur erkennung von nucleinsäuremolekülen codierend für (poly)peptide, welche mit zielmolekülen interagieren |
US6927025B1 (en) | 1997-09-03 | 2005-08-09 | Biovation Limited | Methods for protein screening |
JP4524445B2 (ja) * | 1997-09-03 | 2010-08-18 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | タンパク質のスクリーニング方法 |
US20070166741A1 (en) | 1998-12-14 | 2007-07-19 | Somalogic, Incorporated | Multiplexed analyses of test samples |
EP2360276A1 (de) * | 1999-05-14 | 2011-08-24 | Enterprise Ireland (trading as BioResearch Ireland) | Diagnostische Tests auf der Basis von Nukleinsäuresonden zur Bestimmung von prokaryotischen und eukaryotischen Organismen |
CA2402452A1 (en) * | 2000-03-31 | 2001-10-11 | Cambridge Antibody Technology Limited | Improvements to ribosome display |
ES2335861T3 (es) | 2000-09-08 | 2010-04-06 | Universitat Zurich | Grupos de proteinas repetitivas que comprenden modulos repetitivos. |
EP1348034B1 (de) * | 2000-11-15 | 2016-07-20 | Minerva Biotechnologies Corporation | Oligonukleotididentifikatoren |
DE10060959A1 (de) * | 2000-12-06 | 2002-06-20 | Aventis Res & Tech Gmbh & Co | Verfahren zur Isolierung und Identifizierung von Effektoren |
AU2003209398A1 (en) * | 2002-01-25 | 2003-09-02 | The Board Of Trustees Of The Leland Stanford Junior University | Translation profiling |
US20050123973A1 (en) * | 2002-02-08 | 2005-06-09 | Shaobing Hua | Methods for generating monoclonal antibody against fusion protein containing peptide fragment derived from membrane protein |
US20040067532A1 (en) * | 2002-08-12 | 2004-04-08 | Genetastix Corporation | High throughput generation and affinity maturation of humanized antibody |
EP2048159B1 (de) * | 2002-11-09 | 2014-01-01 | Immunocore Ltd. | T-Zellrezeptorpresentation |
GB0316314D0 (en) * | 2003-07-12 | 2003-08-13 | Univ Belfast | Method |
GB0411771D0 (en) * | 2004-05-26 | 2004-06-30 | Avidex Ltd | Nucleoproteins displaying native T cell receptor libraries |
CN103342751B (zh) | 2005-04-18 | 2015-12-23 | 安进研发(慕尼黑)股份有限公司 | 人粒细胞巨噬细胞集落刺激因子的抗体中和剂 |
US20070111237A1 (en) * | 2005-09-14 | 2007-05-17 | Maurizio Zanetti | Process for identifying antigenized antibodies using ribosome cell free expression system |
PT2339014E (pt) | 2005-11-16 | 2015-10-13 | Ambrx Inc | Métodos e composições compreendendo aminoácidos não-naturais |
HUE025489T2 (en) * | 2006-01-17 | 2016-04-28 | Somalogic Inc | Multiplexed analysis of test samples |
AR059448A1 (es) | 2006-02-13 | 2008-04-09 | Divergence Inc | Polipeptidos quimericos vegetales de union para el reconocimiento molecular universal |
EP1894939A1 (de) * | 2006-09-01 | 2008-03-05 | GSF-Forschungszentrum für Umwelt und Gesundheit GmbH | Neues Supertag und seine Verwendung |
WO2008133705A2 (en) * | 2006-10-20 | 2008-11-06 | Binax, Inc. | Assays and devices for identifying pathogens |
US8680019B2 (en) * | 2007-08-10 | 2014-03-25 | Protelica, Inc. | Universal fibronectin Type III binding-domain libraries |
AU2008287426B2 (en) * | 2007-08-10 | 2014-06-26 | Protelica, Inc. | Universal fibronectin type III binding-domain libraries |
US8470966B2 (en) | 2007-08-10 | 2013-06-25 | Protelica, Inc. | Universal fibronectin type III binding-domain libraries |
US8877688B2 (en) | 2007-09-14 | 2014-11-04 | Adimab, Llc | Rationally designed, synthetic antibody libraries and uses therefor |
BRPI0816785A2 (pt) | 2007-09-14 | 2017-05-02 | Adimab Inc | bibliotecas de anticorpos sintéticos racionalmente desenhadas, e, usos para as mesmas |
RU2396336C2 (ru) | 2007-09-27 | 2010-08-10 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) | СПОСОБ ПОЛУЧЕНИЯ АМИНОКИСЛОТ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ, ПРИНАДЛЕЖАЩЕЙ К РОДУ Escherichia |
US8883146B2 (en) | 2007-11-30 | 2014-11-11 | Abbvie Inc. | Protein formulations and methods of making same |
US8420081B2 (en) | 2007-11-30 | 2013-04-16 | Abbvie, Inc. | Antibody formulations and methods of making same |
US8865179B2 (en) * | 2008-01-26 | 2014-10-21 | Swey-Shen Alexchen | Aptameric IgE peptides in a protein scaffold as an allergy vaccine |
EP2088432A1 (de) * | 2008-02-11 | 2009-08-12 | MorphoSys AG | Verfahren zur Identifikation eines Antikörpers oder eines Targets |
CN102177438A (zh) | 2008-07-25 | 2011-09-07 | 理查德·W·瓦格纳 | 蛋白筛选方法 |
CN102272148A (zh) | 2008-11-03 | 2011-12-07 | 分子组合公司 | 抑制vegf-a受体相互作用的结合蛋白 |
EP3434769B1 (de) | 2009-10-30 | 2020-11-25 | Novartis AG | Unterseitig bindende universelle fibronectin-typ-iii-domänenbibliotheken |
EP2546342A4 (de) | 2010-03-11 | 2013-12-04 | Riken | Verfahren zur auswahl einer polypeptidsequenz, metalloxid oder silicium mit einem bindungspeptid und verwendung davon |
TWI510246B (zh) | 2010-04-30 | 2015-12-01 | Molecular Partners Ag | 抑制vegf-a受體交互作用的經修飾結合性蛋白質 |
KR102024922B1 (ko) | 2010-07-16 | 2019-09-25 | 아디맵 엘엘씨 | 항체 라이브러리 |
EP3222631A3 (de) | 2010-07-30 | 2017-11-22 | Novartis AG | Fibronectin-cradle-moleküle und bibliotheken |
JP6105479B2 (ja) | 2010-11-26 | 2017-03-29 | モレキュラー・パートナーズ・アーゲーMolecular Partners Ag | 血清アルブミンに結合する設計リピートタンパク質 |
JP5948673B2 (ja) | 2011-03-10 | 2016-07-06 | ジーンフロンティア株式会社 | リポ多糖混入量を低減した蛋白質合成用組成物、該組成物を用いた蛋白質製造方法 |
EP2686349B1 (de) | 2011-03-15 | 2020-12-09 | X-Body, Inc. | Antikörper-screening-verfahren |
JP5998203B2 (ja) | 2011-04-28 | 2016-09-28 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 試料に関連するポリヌクレオチドの同定 |
BR112013027766A2 (pt) | 2011-04-29 | 2016-11-29 | Janssen Biotech Inc | proteinas de repetição de ligação de il4/il13 e usos |
WO2012161227A1 (ja) | 2011-05-23 | 2012-11-29 | 独立行政法人理化学研究所 | 核酸構築物、核酸-蛋白質複合体、及びその利用 |
CN104105708B (zh) | 2011-12-05 | 2018-04-03 | X博迪生物科学公司 | PDGF受体β结合多肽 |
JP6209206B2 (ja) | 2012-03-27 | 2017-10-04 | グリーン・クロス・コーポレイションGreen Cross Corp. | 上皮成長因子受容体の表面抗原上のエピトープおよびその用途 |
US9163070B2 (en) | 2012-06-28 | 2015-10-20 | Molecular Partners Ag | Designed ankyrin repeat proteins binding to platelet-derived growth factor |
EP2738180A1 (de) | 2012-11-30 | 2014-06-04 | Molecular Partners AG | Bindeproteine mit mindestens zwei Bindedomänen gegen HER2 |
WO2014176327A2 (en) | 2013-04-25 | 2014-10-30 | Sutro Biopharma, Inc. | Selection of fab fragments using ribosomal display technology |
WO2014176439A1 (en) | 2013-04-25 | 2014-10-30 | Sutro Biopharma, Inc. | The use of lambda-gam protein in ribosomal display technology |
NZ716126A (en) | 2013-06-28 | 2021-12-24 | X Body Inc | Target antigen discovery, phenotypic screens and use thereof for identification of target cell specific target epitopes |
ES2827281T3 (es) | 2013-09-23 | 2021-05-20 | X Body Inc | Métodos y composiciones para la generación de agentes de unión contra antígenos de superficie celular |
EP3280444B1 (de) | 2015-04-10 | 2024-05-08 | Adimab, LLC | Verfahren zur reinigung heterodimerer multispezifischer antikörper aus elterlichen homodimeren antikörperarten |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK0494955T3 (da) * | 1989-10-05 | 1998-10-26 | Optein Inc | Cellefri syntese og isolering af hidtil ukendte gener og polypeptider |
WO1993003172A1 (en) * | 1991-08-01 | 1993-02-18 | University Research Corporation | Systematic polypeptide evolution by reverse translation |
US5466580A (en) * | 1993-09-22 | 1995-11-14 | Xoma Corporation | Method for quantifying BPI in body fluids |
WO1995011922A1 (en) * | 1993-10-29 | 1995-05-04 | Affymax Technologies N.V. | In vitro peptide and antibody display libraries |
US5922545A (en) * | 1993-10-29 | 1999-07-13 | Affymax Technologies N.V. | In vitro peptide and antibody display libraries |
ATE321849T1 (de) * | 1997-04-23 | 2006-04-15 | Univ Zuerich | Verfahren zur erkennung von nucleinsäuremolekülen codierend für (poly)peptide, welche mit zielmolekülen interagieren |
-
1998
- 1998-04-23 AT AT98924190T patent/ATE321849T1/de active
- 1998-04-23 EP EP98924190A patent/EP0975748B1/de not_active Expired - Lifetime
- 1998-04-23 DE DE69834032T patent/DE69834032T2/de not_active Expired - Lifetime
- 1998-04-23 JP JP54503898A patent/JP4086325B2/ja not_active Expired - Fee Related
- 1998-04-23 CA CA002289691A patent/CA2289691C/en not_active Expired - Fee Related
- 1998-04-23 WO PCT/EP1998/002420 patent/WO1998048008A1/en active IP Right Grant
-
1999
- 1999-10-22 US US09/425,585 patent/US6348315B1/en not_active Expired - Lifetime
-
2001
- 2001-09-14 US US09/953,321 patent/US6589741B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US20020115083A1 (en) | 2002-08-22 |
DE69834032T2 (de) | 2006-12-07 |
JP4086325B2 (ja) | 2008-05-14 |
EP0975748A1 (de) | 2000-02-02 |
EP0975748B1 (de) | 2006-03-29 |
US6348315B1 (en) | 2002-02-19 |
CA2289691C (en) | 2008-01-15 |
JP2001521395A (ja) | 2001-11-06 |
WO1998048008A1 (en) | 1998-10-29 |
CA2289691A1 (en) | 1998-10-29 |
ATE321849T1 (de) | 2006-04-15 |
US6589741B2 (en) | 2003-07-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |