DE60129809D1 - In vitro evolution von nukleinsäuren und kodierten polypeptiden - Google Patents
In vitro evolution von nukleinsäuren und kodierten polypeptidenInfo
- Publication number
- DE60129809D1 DE60129809D1 DE60129809T DE60129809T DE60129809D1 DE 60129809 D1 DE60129809 D1 DE 60129809D1 DE 60129809 T DE60129809 T DE 60129809T DE 60129809 T DE60129809 T DE 60129809T DE 60129809 D1 DE60129809 D1 DE 60129809D1
- Authority
- DE
- Germany
- Prior art keywords
- nucleic acid
- protein
- cognate pair
- nucleic acids
- vitro evolution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1062—Isolating an individual clone by screening libraries mRNA-Display, e.g. polypeptide and encoding template are connected covalently
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Computational Biology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20601600P | 2000-05-19 | 2000-05-19 | |
US206016P | 2000-05-19 | ||
PCT/US2001/016210 WO2001090414A1 (en) | 2000-05-19 | 2001-05-18 | In vitro evolution of nucleic acids and encoded polypeptide |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60129809D1 true DE60129809D1 (de) | 2007-09-20 |
DE60129809T2 DE60129809T2 (de) | 2008-04-30 |
Family
ID=22764634
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60129809T Expired - Lifetime DE60129809T2 (de) | 2000-05-19 | 2001-05-18 | In vitro evolution von nukleinsäuren und kodierten polypeptiden |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP1290222B1 (de) |
JP (1) | JP2003533995A (de) |
AT (1) | ATE369442T1 (de) |
AU (2) | AU6177101A (de) |
CA (1) | CA2409305C (de) |
DE (1) | DE60129809T2 (de) |
HK (1) | HK1054410B (de) |
WO (1) | WO2001090414A1 (de) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002102820A1 (en) | 2001-06-20 | 2002-12-27 | Nuevolution A/S | Nucleoside derivatives for library preparation |
CN101006177B (zh) | 2002-03-15 | 2011-10-12 | 纽韦卢森公司 | 改善的用于合成模制分子的方法 |
US10730906B2 (en) | 2002-08-01 | 2020-08-04 | Nuevolutions A/S | Multi-step synthesis of templated molecules |
HUE033651T2 (en) | 2002-10-30 | 2017-12-28 | Nuevolution As | A method for producing two-function complexes |
US9121110B2 (en) | 2002-12-19 | 2015-09-01 | Nuevolution A/S | Quasirandom structure and function guided synthesis methods |
WO2004074429A2 (en) | 2003-02-21 | 2004-09-02 | Nuevolution A/S | Method for producing second-generation library |
DK1670939T3 (da) | 2003-09-18 | 2010-03-01 | Nuevolution As | Fremgangsmåde til opnåelse af strukturel information om et kodet molekyle og fremgangsmåde til udvælgelse af forbindelser |
CA2548465A1 (en) * | 2003-12-12 | 2005-08-11 | Proteonova, Inc. | System and methods for nucleic acid and polypeptide selection |
US10206998B2 (en) | 2005-01-12 | 2019-02-19 | Proteonova, Inc. | Modular targeted therapeutic agents and methods of making same |
US20080199499A1 (en) * | 2005-01-12 | 2008-08-21 | Proteonova, Inc. | Method for Making Targeted Therapeutic Agents |
US9574189B2 (en) | 2005-12-01 | 2017-02-21 | Nuevolution A/S | Enzymatic encoding methods for efficient synthesis of large libraries |
US9080256B2 (en) | 2007-02-12 | 2015-07-14 | Proteonova, Inc. | Generation of library of soluble random polypeptides linked to mRNA |
DK2558577T3 (en) | 2010-04-16 | 2019-04-01 | Nuevolution As | Bi-functional complexes and methods for the preparation and use of such complexes |
GB2500243A (en) * | 2012-03-15 | 2013-09-18 | Isogenica Ltd | Identifying members of immobilised peptide libraries comprising protein-DNA complexes |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4599303A (en) * | 1983-12-12 | 1986-07-08 | Hri Associates, Inc. | Nucleic acid hybridization assay employing probes crosslinkable to target sequences |
US5843701A (en) * | 1990-08-02 | 1998-12-01 | Nexstar Pharmaceticals, Inc. | Systematic polypeptide evolution by reverse translation |
WO1992002536A1 (en) * | 1990-08-02 | 1992-02-20 | The Regents Of The University Of Colorado | Systematic polypeptide evolution by reverse translation |
US5462733A (en) * | 1993-02-04 | 1995-10-31 | Yale University | Immune system modulation using psoralens activated with visible light |
ES2373110T3 (es) * | 1997-01-21 | 2012-01-31 | The General Hospital Corporation | Selección de proteínas usando fusiones de arn-proteína. |
AU3463699A (en) * | 1998-04-03 | 1999-10-25 | Phylos, Inc. | Addressable protein arrays |
-
2001
- 2001-05-18 DE DE60129809T patent/DE60129809T2/de not_active Expired - Lifetime
- 2001-05-18 AU AU6177101A patent/AU6177101A/xx active Pending
- 2001-05-18 WO PCT/US2001/016210 patent/WO2001090414A1/en active IP Right Grant
- 2001-05-18 AT AT01935701T patent/ATE369442T1/de not_active IP Right Cessation
- 2001-05-18 AU AU2001261771A patent/AU2001261771B2/en not_active Ceased
- 2001-05-18 CA CA2409305A patent/CA2409305C/en not_active Expired - Lifetime
- 2001-05-18 JP JP2001586608A patent/JP2003533995A/ja active Pending
- 2001-05-18 EP EP01935701A patent/EP1290222B1/de not_active Expired - Lifetime
-
2003
- 2003-09-11 HK HK03106532.9A patent/HK1054410B/zh not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
HK1054410B (zh) | 2008-03-07 |
JP2003533995A (ja) | 2003-11-18 |
HK1054410A1 (en) | 2003-11-28 |
DE60129809T2 (de) | 2008-04-30 |
WO2001090414A1 (en) | 2001-11-29 |
CA2409305A1 (en) | 2001-11-29 |
EP1290222B1 (de) | 2007-08-08 |
AU2001261771B2 (en) | 2005-06-09 |
AU6177101A (en) | 2001-12-03 |
CA2409305C (en) | 2011-01-11 |
ATE369442T1 (de) | 2007-08-15 |
EP1290222A1 (de) | 2003-03-12 |
EP1290222A4 (de) | 2005-12-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |