ATE369442T1 - In vitro evolution von nukleinsäuren und kodierten polypeptiden - Google Patents

In vitro evolution von nukleinsäuren und kodierten polypeptiden

Info

Publication number
ATE369442T1
ATE369442T1 AT01935701T AT01935701T ATE369442T1 AT E369442 T1 ATE369442 T1 AT E369442T1 AT 01935701 T AT01935701 T AT 01935701T AT 01935701 T AT01935701 T AT 01935701T AT E369442 T1 ATE369442 T1 AT E369442T1
Authority
AT
Austria
Prior art keywords
nucleic acid
protein
cognate pair
nucleic acids
encoded polypeptides
Prior art date
Application number
AT01935701T
Other languages
English (en)
Inventor
Richard B Williams
Original Assignee
Richard B Williams
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richard B Williams filed Critical Richard B Williams
Application granted granted Critical
Publication of ATE369442T1 publication Critical patent/ATE369442T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1062—Isolating an individual clone by screening libraries mRNA-Display, e.g. polypeptide and encoding template are connected covalently

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT01935701T 2000-05-19 2001-05-18 In vitro evolution von nukleinsäuren und kodierten polypeptiden ATE369442T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US20601600P 2000-05-19 2000-05-19

Publications (1)

Publication Number Publication Date
ATE369442T1 true ATE369442T1 (de) 2007-08-15

Family

ID=22764634

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01935701T ATE369442T1 (de) 2000-05-19 2001-05-18 In vitro evolution von nukleinsäuren und kodierten polypeptiden

Country Status (8)

Country Link
EP (1) EP1290222B1 (de)
JP (1) JP2003533995A (de)
AT (1) ATE369442T1 (de)
AU (2) AU6177101A (de)
CA (1) CA2409305C (de)
DE (1) DE60129809T2 (de)
HK (1) HK1054410B (de)
WO (1) WO2001090414A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002102820A1 (en) 2001-06-20 2002-12-27 Nuevolution A/S Nucleoside derivatives for library preparation
EP1487978B1 (de) 2002-03-15 2008-11-19 Nuevolution A/S Eine verbesserte methode zur synthese von matritzenabhängigen molekülen
EP1539980B1 (de) 2002-08-01 2016-02-17 Nuevolution A/S MEHRSTUFENSYNTHESE VON MIT MATRIZEN ASSOZIIERTE MOLEKüLEN
AU2003273792B2 (en) 2002-10-30 2011-07-07 Nuevolution A/S Method for the synthesis of a bifunctional complex
EP2175019A3 (de) 2002-12-19 2011-04-06 Nuevolution A/S Durch Quasizufallsstrukturen und Funktionen geführte Synthesemethoden
WO2004074429A2 (en) 2003-02-21 2004-09-02 Nuevolution A/S Method for producing second-generation library
DE602004023960D1 (de) 2003-09-18 2009-12-17 Nuevolution As Methode zur Gewinnung struktureller Informationen kodierter Moleküle und zur Selektion von Verbindungen
AU2004314705A1 (en) * 2003-12-12 2005-08-11 Proteonova, Inc. System and methods for nucleic acid and polypeptide selection
EP3431503A1 (de) * 2005-01-12 2019-01-23 Proteonova, Inc. Verfahren zur herstellung zielgerichteter therapeutika
US10206998B2 (en) 2005-01-12 2019-02-19 Proteonova, Inc. Modular targeted therapeutic agents and methods of making same
WO2007062664A2 (en) 2005-12-01 2007-06-07 Nuevolution A/S Enzymatic encoding methods for efficient synthesis of large libraries
EP2118344B1 (de) 2007-02-12 2014-07-23 Proteonova, Inc. Erzeugung von bibliotheken aus mit mrna verknüpften löslichen zufallspeptiden
EP3540059A1 (de) 2010-04-16 2019-09-18 Nuevolution A/S Bifunktionelle komplexe und verfahren zur herstellung sowie verwendung derartiger komplexe
GB2500243A (en) * 2012-03-15 2013-09-18 Isogenica Ltd Identifying members of immobilised peptide libraries comprising protein-DNA complexes

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4599303A (en) * 1983-12-12 1986-07-08 Hri Associates, Inc. Nucleic acid hybridization assay employing probes crosslinkable to target sequences
US5843701A (en) * 1990-08-02 1998-12-01 Nexstar Pharmaceticals, Inc. Systematic polypeptide evolution by reverse translation
AU8498091A (en) * 1990-08-02 1992-03-02 Regents Of The University Of Colorado, The Systematic polypeptide evolution by reverse translation
US5462733A (en) * 1993-02-04 1995-10-31 Yale University Immune system modulation using psoralens activated with visible light
DE69835143T2 (de) * 1997-01-21 2007-06-06 The General Hospital Corp., Boston Selektion von proteinen mittels rns-protein fusionen
ATE340870T1 (de) * 1998-04-03 2006-10-15 Compound Therapeutics Inc Adressierbare protein arrays

Also Published As

Publication number Publication date
DE60129809T2 (de) 2008-04-30
AU2001261771B2 (en) 2005-06-09
EP1290222A1 (de) 2003-03-12
HK1054410A1 (en) 2003-11-28
HK1054410B (zh) 2008-03-07
AU6177101A (en) 2001-12-03
WO2001090414A1 (en) 2001-11-29
CA2409305A1 (en) 2001-11-29
CA2409305C (en) 2011-01-11
DE60129809D1 (de) 2007-09-20
JP2003533995A (ja) 2003-11-18
EP1290222B1 (de) 2007-08-08
EP1290222A4 (de) 2005-12-14

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