JP2009268467A5 - - Google Patents
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- Publication number
- JP2009268467A5 JP2009268467A5 JP2009147075A JP2009147075A JP2009268467A5 JP 2009268467 A5 JP2009268467 A5 JP 2009268467A5 JP 2009147075 A JP2009147075 A JP 2009147075A JP 2009147075 A JP2009147075 A JP 2009147075A JP 2009268467 A5 JP2009268467 A5 JP 2009268467A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- acid sequence
- amino acid
- helper cells
- following
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 18
- 229920001184 polypeptide Polymers 0.000 claims 16
- 102000004196 processed proteins & peptides Human genes 0.000 claims 16
- 125000003275 alpha amino acid group Chemical group 0.000 claims 8
- 210000002443 helper t lymphocyte Anatomy 0.000 claims 8
- 238000007792 addition Methods 0.000 claims 4
- 150000001413 amino acids Chemical class 0.000 claims 4
- 230000037430 deletion Effects 0.000 claims 4
- 238000012217 deletion Methods 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 230000035755 proliferation Effects 0.000 claims 4
- 230000001737 promoting effect Effects 0.000 claims 4
- 238000006467 substitution reaction Methods 0.000 claims 4
- 239000002131 composite material Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39309099A | 1999-09-09 | 1999-09-09 | |
| US09/393,090 | 1999-09-09 | ||
| US16461699P | 1999-11-10 | 1999-11-10 | |
| US60/164,616 | 1999-11-10 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006231402A Division JP2007045830A (ja) | 1999-09-09 | 2006-08-28 | 哺乳動物インターロイキン−１２ｐ４０およびインターロイキンｂ３０、その組成物、抗体、薬学的組成物における使用 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010098317A Division JP2010233571A (ja) | 1999-09-09 | 2010-04-21 | 哺乳動物インターロイキン−１２ｐ４０およびインターロイキンｂ３０、その組成物、抗体、薬学的組成物における使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009268467A JP2009268467A (ja) | 2009-11-19 |
| JP2009268467A5 true JP2009268467A5 (https=) | 2010-07-01 |
| JP4969610B2 JP4969610B2 (ja) | 2012-07-04 |
Family
ID=26860707
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001522273A Expired - Lifetime JP4505166B2 (ja) | 1999-09-09 | 2000-09-08 | 哺乳動物インターロイキン−１２ｐ４０およびインターロイキンｂ３０、その組成物、抗体、薬学的組成物における使用 |
| JP2006231402A Withdrawn JP2007045830A (ja) | 1999-09-09 | 2006-08-28 | 哺乳動物インターロイキン−１２ｐ４０およびインターロイキンｂ３０、その組成物、抗体、薬学的組成物における使用 |
| JP2009147075A Expired - Lifetime JP4969610B2 (ja) | 1999-09-09 | 2009-06-19 | 哺乳動物インターロイキン−１２ｐ４０およびインターロイキンｂ３０、その組成物、抗体、薬学的組成物における使用 |
| JP2010098317A Withdrawn JP2010233571A (ja) | 1999-09-09 | 2010-04-21 | 哺乳動物インターロイキン−１２ｐ４０およびインターロイキンｂ３０、その組成物、抗体、薬学的組成物における使用 |
| JP2013040389A Pending JP2013128489A (ja) | 1999-09-09 | 2013-03-01 | 哺乳動物インターロイキン−１２ｐ４０およびインターロイキンｂ３０、その組成物、抗体、薬学的組成物における使用 |
| JP2014206652A Expired - Fee Related JP6140122B2 (ja) | 1999-09-09 | 2014-10-07 | 哺乳動物インターロイキン−１２ｐ４０およびインターロイキンｂ３０、その組成物、抗体、薬学的組成物における使用 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001522273A Expired - Lifetime JP4505166B2 (ja) | 1999-09-09 | 2000-09-08 | 哺乳動物インターロイキン−１２ｐ４０およびインターロイキンｂ３０、その組成物、抗体、薬学的組成物における使用 |
| JP2006231402A Withdrawn JP2007045830A (ja) | 1999-09-09 | 2006-08-28 | 哺乳動物インターロイキン−１２ｐ４０およびインターロイキンｂ３０、その組成物、抗体、薬学的組成物における使用 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010098317A Withdrawn JP2010233571A (ja) | 1999-09-09 | 2010-04-21 | 哺乳動物インターロイキン−１２ｐ４０およびインターロイキンｂ３０、その組成物、抗体、薬学的組成物における使用 |
| JP2013040389A Pending JP2013128489A (ja) | 1999-09-09 | 2013-03-01 | 哺乳動物インターロイキン−１２ｐ４０およびインターロイキンｂ３０、その組成物、抗体、薬学的組成物における使用 |
| JP2014206652A Expired - Fee Related JP6140122B2 (ja) | 1999-09-09 | 2014-10-07 | 哺乳動物インターロイキン−１２ｐ４０およびインターロイキンｂ３０、その組成物、抗体、薬学的組成物における使用 |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP1210434B2 (https=) |
| JP (6) | JP4505166B2 (https=) |
| KR (1) | KR100894359B1 (https=) |
| CN (1) | CN100529076C (https=) |
| AR (1) | AR035560A1 (https=) |
| AT (1) | ATE389019T1 (https=) |
| AU (2) | AU780163B2 (https=) |
| CA (1) | CA2388562C (https=) |
| DE (1) | DE60038304T3 (https=) |
| ES (1) | ES2300276T5 (https=) |
| HK (1) | HK1044170B (https=) |
| HU (1) | HU230679B1 (https=) |
| IL (1) | IL148300A0 (https=) |
| MX (1) | MXPA02002684A (https=) |
| WO (1) | WO2001018051A2 (https=) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2007202362B2 (en) * | 1999-09-03 | 2011-06-23 | Merck Sharp & Dohme Corp. | Mammalian receptor proteins; related reagents and methods |
| US7422743B2 (en) | 2000-05-10 | 2008-09-09 | Schering Corporation | Mammalian receptor protein DCRS5;methods of treatment |
| US6756481B2 (en) | 2000-05-10 | 2004-06-29 | Schering Corporation | IL-23 receptor binding compositions |
| WO2004042009A2 (en) | 2002-10-30 | 2004-05-21 | Genentech, Inc. | Inhibition of il-17 production |
| WO2004058178A2 (en) | 2002-12-23 | 2004-07-15 | Schering Corporation | Uses of mammalian cytokine; related reagents |
| US7282204B2 (en) | 2003-03-10 | 2007-10-16 | Schering Corporation | Uses of IL-23 agonists and antagonists; related reagents |
| CN101052726A (zh) | 2003-05-09 | 2007-10-10 | 森托科尔公司 | IL－23p40特异性免疫球蛋白衍生蛋白、组合物、方法和用途 |
| EP1522858A1 (en) * | 2003-10-10 | 2005-04-13 | Jean-Christophe Roegel | Methods for selecting compounds using antibodies with activity as agonist, antagonist or allosteric modulators |
| WO2005108425A1 (en) * | 2004-05-10 | 2005-11-17 | Cytos Biotechnology Ag | Il-23 p19 antigen array and uses thereof |
| AR051444A1 (es) | 2004-09-24 | 2007-01-17 | Centocor Inc | Proteinas derivadas de inmunoglobulina especifica de il-23p40, composiciones, epitopos, metodos y usos |
| US7820168B2 (en) | 2004-12-20 | 2010-10-26 | Schering Corporation | Treatment of diabetes using antibodies to IL-23, IL-23 receptor and IL-17 |
| SI2452694T1 (sl) | 2005-06-30 | 2019-05-31 | Janssen Biotech, Inc. | Protitelesa proti-IL-23, sestavki in postopki uporabe |
| DE602006015830D1 (de) | 2005-08-25 | 2010-09-09 | Lilly Co Eli | Anti-il-23-antikörper |
| PT1931710T (pt) | 2005-08-31 | 2017-03-28 | Merck Sharp & Dohme | Anticorpos anti-il-23 manipulados |
| HUE034269T2 (en) | 2005-12-29 | 2018-02-28 | Janssen Biotech Inc | Human anti-IL-23 antibodies, preparations, methods and applications |
| PL1966238T3 (pl) | 2005-12-30 | 2012-09-28 | Merck Patent Gmbh | Warianty interleukiny-12p40 o polepszonej stabilności |
| US7910703B2 (en) | 2006-03-10 | 2011-03-22 | Zymogenetics, Inc. | Antagonists to IL-17A, IL-17F, and IL-23P19 and methods of use |
| US7790862B2 (en) | 2006-06-13 | 2010-09-07 | Zymogenetics, Inc. | IL-17 and IL-23 antagonists and methods of using the same |
| TWI426918B (zh) | 2007-02-12 | 2014-02-21 | Merck Sharp & Dohme | Ｉｌ-２３拮抗劑於治療感染之用途 |
| JP2010518858A (ja) | 2007-02-23 | 2010-06-03 | シェーリング コーポレイション | 操作された抗−ｉｌ−２３ｐ１９抗体 |
| ES2708988T3 (es) | 2007-02-23 | 2019-04-12 | Merck Sharp & Dohme | Anticuerpos anti-IL-23p19 obtenidos por ingeniería genética |
| NZ579251A (en) | 2007-02-28 | 2012-06-29 | Schering Corp | Engineered anti-il-23r antibodies |
| CA2679400A1 (en) | 2007-02-28 | 2008-09-04 | Schering Corporation | Combination therapy for treatment of immune disorders |
| EP2650311A3 (en) | 2007-11-27 | 2014-06-04 | Ablynx N.V. | Amino acid sequences directed against heterodimeric cytokines and/or their receptors and polypeptides comprising the same |
| JPWO2009133863A1 (ja) * | 2008-04-28 | 2011-09-01 | 国立大学法人浜松医科大学 | Ｅｐ１アゴニストを含有してなる免疫増強剤 |
| JO3244B1 (ar) | 2009-10-26 | 2018-03-08 | Amgen Inc | بروتينات ربط مستضادات il – 23 البشرية |
| MX2019000046A (es) | 2010-11-04 | 2023-10-05 | Boehringer Ingelheim Int | Anticuerpos anti-il-23. |
| CN102462837B (zh) | 2010-11-19 | 2016-08-03 | 生物林格斯Ip有限公司 | 抗炎组合物 |
| EP2850093B1 (en) | 2012-01-27 | 2019-01-09 | The Board of Trustees of the Leland Stanford Junior University | Therapeutic il-13 polypeptides |
| PL3326649T3 (pl) | 2012-05-03 | 2022-04-25 | Boehringer Ingelheim International Gmbh | Przeciwciała anty-il-23p19 |
| ES2729603T3 (es) | 2012-06-27 | 2019-11-05 | Merck Sharp & Dohme | Anticuerpos IL-23 antihumanos cristalinos |
| CN104619334A (zh) | 2012-08-09 | 2015-05-13 | 利兰斯坦福初级大学董事会 | 超级因子和合成因子:具有新的和增强的信号传导活性的经改造细胞因子 |
| UA117466C2 (uk) | 2012-12-13 | 2018-08-10 | Мерк Шарп Енд Доме Корп. | СТАБІЛЬНИЙ СКЛАД У ВИГЛЯДІ РОЗЧИНУ АНТИТІЛА ДО IL-23p19 |
| WO2014171721A1 (ko) * | 2013-04-16 | 2014-10-23 | 가톨릭대학교 산학협력단 | 아이케이 인자 및 아이케이 인자를 코딩하는 핵산의 약학적 용도 |
| KR101625112B1 (ko) | 2013-04-16 | 2016-05-27 | 가톨릭대학교 산학협력단 | 아이케이 인자 및 아이케이 인자를 코딩하는 핵산의 약학적 용도 |
| EP3049526B1 (en) | 2013-09-24 | 2021-02-24 | Medicenna Therapeutics, Inc. | Interleukin-4 receptor-binding fusion proteins and uses thereof |
| EP3708679A1 (en) | 2014-07-24 | 2020-09-16 | Boehringer Ingelheim International GmbH | Biomarkers useful in the treatment of il-23a related diseases |
| EA202193002A2 (ru) | 2014-09-03 | 2022-03-31 | Бёрингер Ингельхайм Интернациональ Гмбх | Соединение, нацеленное на ил-23a и фно-альфа, и его применение |
| JP6219875B2 (ja) * | 2015-04-10 | 2017-10-25 | 株式会社スクウェア・エニックス | ネットワークゲームシステム、ゲーム装置及びプログラム |
| JP7382232B2 (ja) | 2017-05-02 | 2023-11-16 | メルク・シャープ・アンド・ドーム・エルエルシー | 抗ｌａｇ３抗体の製剤および抗ｌａｇ３抗体と抗ｐｄ－１抗体との共製剤 |
| JOP20190260A1 (ar) | 2017-05-02 | 2019-10-31 | Merck Sharp & Dohme | صيغ ثابتة لأجسام مضادة لمستقبل الموت المبرمج 1 (pd-1) وطرق استخدامها |
| EP3694558B1 (en) | 2017-10-10 | 2024-04-10 | Medicenna Therapeutics Inc. | Il-4-fusion formulations for treatment of central nervous system (cns) tumors |
| WO2019239213A2 (en) | 2018-06-01 | 2019-12-19 | Medicenna Therapeutics Inc. | Uses and methods for oncolytic virus targeting of il-4/il-13 and fusions thereof |
| US12590133B2 (en) | 2018-06-01 | 2026-03-31 | The Board Of Trustees Of The Leland Stanford Junior University | IL-13/IL-4 superkines: immune cell targeting constructs and methods of use thereof |
| WO2020081408A1 (en) | 2018-10-18 | 2020-04-23 | Merck Sharp & Dohme Corp. | Formulations of anti-rsv antibodies and methods of use thereof |
| MX2021004928A (es) | 2018-10-31 | 2021-06-08 | Merck Sharp & Dohme Llc | Cristales de anticuerpo anti-pd-1 humano y metodos de uso de los mismos. |
| EP3876990A4 (en) | 2018-11-07 | 2023-09-06 | Merck Sharp & Dohme LLC | CO-FORMULATIONS OF ANTI-LAG3 ANTIBODIES AND ANTI-PD-1 ANTIBODIES |
| IL283192B2 (en) | 2018-11-20 | 2025-10-01 | Janssen Biotech Inc | A safe and effective method for treating psoriasis with a specific anti-IL-23 antibody |
| JP7805788B2 (ja) | 2019-05-23 | 2026-01-26 | ヤンセン バイオテツク，インコーポレーテツド | Ｉｌ－２３及びｔｎｆアルファに対する抗体の併用療法による炎症性腸疾患の治療方法 |
| TW202535466A (zh) | 2019-09-09 | 2025-09-16 | 德商百靈佳殷格翰國際股份有限公司 | 抗-il-23p19抗體調配物 |
| IL298389A (en) | 2020-05-21 | 2023-01-01 | Janssen Biotech Inc | Method of treating inflammatory bowel disease with a combination therapy of antibodies to il-23 and tnf alpha |
| CN114317430A (zh) * | 2021-12-28 | 2022-04-12 | 河北银丰鼎诚生物技术有限公司 | 一种适用于脐血来源免疫细胞扩增的培养液 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69034249T2 (de) * | 1989-12-22 | 2008-05-29 | F. Hoffmann-La Roche Ag | Monoklonale Antikörper spezifisch für den zytotoxischen Lymphozyten-Reifefaktor |
| DE4315127A1 (de) * | 1993-05-07 | 1994-11-10 | Behringwerke Ag | Arzneimittel enthaltend die Untereinheit p40 von Interleukin-12 |
| US5851523A (en) * | 1994-03-24 | 1998-12-22 | Ludwig Institute For Cancer Research. | Isolated, peptides derived from MAGE tumor rejection antigen precursors which complex with HLA-A2 molecules and uses thereof |
| US5853721A (en) | 1995-01-31 | 1998-12-29 | Hoffmann-La Roche Inc. | Antibody to interleukin-12 receptor |
| GB9609932D0 (en) * | 1996-05-13 | 1996-07-17 | Hoffmann La Roche | Use of IL-12 and IFN alpha for the treatment of infectious diseases |
| EP0956301A2 (en) * | 1996-10-18 | 1999-11-17 | Valentis Inc. | Il-12 gene expression and delivery systems and uses |
| ZA986596B (en) * | 1997-07-25 | 1999-02-08 | Schering Corp | Mammalian cytokine related reagents |
| WO1999040195A1 (en) * | 1998-02-06 | 1999-08-12 | Schering Corporation | Mammalian receptor proteins; related reagents and methods |
-
2000
- 2000-09-08 AU AU73608/00A patent/AU780163B2/en not_active Expired
- 2000-09-08 DE DE60038304.0T patent/DE60038304T3/de not_active Expired - Lifetime
- 2000-09-08 IL IL14830000A patent/IL148300A0/xx active IP Right Grant
- 2000-09-08 MX MXPA02002684A patent/MXPA02002684A/es active IP Right Grant
- 2000-09-08 KR KR1020027003089A patent/KR100894359B1/ko not_active Expired - Lifetime
- 2000-09-08 JP JP2001522273A patent/JP4505166B2/ja not_active Expired - Lifetime
- 2000-09-08 EP EP00961688.9A patent/EP1210434B2/en not_active Expired - Lifetime
- 2000-09-08 HK HK02105118.4A patent/HK1044170B/en not_active IP Right Cessation
- 2000-09-08 WO PCT/US2000/024686 patent/WO2001018051A2/en not_active Ceased
- 2000-09-08 CA CA2388562A patent/CA2388562C/en not_active Expired - Lifetime
- 2000-09-08 ES ES00961688.9T patent/ES2300276T5/es not_active Expired - Lifetime
- 2000-09-08 HU HU0301102A patent/HU230679B1/hu unknown
- 2000-09-08 AT AT00961688T patent/ATE389019T1/de not_active IP Right Cessation
- 2000-09-08 CN CNB008154007A patent/CN100529076C/zh not_active Expired - Lifetime
- 2000-09-11 AR ARP000104753A patent/AR035560A1/es unknown
-
2006
- 2006-08-28 JP JP2006231402A patent/JP2007045830A/ja not_active Withdrawn
-
2008
- 2008-10-31 AU AU2008240348A patent/AU2008240348B2/en not_active Expired
-
2009
- 2009-06-19 JP JP2009147075A patent/JP4969610B2/ja not_active Expired - Lifetime
-
2010
- 2010-04-21 JP JP2010098317A patent/JP2010233571A/ja not_active Withdrawn
-
2013
- 2013-03-01 JP JP2013040389A patent/JP2013128489A/ja active Pending
-
2014
- 2014-10-07 JP JP2014206652A patent/JP6140122B2/ja not_active Expired - Fee Related
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