JP2007535912A5 - - Google Patents
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- Publication number
- JP2007535912A5 JP2007535912A5 JP2006547309A JP2006547309A JP2007535912A5 JP 2007535912 A5 JP2007535912 A5 JP 2007535912A5 JP 2006547309 A JP2006547309 A JP 2006547309A JP 2006547309 A JP2006547309 A JP 2006547309A JP 2007535912 A5 JP2007535912 A5 JP 2007535912A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- peptide
- residue
- antibody
- gdf8
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53371903P | 2003-12-31 | 2003-12-31 | |
| PCT/US2004/043125 WO2005066204A2 (en) | 2003-12-31 | 2004-12-21 | Neutralizing epitope-based growth enhancing vaccine |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011010279A Division JP2011083290A (ja) | 2003-12-31 | 2011-01-20 | 中和エピトープベースの増殖増強性ワクチン |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007535912A JP2007535912A (ja) | 2007-12-13 |
| JP2007535912A5 true JP2007535912A5 (https=) | 2008-02-07 |
Family
ID=34748944
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006547309A Withdrawn JP2007535912A (ja) | 2003-12-31 | 2004-12-21 | 中和エピトープベースの増殖増強性ワクチン |
| JP2011010279A Pending JP2011083290A (ja) | 2003-12-31 | 2011-01-20 | 中和エピトープベースの増殖増強性ワクチン |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011010279A Pending JP2011083290A (ja) | 2003-12-31 | 2011-01-20 | 中和エピトープベースの増殖増強性ワクチン |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US7371726B2 (https=) |
| EP (1) | EP1699820A2 (https=) |
| JP (2) | JP2007535912A (https=) |
| KR (1) | KR20060120229A (https=) |
| CN (1) | CN1902221A (https=) |
| AR (1) | AR047345A1 (https=) |
| AU (1) | AU2004312411B8 (https=) |
| BR (1) | BRPI0418317A (https=) |
| CA (1) | CA2551877A1 (https=) |
| EC (1) | ECSP066683A (https=) |
| IL (1) | IL176494A0 (https=) |
| MX (1) | MXPA06007514A (https=) |
| NO (1) | NO20063478L (https=) |
| NZ (1) | NZ547593A (https=) |
| PE (1) | PE20051050A1 (https=) |
| RU (1) | RU2422460C2 (https=) |
| SG (1) | SG153874A1 (https=) |
| TW (1) | TWI357906B (https=) |
| UA (1) | UA93855C2 (https=) |
| WO (1) | WO2005066204A2 (https=) |
| ZA (1) | ZA200605227B (https=) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8460864B2 (en) | 2003-01-21 | 2013-06-11 | Ptc Therapeutics, Inc. | Methods for identifying compounds that modulate untranslated region-dependent gene expression and methods of using same |
| US9068234B2 (en) * | 2003-01-21 | 2015-06-30 | Ptc Therapeutics, Inc. | Methods and agents for screening for compounds capable of modulating gene expression |
| US8426194B2 (en) * | 2003-01-21 | 2013-04-23 | Ptc Therapeutics, Inc. | Methods and agents for screening for compounds capable of modulating VEGF expression |
| EP1699820A2 (en) * | 2003-12-31 | 2006-09-13 | Schering-Plough Ltd. | Neutralizing epitope-based growth enhancing vaccine |
| EP1799709B1 (en) * | 2004-09-30 | 2012-04-04 | ORICO Limited | Myostatin isoform |
| CA2594276A1 (en) * | 2004-12-30 | 2006-07-13 | Schering-Plough Ltd. | Neutralizing epitope-based growth enhancing vaccine |
| EP1951756B1 (en) | 2005-10-06 | 2015-01-07 | Eli Lilly And Company | Anti-myostatin antibodies |
| UA92504C2 (en) * | 2005-10-12 | 2010-11-10 | Эли Лилли Энд Компани | Anti-myostatin monoclonal antibody |
| CN104761637B (zh) | 2006-03-31 | 2021-10-15 | 中外制药株式会社 | 调控抗体血液动力学的方法 |
| AU2013231037B2 (en) * | 2006-08-03 | 2016-05-12 | Myostin Therapeutics Pty Ltd | Myostatin antagonists |
| CN101522707B (zh) * | 2006-08-03 | 2013-08-28 | 莫约斯汀医疗有限公司 | 肌肉生长抑制素拮抗剂 |
| BRPI0716249A2 (pt) | 2006-09-05 | 2013-09-03 | Lilly Co Eli | anticorpos antimiostatina |
| US8283115B1 (en) | 2007-06-20 | 2012-10-09 | Ptc Therapeutics, Inc. | Methods of screening for compounds for treating muscular dystrophy using UTRN mRNA translation regulation |
| US8283116B1 (en) | 2007-06-22 | 2012-10-09 | Ptc Therapeutics, Inc. | Methods of screening for compounds for treating spinal muscular atrophy using SMN mRNA translation regulation |
| ES2595638T3 (es) | 2007-09-26 | 2017-01-02 | Chugai Seiyaku Kabushiki Kaisha | Método para modificar el punto isoeléctrico de un anticuerpo mediante la sustitución de aminoácidos en una CDR |
| KR102057826B1 (ko) | 2008-04-11 | 2019-12-20 | 추가이 세이야쿠 가부시키가이샤 | 복수 분자의 항원에 반복 결합하는 항원 결합 분자 |
| JO3340B1 (ar) | 2010-05-26 | 2019-03-13 | Regeneron Pharma | مضادات حيوية لـعامل تمايز النمو 8 البشري |
| AR081556A1 (es) * | 2010-06-03 | 2012-10-03 | Glaxo Group Ltd | Proteinas de union al antigeno humanizadas |
| SG187867A1 (en) | 2010-08-16 | 2013-03-28 | Amgen Inc | Antibodies that bind myostatin, compositions and methods |
| EP2647706B1 (en) | 2010-11-30 | 2023-05-17 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly |
| DK2780368T3 (en) | 2011-11-14 | 2018-02-05 | Regeneron Pharma | COMPOSITIONS AND PROCEDURES FOR INCREASING MUSCLE MASS AND MUSCLE STRENGTH BY SPECIFIC ANTAGONIZATION OF GDF8 AND / OR ACTIVIN A |
| WO2014030750A1 (ja) | 2012-08-24 | 2014-02-27 | 中外製薬株式会社 | マウスFcγRII特異的Fc抗体 |
| CN105246914B (zh) | 2013-04-02 | 2021-08-27 | 中外制药株式会社 | Fc区变体 |
| RS61778B1 (sr) | 2013-05-06 | 2021-06-30 | Scholar Rock Inc | Kompozicije i postupci za modulaciju faktora rasta |
| TW201920262A (zh) | 2013-07-30 | 2019-06-01 | 美商再生元醫藥公司 | 抗活化素ａ之抗體及其用途 |
| EP3215175A4 (en) | 2014-11-06 | 2018-06-27 | Scholar Rock, Inc. | Anti-pro/latent-myostatin antibodies and uses thereof |
| KR101860280B1 (ko) | 2014-12-19 | 2018-05-21 | 추가이 세이야쿠 가부시키가이샤 | 항-마이오스타틴 항체, 변이체 Fc 영역을 함유하는 폴리펩타이드, 및 사용 방법 |
| KR102605798B1 (ko) | 2015-02-05 | 2023-11-23 | 추가이 세이야쿠 가부시키가이샤 | 이온 농도 의존적 항원 결합 도메인을 포함하는 항체, Fc 영역 개변체, IL-8에 결합하는 항체, 및 그들의 사용 |
| KR20170135967A (ko) | 2015-04-15 | 2017-12-08 | 리제너론 파마슈티칼스 인코포레이티드 | Gdf8 억제제를 사용하여 강도 및 기능을 증가시키는 방법 |
| HRP20211081T1 (hr) * | 2015-09-15 | 2021-10-15 | Scholar Rock, Inc. | Anti-pro/latentna miostatinska protutijela i njihove uporabe |
| WO2017110981A1 (en) | 2015-12-25 | 2017-06-29 | Chugai Seiyaku Kabushiki Kaisha | Anti-myostatin antibodies and methods of use |
| CN115814077A (zh) | 2016-01-08 | 2023-03-21 | 供石公司 | 抗-原肌生长抑制素/潜伏肌生长抑制素抗体及其使用方法 |
| NZ789269A (en) | 2016-06-13 | 2026-01-30 | Scholar Rock Inc | Use of myostatin inhibitors and combination therapies |
| EP3494991A4 (en) | 2016-08-05 | 2020-07-29 | Chugai Seiyaku Kabushiki Kaisha | COMPOSITION FOR THE PROPHYLAXIS OR TREATMENT OF IL-8 RELATED DISEASES |
| EP4218817A3 (en) | 2017-01-06 | 2023-09-06 | Scholar Rock, Inc. | Methods for treating metabolic diseases by inhibiting myostatin activation |
| MX2020008991A (es) | 2018-03-01 | 2020-12-10 | Regeneron Pharma | Metodos para alterar la composicion corporal. |
| EP4638496A1 (en) | 2022-12-22 | 2025-10-29 | Scholar Rock, Inc. | Selective and potent inhibitory antibodies of myostatin activation |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5977438A (en) | 1988-02-26 | 1999-11-02 | Biosource Technologies, Inc. | Production of peptides in plants as viral coat protein fusions |
| CA2014033C (en) | 1989-04-07 | 1993-02-09 | Stephen D. Acres | Compositions and treatments for pneumonia in animals |
| WO1993008290A1 (en) | 1991-10-16 | 1993-04-29 | University Of Saskatchewan | Enhanced immunogenicity using leukotoxin chimeras |
| US5422110A (en) | 1991-10-16 | 1995-06-06 | University Of Saskatchewan | Enhanced immunogenicity using leukotoxin chimeras |
| DK0690873T3 (da) | 1993-03-19 | 2003-09-29 | Univ Johns Hopkins Med | Vækstdifferentieringsfaktor-8 |
| US6607884B1 (en) | 1993-03-19 | 2003-08-19 | The Johns Hopkins University School Of Medicine | Methods of detecting growth differentiation factor-8 |
| US20030074680A1 (en) | 1993-03-19 | 2003-04-17 | Johns Hopkins University School Of Medicine | Growth differentiation factor-8 |
| US5994618A (en) | 1997-02-05 | 1999-11-30 | Johns Hopkins University School Of Medicine | Growth differentiation factor-8 transgenic mice |
| US6042832A (en) | 1996-08-28 | 2000-03-28 | Thomas Jefferson University | Polypeptides fused with alfalfa mosaic virus or ilarvirus capsid proteins |
| AU6274298A (en) | 1997-02-05 | 1998-08-25 | Johns Hopkins University School Of Medicine, The | Growth differentiation factor-8 |
| CA2279826A1 (en) | 1997-02-05 | 1998-08-13 | Biostar Inc. | Immunization against endogenous molecules |
| US6656475B1 (en) | 1997-08-01 | 2003-12-02 | The Johns Hopkins University School Of Medicine | Growth differentiation factor receptors, agonists and antagonists thereof, and methods of using same |
| GB2333706A (en) | 1998-02-02 | 1999-08-04 | Merck & Co Inc | Method for increasing muscle mass in animals |
| US6369201B1 (en) * | 1998-02-19 | 2002-04-09 | Metamorphix International, Inc. | Myostatin multimers |
| US6004937A (en) | 1998-03-09 | 1999-12-21 | Genetics Institute, Inc. | Use of follistatin to modulate growth and differentiation factor 8 [GDF-8] and bone morphogenic protein 11 [BMP-11] |
| JP4544742B2 (ja) * | 1998-05-06 | 2010-09-15 | メタモーフイクス・インコーポレーテツド | Ｇｄｆ−８の阻害による糖尿病の処置法 |
| US6284882B1 (en) | 1999-06-10 | 2001-09-04 | Abbott Laboratories | Myostatin gene promoter and inhibition of activation thereof |
| TR200400621T2 (tr) * | 1999-07-20 | 2004-08-23 | Pharmexa A/S | GDF-8 aktivitesinin aşağı doğru düzenlenmesi için bir yöntem. |
| US6617440B1 (en) | 1999-07-30 | 2003-09-09 | Pfizer, Inc. | Myostatin regulatory region, nucleotide sequence determination and methods for its use |
| EP1221961A4 (en) | 1999-10-13 | 2004-03-31 | Roswell Park Memorial Inst | INDUCTION OF A STRONG IMMUNE RESPONSE TO A TUMOR-RELATED SELF-ANTIGEN |
| US6730306B1 (en) | 2000-03-08 | 2004-05-04 | Large Scale Biology Corporation | Parvovirus vaccine as viral coat protein fusions |
| US7037501B2 (en) * | 2001-01-04 | 2006-05-02 | Regents Of The University Of Minnesota | Myostatin immnoconjugate |
| US7320789B2 (en) | 2001-09-26 | 2008-01-22 | Wyeth | Antibody inhibitors of GDF-8 and uses thereof |
| MXPA05006113A (es) | 2002-12-11 | 2005-09-30 | Pharmexa As | Epitopos sencillos objetivo. |
| BR0317538A (pt) | 2002-12-20 | 2005-11-29 | Amgen Inc | Agente ligante, sequência de polinucleotìdeo, vetor de expressão, célula hospedeira, composição farmacêutica, e, métodos de inibir a atividade de miostatina, de aumentar a massa muscular magra e a razão de massa muscular magra para gordura, de tratar uma doença de emaciação muscular e um distúrbio metabólico relacionado com miostatina em um indivìduo, de detectar e medir miostatina em uma amostra, e, de diagnosticar um distúrbio relacionado com miostatina em um indivìduo |
| EP1699820A2 (en) * | 2003-12-31 | 2006-09-13 | Schering-Plough Ltd. | Neutralizing epitope-based growth enhancing vaccine |
| US20060281075A1 (en) * | 2004-12-22 | 2006-12-14 | Large Scale Biology Corporation | Purification of viruses, proteins and nucleic acids |
| CA2594276A1 (en) | 2004-12-30 | 2006-07-13 | Schering-Plough Ltd. | Neutralizing epitope-based growth enhancing vaccine |
-
2004
- 2004-12-21 EP EP04815235A patent/EP1699820A2/en not_active Withdrawn
- 2004-12-21 RU RU2006127314/10A patent/RU2422460C2/ru not_active IP Right Cessation
- 2004-12-21 JP JP2006547309A patent/JP2007535912A/ja not_active Withdrawn
- 2004-12-21 BR BRPI0418317-7A patent/BRPI0418317A/pt not_active IP Right Cessation
- 2004-12-21 WO PCT/US2004/043125 patent/WO2005066204A2/en not_active Ceased
- 2004-12-21 SG SG200904421-5A patent/SG153874A1/en unknown
- 2004-12-21 UA UAA200608516A patent/UA93855C2/ru unknown
- 2004-12-21 US US11/019,001 patent/US7371726B2/en not_active Expired - Fee Related
- 2004-12-21 MX MXPA06007514A patent/MXPA06007514A/es active IP Right Grant
- 2004-12-21 NZ NZ547593A patent/NZ547593A/en not_active IP Right Cessation
- 2004-12-21 CA CA002551877A patent/CA2551877A1/en not_active Abandoned
- 2004-12-21 CN CNA2004800395458A patent/CN1902221A/zh active Pending
- 2004-12-21 AU AU2004312411A patent/AU2004312411B8/en not_active Ceased
- 2004-12-21 KR KR1020067013214A patent/KR20060120229A/ko not_active Abandoned
- 2004-12-22 TW TW093140145A patent/TWI357906B/zh not_active IP Right Cessation
- 2004-12-22 AR ARP040104868A patent/AR047345A1/es active IP Right Grant
-
2005
- 2005-01-03 PE PE2005000029A patent/PE20051050A1/es not_active Application Discontinuation
-
2006
- 2006-06-22 IL IL176494A patent/IL176494A0/en unknown
- 2006-06-23 ZA ZA200605227A patent/ZA200605227B/xx unknown
- 2006-06-29 EC EC2006006683A patent/ECSP066683A/es unknown
- 2006-07-28 NO NO20063478A patent/NO20063478L/no not_active Application Discontinuation
-
2008
- 2008-04-02 US US12/061,012 patent/US7585648B2/en not_active Expired - Fee Related
-
2009
- 2009-08-04 US US12/535,298 patent/US7892561B2/en not_active Expired - Fee Related
-
2011
- 2011-01-20 JP JP2011010279A patent/JP2011083290A/ja active Pending
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