JP2011523550A5 - - Google Patents
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- JP2011523550A5 JP2011523550A5 JP2011508949A JP2011508949A JP2011523550A5 JP 2011523550 A5 JP2011523550 A5 JP 2011523550A5 JP 2011508949 A JP2011508949 A JP 2011508949A JP 2011508949 A JP2011508949 A JP 2011508949A JP 2011523550 A5 JP2011523550 A5 JP 2011523550A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- seq
- acid sequence
- acid sequences
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 80
- 150000001413 amino acids Chemical class 0.000 claims 32
- 108090000765 processed proteins & peptides Proteins 0.000 claims 21
- 229920001184 polypeptide Polymers 0.000 claims 20
- 102000004196 processed proteins & peptides Human genes 0.000 claims 20
- 101000922348 Homo sapiens C-X-C chemokine receptor type 4 Proteins 0.000 claims 14
- 102000053523 human CXCR4 Human genes 0.000 claims 14
- 108010003723 Single-Domain Antibodies Proteins 0.000 claims 8
- 102000039446 nucleic acids Human genes 0.000 claims 6
- 108020004707 nucleic acids Proteins 0.000 claims 6
- 150000007523 nucleic acids Chemical class 0.000 claims 6
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 5
- 230000027455 binding Effects 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 101000617130 Homo sapiens Stromal cell-derived factor 1 Proteins 0.000 claims 2
- 102000043525 human CXCL12 Human genes 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 238000012216 screening Methods 0.000 claims 2
- 208000030507 AIDS Diseases 0.000 claims 1
- 235000002198 Annona diversifolia Nutrition 0.000 claims 1
- 108010017384 Blood Proteins Proteins 0.000 claims 1
- 102000004506 Blood Proteins Human genes 0.000 claims 1
- 241000282838 Lama Species 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 230000000903 blocking effect Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000002975 chemoattractant Substances 0.000 claims 1
- 238000012875 competitive assay Methods 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000003599 detergent Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000003053 immunization Effects 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5384708P | 2008-05-16 | 2008-05-16 | |
| US61/053,847 | 2008-05-16 | ||
| US10214208P | 2008-10-02 | 2008-10-02 | |
| US61/102,142 | 2008-10-02 | ||
| PCT/EP2009/056026 WO2009138519A1 (en) | 2008-05-16 | 2009-05-18 | AMINO ACID SEQUENCES DIRECTED AGAINST CXCR4 AND OTHER GPCRs AND COMPOUNDS COMPRISING THE SAME |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011523550A JP2011523550A (ja) | 2011-08-18 |
| JP2011523550A5 true JP2011523550A5 (https=) | 2013-06-13 |
| JP6034023B2 JP6034023B2 (ja) | 2016-11-30 |
Family
ID=40974643
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011508949A Active JP6034023B2 (ja) | 2008-05-16 | 2009-05-18 | Ｃｘｃｒ４及び他のｇｐｃｒに指向性を有するアミノ酸配列及びそれを含む化合物 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US9212226B2 (https=) |
| EP (1) | EP2285833B1 (https=) |
| JP (1) | JP6034023B2 (https=) |
| KR (1) | KR20110020825A (https=) |
| CN (1) | CN102099378B (https=) |
| AU (1) | AU2009248049B2 (https=) |
| BR (1) | BRPI0911984A2 (https=) |
| CA (1) | CA2724208C (https=) |
| IL (1) | IL209176A0 (https=) |
| MX (1) | MX2010012518A (https=) |
| NZ (1) | NZ589036A (https=) |
| RU (1) | RU2010151725A (https=) |
| WO (1) | WO2009138519A1 (https=) |
| ZA (1) | ZA201008180B (https=) |
Families Citing this family (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9512236B2 (en) | 2006-12-19 | 2016-12-06 | Ablynx N.V. | Amino acid sequences directed against GPCRS and polypeptides comprising the same for the treatment of GPCR-related diseases and disorders |
| NZ589036A (en) | 2008-05-16 | 2012-07-27 | Ablynx Nv | AMINO ACID SEQUENCES DIRECTED AGAINST CXCR4 AND OTHER GPCRs AND COMPOUNDS COMPRISING THE SAME |
| EP2352764B1 (en) * | 2008-10-14 | 2018-03-28 | Ablynx N.V. | AMINO ACID SEQUENCES TARGETING HUMAN CD4 and CXCR4, CCR5, TLR4, ALPHAV INTEGRIN, BETA3-INTEGRIN,BETA1-INTEGRIN, HUMAN ALPHA2-INTEGRIN, CD81, SR-BI, CLAUDIN-1, CLAUDIN-6 AND/OR CLAUDIN-9, RESPECTIVELY, AND NEUTRALIZING VIRAL ENTRY |
| EP3470425A3 (en) | 2008-12-19 | 2019-07-17 | Ablynx N.V. | Immunoglobulins against cell-associatd antigens such as p2x7 |
| WO2011042398A1 (en) | 2009-10-09 | 2011-04-14 | Ablynx Nv | Immunoglobulin single variable domain directed against human cxcr4 and other cell associated proteins and methods to generate them |
| WO2011083141A2 (en) * | 2010-01-08 | 2011-07-14 | Ablynx Nv | Method for generation of immunoglobulin sequences by using lipoprotein particles |
| US8937164B2 (en) | 2010-03-26 | 2015-01-20 | Ablynx N.V. | Biological materials related to CXCR7 |
| EP2371863A1 (en) * | 2010-03-30 | 2011-10-05 | Pierre Fabre Médicament | Humanized anti CXCR4 antibodies for the treatment of cancer |
| WO2011161266A1 (en) | 2010-06-25 | 2011-12-29 | Ablynx Nv | Improved immunoglobulin single variable domains and constructs thereof directed against cxcr4 |
| GB201014715D0 (en) | 2010-09-06 | 2010-10-20 | Vib Vzw | Nanobodies stabilizing functional conformational states of GPCRS |
| US11644471B2 (en) * | 2010-09-30 | 2023-05-09 | Ablynx N.V. | Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains |
| EP2621953B1 (en) | 2010-09-30 | 2017-04-05 | Ablynx N.V. | Biological materials related to c-met |
| EA202092589A3 (ru) * | 2010-11-08 | 2021-06-30 | Аблинкс Н.В. | Cxcr2-связывающие полипептиды |
| FR2970781B1 (fr) * | 2011-01-25 | 2013-02-08 | Centre Nat Rech Scient | Procede de fabrication d'un support d'analyse et utilisation pour la detection de toxines |
| CN103917560B (zh) | 2011-03-28 | 2017-05-24 | 埃博灵克斯股份有限公司 | 双特异性抗‑cxcr7免疫球蛋白单可变结构域 |
| UA117218C2 (uk) | 2011-05-05 | 2018-07-10 | Мерк Патент Гмбх | Поліпептид, спрямований проти il-17a, il-17f та/або il17-a/f |
| CN104053667B (zh) * | 2011-06-21 | 2017-09-15 | 非营利性组织佛兰芒综合大学生物技术研究所 | 针对gpcr:g蛋白复合物的结合结构域及来自其的用途 |
| DK2723769T4 (da) | 2011-06-23 | 2022-09-05 | Ablynx Nv | Teknikker til at forudsige, påvise og reducere uspecifik proteininterferens i assays, som involverer variable immunglobulin-enkeltdomæner |
| EP2944653A1 (en) | 2011-06-23 | 2015-11-18 | Ablynx N.V. | Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobin single variable domains |
| DK2974737T3 (da) | 2011-06-23 | 2026-01-19 | Ablynx Nv | Fremgangsmåder til forudsigelse, påvisning og reduktion af en specifik proteininterferens i assays, der involverer variable immunglobulin-enkeltdomæner |
| CN106046168A (zh) | 2011-06-23 | 2016-10-26 | 埃博灵克斯股份有限公司 | 结合血清白蛋白的蛋白 |
| EP2723380B1 (en) | 2011-06-24 | 2019-08-21 | Stephen D. Gillies | Light chain immunoglobulin fusion proteins and methods of use thereof |
| CN103889451B (zh) | 2011-09-30 | 2016-06-29 | 埃博灵克斯股份有限公司 | 与C-Met相关的生物物质 |
| US9346884B2 (en) | 2011-09-30 | 2016-05-24 | Ablynx N.V. | Biological materials related to c-Met |
| KR20160098514A (ko) * | 2011-10-17 | 2016-08-18 | 리제너론 파아마슈티컬스, 인크. | 제한된 면역글로불린 중쇄 마우스 |
| US9328174B2 (en) | 2012-05-09 | 2016-05-03 | Novartis Ag | Chemokine receptor binding polypeptides |
| US11339208B1 (en) | 2012-05-31 | 2022-05-24 | United States Of America As Represented By The Secretary Of The Air Force | Camelidae single-domain antibodies against Yersinia pestis and methods of use |
| CN102993295A (zh) * | 2012-09-29 | 2013-03-27 | 张文彬 | 双峰驼褪黑素受体、编码基因及其获取方法 |
| UY35144A (es) * | 2012-11-20 | 2014-06-30 | Novartis Ag | Miméticos lineales sintéticos de apelina para el tratamiento de insuficiencia cardiaca |
| WO2015026884A1 (en) * | 2013-08-21 | 2015-02-26 | Boehringer Ingelheim International Gmbh | Cx3cr1-targeting imaging agents and their use in the diagnosis and treatment of disease |
| KR20250099289A (ko) * | 2014-05-16 | 2025-07-01 | 아블린쓰 엔.브이. | 개선된 면역글로불린 가변 도메인 |
| ES2900852T3 (es) | 2014-05-16 | 2022-03-18 | Ablynx Nv | Métodos de detección y/o medición de anticuerpos anti-fármaco, en particular anticuerpos anti-fármaco que se presentan durante el tratamiento |
| PL3248986T3 (pl) | 2014-05-16 | 2022-05-16 | Ablynx Nv | Domeny zmienne immunoglobuliny |
| US10273305B2 (en) | 2015-04-02 | 2019-04-30 | Ablynx N.V. | Bispecific CXCR4-CD4 polypeptides with potent anti-HIV activity |
| NO2768984T3 (https=) | 2015-11-12 | 2018-06-09 | ||
| CN115925919A (zh) | 2015-11-13 | 2023-04-07 | 埃博灵克斯股份有限公司 | 改进的血清白蛋白结合免疫球蛋白可变结构域 |
| CN120535622A (zh) | 2015-11-18 | 2025-08-26 | 埃博灵克斯股份有限公司 | 改进的血清白蛋白结合剂 |
| US10544222B2 (en) | 2015-11-18 | 2020-01-28 | Merck Sharp & Dohme Corp. | PD1/CTLA4 binders |
| CR20180279A (es) | 2015-11-18 | 2018-08-24 | Merck Sharp & Dohme | Enlazadores de ctla4 |
| MA43260A (fr) | 2015-11-18 | 2018-09-26 | Merck Sharp & Dohme | Liants pd1 et/ou lag3 |
| JP7540877B2 (ja) | 2016-02-12 | 2024-08-27 | アブリンクス エン．ヴェー． | 免疫グロブリン単一可変ドメインの生成方法 |
| KR102379464B1 (ko) | 2016-06-20 | 2022-03-29 | 키맵 리미티드 | 항-pd-l1 항체 |
| MX2018016413A (es) | 2016-06-23 | 2019-05-09 | Ablynx Nv | Ensayos farmacocineticos mejorados para dominios variables unicos de inmunoglobulina. |
| TWI781108B (zh) | 2016-07-20 | 2022-10-21 | 比利時商健生藥品公司 | 抗ｇｐｒｃ５ｄ抗體、結合ｇｐｒｃ５ｄ與ｃｄ３之雙特異性抗原結合分子及其用途 |
| RU2022101604A (ru) | 2016-12-07 | 2022-03-29 | Аблинкс Нв | Улучшенные отдельные вариабельные домены иммуноглобулина, связывающиеся с сывороточным альбумином |
| SG10202108972RA (en) | 2017-01-17 | 2021-09-29 | Ablynx Nv | Improved serum albumin binders |
| HRP20241501T1 (hr) | 2017-01-17 | 2025-01-03 | Ablynx Nv | Poboljšana veziva albumina u serumu |
| EP3602056A1 (en) | 2017-03-31 | 2020-02-05 | Ablynx N.V. | Improved immunogenicity assays |
| CN111741752A (zh) | 2017-12-19 | 2020-10-02 | Gpcr治疗公司 | Gpcr异聚体抑制剂及其用途 |
| LT3638698T (lt) | 2018-01-26 | 2021-04-12 | Regeneron Pharmaceuticals, Inc. | Antikūnai prieš tmprss2 ir antigeną surišantys fragmentai |
| CN110669137B (zh) * | 2019-10-24 | 2021-07-16 | 高新 | 一种多特异性抗体及其制备方法和用途 |
| MX2022009476A (es) | 2020-02-10 | 2022-08-22 | Regeneron Pharma | Anticuerpos anti-tmprss2 y fragmentos de union a antigeno. |
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| JP2023527352A (ja) | 2020-05-26 | 2023-06-28 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 抗ｓａｒｓ－ｃｏｖ－２－スパイク糖タンパク質抗体及び抗原結合断片 |
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| WO2021254979A1 (en) * | 2020-06-16 | 2021-12-23 | Ludwig-Maximilians-Universität München | Chemokine-selective cxcr4 ectodomain-derived (poly)peptide |
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-
2009
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- 2009-05-18 BR BRPI0911984A patent/BRPI0911984A2/pt not_active IP Right Cessation
- 2009-05-18 RU RU2010151725/10A patent/RU2010151725A/ru not_active Application Discontinuation
- 2009-05-18 CA CA2724208A patent/CA2724208C/en active Active
- 2009-05-18 MX MX2010012518A patent/MX2010012518A/es not_active Application Discontinuation
- 2009-05-18 WO PCT/EP2009/056026 patent/WO2009138519A1/en not_active Ceased
- 2009-05-18 US US12/992,982 patent/US9212226B2/en active Active
- 2009-05-18 EP EP09745851.7A patent/EP2285833B1/en active Active
- 2009-05-18 KR KR1020107028173A patent/KR20110020825A/ko not_active Withdrawn
- 2009-05-18 JP JP2011508949A patent/JP6034023B2/ja active Active
- 2009-05-18 AU AU2009248049A patent/AU2009248049B2/en active Active
- 2009-05-18 CN CN200980127612.4A patent/CN102099378B/zh active Active
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