JP2011523550A5 - - Google Patents
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- JP2011523550A5 JP2011523550A5 JP2011508949A JP2011508949A JP2011523550A5 JP 2011523550 A5 JP2011523550 A5 JP 2011523550A5 JP 2011508949 A JP2011508949 A JP 2011508949A JP 2011508949 A JP2011508949 A JP 2011508949A JP 2011523550 A5 JP2011523550 A5 JP 2011523550A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- seq
- acid sequence
- acid sequences
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 80
- 150000001413 amino acids Chemical class 0.000 claims 32
- 108090000765 processed proteins & peptides Proteins 0.000 claims 21
- 229920001184 polypeptide Polymers 0.000 claims 20
- 102000004196 processed proteins & peptides Human genes 0.000 claims 20
- 101000922348 Homo sapiens C-X-C chemokine receptor type 4 Proteins 0.000 claims 14
- 102000053523 human CXCR4 Human genes 0.000 claims 14
- 108010003723 Single-Domain Antibodies Proteins 0.000 claims 8
- 102000039446 nucleic acids Human genes 0.000 claims 6
- 108020004707 nucleic acids Proteins 0.000 claims 6
- 150000007523 nucleic acids Chemical class 0.000 claims 6
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 5
- 230000027455 binding Effects 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 101000617130 Homo sapiens Stromal cell-derived factor 1 Proteins 0.000 claims 2
- 102000043525 human CXCL12 Human genes 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 238000012216 screening Methods 0.000 claims 2
- 208000030507 AIDS Diseases 0.000 claims 1
- 235000002198 Annona diversifolia Nutrition 0.000 claims 1
- 108010017384 Blood Proteins Proteins 0.000 claims 1
- 102000004506 Blood Proteins Human genes 0.000 claims 1
- 241000282838 Lama Species 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 230000000903 blocking effect Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000002975 chemoattractant Substances 0.000 claims 1
- 238000012875 competitive assay Methods 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000003599 detergent Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000003053 immunization Effects 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5384708P | 2008-05-16 | 2008-05-16 | |
| US61/053,847 | 2008-05-16 | ||
| US10214208P | 2008-10-02 | 2008-10-02 | |
| US61/102,142 | 2008-10-02 | ||
| PCT/EP2009/056026 WO2009138519A1 (en) | 2008-05-16 | 2009-05-18 | AMINO ACID SEQUENCES DIRECTED AGAINST CXCR4 AND OTHER GPCRs AND COMPOUNDS COMPRISING THE SAME |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011523550A JP2011523550A (ja) | 2011-08-18 |
| JP2011523550A5 true JP2011523550A5 (https=) | 2013-06-13 |
| JP6034023B2 JP6034023B2 (ja) | 2016-11-30 |
Family
ID=40974643
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011508949A Active JP6034023B2 (ja) | 2008-05-16 | 2009-05-18 | Ｃｘｃｒ４及び他のｇｐｃｒに指向性を有するアミノ酸配列及びそれを含む化合物 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US9212226B2 (https=) |
| EP (1) | EP2285833B1 (https=) |
| JP (1) | JP6034023B2 (https=) |
| KR (1) | KR20110020825A (https=) |
| CN (1) | CN102099378B (https=) |
| AU (1) | AU2009248049B2 (https=) |
| BR (1) | BRPI0911984A2 (https=) |
| CA (1) | CA2724208C (https=) |
| IL (1) | IL209176A0 (https=) |
| MX (1) | MX2010012518A (https=) |
| NZ (1) | NZ589036A (https=) |
| RU (1) | RU2010151725A (https=) |
| WO (1) | WO2009138519A1 (https=) |
| ZA (1) | ZA201008180B (https=) |
Families Citing this family (80)
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|---|---|---|---|---|
| US9512236B2 (en) | 2006-12-19 | 2016-12-06 | Ablynx N.V. | Amino acid sequences directed against GPCRS and polypeptides comprising the same for the treatment of GPCR-related diseases and disorders |
| EP2285833B1 (en) | 2008-05-16 | 2014-12-17 | Ablynx N.V. | AMINO ACID SEQUENCES DIRECTED AGAINST CXCR4 AND OTHER GPCRs AND COMPOUNDS COMPRISING THE SAME |
| US9005963B2 (en) * | 2008-10-14 | 2015-04-14 | Ablynx N.V. | Amino acid sequences directed against cellular receptors for viruses and bacteria |
| CN102257003B (zh) | 2008-12-19 | 2017-04-05 | 埃博灵克斯股份有限公司 | 用于产生针对细胞相关抗原如p2x7、cxcr7或cxcr4的免疫球蛋白的基因免疫 |
| WO2011042398A1 (en) | 2009-10-09 | 2011-04-14 | Ablynx Nv | Immunoglobulin single variable domain directed against human cxcr4 and other cell associated proteins and methods to generate them |
| WO2011083140A1 (en) | 2010-01-08 | 2011-07-14 | Ablynx Nv | Immunoglobulin single variable domain directed against human cxcr4 |
| WO2011117423A1 (en) | 2010-03-26 | 2011-09-29 | Ablynx N.V. | Immunoglobulin single variable domains directed against cxcr7 |
| EP2371863A1 (en) * | 2010-03-30 | 2011-10-05 | Pierre Fabre Médicament | Humanized anti CXCR4 antibodies for the treatment of cancer |
| WO2011161266A1 (en) | 2010-06-25 | 2011-12-29 | Ablynx Nv | Improved immunoglobulin single variable domains and constructs thereof directed against cxcr4 |
| GB201014715D0 (en) | 2010-09-06 | 2010-10-20 | Vib Vzw | Nanobodies stabilizing functional conformational states of GPCRS |
| US11644471B2 (en) * | 2010-09-30 | 2023-05-09 | Ablynx N.V. | Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains |
| EP2621953B1 (en) | 2010-09-30 | 2017-04-05 | Ablynx N.V. | Biological materials related to c-met |
| AU2011328246B2 (en) * | 2010-11-08 | 2016-06-30 | Ablynx N.V. | CXCR2 binding polypeptides |
| FR2970781B1 (fr) * | 2011-01-25 | 2013-02-08 | Centre Nat Rech Scient | Procede de fabrication d'un support d'analyse et utilisation pour la detection de toxines |
| CN103917560B (zh) | 2011-03-28 | 2017-05-24 | 埃博灵克斯股份有限公司 | 双特异性抗‑cxcr7免疫球蛋白单可变结构域 |
| UA117218C2 (uk) * | 2011-05-05 | 2018-07-10 | Мерк Патент Гмбх | Поліпептид, спрямований проти il-17a, il-17f та/або il17-a/f |
| EP4350345A3 (en) | 2011-06-23 | 2024-07-24 | Ablynx N.V. | Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobin single variable domains |
| SG10201805064SA (en) | 2011-06-23 | 2018-07-30 | Ablynx Nv | Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains |
| RS55775B2 (sr) | 2011-06-23 | 2022-10-31 | Ablynx Nv | Tehnike za predviđanje, otkrivanje i smanjenje nespecifične proteinske interferencije u testovima koji uključuju pojedinačne varijabilne domene imunoglobulina |
| EP2723771B1 (en) | 2011-06-23 | 2019-09-11 | Ablynx NV | Serum albumin binding proteins |
| EP2723380B1 (en) | 2011-06-24 | 2019-08-21 | Stephen D. Gillies | Light chain immunoglobulin fusion proteins and methods of use thereof |
| NO2723764T3 (https=) * | 2011-09-15 | 2018-05-26 | ||
| JP6219287B2 (ja) | 2011-09-30 | 2017-10-25 | アブリンクス エン．ヴェー． | ｃ−Ｍｅｔに関連する生物学的物質 |
| US9346884B2 (en) | 2011-09-30 | 2016-05-24 | Ablynx N.V. | Biological materials related to c-Met |
| SG11201401181YA (en) * | 2011-10-17 | 2014-04-28 | Regeneron Pharma | Restricted immunoglobulin heavy chain mice |
| US9328174B2 (en) * | 2012-05-09 | 2016-05-03 | Novartis Ag | Chemokine receptor binding polypeptides |
| US11339208B1 (en) | 2012-05-31 | 2022-05-24 | United States Of America As Represented By The Secretary Of The Air Force | Camelidae single-domain antibodies against Yersinia pestis and methods of use |
| CN102993295A (zh) * | 2012-09-29 | 2013-03-27 | 张文彬 | 双峰驼褪黑素受体、编码基因及其获取方法 |
| UY35144A (es) | 2012-11-20 | 2014-06-30 | Novartis Ag | Miméticos lineales sintéticos de apelina para el tratamiento de insuficiencia cardiaca |
| EP3035970A1 (en) * | 2013-08-21 | 2016-06-29 | Boehringer Ingelheim International GmbH | Cx3cr1-targeting imaging agents and their use in the diagnosis and treatment of disease |
| US11009511B2 (en) | 2014-05-16 | 2021-05-18 | Ablynx N.V. | Methods for detecting and/or measuring anti-drug antibodies, in particular treatment-emergent anti-drug antibodies |
| EP4707303A2 (en) | 2014-05-16 | 2026-03-11 | Ablynx NV | Improved immunoglobulin variable domains |
| IL318433A (en) * | 2014-05-16 | 2025-03-01 | Ablynx Nv | Improved immunoglobulin variable complexes |
| ES3029413T3 (en) | 2015-04-02 | 2025-06-24 | Ablynx Nv | Bispecific cxcr4-cd-4 polypeptides with potent anti-hiv activity |
| NO2768984T3 (https=) | 2015-11-12 | 2018-06-09 | ||
| LT3374392T (lt) | 2015-11-13 | 2022-01-25 | Ablynx Nv | Patobulinti serumo albuminą surišantys imunoglobulino kintami domenai |
| IL300122A (en) | 2015-11-18 | 2023-03-01 | Merck Sharp ַ& Dohme Llc | Substances that bind to PD1 and/or LAG3 |
| AU2016355569B2 (en) | 2015-11-18 | 2020-01-02 | Merck Sharp & Dohme Llc | CTLA4 binders |
| AU2016357460B2 (en) | 2015-11-18 | 2023-07-27 | Ablynx Nv | Improved serum albumin binders |
| CA3003777A1 (en) | 2015-11-18 | 2017-05-26 | Merck Sharp & Dohme Corp. | Pd1/ctla4 binders |
| JP7540877B2 (ja) | 2016-02-12 | 2024-08-27 | アブリンクス エン．ヴェー． | 免疫グロブリン単一可変ドメインの生成方法 |
| RU2769282C2 (ru) | 2016-06-20 | 2022-03-30 | Кимаб Лимитед | Анти-PD-L1 и IL-2 цитокины |
| AU2017281421B2 (en) | 2016-06-23 | 2024-07-25 | Ablynx N.V. | Improved pharmacokinetic assays for immunoglobulin single variable domains |
| TWI781108B (zh) | 2016-07-20 | 2022-10-21 | 比利時商健生藥品公司 | 抗ｇｐｒｃ５ｄ抗體、結合ｇｐｒｃ５ｄ與ｃｄ３之雙特異性抗原結合分子及其用途 |
| RU2022101604A (ru) | 2016-12-07 | 2022-03-29 | Аблинкс Нв | Улучшенные отдельные вариабельные домены иммуноглобулина, связывающиеся с сывороточным альбумином |
| JP7219220B2 (ja) | 2017-01-17 | 2023-02-07 | アブリンクス エン．ヴェー． | 改善された血清アルブミン結合剤 |
| IL267897B2 (en) | 2017-01-17 | 2025-02-01 | Ablynx Nv | Improved serum albumin binders |
| US12480957B2 (en) | 2017-03-31 | 2025-11-25 | Ablynx N.V. | Method of screening for anti-drug antibodies against immunoglobulin single variable domain-based drugs |
| EP3727371A4 (en) | 2017-12-19 | 2021-10-27 | GPCR Therapeutics, Inc. | GPCR HETEROMER INHIBITORS AND THEIR USES |
| CN111936517B (zh) | 2018-01-26 | 2025-04-18 | 瑞泽恩制药公司 | 抗tmprss2抗体和抗原结合片段 |
| CN110669137B (zh) | 2019-10-24 | 2021-07-16 | 高新 | 一种多特异性抗体及其制备方法和用途 |
| MX2022009476A (es) | 2020-02-10 | 2022-08-22 | Regeneron Pharma | Anticuerpos anti-tmprss2 y fragmentos de union a antigeno. |
| KR20250107297A (ko) | 2020-04-02 | 2025-07-11 | 리제너론 파아마슈티컬스, 인크. | 항-sars-cov-2 스파이크 당단백질 항체 및 항원-결합 단편 |
| MX2022014598A (es) | 2020-05-26 | 2023-03-31 | Regeneron Pharma | Anticuerpos anti-glicoproteína espicular sars-cov-2 y fragmentos de unión al antígeno. |
| CN111596070B (zh) * | 2020-06-10 | 2023-05-12 | 宁波大学 | 一种三疣梭子蟹原肌球蛋白过敏检测试剂的应用 |
| CA3181741A1 (en) * | 2020-06-16 | 2021-12-23 | Jurgen Bernhagen | Chemokine-selective cxcr4 ectodomain-derived (poly)peptide |
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-
2009
- 2009-05-18 EP EP09745851.7A patent/EP2285833B1/en active Active
- 2009-05-18 WO PCT/EP2009/056026 patent/WO2009138519A1/en not_active Ceased
- 2009-05-18 BR BRPI0911984A patent/BRPI0911984A2/pt not_active IP Right Cessation
- 2009-05-18 AU AU2009248049A patent/AU2009248049B2/en active Active
- 2009-05-18 CN CN200980127612.4A patent/CN102099378B/zh active Active
- 2009-05-18 NZ NZ589036A patent/NZ589036A/en not_active IP Right Cessation
- 2009-05-18 CA CA2724208A patent/CA2724208C/en active Active
- 2009-05-18 MX MX2010012518A patent/MX2010012518A/es not_active Application Discontinuation
- 2009-05-18 RU RU2010151725/10A patent/RU2010151725A/ru not_active Application Discontinuation
- 2009-05-18 KR KR1020107028173A patent/KR20110020825A/ko not_active Withdrawn
- 2009-05-18 US US12/992,982 patent/US9212226B2/en active Active
- 2009-05-18 JP JP2011508949A patent/JP6034023B2/ja active Active
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2010
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- 2010-11-15 ZA ZA2010/08180A patent/ZA201008180B/en unknown
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