JP2011521662A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2011521662A5 JP2011521662A5 JP2011512149A JP2011512149A JP2011521662A5 JP 2011521662 A5 JP2011521662 A5 JP 2011521662A5 JP 2011512149 A JP2011512149 A JP 2011512149A JP 2011512149 A JP2011512149 A JP 2011512149A JP 2011521662 A5 JP2011521662 A5 JP 2011521662A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- amino acid
- compound
- construct
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 81
- 102000004196 processed proteins & peptides Human genes 0.000 claims 81
- 229920001184 polypeptide Polymers 0.000 claims 80
- 125000003275 alpha amino acid group Chemical group 0.000 claims 39
- 150000001875 compounds Chemical class 0.000 claims 39
- 150000001413 amino acids Chemical class 0.000 claims 11
- 239000000203 mixture Substances 0.000 claims 11
- 239000008194 pharmaceutical composition Substances 0.000 claims 10
- 241000700605 Viruses Species 0.000 claims 9
- 101710091045 Envelope protein Proteins 0.000 claims 8
- 102100034349 Integrase Human genes 0.000 claims 8
- 101710188315 Protein X Proteins 0.000 claims 8
- 108010003723 Single-Domain Antibodies Proteins 0.000 claims 8
- 230000003612 virological effect Effects 0.000 claims 8
- 230000000890 antigenic effect Effects 0.000 claims 7
- 102000039446 nucleic acids Human genes 0.000 claims 7
- 108020004707 nucleic acids Proteins 0.000 claims 7
- 150000007523 nucleic acids Chemical class 0.000 claims 7
- 239000004480 active ingredient Substances 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 108010003533 Viral Envelope Proteins Proteins 0.000 claims 5
- 239000003795 chemical substances by application Substances 0.000 claims 5
- 239000002773 nucleotide Substances 0.000 claims 5
- 125000003729 nucleotide group Chemical group 0.000 claims 5
- 108010068327 4-hydroxyphenylpyruvate dioxygenase Proteins 0.000 claims 4
- 108070000030 Viral receptors Proteins 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 230000001404 mediated effect Effects 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 108010017384 Blood Proteins Proteins 0.000 claims 3
- 102000004506 Blood Proteins Human genes 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 230000002265 prevention Effects 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 102100035360 Cerebellar degeneration-related antigen 1 Human genes 0.000 claims 2
- 102000008100 Human Serum Albumin Human genes 0.000 claims 2
- 108091006905 Human Serum Albumin Proteins 0.000 claims 2
- 239000000443 aerosol Substances 0.000 claims 2
- 230000004071 biological effect Effects 0.000 claims 2
- 230000008236 biological pathway Effects 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 230000009545 invasion Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000003472 neutralizing effect Effects 0.000 claims 2
- 230000000144 pharmacologic effect Effects 0.000 claims 2
- 210000004879 pulmonary tissue Anatomy 0.000 claims 2
- 230000029812 viral genome replication Effects 0.000 claims 2
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 1
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229940112141 dry powder inhaler Drugs 0.000 claims 1
- 230000001747 exhibiting effect Effects 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 239000011859 microparticle Substances 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 230000002685 pulmonary effect Effects 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5905508P | 2008-06-05 | 2008-06-05 | |
| US61/059,055 | 2008-06-05 | ||
| US9299108P | 2008-08-29 | 2008-08-29 | |
| US61/092,991 | 2008-08-29 | ||
| US13913008P | 2008-12-19 | 2008-12-19 | |
| US61/139,130 | 2008-12-19 | ||
| US14465309P | 2009-01-14 | 2009-01-14 | |
| US61/144,653 | 2009-01-14 | ||
| US17291409P | 2009-04-27 | 2009-04-27 | |
| US61/172,914 | 2009-04-27 | ||
| US17410809P | 2009-04-30 | 2009-04-30 | |
| US61/174,108 | 2009-04-30 | ||
| PCT/EP2009/056975 WO2009147248A2 (en) | 2008-06-05 | 2009-06-05 | Amino acid sequences directed against envelope proteins of a virus and polypeptides comprising the same for the treatment of viral diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015093215A Division JP2015156867A (ja) | 2008-06-05 | 2015-04-30 | ウイルスのエンベロープタンパク質に指向性を有するアミノ酸配列、及びウイルス疾患の治療のためのこれを含むポリペプチド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011521662A JP2011521662A (ja) | 2011-07-28 |
| JP2011521662A5 true JP2011521662A5 (https=) | 2012-06-28 |
| JP5809557B2 JP5809557B2 (ja) | 2015-11-11 |
Family
ID=41055279
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011512149A Expired - Fee Related JP5809557B2 (ja) | 2008-06-05 | 2009-06-05 | ウイルスのエンベロープタンパク質に指向性を有するアミノ酸配列、及びウイルス疾患の治療のためのこれを含むポリペプチド |
| JP2015093215A Pending JP2015156867A (ja) | 2008-06-05 | 2015-04-30 | ウイルスのエンベロープタンパク質に指向性を有するアミノ酸配列、及びウイルス疾患の治療のためのこれを含むポリペプチド |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015093215A Pending JP2015156867A (ja) | 2008-06-05 | 2015-04-30 | ウイルスのエンベロープタンパク質に指向性を有するアミノ酸配列、及びウイルス疾患の治療のためのこれを含むポリペプチド |
Country Status (17)
| Country | Link |
|---|---|
| US (4) | US9193780B2 (https=) |
| EP (2) | EP3424526A1 (https=) |
| JP (2) | JP5809557B2 (https=) |
| CN (1) | CN102112155B (https=) |
| AU (1) | AU2009254501B2 (https=) |
| CA (1) | CA2726652A1 (https=) |
| CY (1) | CY1121687T1 (https=) |
| DK (1) | DK2285408T3 (https=) |
| ES (1) | ES2713864T3 (https=) |
| HR (1) | HRP20182195T1 (https=) |
| HU (1) | HUE042053T2 (https=) |
| LT (1) | LT2285408T (https=) |
| PL (1) | PL2285408T3 (https=) |
| PT (1) | PT2285408T (https=) |
| SI (1) | SI2285408T1 (https=) |
| WO (1) | WO2009147248A2 (https=) |
| ZA (1) | ZA201009135B (https=) |
Families Citing this family (105)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9023352B2 (en) | 2007-02-20 | 2015-05-05 | Tufts University | Methods, compositions and kits for treating a subject using a recombinant heteromultimeric neutralizing binding protein |
| LT2285408T (lt) | 2008-06-05 | 2019-01-25 | Ablynx N.V. | Aminorūgščių sekos, nukreiptos prieš viruso apvalkalo baltymus, ir tokias sekas turintys polipeptidai, skirti virusinių ligų gydymui |
| AU2009324354B2 (en) | 2008-12-10 | 2016-04-14 | Ablynx Nv | Amino acid sequences directed against the Angiopoietin/Tie system and polypeptides comprising the same for the treatment of diseases and disorders related to angiogenesis |
| AU2015200057B9 (en) * | 2009-06-05 | 2017-03-09 | Ablynx Nv | Monovalent, bivalent and trivalent anti human respiratory syncytial virus (hRSV) Nanobody constructs for the prevention and/or treatment of respiratory tract infections |
| PT2438087T (pt) * | 2009-06-05 | 2017-08-04 | Ablynx Nv | Construções de nanobody trivalentes de vírus sincicial respiratório humano (hrsv) para a prevenção e/ou tratamento de infeções do trato respiratório |
| WO2011064382A1 (en) | 2009-11-30 | 2011-06-03 | Ablynx N.V. | Improved amino acid sequences directed against human respiratory syncytial virus (hrsv) and polypeptides comprising the same for the prevention and/or treatment of respiratory tract infections |
| DK2533761T3 (da) | 2010-02-11 | 2019-06-24 | Ablynx Nv | Fremgangsmåder og sammensætninger til fremstilling af aerosoler |
| GB201014715D0 (en) * | 2010-09-06 | 2010-10-20 | Vib Vzw | Nanobodies stabilizing functional conformational states of GPCRS |
| EP2621953B1 (en) | 2010-09-30 | 2017-04-05 | Ablynx N.V. | Biological materials related to c-met |
| US11644471B2 (en) | 2010-09-30 | 2023-05-09 | Ablynx N.V. | Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains |
| UY33826A (es) * | 2010-12-22 | 2012-07-31 | Abbott Lab | Proteínas de unión con dominios trivariables y sus usos |
| US9527925B2 (en) | 2011-04-01 | 2016-12-27 | Boehringer Ingelheim International Gmbh | Bispecific binding molecules binding to VEGF and ANG2 |
| EP2723772A1 (en) | 2011-06-23 | 2014-04-30 | Ablynx N.V. | Immunoglobulin single variable domains directed against ige |
| EP2723771B1 (en) | 2011-06-23 | 2019-09-11 | Ablynx NV | Serum albumin binding proteins |
| SG10201805064SA (en) | 2011-06-23 | 2018-07-30 | Ablynx Nv | Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains |
| CA2880791A1 (en) * | 2011-08-03 | 2013-02-07 | Children's Medical Center Corporation | A broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza hemagglutinin |
| US9346884B2 (en) | 2011-09-30 | 2016-05-24 | Ablynx N.V. | Biological materials related to c-Met |
| PH12021553014A1 (en) | 2012-02-27 | 2022-09-05 | Ablynx Nv | Cx3cr1-binding polypeptides |
| SI2831111T1 (sl) * | 2012-03-30 | 2019-06-28 | Boehringer Ingelheim International Gmbh | Ang2-vezavne molekule |
| US9969794B2 (en) | 2012-05-10 | 2018-05-15 | Visterra, Inc. | HA binding agents |
| US11339208B1 (en) | 2012-05-31 | 2022-05-24 | United States Of America As Represented By The Secretary Of The Air Force | Camelidae single-domain antibodies against Yersinia pestis and methods of use |
| WO2014087010A1 (en) | 2012-12-07 | 2014-06-12 | Ablynx N.V. | IMPROVED POLYPEPTIDES DIRECTED AGAINST IgE |
| US9624272B2 (en) | 2013-03-14 | 2017-04-18 | University Of Washington Through Its Center For Commercialization | Polypeptides for treating and/or limiting influenza infection |
| PL2970449T3 (pl) * | 2013-03-15 | 2020-04-30 | Amgen Research (Munich) Gmbh | Jednołańcuchowe cząsteczki wiążące zawierające N-końcowy ABP |
| JP2016522168A (ja) * | 2013-04-05 | 2016-07-28 | ジェネンテック， インコーポレイテッド | 抗ｉｌ−４抗体及び二重特異性抗体及びその使用 |
| EP3035970A1 (en) * | 2013-08-21 | 2016-06-29 | Boehringer Ingelheim International GmbH | Cx3cr1-targeting imaging agents and their use in the diagnosis and treatment of disease |
| KR20160079818A (ko) * | 2013-11-25 | 2016-07-06 | 옥스포드 바이오테라퓨틱스 리미티드 | 암 치료용 항-매트립타제 항체 |
| US10561805B2 (en) * | 2014-10-10 | 2020-02-18 | Ablynx N.V. | Methods of treating RSV infections |
| US11001625B2 (en) | 2014-12-10 | 2021-05-11 | Tufts University | VHH based binding antibodies for anthrax and botulinum toxins and methods of making and using therefor |
| JP7001474B2 (ja) | 2015-01-21 | 2022-01-19 | インヒブルクス，インコーポレイティド | 非免疫原性単一ドメイン抗体 |
| MY186585A (en) | 2015-02-05 | 2021-07-28 | Janssen Vaccines & Prevention Bv | Binding molecules directed against influenza hemagglutinin and uses thereof |
| EP3271391A1 (en) * | 2015-03-20 | 2018-01-24 | Ablynx N.V. | Glycosylated immunoglobulin single variable domains |
| SG11201706840WA (en) | 2015-03-31 | 2017-09-28 | Vhsquared Ltd | Peptide construct having a protease-cleavable linker |
| EP3277706A1 (en) * | 2015-03-31 | 2018-02-07 | VHsquared Limited | Polypeptide comprising an immunoglobulin chain variable domain which binds to clostridium difficile toxin b |
| CA3255406A1 (en) | 2015-03-31 | 2025-07-03 | Sorriso Pharmaceuticals, Inc. | Tnf-alpha binding polypeptides |
| WO2016156468A1 (en) | 2015-03-31 | 2016-10-06 | Vhsquared Limited | Polypeptides |
| US9708412B2 (en) | 2015-05-21 | 2017-07-18 | Harpoon Therapeutics, Inc. | Trispecific binding proteins and methods of use |
| MY192870A (en) | 2015-06-18 | 2022-09-13 | Univ Gent | Immunoglobulin single variable domain antibody against rsv prefusion f protein |
| EP3124042A1 (en) | 2015-07-28 | 2017-02-01 | VIB, vzw | Immunoglobulin single variable domain antibody against rsv prefusion f protein |
| CA2991634C (en) * | 2015-07-16 | 2026-03-17 | Inhibrx Biosciences, Inc. | Multivalent and multispecific dr5-binding fusion proteins |
| JP2017036258A (ja) * | 2015-08-07 | 2017-02-16 | パナソニックＩｐマネジメント株式会社 | インフルエンザウィルスに結合する抗体 |
| US10538557B2 (en) * | 2015-09-02 | 2020-01-21 | Janssen Vaccines & Prevention B.V. | Stabilized viral class I fusion proteins |
| EP3374390A1 (en) | 2015-11-13 | 2018-09-19 | Visterra, Inc. | Compositions and methods for treating and preventing influenza |
| AU2017222564A1 (en) | 2016-02-24 | 2018-09-06 | Visterra, Inc. | Formulations of antibody molecules to influenza virus |
| WO2017201493A1 (en) | 2016-05-20 | 2017-11-23 | Harpoon Therapeutics, Inc. | Single chain variable fragment cd3 binding proteins |
| EP3493844A4 (en) | 2016-05-20 | 2021-03-24 | Harpoon Therapeutics Inc. | SINGLE DOMAIN SERUM ALBUMIN BINDING PROTEIN |
| US11623958B2 (en) | 2016-05-20 | 2023-04-11 | Harpoon Therapeutics, Inc. | Single chain variable fragment CD3 binding proteins |
| WO2018098356A1 (en) | 2016-11-23 | 2018-05-31 | Harpoon Therapeutics, Inc. | Psma targeting trispecific proteins and methods of use |
| AU2017363300A1 (en) | 2016-11-23 | 2019-06-20 | Harpoon Therapeutics, Inc. | Prostate specific membrane antigen binding protein |
| US11535668B2 (en) | 2017-02-28 | 2022-12-27 | Harpoon Therapeutics, Inc. | Inducible monovalent antigen binding protein |
| EP3621994A4 (en) | 2017-05-12 | 2020-12-30 | Harpoon Therapeutics, Inc. | MESOTHELIN BINDING PROTEINS |
| WO2018209304A1 (en) * | 2017-05-12 | 2018-11-15 | Harpoon Therapeutics, Inc. | Msln targeting trispecific proteins and methods of use |
| US11505601B2 (en) | 2017-10-11 | 2022-11-22 | Nanjing Legend Biotech Co., Ltd | Compositions and methods using a single-domain antibody binding transferrin and protein A for increasing protein half-life in serum |
| IL315737A (en) | 2017-10-13 | 2024-11-01 | Harpoon Therapeutics Inc | B-cell maturation antigen-binding proteins |
| MX2020003915A (es) | 2017-10-13 | 2020-10-08 | Harpoon Therapeutics Inc | Proteinas trispecificas y metodos de uso. |
| CN112262215B (zh) * | 2018-04-23 | 2025-03-18 | 美国卫生和人力服务部 | 嵌合载体 |
| BR112020023330A2 (pt) | 2018-05-14 | 2021-04-20 | Harpoon Therapeutics, Inc. | porção de ligação para ativação condicional de moléculas de imunoglobulina |
| CN108794626B (zh) * | 2018-06-18 | 2021-10-12 | 上海大学 | 一种多肽以及能靶向HIV包膜蛋白gp120的金纳米抗体 |
| CN108640978A (zh) * | 2018-06-20 | 2018-10-12 | 上海大学 | 特异性结合HIV病毒上蛋白gp120的多肽及其应用 |
| WO2020029860A1 (zh) * | 2018-08-09 | 2020-02-13 | 北京智仁美博生物科技有限公司 | 针对狂犬病病毒的双特异性抗体及其用途 |
| JP7190675B2 (ja) | 2018-08-23 | 2022-12-16 | パナソニックＩｐマネジメント株式会社 | ノロウイルスに結合する抗体、複合体、それを用いた検出装置及び検出方法 |
| JP7190674B2 (ja) | 2018-08-23 | 2022-12-16 | パナソニックＩｐマネジメント株式会社 | ノロウイルスに結合する抗体、複合体、それを用いた検出装置及び検出方法 |
| CN109097341B (zh) * | 2018-08-28 | 2021-09-24 | 青岛农业大学 | 一种同时表达ha和hef的复制缺陷型重组流感病毒 |
| US12195544B2 (en) | 2018-09-21 | 2025-01-14 | Harpoon Therapeutics, Inc. | EGFR binding proteins and methods of use |
| US10815311B2 (en) | 2018-09-25 | 2020-10-27 | Harpoon Therapeutics, Inc. | DLL3 binding proteins and methods of use |
| CA3116292A1 (en) | 2018-10-25 | 2020-04-30 | Km Biologics Co., Ltd. | Modified cmv gb protein and cmv vaccine including same |
| WO2020144164A1 (en) | 2019-01-07 | 2020-07-16 | Bactolife Aps | Pathogen binding proteins |
| US11230593B2 (en) | 2019-03-25 | 2022-01-25 | Visterra, Inc. | Compositions and methods for treating and preventing influenza |
| AU2020275002A1 (en) | 2019-05-14 | 2021-12-23 | Harpoon Therapeutics, Inc. | EpCAM binding proteins and methods of use |
| US12559552B2 (en) | 2019-06-21 | 2026-02-24 | Sorriso Pharmaceuticals, Inc. | IL-23 and TNF-alpha binding bi-specific heavy chain polypeptides |
| KR20220063148A (ko) | 2019-06-21 | 2022-05-17 | 소리소 파마슈티컬스 인크. | 조성물 |
| CA3144567A1 (en) | 2019-06-21 | 2020-12-24 | Scott Crowe | Polypeptides |
| EP4100055A2 (en) * | 2020-02-06 | 2022-12-14 | Vib Vzw | Corona virus binders |
| CN115768463A (zh) | 2020-02-21 | 2023-03-07 | 哈普恩治疗公司 | Flt3结合蛋白及使用方法 |
| CN111393512B (zh) * | 2020-03-24 | 2021-03-02 | 北京中科微盾生物科技有限责任公司 | 一种抑制流感病毒的多肽及其在制备预防和治疗流感病毒感染药物中的应用 |
| JP7512413B2 (ja) * | 2020-03-31 | 2024-07-08 | ビオテウス・インコーポレイテッド | 抗ｐｄ－ｌ１およびｐｄ－ｌ２抗体ならびにその誘導体および用途 |
| CN116194083B (zh) * | 2020-04-20 | 2025-01-24 | 华润生物医药有限公司 | 抗冠状病毒抗体和其用途 |
| US20210330700A1 (en) * | 2020-04-23 | 2021-10-28 | Johnson & Johnson Consumer Inc. | Methods and compositions for inhibiting influenza viruses using low molecular weight hydrophobically modified polymers and polyalkylene glycols |
| AU2021271016A1 (en) * | 2020-05-12 | 2023-01-19 | The Regents Of The University Of California | SARS-CoV2 neutralizing single domain antibody constructs |
| US12077576B2 (en) | 2020-07-02 | 2024-09-03 | Trustees Of Tufts College | VHH polypeptides that bind to Clostridium difficile toxin b and methods of use thereof |
| CA3189896A1 (en) * | 2020-08-19 | 2022-02-24 | Yi Shi | Coronavirus nanobodies and methods for their use and identification |
| WO2022072550A2 (en) * | 2020-09-29 | 2022-04-07 | Academia Sinica | Clec2 fusion protein and uses thereof |
| US20240109963A1 (en) * | 2020-11-16 | 2024-04-04 | Ab Therapeutics, Inc. | Multispecific antibodies and uses thereof |
| CN112851811B (zh) * | 2021-01-28 | 2022-08-09 | 姜国胜 | 一种cd44v6纳米抗体及其作为白血病研究试剂的应用 |
| JP2022165899A (ja) * | 2021-04-20 | 2022-11-01 | 株式会社デンソー | 融合体 |
| CN113234151B (zh) * | 2021-06-08 | 2022-02-15 | 皖南医学院第一附属医院（皖南医学院弋矶山医院） | 一种基于靶向SARS-CoV2病毒S蛋白的三聚体纳米抗体的CAR-NK的研制 |
| US11970548B2 (en) * | 2021-08-27 | 2024-04-30 | Innovative Cellular Therapeutics Holdings, Ltd. | Nanobody target GCC and uses in chimeric antigen receptor cell therapy |
| WO2023039528A1 (en) * | 2021-09-10 | 2023-03-16 | The Board Of Trustees Of The Leland Stanford Junior University | Nanobody-mediated control of gene expression and epigenetic memory |
| WO2023177821A2 (en) * | 2022-03-16 | 2023-09-21 | Myeloid Therapeutics, Inc. | Binding domains and methods of use thereof |
| EP4594348A1 (en) * | 2022-09-27 | 2025-08-06 | Vib Vzw | Antivirals against human parainfluenza virus |
| AR131494A1 (es) | 2022-12-23 | 2025-03-26 | Ablynx Nv | Vehículos de conjugación a base de proteína |
| TW202448926A (zh) | 2023-02-17 | 2024-12-16 | 比利時商艾伯霖克斯公司 | 結合新生兒fc受體之多肽 |
| CN116375852B (zh) * | 2023-03-10 | 2024-02-02 | 华南农业大学 | 重组荧光纳米抗体及其在制备狂犬病病毒检测试剂中的应用 |
| CN116751284B (zh) * | 2023-06-13 | 2024-06-04 | 康元医疗科技(大连)有限公司 | 一种纳米抗体、包含该纳米抗体的多肽及其应用 |
| WO2024259305A1 (en) | 2023-06-14 | 2024-12-19 | The Broad Institute, Inc. | Vhh polypeptides that bind to mesothelin, compositions and methods of use thereof |
| CN116987194B (zh) * | 2023-09-26 | 2023-12-26 | 江西乐成欣生生物技术研究有限责任公司 | 人st2抗原的模拟表位肽的抗独特型纳米抗体及应用 |
| CN117683137B (zh) * | 2023-12-04 | 2024-09-17 | 江苏省农业科学院 | 靶向新城疫病毒和h9亚型禽流感病毒的重组双特异性纳米抗体及其制备方法和应用 |
| TW202543670A (zh) | 2023-12-22 | 2025-11-16 | 比利時商艾伯霖克斯公司 | 用於核內投予之基於蛋白質的接合載劑 |
| CN117843801B (zh) * | 2023-12-29 | 2024-08-02 | 北京贝来药业有限公司 | 以白介素家族成员为靶点的新型抗体以及下游产品 |
| CN117986360B (zh) * | 2024-02-01 | 2024-08-27 | 生物岛实验室 | Il18蛋白的特异性抗体及其制备方法与应用 |
| US20260007757A1 (en) | 2024-06-18 | 2026-01-08 | Ablynx Nv | Antibody-recruiting molecules |
| WO2026060159A1 (en) * | 2024-09-13 | 2026-03-19 | Gilead Sciences, Inc. | Vhhs against hsv and uses of the same |
| WO2026076388A1 (en) | 2024-10-03 | 2026-04-09 | The Broad Institute, Inc. | Vhh polypeptides that bind to claudin-18, compositions and methods of use thereof |
| CN119978135B (zh) * | 2025-01-02 | 2025-11-21 | 生物岛实验室 | Sumo标签蛋白的特异性抗体及其制备方法与应用 |
| CN119462912B (zh) * | 2025-01-15 | 2025-08-19 | 中国人民解放军军事科学院军事医学研究院 | 抗埃博拉病毒vp40蛋白的纳米抗体及在病毒检测中的应用 |
Family Cites Families (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1120945A (en) | 1964-08-11 | 1968-07-24 | Fisons Pharmaceuticals Ltd | Applicator in combination with a pressurised aerosol dispensing container |
| EP0368684B2 (en) | 1988-11-11 | 2004-09-29 | Medical Research Council | Cloning immunoglobulin variable domain sequences. |
| SE509359C2 (sv) | 1989-08-01 | 1999-01-18 | Cemu Bioteknik Ab | Användning av stabiliserade protein- eller peptidkonjugat för framställning av ett läkemedel |
| CA2090126C (en) | 1990-08-02 | 2002-10-22 | John W. Schrader | Methods for the production of proteins with a desired function |
| US5824307A (en) * | 1991-12-23 | 1998-10-20 | Medimmune, Inc. | Human-murine chimeric antibodies against respiratory syncytial virus |
| EP0640130B1 (en) | 1992-05-08 | 1998-04-15 | Creative Biomolecules, Inc. | Chimeric multivalent protein analogues and methods of use thereof |
| US5811524A (en) | 1995-06-07 | 1998-09-22 | Idec Pharmaceuticals Corporation | Neutralizing high affinity human monoclonal antibodies specific to RSV F-protein and methods for their manufacture and therapeutic use thereof |
| US6020182A (en) | 1996-07-12 | 2000-02-01 | Connaught Laboratories Limited | Subunit respiratory syncytial virus vaccine preparation |
| EP0977590A4 (en) | 1996-11-01 | 2001-03-14 | Smithkline Beecham Corp | HUMAN MONOCLONAL ANTIBODIES |
| US7122636B1 (en) * | 1997-02-21 | 2006-10-17 | Genentech, Inc. | Antibody fragment-polymer conjugates and uses of same |
| AU3596599A (en) | 1998-01-26 | 1999-08-09 | Unilever Plc | Method for producing antibody fragments |
| DK1144616T4 (da) | 1999-01-19 | 2009-03-30 | Unilever Nv | Fremgangsmåde til fremstilling af antistoffragmenter |
| CA2370351A1 (en) * | 1999-04-22 | 2000-11-02 | Unilever Plc | Inhibition of viral infection using monovalent antigen-binding proteins |
| US6133571A (en) * | 1999-04-26 | 2000-10-17 | Lockheed Martin Corporation | Resonant cavity field enhancing boundary |
| US7550143B2 (en) * | 2005-04-06 | 2009-06-23 | Ibc Pharmaceuticals, Inc. | Methods for generating stably linked complexes composed of homodimers, homotetramers or dimers of dimers and uses |
| AR030019A1 (es) | 1999-05-18 | 2003-08-13 | Smithkline Beecham Corp | Anticuerpos monoclonales humanos y fragmentos funcionales del mismo, un procedimiento para su produccion, composiciones farmaceuticas que los comprenden, una molecula aislada de acido nucleico, un plasmido recombinante, una celula hospedante y el uso de dichos anticuerpos para la manufactura de un m |
| EP1240337B1 (en) | 1999-12-24 | 2006-08-23 | Genentech, Inc. | Methods and compositions for prolonging elimination half-times of bioactive compounds |
| CA2441903C (en) | 2000-05-26 | 2012-07-31 | National Research Council Of Canada | Single-domain brain-targeting antibody fragments derived from llama antibodies |
| US20030190598A1 (en) | 2000-05-26 | 2003-10-09 | Jasmid Tanha | Single-domain antigen-binding antibody fragments derived from llama antibodies |
| US6818216B2 (en) * | 2000-11-28 | 2004-11-16 | Medimmune, Inc. | Anti-RSV antibodies |
| AU2002335930B2 (en) | 2001-03-09 | 2005-07-28 | Morphosys Ag | Serum albumin binding moieties |
| GB0110029D0 (en) | 2001-04-24 | 2001-06-13 | Grosveld Frank | Transgenic animal |
| US20060073141A1 (en) | 2001-06-28 | 2006-04-06 | Domantis Limited | Compositions and methods for treating inflammatory disorders |
| JP4213586B2 (ja) | 2001-09-13 | 2009-01-21 | 株式会社抗体研究所 | ラクダ抗体ライブラリーの作製方法 |
| JP2005289809A (ja) | 2001-10-24 | 2005-10-20 | Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) | 突然変異重鎖抗体 |
| EP1456410A2 (en) | 2001-12-11 | 2004-09-15 | AlgoNomics N.V. | Method for displaying loops from immunoglobulin domains in different contexts |
| EP1461080A2 (en) * | 2001-12-18 | 2004-09-29 | Innogenetics N.V. | Purified hepatitis c virus envelope proteins for diagnostic and therapeutic use |
| EP1456237A2 (en) | 2001-12-21 | 2004-09-15 | Vlaams Interuniversitair Instituut voor Biotechnologie vzw. | Method for cloning of variable domain sequences |
| AU2003210060B2 (en) | 2002-03-22 | 2010-02-25 | Aprogen, Inc. | Humanized antibody and process for preparing same |
| US7132100B2 (en) | 2002-06-14 | 2006-11-07 | Medimmune, Inc. | Stabilized liquid anti-RSV antibody formulations |
| AU2003244817B2 (en) | 2002-06-28 | 2010-08-26 | Domantis Limited | Antigen-binding immunoglobulin single variable domains and dual-specific constructs |
| GB0228210D0 (en) | 2002-12-03 | 2003-01-08 | Babraham Inst | Single chain antibodies |
| ES2374068T3 (es) | 2002-12-03 | 2012-02-13 | Ucb Pharma, S.A. | Ensayo para identificar células productoras de anticuerpos. |
| WO2004106375A1 (en) * | 2003-05-30 | 2004-12-09 | Merus Biopharmaceuticals B.V. I.O. | Fab library for the preparation of anti vegf and anti rabies virus fabs |
| GB0312481D0 (en) | 2003-05-30 | 2003-07-09 | Celltech R&D Ltd | Antibodies |
| US7070786B2 (en) * | 2003-06-06 | 2006-07-04 | Centocor, Inc. | RSV proteins, antibodies, compositions, methods and uses |
| EP1656128A4 (en) | 2003-08-12 | 2007-02-28 | William M Yarbrough | SINGLE ACNE TREATMENT AND METHOD OF USE |
| ES2385829T3 (es) | 2003-08-20 | 2012-08-01 | Ucb Pharma, S.A. | Métodos para obtener anticuerpos |
| EP1737971B1 (en) * | 2004-01-20 | 2017-08-16 | Merus N.V. | Mixtures of binding proteins |
| EP1720908A2 (en) * | 2004-02-17 | 2006-11-15 | Absalus, Inc. | Super-humanized antibodies against respiratory syncytial virus |
| US7632924B2 (en) * | 2004-06-18 | 2009-12-15 | Ambrx, Inc. | Antigen-binding polypeptides and their uses |
| US20050279676A1 (en) | 2004-06-21 | 2005-12-22 | Izzy Zuhair A | Fluid filter assembly for a dispensing faucet |
| KR101151957B1 (ko) | 2004-07-22 | 2012-06-01 | 로저 킹돈 크레이그 | 결합 분자 |
| US7563443B2 (en) | 2004-09-17 | 2009-07-21 | Domantis Limited | Monovalent anti-CD40L antibody polypeptides and compositions thereof |
| EP1793850A4 (en) | 2004-09-21 | 2010-06-30 | Medimmune Inc | ANTIBODIES TO THE METHOD AND METHOD FOR THE PRODUCTION OF VACCINES AGAINST THE RESPIRATORY SYNCYTIAL VIRUS |
| WO2006040153A2 (en) | 2004-10-13 | 2006-04-20 | Ablynx N.V. | Single domain camelide anti -amyloid beta antibodies and polypeptides comprising the same for the treatment and diagnosis of degenarative neural diseases such as alzheimer's disease |
| WO2006040154A2 (en) | 2004-10-14 | 2006-04-20 | Dublin City University | Prokaryotic two hybrid system |
| TW200636064A (en) | 2004-10-28 | 2006-10-16 | Centocor Inc | Anti-respiratory syncytial virus antibodies, antigens and uses thereof |
| WO2006050166A2 (en) | 2004-10-29 | 2006-05-11 | Medimmune, Inc. | Methods of preventing and treating rsv infections and related conditions |
| AU2005325801A1 (en) | 2005-01-31 | 2006-08-03 | Ablynx N.V. | Method for generating variable domain sequences of heavy chain antibodies |
| CA2604032C (en) | 2005-04-06 | 2017-08-22 | Ibc Pharmaceuticals, Inc. | Methods for generating stably linked complexes composed of homodimers, homotetramers or dimers of dimers and uses |
| JP4976376B2 (ja) * | 2005-04-08 | 2012-07-18 | メディミューン，エルエルシー | 哺乳動物メタニューモウイルスに対する抗体 |
| AU2007237501A1 (en) | 2006-04-14 | 2007-10-25 | Ablynx N.V. | DP-78-like nanobodies |
| EP2040995A1 (en) | 2006-06-26 | 2009-04-01 | Aida Centre, S.L. | Blister package integrating rfid based tags |
| WO2008020079A1 (en) | 2006-08-18 | 2008-02-21 | Ablynx N.V. | Amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of deseases and disorders associated with il-6-mediated signalling |
| CA2667466A1 (en) | 2006-10-27 | 2008-05-02 | Ablynx N.V. | Intranasal delivery of polypeptides and proteins |
| US20080267949A1 (en) | 2006-12-05 | 2008-10-30 | Ablynx N.V. | Peptides capable of binding to serum proteins |
| WO2008077945A2 (en) * | 2006-12-22 | 2008-07-03 | Ablynx N.V. | Anti-chemokine (ccl2, ccl3, ccl5, cxcl11, cxcl12) single-domain antibodies |
| EP2096121A1 (en) * | 2008-02-29 | 2009-09-02 | Institut Pasteur Of Shanghai | Antiviral peptides comprising lipid attachment signals and methods of use |
| LT2285408T (lt) * | 2008-06-05 | 2019-01-25 | Ablynx N.V. | Aminorūgščių sekos, nukreiptos prieš viruso apvalkalo baltymus, ir tokias sekas turintys polipeptidai, skirti virusinių ligų gydymui |
| PT2387583T (pt) | 2009-01-14 | 2018-12-24 | Ablynx Nv | Administração pulmonar de domínios de variável única de imunoglobulina e construtos dos mesmos |
| AU2010243551B2 (en) | 2009-04-30 | 2015-03-26 | Ablynx Nv | Method for the production of domain antibodies |
| PT2438087T (pt) | 2009-06-05 | 2017-08-04 | Ablynx Nv | Construções de nanobody trivalentes de vírus sincicial respiratório humano (hrsv) para a prevenção e/ou tratamento de infeções do trato respiratório |
| WO2011064382A1 (en) * | 2009-11-30 | 2011-06-03 | Ablynx N.V. | Improved amino acid sequences directed against human respiratory syncytial virus (hrsv) and polypeptides comprising the same for the prevention and/or treatment of respiratory tract infections |
-
2009
- 2009-06-05 LT LTEP09757629.2T patent/LT2285408T/lt unknown
- 2009-06-05 CA CA2726652A patent/CA2726652A1/en not_active Abandoned
- 2009-06-05 DK DK09757629.2T patent/DK2285408T3/en active
- 2009-06-05 WO PCT/EP2009/056975 patent/WO2009147248A2/en not_active Ceased
- 2009-06-05 JP JP2011512149A patent/JP5809557B2/ja not_active Expired - Fee Related
- 2009-06-05 CN CN200980130125.3A patent/CN102112155B/zh not_active Expired - Fee Related
- 2009-06-05 PT PT09757629T patent/PT2285408T/pt unknown
- 2009-06-05 HU HUE09757629A patent/HUE042053T2/hu unknown
- 2009-06-05 SI SI200931914T patent/SI2285408T1/sl unknown
- 2009-06-05 EP EP18189511.1A patent/EP3424526A1/en not_active Withdrawn
- 2009-06-05 AU AU2009254501A patent/AU2009254501B2/en not_active Ceased
- 2009-06-05 US US12/996,074 patent/US9193780B2/en active Active
- 2009-06-05 PL PL09757629T patent/PL2285408T3/pl unknown
- 2009-06-05 HR HRP20182195TT patent/HRP20182195T1/hr unknown
- 2009-06-05 ES ES09757629T patent/ES2713864T3/es active Active
- 2009-06-05 EP EP09757629.2A patent/EP2285408B1/en active Active
-
2010
- 2010-12-20 ZA ZA2010/09135A patent/ZA201009135B/en unknown
-
2015
- 2015-04-30 JP JP2015093215A patent/JP2015156867A/ja active Pending
- 2015-10-29 US US14/926,381 patent/US9834595B2/en active Active
-
2017
- 2017-10-17 US US15/785,604 patent/US10550174B2/en active Active
-
2019
- 2019-01-15 CY CY20191100039T patent/CY1121687T1/el unknown
- 2019-08-01 US US16/528,837 patent/US11518799B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2011521662A5 (https=) | ||
| JP7453206B2 (ja) | 改良された血清アルブミン結合剤 | |
| EP3048115B1 (en) | Monoclonal antibodies for ebola and marburg viruses | |
| JP2018537966A (ja) | Ｈｉｖ感染症の予防または処置のための三重特異性および／または三価結合タンパク質 | |
| Bessalah et al. | Perspective on therapeutic and diagnostic potential of camel nanobodies for coronavirus disease-19 (COVID-19) | |
| JP2012518425A5 (https=) | ||
| JP2016524592A5 (https=) | ||
| CN103483421A (zh) | 用于治疗hbv感染及相关疾病的多肽及抗体 | |
| WO2020173460A1 (zh) | 抗呼吸道合胞病毒的全人广谱中和抗体4f1及其应用 | |
| CN116813758B (zh) | 纳米抗体s43的构建体及其应用 | |
| US20240409620A1 (en) | Design and application of fully human antibody for neutralizing respiratory syncytial virus | |
| JP2021063092A (ja) | Ｂ型肝炎表面抗原に対する抗体及びその使用 | |
| TW200825103A (en) | Novel polypeptides and uses thereof | |
| WO2018184593A1 (zh) | 用于治疗乙肝感染及相关疾病的抗体 | |
| CN116813757B (zh) | 纳米抗体r14的构建体及其应用 | |
| CN102333789B (zh) | 抗单纯疱疹病毒抗体及其使用方法 | |
| WO2023040835A1 (zh) | 一株羊驼源纳米抗体及其应用 | |
| CN112390884B (zh) | Semaphorin7A单克隆抗体及其在制备用于治疗炎症疾病药物方面的应用 | |
| WO2023040834A1 (zh) | 一株羊驼源纳米抗体及其应用 | |
| KR20110071139A (ko) | Ｄｃｓｉｇｎ에 대한 결합 특이성을 갖는 리간드 | |
| US20240358817A1 (en) | Structures of langya virus fusion protein ectodomain and immunogenic compositions derived therefrom | |
| CN108191973B (zh) | 一种靶向埃博拉病毒囊膜蛋白的高亲和力单域抗体及其制备方法与应用 | |
| CN111196848A (zh) | 抗流感病毒的全人中和性抗体26Ab及其应用 | |
| TW202411246A (zh) | 經工程化之b型肝炎病毒中和抗體及其用途 | |
| CN116457370A (zh) | 包含抗原和其醣工程化抗体的免疫组合物 |